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  1. Article ; Online: Updates in Pathology for Retroperitoneal Soft Tissue Sarcoma.

    Mack, Tanner / Purgina, Bibianna

    Current oncology (Toronto, Ont.)

    2022  Volume 29, Issue 9, Page(s) 6400–6418

    Abstract: Retroperitoneal tumors are extremely rare. More than 70% of primary retroperitoneal soft tissue tumors are malignant. The most common sarcomas in the retroperitoneum include liposarcomas and leiomyosarcoma, however other sarcomas, along with benign ... ...

    Abstract Retroperitoneal tumors are extremely rare. More than 70% of primary retroperitoneal soft tissue tumors are malignant. The most common sarcomas in the retroperitoneum include liposarcomas and leiomyosarcoma, however other sarcomas, along with benign mesenchymal tumors, can occur. Sarcomas are a heterogenous group of tumors with overlapping microscopic features, posing a diagnostic challenge for the pathologist. Correct tumor classification has become important for prognostication and the evolving targeted therapies for sarcoma subtypes. In this review, the pathology of retroperitoneal soft tissue sarcomas is discussed, which is important to the surgical oncologist. In addition, less common sarcomas and benign mesenchymal tumors of the retroperitoneum, which may mimic sarcoma clinically and pathologically, are also discussed.
    MeSH term(s) Humans ; Leiomyosarcoma/pathology ; Liposarcoma/pathology ; Retroperitoneal Neoplasms/pathology ; Sarcoma/pathology ; Soft Tissue Neoplasms
    Language English
    Publishing date 2022-09-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol29090504
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Glial Fibrillary Acidic Protein Expression Helps Distinguish Pleomorphic Adenoma from Histologic Mimics.

    Gorski, Zuzanna / Purgina, Bibianna / Wasserman, Jason K

    Head and neck pathology

    2022  Volume 16, Issue 3, Page(s) 695–702

    Abstract: Pleomorphic adenoma (PA) is the most common biphasic type of salivary gland tumour to arise in adults. It is a biphasic tumour composed of both luminal (ductal) cells and abluminal (basal and myoepithelial) cells. Other biphasic salivary gland type ... ...

    Abstract Pleomorphic adenoma (PA) is the most common biphasic type of salivary gland tumour to arise in adults. It is a biphasic tumour composed of both luminal (ductal) cells and abluminal (basal and myoepithelial) cells. Other biphasic salivary gland type tumours, both benign and malignant, can mimic PA, especially on small biopsies. Previous studies have shown that glial fibrillary acidic protein (GFAP) is preferentially expressed in PA and can be useful in the distinction from other salivary gland tumours. However, most of these studies were performed on a small subset of tumour types at a time when the classification of salivary gland type tumours was less refined. The purpose of this study was to assess the expression of glial fibrillary acidic protein (GFAP) in a broad group of both benign and malignant salivary gland tumours. The expression of GFAP was assessed in 99 tumours including 54 PAs, 5 basal cell adenomas, 1 myoepitheliomas, 5 adenoid cystic carcinomas, 6 epithelial-myoepithelial carcinomas (EMCA), 6 mucoepidermoid carcinomas, 7 salivary duct carcinomas, 1 adenocarcinomas NOS, 2 myoepithelial carcinomas, 4 basal cell adenocarcinomas, 5 acinic cell carcinomas and 3 polymorphous adenocarcinomas. Of the malignant cases, 8 were classified as carcinomas ex PA. GFAP was also assessed in 19 concurrent biopsy specimens. GFAP was expressed in the resections of 51 PAs examined (94%). Expression was predominantly strong and diffusely seen in myoepithelial cells. Strong and diffuse GFAP expression was also seen in two EMCAs (33%) and one myoepithelial carcinoma (50%). On biopsy specimens, 100% of PAs and basal cell adenomas expressed GFAP. GFAP was also seen in 1 out of 3 carcinomas ex PAs on biopsies. Almost all PAs show strong and diffuse expression of GFAP. In contrast, most malignant neoplasms that can mimic PA on biopsies show only rare, focal expression. Other benign tumours composed of abluminal/myoepithelial cells also show focal expression of GFAP, highlighting the spectrum these tumours share with PA. Overall, the presence of strong and diffuse GFAP expression can favour a benign neoplasm, specifically a PA, on limited biopsy specimens.
    MeSH term(s) Adenoma ; Adenoma, Pleomorphic ; Adult ; Biomarkers, Tumor ; Carcinoma ; Carcinoma, Acinar Cell ; Glial Fibrillary Acidic Protein ; Humans ; Immunohistochemistry ; Myoepithelioma ; Salivary Gland Neoplasms
    Chemical Substances Biomarkers, Tumor ; Glial Fibrillary Acidic Protein
    Language English
    Publishing date 2022-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2407834-7
    ISSN 1936-0568 ; 1936-055X
    ISSN (online) 1936-0568
    ISSN 1936-055X
    DOI 10.1007/s12105-021-01409-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Vertebral Ischemic Necrosis in Diabetic Lumbosacral Radiculoplexus Neuropathy.

    Breiner, Ari / Nguyen, Thanh B / Purgina, Bibianna / Bourque, Pierre R

    Diabetes care

    2021  Volume 44, Issue 3, Page(s) e53–e54

    MeSH term(s) Diabetes Mellitus ; Diabetic Neuropathies/diagnosis ; Humans ; Necrosis
    Language English
    Publishing date 2021-01-21
    Publishing country United States
    Document type Letter
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc20-2787
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mammary-type myofibroblastoma of the thigh mimicking liposarcoma.

    Akhlaq, Natasha / Purgina, Bibianna / Werier, Joel / Jibri, Zaid

    Skeletal radiology

    2021  Volume 51, Issue 2, Page(s) 441–445

    Abstract: Myofibroblastoma is a rare tumor that was originally described in the breast but has since been found in extra-mammary locations, where it been renamed mammary-type myofibroblastoma (MTM). We describe a case of MTM occurring in the anterior compartment ... ...

    Abstract Myofibroblastoma is a rare tumor that was originally described in the breast but has since been found in extra-mammary locations, where it been renamed mammary-type myofibroblastoma (MTM). We describe a case of MTM occurring in the anterior compartment of the thigh, which was initially interpreted as a possible a liposarcoma on MRI. Two subsequent biopsy samples and eventual excision revealed the tumor to have the characteristic pathology of MTM. This benign tumor, albeit rare, needs to be considered in the imaging differential diagnosis of fat containing deep soft tissue masses of the extremity.
    MeSH term(s) Diagnosis, Differential ; Humans ; Liposarcoma/diagnostic imaging ; Magnetic Resonance Imaging ; Neoplasms, Muscle Tissue/diagnostic imaging ; Neoplasms, Muscle Tissue/surgery ; Thigh/diagnostic imaging
    Language English
    Publishing date 2021-08-25
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 527592-1
    ISSN 1432-2161 ; 0364-2348
    ISSN (online) 1432-2161
    ISSN 0364-2348
    DOI 10.1007/s00256-021-03891-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Paraneoplastic manifestations of salivary gland tumours: A case report and review.

    Nasser, Abdullah / Purgina, Bibianna / Laurie, Scott

    Oral oncology

    2020  Volume 103, Page(s) 104582

    Abstract: Salivary gland cancers are an uncommon and heterogenous group of malignancies, accounting for approximately 3% of head and neck tumors. We describe a case of a patient who presented with paraneoplastic Cushing's syndrome secondary to metastatic salivary ... ...

    Abstract Salivary gland cancers are an uncommon and heterogenous group of malignancies, accounting for approximately 3% of head and neck tumors. We describe a case of a patient who presented with paraneoplastic Cushing's syndrome secondary to metastatic salivary ductal carcinoma (SDC). Paraneoplastic ACTH secretion initially responded to chemotherapy with complete resolution of clinical symptoms. To our knowledge, this is the first described case of an ACTH-secreting SDC. We also review other paraneoplastic syndromes (PNS) that have been reported in association with salivary gland cancers.
    MeSH term(s) Adult ; Female ; Humans ; Paraneoplastic Syndromes/etiology ; Paraneoplastic Syndromes/pathology ; Salivary Gland Neoplasms/complications ; Salivary Gland Neoplasms/pathology
    Language English
    Publishing date 2020-02-13
    Publishing country England
    Document type Case Reports ; Letter ; Review
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2020.104582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Subperiosteal chondromyxoid fibroma: a rare case involving the humeral diaphysis.

    Delorme, Jean-Philippe / Purgina, Bibianna / Jibri, Zaid

    Skeletal radiology

    2020  Volume 50, Issue 3, Page(s) 597–602

    Abstract: Initially described, in 1948, as a tumor that could be mistaken with chondrosarcoma at histopathology, chondromyxoid fibroma is now a well-recognized entity. Surface-type chondromyxoid fibroma, however, remains an extremely rare occurrence. We present a ... ...

    Abstract Initially described, in 1948, as a tumor that could be mistaken with chondrosarcoma at histopathology, chondromyxoid fibroma is now a well-recognized entity. Surface-type chondromyxoid fibroma, however, remains an extremely rare occurrence. We present a case of a 55-year-old woman, who experienced right arm pain for 5 years. After unsuccessful treatment for presumed thoracic outlet syndrome, MRI revealed a large mass abutting the anteromedial cortex of the distal humeral diaphysis in a subperiosteal location. Further characterization was made with radiography, CT, and bone scan, which were followed by ultrasound-guided biopsy. Although histopathologic features were suggestive of chondromyxoid fibroma, the diagnosis remained somewhat uncertain initially due to the very unusual location involving the diaphysis of the humerus. Surgical resection was performed, and subsequent histopathologic analysis confirmed the diagnosis of chondromyxoid fibroma. Despite being a rare entity, surface-type chondromyxoid fibroma would need to be considered in the differential when dealing with expansile surface diaphyseal lesions.
    MeSH term(s) Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/surgery ; Chondromatosis ; Diaphyses ; Female ; Fibroma/diagnostic imaging ; Fibroma/surgery ; Humans ; Humerus/diagnostic imaging ; Humerus/surgery ; Middle Aged
    Keywords covid19
    Language English
    Publishing date 2020-08-15
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 527592-1
    ISSN 1432-2161 ; 0364-2348
    ISSN (online) 1432-2161
    ISSN 0364-2348
    DOI 10.1007/s00256-020-03581-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Putting the patient at the centre of pathology: an innovative approach to patient education-MyPathologyReport.ca.

    Lafreniere, Anthea / Purgina, Bibianna / Wasserman, Jason K

    Journal of clinical pathology

    2020  Volume 73, Issue 8, Page(s) 454–455

    Abstract: In many centres, patients now have access to their electronic medical record (EMR) and laboratory results, including pathology reports, are amongst the most frequently accessed pieces of information. The pathology report is an important but highly ... ...

    Abstract In many centres, patients now have access to their electronic medical record (EMR) and laboratory results, including pathology reports, are amongst the most frequently accessed pieces of information. The pathology report is an important but highly technical medical document that can be difficult for patient and clinicians alike to interpret. To improve communication and patient safety, pathologists are being called upon to play a more direct role in patient care. Novel approaches have been undertaken by pathologists to address this need, including the addition of patient-friendly summaries at the beginning of pathology reports and the development of patient education tools. MyPathologyReport.ca is a novel website exclusively providing pathology education to patients. It has been designed to help patients understand the language of pathology and to effectively navigate their pathology report. At present, the website includes over 150 diagnostic articles and over 125 pathology dictionary definitions. The diagnostic articles span all body sites and include a variety of malignant, benign and non-neoplastic conditions. Since its creation, this website has been visited over 14 000 times, with cancer-related diagnoses and definitions representing the most commonly accessed articles. This website has been embedded in patient accessible EMRs and shared through partnerships with patients, caregivers and their respective advocacy groups. Our next steps involve longitudinal assessment of MyPathologyReport.ca from non-medical community members, evaluation of patient satisfaction and understanding and further collaboration with hospitals and care-providers to increase patient access to this resource.
    MeSH term(s) Communication ; Consumer Health Information ; Electronic Health Records ; Humans ; Internet/statistics & numerical data ; Pathology, Clinical/education ; Patient Education as Topic/methods ; Patient-Centered Care/methods ; Professional-Patient Relations
    Language English
    Publishing date 2020-02-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80261-x
    ISSN 1472-4146 ; 0021-9746
    ISSN (online) 1472-4146
    ISSN 0021-9746
    DOI 10.1136/jclinpath-2019-206370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Distinctive Head and Neck Bone and Soft Tissue Neoplasms.

    Purgina, Bibianna / Lai, Chi K

    Surgical pathology clinics

    2017  Volume 10, Issue 1, Page(s) 223–279

    Abstract: Benign and malignant primary bone and soft tissue lesions of the head and neck are rare. The uncommon nature of these tumors, combined with the complex anatomy of the head and neck, pose diagnostic challenges to pathologists. This article describes the ... ...

    Abstract Benign and malignant primary bone and soft tissue lesions of the head and neck are rare. The uncommon nature of these tumors, combined with the complex anatomy of the head and neck, pose diagnostic challenges to pathologists. This article describes the pertinent clinical, radiographic, and pathologic features of selected bone and soft tissue tumors involving the head and neck region, including angiofibroma, glomangiopericytoma, rhabdomyosarcoma, biphenotypic sinonasal sarcoma, chordoma, chondrosarcoma, and osteosarcoma. Emphasis is placed on key diagnostic pitfalls, differential diagnosis, and the importance of correlating clinical and radiographic information, particularly for tumors involving bone.
    MeSH term(s) Angiofibroma/diagnosis ; Angiofibroma/pathology ; Bone Neoplasms/diagnosis ; Bone Neoplasms/pathology ; Chordoma/diagnosis ; Chordoma/pathology ; Diagnosis, Differential ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/pathology ; Humans ; Radiography ; Sarcoma/diagnosis ; Sarcoma/pathology ; Soft Tissue Neoplasms/diagnosis ; Soft Tissue Neoplasms/pathology
    Language English
    Publishing date 2017-03
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1875-9157
    ISSN (online) 1875-9157
    DOI 10.1016/j.path.2016.11.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Subperiosteal chondromyxoid fibroma: a rare case involving the humeral diaphysis

    Delorme, Jean-Philippe / Purgina, Bibianna / Jibri, Zaid

    Skelet. radiol

    Abstract: Initially described, in 1948, as a tumor that could be mistaken with chondrosarcoma at histopathology, chondromyxoid fibroma is now a well-recognized entity. Surface-type chondromyxoid fibroma, however, remains an extremely rare occurrence. We present a ... ...

    Abstract Initially described, in 1948, as a tumor that could be mistaken with chondrosarcoma at histopathology, chondromyxoid fibroma is now a well-recognized entity. Surface-type chondromyxoid fibroma, however, remains an extremely rare occurrence. We present a case of a 55-year-old woman, who experienced right arm pain for 5 years. After unsuccessful treatment for presumed thoracic outlet syndrome, MRI revealed a large mass abutting the anteromedial cortex of the distal humeral diaphysis in a subperiosteal location. Further characterization was made with radiography, CT, and bone scan, which were followed by ultrasound-guided biopsy. Although histopathologic features were suggestive of chondromyxoid fibroma, the diagnosis remained somewhat uncertain initially due to the very unusual location involving the diaphysis of the humerus. Surgical resection was performed, and subsequent histopathologic analysis confirmed the diagnosis of chondromyxoid fibroma. Despite being a rare entity, surface-type chondromyxoid fibroma would need to be considered in the differential when dealing with expansile surface diaphyseal lesions.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32803376
    Database COVID19

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  10. Article ; Online: Fatal traumatic aneurysm of the posterior inferior cerebellar artery with delayed rupture.

    Purgina, Bibianna / Milroy, Christopher Mark

    Forensic science international

    2015  Volume 247, Page(s) e1–5

    Abstract: Traumatic aneurysms of intracranial arteries are rare, forming less than 1% of all intracranial arteries. They may be associated with penetrating and non-penetrating trauma. Most cases are associated with fracturing of the skull. Rupture of traumatic ... ...

    Abstract Traumatic aneurysms of intracranial arteries are rare, forming less than 1% of all intracranial arteries. They may be associated with penetrating and non-penetrating trauma. Most cases are associated with fracturing of the skull. Rupture of traumatic aneurysms occur in up to 50% of cases and are typically delayed from days to weeks following the initiating trauma. We report a case of a 22-year-old man who was punched to the head. He was rendered unconscious but recovered and had a GCS of 14 on admission. CT scans showed subarachnoid hemorrhage. An initial angiogram was negative but on day 7 following the incident he was noted to have a 1 mm aneurysm of the posterior inferior cerebellar artery on CT angiogram. On day 9 he collapsed and was found to have new subarachnoid hemorrhage and to have a 4.0 mm × 3.7 mm. He did not recover and was declared brain dead on day 12. At autopsy, there was a 4.0 mm aneurysm of the left PICA just after the origin of the artery. Histological examination confirmed the presence of a traumatic false aneurysm in the left PICA. This case study shows sequential radiological imaging with pathologiocal correlation.
    MeSH term(s) Aneurysm, False/etiology ; Aneurysm, False/pathology ; Aneurysm, Ruptured/etiology ; Aneurysm, Ruptured/pathology ; Brain Death ; Forensic Pathology ; Head Injuries, Closed/complications ; Humans ; Intracranial Aneurysm/etiology ; Intracranial Aneurysm/pathology ; Male ; Radiography ; Subarachnoid Hemorrhage/diagnostic imaging ; Subarachnoid Hemorrhage/pathology ; Violence ; Young Adult
    Language English
    Publishing date 2015-02
    Publishing country Ireland
    Document type Case Reports ; Journal Article
    ZDB-ID 424042-x
    ISSN 1872-6283 ; 0379-0738
    ISSN (online) 1872-6283
    ISSN 0379-0738
    DOI 10.1016/j.forsciint.2014.11.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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