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  1. Article: Performance of a Risk Analytic Tool (Index of Tissue Oxygen Delivery "IDO2") in Pediatric Cardiac Intensive Care Unit of a Developing Country.

    Abbas, Qalab / Hussain, Muhammad Zaid H / Shahbaz, Fatima Farrukh / Siddiqui, Naveed Ur Rehman / Hasan, Babar S

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 846074

    Abstract: Objective: To determine the performance of a commercially available risk analytic tool (IDO2) to estimate the risk for SVO2 < 40% in patients admitted in cardiac intensive care unit (CICU).: Methods: Medical and T3 records of all patients (aged 1 day ...

    Abstract Objective: To determine the performance of a commercially available risk analytic tool (IDO2) to estimate the risk for SVO2 < 40% in patients admitted in cardiac intensive care unit (CICU).
    Methods: Medical and T3 records of all patients (aged 1 day to 12 years, weight >2 kg) who received care in the CICU between October 1st, 2019 and October 1st, 2020, had SvO2 lab(s) drawn during CICU course and whose data was transmitted to T3, were included. The average IDO2 Index was computed in the 30-min period immediately prior to each SvO2 measurement and used as a predictor score for SvO2 < 40%.
    Results: A total of 69 CICU admissions from 65 patients, median age 9.3 months (interquartile range 20.8) were identified. Surgical and medical patients were 61 (88%) and 8 (12%) respectively; 4 (5.7%) patients had single ventricle physiology. Tetralogy of Fallot
    Conclusion: IDO2 performed well in estimating low SvO2 (<40%) in pediatric patients presenting to a CICU in a low resource setting. Future work is needed to determine the effect of this risk analytic tool on clinical outcomes in such a setting.
    Language English
    Publishing date 2022-06-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.846074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A Review of Coronaviruses Associated With Kawasaki Disease: Possible Implications for Pathogenesis of the Multisystem Inflammatory Syndrome Associated With COVID-19.

    Shahbaz, Fatima Farrukh / Martins, Russell Seth / Umair, Abdullah / Ukrani, Ronika Devi / Jabeen, Kausar / Sohail, M Rizwan / Khan, Erum

    Clinical medicine insights. Pediatrics

    2022  Volume 16, Page(s) 11795565221075319

    Abstract: Multisystem Inflammatory Syndrome in Children (MIS-C), representing a new entity in the spectrum of manifestations of COVID-19, bears symptomatic resemblance with Kawasaki Disease (KD). This review explores the possible associations between KD and the ... ...

    Abstract Multisystem Inflammatory Syndrome in Children (MIS-C), representing a new entity in the spectrum of manifestations of COVID-19, bears symptomatic resemblance with Kawasaki Disease (KD). This review explores the possible associations between KD and the human coronaviruses and discusses the pathophysiological similarities between KD and MIS-C and proposes implications for the pathogenesis of MIS-C in COVID-19. Since 2005, when a case-control study demonstrated the association of a strain of human coronavirus with KD, several studies have provided evidence regarding the association of different strains of the human coronaviruses with KD. Thus, the emergence of the KD-like disease MIS-C in COVID-19 may not be an unprecedented phenomenon. KD and MIS-C share a range of similarities in pathophysiology and possibly even genetics. Both share features of a cytokine storm, leading to a systemic inflammatory response and oxidative stress that may cause vasculitis and precipitate multi-organ failure. Moreover, antibody-dependent enhancement, a phenomenon demonstrated in previous coronaviruses, and the possible superantigenic behavior of SARS-CoV-2, possibly may also contribute toward the pathogenesis of MIS-C. Lastly, there is some evidence of complement-mediated microvascular injury in COVID-19, as well as of endotheliitis. Genetics may also represent a possible link between MIS-C and KD, with variations in FcγRII and IL-6 genes potentially increasing susceptibility to both conditions. Early detection and treatment are essential for the management of MIS-C in COVID-19. By highlighting the potential pathophysiological mechanisms that contribute to MIS-C, our review holds important implications for diagnostics, management, and further research of this rare manifestation of COVID-19.
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2579551-X
    ISSN 1179-5565
    ISSN 1179-5565
    DOI 10.1177/11795565221075319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Clinical and epidemiological features of pediatric population hospitalized with COVID-19: a multicenter longitudinal study (March 2020-December 2021) from Pakistan.

    Abbas, Qalab / Khalid, Farah / Shahbaz, Fatima Farrukh / Khan, Javeria / Mohsin, Shazia / Gowa, Murtaza Ali / Shaikh, Abdul Sattar / Asghar, Rai Muhammad / Khalid, Javairia / Karim, Sehrish / Jehan, Fyezah / Sadiq, Masood / Rashid, Junaid

    The Lancet regional health. Southeast Asia

    2023  Volume 11, Page(s) 100176

    Abstract: Background: We aimed to explore the epidemiological, clinical, and phenotypic parameters of pediatric patients hospitalized with COVID-19 in Pakistan.: Methods: This longitudinal cohort study was conducted in five tertiary care hospitals in Pakistan ... ...

    Abstract Background: We aimed to explore the epidemiological, clinical, and phenotypic parameters of pediatric patients hospitalized with COVID-19 in Pakistan.
    Methods: This longitudinal cohort study was conducted in five tertiary care hospitals in Pakistan from March 2020 to December 2021. Data on various epidemiological and clinical variables were collected using Case Report Forms (CRFs) adapted from the WHO COVID-19 clinical data platform at baseline and at monthly follow-ups for 3 months.
    Findings: A total of 1090 children were included. The median age was 5 years (Interquartile range 1-10), and the majority presented due to new signs/symptoms associated with COVID-19 (57.8%; n = 631), the most common being general and respiratory symptoms. Comorbidities were present in 417 (38.3%) children. Acute COVID-19 alone was found in 932 (85.5%) children, 81 (7.4%) had multisystem inflammatory syndrome (MIS-C), 77 (7.0%) had overlapping features of acute COVID-19 and MIS-C, and severe disease was found in 775/1086 (71.4%). Steroids were given to 351 (32.2%) patients while 77 (7.1%) children received intravenous immunoglobulins. Intensive care unit (ICU) care was required in 334 (31.6%) patients, and 203 (18.3%) deaths were reported during the study period. The largest spike in cases and mortality was from July to September 2021 when the Delta variant first emerged. During the first and second follow-ups, 37 and 10 children expired respectively, and medical care after discharge was required in 204 (25.4%), 94 (16.6%), and 70 (13.7%) children respectively during each monthly follow-up.
    Interpretation: Our study highlights that acute COVID-19 was the major phenotype associated with high severity and mortality in children in Pakistan in contrast to what has been observed globally.
    Funding: The study was supported by the World Health Organization (WHO), which was involved in the study design but played no role in its analysis, writeup, or publication.
    Language English
    Publishing date 2023-03-03
    Publishing country England
    Document type Journal Article
    ISSN 2772-3682
    ISSN (online) 2772-3682
    DOI 10.1016/j.lansea.2023.100176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Evaluation of the Resources and Inequities Among Pediatric Critical Care Facilities in Pakistan.

    Abbas, Qalab / Shahbaz, Fatima Farrukh / Hussain, Muhammad Zaid H / Khan, Mustafa Ali / Shahbaz, Hamna / Atiq, Huba / Siddiqui, Naveed Ur Rehman / Gowa, Murtaza Ali / Jamil, Muhammad Tariq / Ali, Farman / Khan, Ata Ullah / Ahmed, Abdul Rahim / Haque, Anwar Ul / Hamid, Muhammad Haroon / Latif, Asad / Bhutta, Adnan

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2023  Volume 24, Issue 12, Page(s) e611–e620

    Abstract: Objectives: To evaluate nationwide pediatric critical care facilities and resources in Pakistan.: Design: Cross-sectional observational study.: Setting: Accredited pediatric training facilities in Pakistan.: Patients: None.: Interventions: ... ...

    Abstract Objectives: To evaluate nationwide pediatric critical care facilities and resources in Pakistan.
    Design: Cross-sectional observational study.
    Setting: Accredited pediatric training facilities in Pakistan.
    Patients: None.
    Interventions: None.
    Measurements and main results: A survey was conducted using the Partners in Health 4S (space, staff, stuff, systems) framework, via email or telephone correspondence. We used a scoring system in which each item in our checklist was given a score of 1, if available. Total scores were added up for each component. Additionally, we stratified and analyzed the data between the public and private healthcare sectors. Out of 114 hospitals (accredited for pediatric training), 76 (67%) responded. Fifty-three (70%) of these hospitals had a PICU, with a total of 667 specialized beds and 217 mechanical ventilators. There were 38 (72%) public hospitals and 15 (28%) private hospitals. There were 20 trained intensivists in 16 of 53 PICUs (30%), while 25 of 53 PICUs (47%) had a nurse-patient ratio less than 1:3. Overall, private hospitals were better resourced in many domains of our four Partners in Health framework. The Stuff component scored more than the other three components using analysis of variance testing ( p = 0.003). On cluster analysis, private hospitals ranked higher in Space and Stuff, along with the overall scoring.
    Conclusions: There is a general lack of resources, seen disproportionately in the public sector. The scarcity of qualified intensivists and nursing staff poses a challenge to Pakistan's PICU infrastructure.
    MeSH term(s) Humans ; Child ; Pakistan ; Cross-Sectional Studies ; Surveys and Questionnaires ; Hospitals, Public ; Critical Care
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000003285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Clinical and epidemiological features of pediatric population hospitalized with COVID-19

    Qalab Abbas / Farah Khalid / Fatima Farrukh Shahbaz / Javeria Khan / Shazia Mohsin / Murtaza Ali Gowa / Abdul Sattar Shaikh / Rai Muhammad Asghar / Javairia Khalid / Sehrish Karim / Fyezah Jehan / Masood Sadiq / Junaid Rashid

    The Lancet Regional Health - Southeast Asia, Vol 11, Iss , Pp 100176- (2023)

    a multicenter longitudinal study (March 2020–December 2021) from PakistanResearch in context

    2023  

    Abstract: Summary: Background: We aimed to explore the epidemiological, clinical, and phenotypic parameters of pediatric patients hospitalized with COVID-19 in Pakistan. Methods: This longitudinal cohort study was conducted in five tertiary care hospitals in ... ...

    Abstract Summary: Background: We aimed to explore the epidemiological, clinical, and phenotypic parameters of pediatric patients hospitalized with COVID-19 in Pakistan. Methods: This longitudinal cohort study was conducted in five tertiary care hospitals in Pakistan from March 2020 to December 2021. Data on various epidemiological and clinical variables were collected using Case Report Forms (CRFs) adapted from the WHO COVID-19 clinical data platform at baseline and at monthly follow-ups for 3 months. Findings: A total of 1090 children were included. The median age was 5 years (Interquartile range 1–10), and the majority presented due to new signs/symptoms associated with COVID-19 (57.8%; n = 631), the most common being general and respiratory symptoms. Comorbidities were present in 417 (38.3%) children. Acute COVID-19 alone was found in 932 (85.5%) children, 81 (7.4%) had multisystem inflammatory syndrome (MIS-C), 77 (7.0%) had overlapping features of acute COVID-19 and MIS-C, and severe disease was found in 775/1086 (71.4%). Steroids were given to 351 (32.2%) patients while 77 (7.1%) children received intravenous immunoglobulins. Intensive care unit (ICU) care was required in 334 (31.6%) patients, and 203 (18.3%) deaths were reported during the study period. The largest spike in cases and mortality was from July to September 2021 when the Delta variant first emerged. During the first and second follow-ups, 37 and 10 children expired respectively, and medical care after discharge was required in 204 (25.4%), 94 (16.6%), and 70 (13.7%) children respectively during each monthly follow-up. Interpretation: Our study highlights that acute COVID-19 was the major phenotype associated with high severity and mortality in children in Pakistan in contrast to what has been observed globally. Funding: The study was supported by the World Health Organization (WHO), which was involved in the study design but played no role in its analysis, writeup, or publication.
    Keywords Pediatric COVID-19 ; Epidemiology ; SARS-CoV-2 ; Pakistan ; Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Impact of Perfectionism and Resilience on Empathy in Medical Students: A Cross-Sectional Study.

    Rafaqat, Wardah / Sami, Ashmal / Ibrahim, Muhammad Talal / Ibad, Hamza / Awais, Sheharbano / Memon, Ayesha / Shahbaz, Fatima Farrukh / Ahmed, Daniyaal / Zindani, Shahzaib / Leghari, Abdul Lateef / Saleem, Sarah

    Journal of patient experience

    2022  Volume 9, Page(s) 23743735221106603

    Abstract: Empathy is a cognitive attribute that forms the cornerstone for good doctor-patient encounters. The formative period for the development of empathy toward patients begins with clinical encounters within medical school. An individual medical student's ... ...

    Abstract Empathy is a cognitive attribute that forms the cornerstone for good doctor-patient encounters. The formative period for the development of empathy toward patients begins with clinical encounters within medical school. An individual medical student's empathy levels may in part be a product of their resilience and perfectionist attitudes. A cross-sectional study with 320 medical students across all years of study was conducted to determine the correlation of perfectionism and resilience with clinical empathy in medical students. The JSE-S, CD-RISC 10, and APS-R scales were used to assess levels of empathy, resilience, and perfectionism, respectively. The study found that a positive correlation exists between resilience (
    Language English
    Publishing date 2022-06-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2857285-3
    ISSN 2374-3743 ; 2374-3735
    ISSN (online) 2374-3743
    ISSN 2374-3735
    DOI 10.1177/23743735221106603
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  7. Article ; Online: Impact of Perfectionism and Resilience on Empathy in Medical Students

    Wardah Rafaqat / Ashmal Sami / Muhammad Talal Ibrahim / Hamza Ibad / Sheharbano Awais / Ayesha Memon / Fatima Farrukh Shahbaz / Daniyaal Ahmed / Shahzaib Zindani / Abdul Lateef Leghari / Sarah Saleem

    Journal of Patient Experience, Vol

    A Cross-Sectional Study

    2022  Volume 9

    Abstract: Empathy is a cognitive attribute that forms the cornerstone for good doctor–patient encounters. The formative period for the development of empathy toward patients begins with clinical encounters within medical school. An individual medical student's ... ...

    Abstract Empathy is a cognitive attribute that forms the cornerstone for good doctor–patient encounters. The formative period for the development of empathy toward patients begins with clinical encounters within medical school. An individual medical student's empathy levels may in part be a product of their resilience and perfectionist attitudes. A cross-sectional study with 320 medical students across all years of study was conducted to determine the correlation of perfectionism and resilience with clinical empathy in medical students. The JSE-S, CD-RISC 10, and APS-R scales were used to assess levels of empathy, resilience, and perfectionism, respectively. The study found that a positive correlation exists between resilience ( r = 0.174) and academic year with empathy, and a negative correlation exists between maladaptive perfectionism and empathy ( r = −0.138). The resilience score declined progressively as the year of study progressed with a statistically significant. Mean empathy scores were lowest in fifth-year students (96.8 ± 12.5) and highest in third-year students (107.8 ± 13.2). Further longitudinal studies are necessary to better understand the impact of resilience and perfectionism on empathy.
    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Improved project control for sustainable development of construction sector to reduce environment risks

    Malik, Summaira / Fatima, Fareena / Imran, Asma / Chuah, Lai Fatt / Klemeš, Jiří Jaromír / Khaliq, Imran Hameed / Asif, Saira / Aslam, Muhammad / Jamil, Farrukh / Durrani, Abdullah Khan / Akbar, Majid Majeed / Shahbaz, Muhammad / Usman, Muhammad / Atabani, A.E / Naqvi, Salman Raza / Yusup, Suzana / Bokhari, Awais

    Journal of cleaner production. 2019 Aug. 27,

    2019  

    Abstract: This study examines how environmental concerns impact the connectivity amid formal, informal control and performance based on data gathered from different 156 construction companies. The empirical outcomes illustrate that behaviour, outcome relationship ... ...

    Abstract This study examines how environmental concerns impact the connectivity amid formal, informal control and performance based on data gathered from different 156 construction companies. The empirical outcomes illustrate that behaviour, outcome relationship between variables and clan control affirmatively affect performance on construction projects. However, self-control is unimportantly identified with project execution. This research uncovers that in construction projects, the adequacy of managerial control varies. The results further suggest that interior environmental concerns contrarily moderate the consequence of control of cleaner merchandise enactment during projects. However, external natural hazards emphatically direct the adequacy of project control, showing noteworthy and assorted roles played by different ecological dangers in the assembly of control and project execution. The interactive empirical outcomes between formal control and external environmental hazards are significantly related to project performance(t > 2, and p < 0.05) however the controlling impact of the inner environmental hazard on project control is relatively lower (β = 0.338, p > 0.05). The study concluded the least significant of all controller means towards the enactment of construction projects. Results showed that for complex projects, operative control approaches should be prioritised over ineffective control methods.
    Keywords business enterprises ; control methods ; environmental hazards ; risk ; sustainable development
    Language English
    Dates of publication 2019-0827
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ISSN 0959-6526
    DOI 10.1016/j.jclepro.2019.118214
    Database NAL-Catalogue (AGRICOLA)

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