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  1. Article ; Online: Assays for Detecting Henipavirus Antibodies.

    Wang, Lin-Fa / Mani, Shailendra / Tan, Chee Wah / Anderson, Danielle E

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2682, Page(s) 245–258

    Abstract: While molecular detection has increasingly become the detection method of choice for infectious diseases, antibody detection remains an important approach for diagnosis and surveillance. For henipaviruses, antibody detection methods such as ELISA and ... ...

    Abstract While molecular detection has increasingly become the detection method of choice for infectious diseases, antibody detection remains an important approach for diagnosis and surveillance. For henipaviruses, antibody detection methods such as ELISA and Western blot played a key role in the initial discovery of bats as the natural reservoir host. Here, we will describe three additional antibody detection methods (LIPS, Luminex, and pseudovirus systems), which can be used in most BSL2 laboratories without the need for live virus and a high containment BSL4 facility.
    MeSH term(s) Animals ; Antibodies ; Enzyme-Linked Immunosorbent Assay ; Biological Assay ; Blotting, Western ; Chiroptera ; Henipavirus
    Chemical Substances Antibodies
    Language English
    Publishing date 2023-08-22
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3283-3_18
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  2. Article ; Online: Pteropine orthoreoviruses use cell surface heparan sulphate as an attachment receptor.

    Tan, Chee Wah / Gamage, Akshamal M / Yap, Wee Chee / Wei Tang, Leon Jia / Sun, Yuan / Yang, Xing-Lou / Pyke, Alyssa / Chua, Kaw Bing / Wang, Lin-Fa

    Emerging microbes & infections

    2023  Volume 12, Issue 1, Page(s) 2208683

    Abstract: Pteropine orthoreoviruses (PRVs) are an emerging group of fusogenic, bat-borne viruses from ... ...

    Abstract Pteropine orthoreoviruses (PRVs) are an emerging group of fusogenic, bat-borne viruses from the
    MeSH term(s) Animals ; Humans ; Reoviridae Infections ; Orthoreovirus/genetics ; Indonesia ; Malaysia ; Orthoreovirus, Mammalian/genetics ; Mammals
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2023.2208683
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  3. Article ; Online: Immunogenicity and safety of Sinovac-CoronaVac booster vaccinations in 12-17- year-olds with clinically significant reactions from Pfizer-BNT162b2 vaccination.

    Chong, Chia-Yin / Kam, Kai-Qian / Zhang, Jinyan / Bertoletti, Antonio / Hariharaputran, Smrithi / Sultana, Rehena / Piragasam, Rupini / Mah, Yun-Yan / Tan, Chee-Wah / Wang, Linfa / Yung, Chee-Fu

    Vaccine

    2024  Volume 42, Issue 12, Page(s) 2951–2954

    Abstract: Heterologous Sinovac-CoronaVac booster(s) in 12-17-year-olds who had a moderate/severe reaction to Pfizer-BNT162b2 mRNA vaccine was found to safe with no serious adverse events reported. In those primed with 1 dose of Pfizer-BNT162b2 vaccine, subsequent ... ...

    Abstract Heterologous Sinovac-CoronaVac booster(s) in 12-17-year-olds who had a moderate/severe reaction to Pfizer-BNT162b2 mRNA vaccine was found to safe with no serious adverse events reported. In those primed with 1 dose of Pfizer-BNT162b2 vaccine, subsequent boosters with 2 doses of Sinovac-CoronaVac vaccines achieved neutralizing antibody levels which were comparable to those who had received 2 doses of Pfizer-BNT162b2 vaccines followed by 1 dose of Sinovac-CoronaVac vaccination. Adolescents with 1 Pfizer-BNT162b2 followed by 2 Sinovac-CoronaVac vaccines developed T-cell responses against broad peptides including membrane, nucleoprotein 1 and 2 but levels were highest for Spike protein and lasted until day 150 post-vaccination.
    MeSH term(s) Adolescent ; Humans ; Antibodies, Neutralizing ; Antibodies, Viral ; BNT162 Vaccine/adverse effects ; Vaccination/adverse effects ; Vaccines, Inactivated/adverse effects ; Child
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; BNT162 Vaccine ; sinovac COVID-19 vaccine ; Vaccines, Inactivated
    Language English
    Publishing date 2024-04-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2024.04.011
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  4. Article ; Online: Comparative neutralisation profile of SARS-CoV-2 omicron subvariants BA.2.75 and BA.5.

    Tan, Chee-Wah / Lim, Beng-Lee / Young, Barnaby E / Yeoh, Aileen Ying-Yan / Yung, Chee-Fu / Yap, Wee-Chee / Althaus, Thomas / Chia, Wan-Ni / Zhu, Feng / Lye, David Chien / Wang, Lin-Fa

    The Lancet. Microbe

    2022  Volume 3, Issue 12, Page(s) e898

    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19
    Language English
    Publishing date 2022-08-10
    Publishing country England
    Document type Letter
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(22)00220-8
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  5. Article ; Online: Broad-spectrum pan-genus and pan-family virus vaccines.

    Tan, Chee Wah / Valkenburg, Sophie A / Poon, Leo L M / Wang, Lin-Fa

    Cell host & microbe

    2023  Volume 31, Issue 6, Page(s) 902–916

    Abstract: Although the development and clinical application of SARS-CoV-2 vaccines during the COVID-19 pandemic demonstrated unprecedented vaccine success in a short time frame, it also revealed a limitation of current vaccines in their inability to provide broad- ... ...

    Abstract Although the development and clinical application of SARS-CoV-2 vaccines during the COVID-19 pandemic demonstrated unprecedented vaccine success in a short time frame, it also revealed a limitation of current vaccines in their inability to provide broad-spectrum or universal protection against emerging variants. Broad-spectrum vaccines, therefore, remain a dream and challenge for vaccinology. This review will focus on current and future efforts in developing universal vaccines targeting different viruses at the genus and/or family levels, with a special focus on henipaviruses, influenza viruses, and coronaviruses. It is evident that strategies for developing broad-spectrum vaccines will be virus-genus or family specific, and it is almost impossible to adopt a universal approach for different viruses. On the other hand, efforts in developing broad-spectrum neutralizing monoclonal antibodies have been more successful and it is worth considering broad-spectrum antibody-mediated immunization, or "universal antibody vaccine," as an alternative approach for early intervention for future disease X outbreaks.
    MeSH term(s) Humans ; Orthomyxoviridae Infections ; Influenza Vaccines ; COVID-19 Vaccines ; Pandemics/prevention & control ; Antibodies, Viral ; COVID-19/prevention & control ; SARS-CoV-2 ; Antibodies, Neutralizing
    Chemical Substances Influenza Vaccines ; COVID-19 Vaccines ; Antibodies, Viral ; Antibodies, Neutralizing
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2023.05.017
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  6. Article ; Online: Human cytokeratin 1 plays a role in the interaction of Pteropine orthoreovirus with Hek293 cells but not HeLa cells.

    Siew, Zhen Yun / Tan, Yeh Fong / Iswara, Reuben Parama / Wong, Shew Fung / Wong, Siew Tung / Tan, Boon Keat / Leong, Pooi Pooi / Tan, Chee Wah / Wang, Lin-Fa / Leong, Chee Onn / Voon, Kenny

    Microbes and infection

    2023  Volume 26, Issue 1-2, Page(s) 105243

    Abstract: Pteropine orthoreovirus (PRV) causes respiratory tract infections in humans. Despite its emergence as a zoonotic and respiratory virus, little is known about its cell tropism, which hampers progress in fully understanding its pathogenesis in humans. ... ...

    Abstract Pteropine orthoreovirus (PRV) causes respiratory tract infections in humans. Despite its emergence as a zoonotic and respiratory virus, little is known about its cell tropism, which hampers progress in fully understanding its pathogenesis in humans. Hek293 cells are most susceptible to PRV infection, while HeLa cells are the least. Human cytokeratin 1 (CK1) was identified as the protein that interacts with PRV. The immunofluorescence assay and qPCR results revealed prior treatment with anti-CK1 may provide Hek293 cells protection against PRV. The KRT1-knockout Hek293 cells were less susceptible to PRV infection. Further study into the pathogenesis of PRV in humans is needed.
    MeSH term(s) Animals ; Humans ; Fish Diseases ; HEK293 Cells ; HeLa Cells ; Keratins ; Orthoreovirus ; Reoviridae Infections/pathology
    Chemical Substances Keratins (68238-35-7) ; KRT1 protein, human
    Language English
    Publishing date 2023-10-30
    Publishing country France
    Document type Journal Article
    ZDB-ID 1465093-9
    ISSN 1769-714X ; 1286-4579
    ISSN (online) 1769-714X
    ISSN 1286-4579
    DOI 10.1016/j.micinf.2023.105243
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    Zs.A 5014: Show issues Location:
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  7. Article ; Online: Chitosan and its derivatives as polymeric anti-viral therapeutics and potential anti-SARS-CoV-2 nanomedicine.

    Tan, Rebecca Shu Ling / Hassandarvish, Pouya / Chee, Chin Fei / Chan, Lai Wah / Wong, Tin Wui

    Carbohydrate polymers

    2022  Volume 290, Page(s) 119500

    Abstract: The coronavirus pandemic, COVID-19 has a global impact on the lives and livelihoods of people. It is characterized by a widespread infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), where infected patients may develop serious ... ...

    Abstract The coronavirus pandemic, COVID-19 has a global impact on the lives and livelihoods of people. It is characterized by a widespread infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), where infected patients may develop serious medical complications or even face death. Development of therapeutic is essential to reduce the morbidity and mortality of infected patients. Chitosan is a versatile biomaterial in nanomedicine and exhibits anti-microbial, anti-cancer and immunomodulatory properties. This review highlights the progress in chitosan design and application pertaining to the anti-viral effects of chitosan and chitosan derivatives (hydroxypropyl trimethylammonium, sulfate, carboxymethyl, bromine, sialylglycopolymer, peptide and phosphonium conjugates) as a function of molecular weight, degree of deacetylation, type of substituents and their degree and site of substitution. The physicochemical attributes of these polymeric therapeutics are identified against the possibility of processing them into nanomedicine which can confer a higher level of anti-viral efficacy. The designs of chitosan for the purpose of targeting SARS-CoV-2, as well as the ever-evolving strains of viruses with a broad spectrum anti-viral activity to meet pandemic preparedness at the early stages of outbreak are discussed.
    MeSH term(s) Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Chitosan/chemistry ; Humans ; Nanomedicine ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; Chitosan (9012-76-4)
    Language English
    Publishing date 2022-04-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2022.119500
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  8. Article ; Online: Efficacy of platelet-rich plasma in Asians with androgenetic alopecia: A randomized controlled trial.

    Chuah, Sai Yee / Tan, Chee Hian / Wang, Etienne Cho Ee / Tan, Kian Teo / Chan, Roy Kum Wah / Zhao, Xiahong / Lee, Siong See Joyce

    Indian journal of dermatology, venereology and leprology

    2022  Volume 89, Issue 1, Page(s) 135–138

    MeSH term(s) Humans ; Asian ; Alopecia/diagnosis ; Alopecia/therapy ; Platelet-Rich Plasma ; Treatment Outcome
    Language English
    Publishing date 2022-11-29
    Publishing country United States
    Document type Randomized Controlled Trial ; Letter ; Comment
    ZDB-ID 416068-x
    ISSN 0973-3922 ; 0019-5162 ; 0378-6323
    ISSN (online) 0973-3922
    ISSN 0019-5162 ; 0378-6323
    DOI 10.25259/IJDVL_512_2021
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    Zs.A 85: Show issues Location:
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  9. Article ; Online: Bat virome research: the past, the present and the future.

    Tan, Chee Wah / Yang, Xinglou / Anderson, Danielle E / Wang, Lin-Fa

    Current opinion in virology

    2021  Volume 49, Page(s) 68–80

    Abstract: Bats have been increasingly recognised as an exceptional reservoir for emerging zoonotic viruses for the past few decades. Recent studies indicate that the unique bat immune system may be partially responsible for their ability to co-exist with viruses ... ...

    Abstract Bats have been increasingly recognised as an exceptional reservoir for emerging zoonotic viruses for the past few decades. Recent studies indicate that the unique bat immune system may be partially responsible for their ability to co-exist with viruses with minimal or no clinical diseases. In this review, we discuss the history and importance of bat virome studies and contrast the vast difference between such studies before and after the introduction of next generation sequencing (NGS) in this area of research. We also discuss the role of discovery serology and high-throughput single cell RNA-seq in future bat virome research.
    MeSH term(s) Animals ; Chiroptera/virology ; Disease Reservoirs ; Genome, Viral ; High-Throughput Nucleotide Sequencing ; Humans ; Viral Zoonoses ; Virome ; Virus Diseases/veterinary ; Virus Diseases/virology ; Viruses/genetics ; Viruses/isolation & purification
    Language English
    Publishing date 2021-05-27
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2611378-8
    ISSN 1879-6265 ; 1879-6257
    ISSN (online) 1879-6265
    ISSN 1879-6257
    DOI 10.1016/j.coviro.2021.04.013
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  10. Article ; Online: Low postpandemic wave SARS-CoV-2 seroprevalence in Kuala Lumpur and Selangor, Malaysia.

    Sam, I-Ching / Chong, Yoong Min / Tan, Chee Wah / Chan, Yoke Fun

    Journal of medical virology

    2020  Volume 93, Issue 2, Page(s) 647–648

    MeSH term(s) Adolescent ; Adult ; Aged ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19 Serological Testing ; Child ; Child, Preschool ; Female ; Humans ; Malaysia/epidemiology ; Male ; Mass Screening/statistics & numerical data ; Middle Aged ; Seroepidemiologic Studies ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-08-21
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26426
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