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Article: A Single Session of Virtual Reality Improved Tiredness, Shortness of Breath, Anxiety, Depression and Well-Being in Hospitalized Individuals with COVID-19: A Randomized Clinical Trial.

Rodrigues, Isabele Moraes / Lima, Adriana Gomes / Santos, Ana Evelyn Dos / Santos, Anne Carolline Almeida / Nascimento, Luciana Silva do / Serra, Maria Veronica Cavalcanti Lins / Pereira, Terezinha de Jesus Santos / Barbosa, Felipe Douglas Silva / Seixas, Valquiria Martins / Monte-Silva, Katia / Scipioni, Kelly Regina Dias da Silva / Cruz, Daniel Marinho Cezar da / Piscitelli, Daniele / Goffredo, Michela / Gois-Junior, Miburge Bolivar / Zanona, Aristela de Freitas

Journal of personalized medicine

2022 Volume 12, Issue 5

Abstract: Background: In 2020, the world was surprised by the spread and mass contamination of the new Coronavirus (COVID-19). COVID-19 produces symptoms ranging from a common cold to severe symptoms that can lead to death. Several strategies have been ... ...

Abstract	Background: In 2020, the world was surprised by the spread and mass contamination of the new Coronavirus (COVID-19). COVID-19 produces symptoms ranging from a common cold to severe symptoms that can lead to death. Several strategies have been implemented to improve the well-being of patients during their hospitalization, and virtual reality (VR) has been used. However, whether patients hospitalized for COVID-19 can benefit from this intervention remains unclear. Therefore, this study aimed to investigate whether VR contributes to the control of pain symptoms, the sensation of dyspnea, perception of well-being, anxiety, and depression in patients hospitalized with COVID-19. Methods: A randomized, double-blind clinical trial was designed. Patients underwent a single session of VR and usual care. The experimental group ( Results: The experimental group reported a significant decrease in tiredness, shortness of breath, anxiety, and an increase in the feeling of well-being, whereas the control group showed improvement only in the tiredness and anxiety. Conclusions: VR is a resource that may improve the symptoms of tiredness, shortness of breath, anxiety, and depression in patients hospitalized with COVID-19. Future studies should investigate the effect of multiple VR sessions on individuals with COVID-19.
Language	English
Publishing date	2022-05-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm12050829
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Article ; Online: A Single Session of Virtual Reality Improved Tiredness, Shortness of Breath, Anxiety, Depression and Well-Being in Hospitalized Individuals with COVID-19

Isabele Moraes Rodrigues / Adriana Gomes Lima / Ana Evelyn dos Santos / Anne Carolline Almeida Santos / Luciana Silva do Nascimento / Maria Veronica Cavalcanti Lins Serra / Terezinha de Jesus Santos Pereira / Felipe Douglas Silva Barbosa / Valquiria Martins Seixas / Katia Monte-Silva / Kelly Regina Dias da Silva Scipioni / Daniel Marinho Cezar da Cruz / Daniele Piscitelli / Michela Goffredo / Miburge Bolivar Gois-Junior / Aristela de Freitas Zanona

Journal of Personalized Medicine, Vol 12, Iss 829, p

A Randomized Clinical Trial

2022 Volume 829

Abstract	Background: In 2020, the world was surprised by the spread and mass contamination of the new Coronavirus (COVID-19). COVID-19 produces symptoms ranging from a common cold to severe symptoms that can lead to death. Several strategies have been implemented to improve the well-being of patients during their hospitalization, and virtual reality (VR) has been used. However, whether patients hospitalized for COVID-19 can benefit from this intervention remains unclear. Therefore, this study aimed to investigate whether VR contributes to the control of pain symptoms, the sensation of dyspnea, perception of well-being, anxiety, and depression in patients hospitalized with COVID-19. Methods: A randomized, double-blind clinical trial was designed. Patients underwent a single session of VR and usual care. The experimental group ( n = 22) received VR content to promote relaxation, distraction, and stress relief, whereas the control group ( n = 22) received non-specific VR content. Results: The experimental group reported a significant decrease in tiredness, shortness of breath, anxiety, and an increase in the feeling of well-being, whereas the control group showed improvement only in the tiredness and anxiety. Conclusions: VR is a resource that may improve the symptoms of tiredness, shortness of breath, anxiety, and depression in patients hospitalized with COVID-19. Future studies should investigate the effect of multiple VR sessions on individuals with COVID-19.
Keywords	COVID-19 ; virtual reality ; well-being ; symptom assessment ; occupational therapy ; Medicine ; R
Subject code	150
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Mental Health and Emotional Disorders During the COVID-19 Pandemics: Prevalence and Extent in PICU Staff.

Lima-Setta, Fernanda / de Moraes, Claudia Leite / Silami, Pedro Henrique Nunes Costa / Reichenheim, Michael Eduardo / de Mello E Silva, Juliana Freitas / Stochero, Luciane / de Oliveira, Mariana Barros Genuíno / Robaina, Jaqueline Rodrigues / Rodrigues-Santos, Gustavo / de Almeida, Carlos Gustavo / Amoretti, Carolina Friedrich / Bellinat, Ana Paula Novaes / Brandão, Igor Bromonschenkel / de Carvalho, Patrícia Barbosa / Falcão, Ricardo Viana / Gregory, Simone Camera / de Lorena Jacques, Melissa / Sapolnik, Roberto / Jae, Claudia Mei Lan /

Koliski, Adriana / Krauzer, João Ronaldo Mafalda / de Lima, Lúcio Flávio Peixoto / Lorenzo, Vivian Botelho / Cobas Macedo, João Henrique Garcia / Zaponi Melek, Sandra Lange / Fonseca da Mota, Isabele Coelho / Neves, Cinara Carneiro / Castro, Mirela Alves / Rascão, Fernanda Lobo / Massaud-Ribeiro, Letícia / Riveiro, Paula Marins / Rodrigues, Klara Amanda / Scarlato, Ana Carolina Cabral Pinheiro / Peres da Silva, Thiago / Souza, Ana Carolina Miranda C F F / de Araújo Torreão, Lara / de Seixas Zeitel, Raquel / Alves da Cunha, Antonio José Ledo / Prata-Barbosa, Arnaldo / de Magalhães-Barbosa, Maria Clara

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

2022 Volume 24, Issue 4, Page(s) 277–288

Abstract: Objectives: To assess the prevalence of burnout, anxiety and depression symptoms, and posttraumatic stress disorder (PTSD) in PICU workers in Brazil during the first peak of the COVID-19 pandemic. To compare the results of subgroups stratified by age, ... ...

Abstract	Objectives: To assess the prevalence of burnout, anxiety and depression symptoms, and posttraumatic stress disorder (PTSD) in PICU workers in Brazil during the first peak of the COVID-19 pandemic. To compare the results of subgroups stratified by age, gender, professional category, health system, and previous mental health disorders. Design: Multicenter, cross-sectional study using an electronic survey. Setting: Twenty-nine public and private Brazilian PICUs. Subjects: Multidisciplinary PICU workers. Interventions: None. Measurements and main results: Self-reported questionnaires were used to measure burnout (Maslach Burnout Inventory), anxiety and depression (Hospital Anxiety and Depression Scale), and PTSD (Posttraumatic Stress Disorder Checklist for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition [PCL-5]) in 1,084 respondents. Subjects were mainly young (37.1 ± 8.4 yr old) and females (85%), with a median workload of 50 hours per week. The prevalence of anxiety and depression was 33% and 19%, respectively, whereas PTSD was 13%. The overall median burnout scores were high in the emotional exhaustion and personal accomplishment dimensions (16 [interquartile range (IQR), 8-24] and 40 [IQR, 33-44], respectively) whereas low in the depersonalization one (2 [IQR, 0-5]), suggesting a profile of overextended professionals, with a burnout prevalence of 24%. Professionals reporting prior mental health disorders had higher prevalence of burnout (30% vs 22%; p = 0.02), anxiety (51% vs 29%; p < 0.001), and depression symptoms (32.5% vs 15%; p < 0.001), with superior PCL-5 scores for PTSD ( p < 0.001). Public hospital workers presented more burnout (29% vs 18.6%, p < 0.001) and more PTSD levels (14.8% vs 10%, p = 0.03). Younger professionals were also more burned out ( p < 0.05 in all three dimensions). Conclusions: The prevalence of mental health disorders in Brazilian PICU workers during the first 2020 peak of COVID-19 was as high as those described in adult ICU workers. Some subgroups, particularly those reporting previous mental disorders and younger professionals, should receive special attention to prevent future crises.
MeSH term(s)	Female ; Humans ; Child ; Mental Health ; COVID-19/epidemiology ; Pandemics ; Prevalence ; Cross-Sectional Studies ; Burnout, Professional/epidemiology ; Burnout, Professional/psychology ; Intensive Care Units, Pediatric ; Health Personnel/psychology
Language	English
Publishing date	2022-12-19
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2052349-X
ISSN	1947-3893 ; 1529-7535
ISSN (online)	1947-3893
ISSN	1529-7535
DOI	10.1097/PCC.0000000000003119
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Article: A Complete Sustained Response of Advanced Non-Small-Cell Lung Cancer After Immune Checkpoint Inhibitor, Radiotherapy, and Chemotherapy.

Vilas-Boas, Isabel / Moreira, Inês / Rodrigues, Ana

Cureus

2022 Volume 14, Issue 12, Page(s) e32585

Abstract: Lung cancer is the leading cause of cancer-related mortality worldwide. The treatment of advanced lung cancer is improving with the development of new treatments like immune checkpoint inhibitors (ICIs) and various molecular targeted agents, which have ... ...

Abstract	Lung cancer is the leading cause of cancer-related mortality worldwide. The treatment of advanced lung cancer is improving with the development of new treatments like immune checkpoint inhibitors (ICIs) and various molecular targeted agents, which have extended overall survival (OS). However, complete remissions remain rare. The efficacy of chemotherapy is modest, which makes a complete sustained response very unlikely, especially when compared with more recent options. In this article, we report a stage IV non-small-cell lung cancer (SCLC) that achieved a complete response in 2018 with chemotherapy (cisplatin and paclitaxel) after pembrolizumab and after the patient had received radiotherapy for superior vena cava syndrome (SVCS). The patient remains in complete response as of October 2022. We hypothesized that the overlap between circulating anti-PD-1, radiotherapy, and cytotoxic agents could explain this outcome.
Language	English
Publishing date	2022-12-16
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.32585
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Article ; Online: Cohort Profile Update: 2015 Pelotas (Brazil) Birth Cohort Study－follow-ups from 2 to 6-7 years, with COVID-19 impact assessment.

Murray, Joseph / Leão, Otavio Amaral de Andrade / Flores, Thaynã Ramos / Demarco, Flavio Fernando / Tovo-Rodrigues, Luciana / Oliveira, Isabel O / Arteche, Adriane / Blumenberg, Cauane / Bertoldi, Andréa Dâmaso / Domingues, Marlos Rodrigues / Silveira, Mariangela Freitas / Hallal, Pedro Curi

International journal of epidemiology

2024 Volume 53, Issue 3

MeSH term(s)	Humans ; Brazil/epidemiology ; Cohort Studies ; Follow-Up Studies ; COVID-19/epidemiology
Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	187909-1
ISSN	1464-3685 ; 0300-5771
ISSN (online)	1464-3685
ISSN	0300-5771
DOI	10.1093/ije/dyae048
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Article ; Online: Factors Associated with Behavioral Disorders in Children with Congenital Zika Syndrome and Their Families-A Cross-Sectional Study.

Arrais, Nívia Maria Rodrigues / Maia, Claudia Rodrigues Souza / de Amorim Rodrigues, Nathália Allana / Moreira, Rafaela Silva / de Almeida, Valeria Azevedo / Pereira, Silvana Alves / de Moraes Pinto, Maria Isabel

International journal of environmental research and public health

2022 Volume 19, Issue 15

Abstract: The Zika virus was responsible for an outbreak between 2015 and 2016 in Brazil: an alarming public health problem of international relevance. The Congenital Zika Syndrome (CZS) is often associated with manifestations that are responsible for cognitive ... ...

Abstract	The Zika virus was responsible for an outbreak between 2015 and 2016 in Brazil: an alarming public health problem of international relevance. The Congenital Zika Syndrome (CZS) is often associated with manifestations that are responsible for cognitive and motor development delays and behavioral disorders. Thus, we aimed to characterize the clinical-epidemiological and familial context of those children and to identify factors associated with the risk of behavioral disorders using the Survey of Well-Being of Young Children questionnaire (SWYC). In total, 52 children diagnosed with CZS were evaluated. Logistic regressions were employed to assess predictive variables for behavioral alteration. Eighteen (35%) of the children presented a risk of behavioral alteration. Children born normocephalic were 36-fold more likely to present behavioral alteration (95% CI: 3.82 to 337.92,
MeSH term(s)	Brazil/epidemiology ; Child ; Child, Preschool ; Craniosynostoses/complications ; Cross-Sectional Studies ; Female ; Humans ; Microcephaly/epidemiology ; Microcephaly/etiology ; Pregnancy ; Pregnancy Complications, Infectious ; Zika Virus ; Zika Virus Infection/complications ; Zika Virus Infection/epidemiology
Language	English
Publishing date	2022-08-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19159554
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Article ; Online: Factors Associated With Long Survival in Patients With Cancer Admitted to Palliative Care: An Exploratory Study.

Ferraz-Gonçalves, José António / Alves, Adelaide / Silva, Álvaro José / Valente, Ana Carmo / Pina, Ana / Lima, Áurea / Antunes, Daniela / Cubal, Francisco / Costa, Isabel / Rodrigues, Jorge / Costa, Mariana / Ramos, Mariana / Luis, Michael / Soares, Sofia Garcês / Sousa, Sofia / Moreira, Teresa Dias / Sá-Araújo, Vânia / Bento, Maria José

Journal of palliative care

2024 , Page(s) 8258597241231005

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2024-02-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	639326-3
ISSN	2369-5293 ; 0825-8597
ISSN (online)	2369-5293
ISSN	0825-8597
DOI	10.1177/08258597241231005
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Article ; Online: Congenital Zika Virus Syndrome and Autoimmunity: Two Case Reports of Type 1 Diabetes Mellitus.

Arrais, Nivia Maria Rodrigues / Arrais, Ricardo Fernando / Coelho, Marília Costa / Deghaide, Neifi Hassan Saloum / Donadi, Eduardo Antônio / Maia, Claudia Rodrigues Souza / de Moraes-Pinto, Maria Isabel

The Pediatric infectious disease journal

2023 Volume 42, Issue 5, Page(s) e183–e185

MeSH term(s)	Humans ; Pregnancy ; Female ; Zika Virus ; Autoimmunity ; Diabetes Mellitus, Type 1/complications ; Zika Virus Infection/complications ; Zika Virus Infection/diagnosis ; Zika Virus Infection/congenital ; Microcephaly ; Pregnancy Complications, Infectious
Language	English
Publishing date	2023-02-14
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000003864
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Article ; Online: Factors Associated with Behavioral Disorders in Children with Congenital Zika Syndrome and Their Families—A Cross-Sectional Study

Nívia Maria Rodrigues Arrais / Claudia Rodrigues Souza Maia / Nathália Allana de Amorim Rodrigues / Rafaela Silva Moreira / Valeria Azevedo de Almeida / Silvana Alves Pereira / Maria Isabel de Moraes Pinto

International Journal of Environmental Research and Public Health, Vol 19, Iss 9554, p

2022 Volume 9554

Abstract	The Zika virus was responsible for an outbreak between 2015 and 2016 in Brazil: an alarming public health problem of international relevance. The Congenital Zika Syndrome (CZS) is often associated with manifestations that are responsible for cognitive and motor development delays and behavioral disorders. Thus, we aimed to characterize the clinical-epidemiological and familial context of those children and to identify factors associated with the risk of behavioral disorders using the Survey of Well-Being of Young Children questionnaire (SWYC). In total, 52 children diagnosed with CZS were evaluated. Logistic regressions were employed to assess predictive variables for behavioral alteration. Eighteen (35%) of the children presented a risk of behavioral alteration. Children born normocephalic were 36-fold more likely to present behavioral alteration (95% CI: 3.82 to 337.92, p = 0.002). Children with hearing and visual impairments showed reduced risks. In total, 35% percent of families reported food insecurity and 21% were at risk for maternal depression. Our findings suggest better social interactions and conditions to externalize reactions for children with CZS born normocephalic. The continuous assessment of these children and families may identify conditions associated with behavioral alteration and psychosocial vulnerabilities that help in decision-making, therefore optimizing patient–family interactions.
Keywords	Zika virus ; child development ; behavior ; psychosocial risk ; survey of well-being of young children ; Medicine ; R
Subject code	360
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Designing and characterization of curcumin-loaded nanotechnological dressings: A promising platform for skin burn treatment.

de Moraes Soares Araújo, Gabriela / Lima Rodrigues, Jamile / Campello Yurgel, Virginia / Silva, Carla / Manuel Cavaco Paulo, Artur / Isabel Saì Loureiro, Ana / Lima Dora, Cristiana

International journal of pharmaceutics

2023 Volume 635, Page(s) 122712

Abstract: Burns affect the skin and appendages, impair their function, and become favorable regions for bacterial infections. Owing to time-consuming and costly treatments, burns have been considered a public health problem. The limitations of the treatments used ... ...

Abstract	Burns affect the skin and appendages, impair their function, and become favorable regions for bacterial infections. Owing to time-consuming and costly treatments, burns have been considered a public health problem. The limitations of the treatments used for burns have motivated the search for more efficient alternatives. Curcumin has several potential properties such as anti-inflammatory, healing, and antimicrobial activities. However, this compound is unstable and has low bioavailability. Therefore, nanotechnology could offer a solution for its application. This study aimed to develop and characterize dressings (or gauzes) impregnated with curcumin nanoemulsions that were prepared using two different techniques as a promising platform for skin burn treatment. In addition, the effect of cationization on curcumin release from the gauze was evaluated. Nanoemulsions were successfully prepared using two methods, ultrasound and a high-pressure homogenizer, with sizes of 135 nm and 144.55 nm, respectively. These nanoemulsions exhibited a low polydispersity index, adequate zeta potential, high encapsulation efficiency, and stability for up to 120 d. In vitro assays demonstrated a controlled release of curcumin between 2 and 240 h. No cytotoxicity was observed at concentrations of curcumin up to 75 µg/mL, and cell proliferation was observed. The incorporation of nanoemulsions in the gauze was successfully achieved, and the evaluation of curcumin release showed a faster release from cationized gauzes, whereas the non-cationized gauze promoted a more constant release.
MeSH term(s)	Humans ; Curcumin/pharmacology ; Administration, Cutaneous ; Wound Healing ; Nanotechnology ; Burns/drug therapy
Chemical Substances	Curcumin (IT942ZTH98)
Language	English
Publishing date	2023-02-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2023.122712
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