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  1. Book: Lupus

    Kim, Alfred H. J.

    (Rheumatic disease clinics of North America ; volume 47, number 3 (August 2021))

    2021  

    Author's details editors Alfred H.J. Kim, Zahi Touma
    Series title Rheumatic disease clinics of North America ; volume 47, number 3 (August 2021)
    Collection
    Language English
    Size xvi Seiten, Seite 298-530, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT021085097
    ISBN 978-0-323-83556-5 ; 0-323-83556-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 363 -47,3- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Additional Reassuring Data for SARS-CoV-2 Vaccination in Immune-Mediated Inflammatory Diseases, but With a Catch.

    Kim, Alfred H J

    The Journal of rheumatology

    2024  Volume 51, Issue 4, Page(s) 332–335

    MeSH term(s) Humans ; COVID-19 Vaccines/therapeutic use ; SARS-CoV-2 ; COVID-19/prevention & control ; Vaccination ; Antibodies, Viral
    Chemical Substances COVID-19 Vaccines ; Antibodies, Viral
    Language English
    Publishing date 2024-04-01
    Publishing country Canada
    Document type Editorial
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.2024-0006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1168: Show issues Location:
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    Zs.MO 135: Show issues

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  3. Article: The Role of Complement in Autoimmune Disease-Associated Thrombotic Microangiopathy and the Potential for Therapeutics.

    Java, Anuja / Kim, Alfred H J

    The Journal of rheumatology

    2023  Volume 50, Issue 6, Page(s) 730–740

    Abstract: The complement system is a tightly regulated, cascading protein network representing a key component linking the innate and humoral immune systems. However, if misdirected or dysregulated, it can be similarly damaging to host-tissue. The role of ... ...

    Abstract The complement system is a tightly regulated, cascading protein network representing a key component linking the innate and humoral immune systems. However, if misdirected or dysregulated, it can be similarly damaging to host-tissue. The role of complement dysregulation on vascular endothelial cells has been well established in atypical hemolytic uremic syndrome (aHUS), a thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and target organ injury. Yet, a great deal of complexity exists around the role of complement in TMA associated with other diseases. A further complicating factor is the cross-talk between complement, neutrophils, and coagulation pathways in the pathophysiology of TMA. Advancements in the understanding of the etiopathogenesis of aHUS paved the way for the successful development of anticomplement therapies (complement C5 inhibitors), which have revolutionized the treatment of aHUS. Therefore, a clearer understanding of the role of the complement system in TMA associated with other conditions will help to identify patients who would benefit from these therapies. This review aims to provide an assessment of the nature and extent of complement involvement in TMA associated with autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, and scleroderma renal crisis. Defining the role of complement in TMA in these conditions will help to guide timely diagnosis and management.
    MeSH term(s) Humans ; Endothelial Cells/pathology ; Thrombotic Microangiopathies/complications ; Complement System Proteins ; Lupus Erythematosus, Systemic/complications ; Atypical Hemolytic Uremic Syndrome/complications ; Atypical Hemolytic Uremic Syndrome/pathology ; Complement C5
    Chemical Substances Complement System Proteins (9007-36-7) ; Complement C5
    Language English
    Publishing date 2023-01-15
    Publishing country Canada
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.220752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Immunosuppression and SARS-CoV-2 breakthrough infections.

    Kim, Alfred H J / Sparks, Jeffrey A

    The Lancet. Rheumatology

    2022  Volume 4, Issue 6, Page(s) e379–e380

    Language English
    Publishing date 2022-04-29
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(22)00127-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Systemic Lupus Erythematosus: The Next Generation of Ideas and Scientists.

    Kim, Alfred H J / Touma, Zahi

    Rheumatic diseases clinics of North America

    2021  Volume 47, Issue 3, Page(s) xv–xvi

    MeSH term(s) Humans ; Lupus Erythematosus, Systemic
    Language English
    Publishing date 2021-06-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2021.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: B cells: more than just for antibodies in SARS-CoV-2 vaccine responses.

    Paley, Michael A / Kim, Alfred H J

    The Lancet. Rheumatology

    2021  Volume 3, Issue 11, Page(s) e741–e743

    Language English
    Publishing date 2021-09-07
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(21)00280-0
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  7. Article ; Online: Immunogenicity, breakthrough infection, and underlying disease flare after SARS-CoV-2 vaccination among individuals with systemic autoimmune rheumatic diseases.

    Paik, Julie J / Sparks, Jeffrey A / Kim, Alfred H J

    Current opinion in pharmacology

    2022  Volume 65, Page(s) 102243

    Abstract: Many patients with systemic autoimmune rheumatic diseases (SARDs) require immunosuppression to reduce disease activity, but this also has important possible detrimental impacts on immune responses following vaccination. The phase III clinical trials for ... ...

    Abstract Many patients with systemic autoimmune rheumatic diseases (SARDs) require immunosuppression to reduce disease activity, but this also has important possible detrimental impacts on immune responses following vaccination. The phase III clinical trials for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines did not include those who are immunosuppressed. Fortunately, we now have a clearer idea of how immune responses following SARS-CoV-2 vaccination has for the immunosuppressed, with much of the data being within a year of its introduction. Here, we summarize what is known in this rapidly evolving field about the impact immunosuppression has on humoral immunogenicity including waning immunity and additional doses, breakthrough infection rates and severity, disease flare rates, along with additional considerations and remaining unanswered questions.
    MeSH term(s) Antibodies, Viral ; COVID-19/prevention & control ; COVID-19 Vaccines/therapeutic use ; Humans ; Rheumatic Diseases/drug therapy ; SARS-CoV-2 ; Symptom Flare Up ; Vaccination ; Viral Vaccines
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines ; Viral Vaccines
    Language English
    Publishing date 2022-05-02
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2022.102243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know.

    Yazdany, Jinoos / Kim, Alfred H J

    Annals of internal medicine

    2020  Volume 172, Issue 11, Page(s) 754–755

    MeSH term(s) Betacoronavirus ; Chloroquine/supply & distribution ; Chloroquine/therapeutic use ; Coronavirus Infections/drug therapy ; Drug Repositioning ; Humans ; Hydroxychloroquine/supply & distribution ; Hydroxychloroquine/therapeutic use ; Pandemics ; Pneumonia, Viral/drug therapy ; Randomized Controlled Trials as Topic ; Rheumatic Diseases/drug therapy
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH) ; Chloroquine (886U3H6UFF)
    Keywords covid19
    Language English
    Publishing date 2020-03-31
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M20-1334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Addressing the challenges of the SARS-CoV-2 pandemic in patients affected by autoimmune and rheumatic disease.

    Robinson, Philip C / Kim, Alfred H J

    Best practice & research. Clinical rheumatology

    2021  Volume 35, Issue 1, Page(s) 101664

    MeSH term(s) Autoimmune Diseases/epidemiology ; COVID-19 ; Humans ; Pandemics ; Rheumatic Diseases/epidemiology ; SARS-CoV-2
    Language English
    Publishing date 2021-02-17
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2021.101664
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  10. Article ; Online: COVID-19 Breakthrough Infection Among Immunocompromised Persons.

    Kim, Alfred H J / Nakamura, Mary C

    JAMA internal medicine

    2021  Volume 182, Issue 2, Page(s) 163–164

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; Immunocompromised Host ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-12-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2021.7033
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