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Article ; Online: Routine third-trimester ultrasound assessment for intrauterine growth restriction.

Caradeux, Javier / Martínez-Portilla, Raigam J / Martínez-Egea, Judit / Ávila, Francisco / Figueras, Francesc

American journal of obstetrics & gynecology MFM

2024 , Page(s) 101294

Abstract: Intrauterine growth restriction significantly impacts perinatal outcomes. Undetected IUGR escalates the risk of adverse outcomes. Serial symphysis-fundal height measurement, a recommended strategy, is insufficient in detecting abnormal fetal growth. ... ...

Abstract	Intrauterine growth restriction significantly impacts perinatal outcomes. Undetected IUGR escalates the risk of adverse outcomes. Serial symphysis-fundal height measurement, a recommended strategy, is insufficient in detecting abnormal fetal growth. Routine third-trimester ultrasounds significantly improve detection rates compared with this approach, but direct high-quality evidence supporting enhanced perinatal outcomes from routine scanning is lacking. In assessing fetal growth, abdominal circumference alone performs comparably to estimated fetal weight. Hadlock formulas demonstrate accurate fetal weight estimation across diverse gestational ages and settings. When choosing growth charts, prescriptive standards (encompassing healthy pregnancies) should be prioritized over descriptive ones. Customized fetal standards may enhance antenatal IUGR detection, but conclusive high-quality evidence is elusive. Emerging observational data suggest that longitudinal fetal growth assessment could predict adverse outcomes better. However, direct randomized trial evidence supporting this remains insufficient.
Language	English
Publishing date	2024-01-27
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2589-9333
ISSN (online)	2589-9333
DOI	10.1016/j.ajogmf.2024.101294
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Article ; Online: ASO Author Reflections: Lymph Node Assessment with Indocyanine Green Fluorescence in Esophageal Cancer Surgery.

de Lacy, Borja / Martinez-Portilla, Raigam J

Annals of surgical oncology

2021 Volume 28, Issue 9, Page(s) 4878–4879

MeSH term(s)	Esophageal Neoplasms/surgery ; Fluorescence ; Humans ; Indocyanine Green ; Lymph Node Excision ; Lymph Nodes/surgery ; Sentinel Lymph Node ; Sentinel Lymph Node Biopsy
Chemical Substances	Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2021-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-021-09634-3
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Article ; Online: Diagnostic yield of exome sequencing in isolated fetal growth restriction: Systematic review and meta-analysis.

Pauta, Montse / Martinez-Portilla, Raigam J / Meler, Eva / Otaño, Juan / Borrell, Antoni

Prenatal diagnosis

2023 Volume 43, Issue 5, Page(s) 596–604

Abstract: The aim of this study was to determine the diagnostic yield of exome sequencing (ES) above that of chromosomal microarray analysis (CMA) or karyotyping in fetuses with isolated fetal growth restriction (FGR). This was a systematic review conducted in ... ...

Abstract	The aim of this study was to determine the diagnostic yield of exome sequencing (ES) above that of chromosomal microarray analysis (CMA) or karyotyping in fetuses with isolated fetal growth restriction (FGR). This was a systematic review conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Selected studies included those with (a) only fetuses with FGR in the absence of fetal structural anomalies and (b) negative CMA or karyotyping results. Only positive variants classified as likely pathogenic or pathogenic determined as causative of the fetal phenotype were considered. A negative CMA or karyotype result was treated as the reference standard. Eight studies with data on ES diagnostic yield, including 146 fetuses with isolated FGR, were identified. Overall, a pathogenic variant determined as potentially causative of the fetal phenotype was found in 17 cases, resulting in a 12% (95% CI: 7%-18%) incremental performance pool of ES. The vast majority were studied before 32 weeks'gestation. In conclusion, a monogenic disorder was prenatally found in association with apparently isolated FGR in 12% of these fetuses.
MeSH term(s)	Pregnancy ; Humans ; Female ; Fetal Growth Retardation/diagnosis ; Fetal Growth Retardation/genetics ; Exome Sequencing ; Ultrasonography, Prenatal ; Karyotyping ; Microarray Analysis/methods
Language	English
Publishing date	2023-03-25
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	82031-3
ISSN	1097-0223 ; 0197-3851
ISSN (online)	1097-0223
ISSN	0197-3851
DOI	10.1002/pd.6339
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Article ; Online: Effect of multiple pregnancy and laterality on infant neurodevelopment.

Figueras, Maria / Cabot, Rosabel / Viñes, Maricarmen / Torres, Ximena / Martinez-Portilla, Raigam J

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2021 Volume 35, Issue 25, Page(s) 5236–5243

Abstract: Objective: The objective of this study is to investigate the effect of type of pregnancy (singleton, dizygotic, and monozygotic) on infant neurodevelopment and to explore how laterality operates in this relationship.: Methods: We constructed a ... ...

Abstract	Objective: The objective of this study is to investigate the effect of type of pregnancy (singleton, dizygotic, and monozygotic) on infant neurodevelopment and to explore how laterality operates in this relationship. Methods: We constructed a prospective cohort of low-risk women with singleton, monozygotic, and dizygotic pregnancies. Laterality was evaluated using the Edinburgh's scale of laterality, while neurodevelopment was assessed using the Ages & Stages Questionnaire (ASQ). The confounding, modifying, and mediating effect of laterality on the relationship between multiple pregnancy and neurodevelopment was explored by linear regression. Results: We included 207 singletons, 77 dizygotic, and 75 monozygotic pregnancies. The mean age (SD) at assessment of neurodevelopment was 48.5 (7.5) months. There was a significant trend to poorer neurodevelopment across singleton, dizygotic and monozygotic pregnancies in communication (52.2, 47.6 and 42.3; Conclusion: The association of multiple pregnancy to poorer neurodevelopment was independent of children laterality.
MeSH term(s)	Pregnancy ; Infant ; Child ; Female ; Humans ; Child, Preschool ; Prospective Studies ; Pregnancy, Multiple ; Twins, Monozygotic ; Twins, Dizygotic
Language	English
Publishing date	2021-01-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2021.1876023
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Article ; Online: A Spanish-translated clinical algorithm for management of suspected SARS-CoV-2 infection in pregnant women.

Martinez-Portilla, Raigam J / Goncé, Anna / Hawkins-Villarreal, Ameth / Figueras, Francesc

The Lancet. Infectious diseases

2020 Volume 20, Issue 6, Page(s) 655

MeSH term(s)	Algorithms ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Female ; Humans ; Pandemics ; Pneumonia, Viral ; Pregnancy ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome
Keywords	covid19
Language	English
Publishing date	2020-04-09
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(20)30285-1
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Article: Prediction of Neonatal Respiratory Morbidity Assessed by Quantitative Ultrasound Lung Texture Analysis in Twin Pregnancies.

Moreno-Espinosa, Ana L / Hawkins-Villarreal, Ameth / Coronado-Gutierrez, David / Burgos-Artizzu, Xavier P / Martínez-Portilla, Raigam J / Peña-Ramirez, Tatiana / Gallo, Dahiana M / Hansson, Stefan R / Gratacòs, Eduard / Palacio, Montse

Journal of clinical medicine

2022 Volume 11, Issue 16

Abstract: The objective of this study was to evaluate the performance of quantitative ultrasound of fetal lung texture analysis in predicting neonatal respiratory morbidity (NRM) in twin pregnancies. This was an ambispective study involving consecutive cases. ... ...

Abstract	The objective of this study was to evaluate the performance of quantitative ultrasound of fetal lung texture analysis in predicting neonatal respiratory morbidity (NRM) in twin pregnancies. This was an ambispective study involving consecutive cases. Eligible cases included twin pregnancies between 27.0 and 38.6 weeks of gestation, for which an ultrasound image of the fetal thorax was obtained within 48 h of delivery. Images were analyzed using quantusFLM
Language	English
Publishing date	2022-08-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11164895
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Article ; Online: The heart after surviving twin-to-twin transfusion syndrome.

Torres, Ximena / Bennasar, Mar / Bautista-Rodríguez, Carles / Martínez-Portilla, Raigam J / Gómez, Olga / Micheletti, Talita / Eixarch, Elisenda / Crispi, Fátima / Gratacós, Eduard / Martínez, Josep M

American journal of obstetrics and gynecology

2022 Volume 227, Issue 3, Page(s) 502.e1–502.e25

Abstract: Background: The persistent changes in cardiac structure and function in children who survived twin-to-twin transfusion syndrome remain a matter of concern and controversy. Current fetal echocardiographic parameters and their postnatal evolution can help ...

Abstract	Background: The persistent changes in cardiac structure and function in children who survived twin-to-twin transfusion syndrome remain a matter of concern and controversy. Current fetal echocardiographic parameters and their postnatal evolution can help improve our understanding of the subject. Objective: To describe the echocardiographic changes of monochorionic fetuses affected by twin-to-twin transfusion syndrome, the recipient and the donor, before and after laser photocoagulation and to determine their evolution in the third trimester and during their first year of life. Study design: An observational study was conducted including 55 uncomplicated monochorionic diamniotic twins and 78 pairs with twin-to-twin transfusion syndrome, 44 stage I-II and 34 stage III-IV, prospectively enrolled from 2015 until 2018. Comprehensive echocardiography was performed at 4 time periods: before laser photocoagulation, at 24 to 72 hours after surgery, at 28 to 30 weeks of gestation, and at 6 to 12 months after birth. Echocardiographic parameters were transformed to z-scores or indexed for heart area, estimated fetal weight, or body mass surface. Results: At diagnosis, recipients in all stages presented larger hearts (cardiothoracic ratio z-score: 2.77 [0.8] vs controls: -0.03 [0.5]; P<.001) and signs of ventricular hypertrophy (left end-diastolic ventricle wall thickness: 2.68 [0.7] vs controls -0.03 [0.7]; P<.001), along with systolic (cardiac index recipients: 317 [114] mL/min/kg vs controls: 400 [120] mL/min/kg, P<.001) and diastolic impairment (isovolumetric relaxation time z-score: 2.76 [0.6] vs controls: 0.05 [0.6]; P<.001). Donors presented smaller ventricular areas and diameters when compared with controls (left end-diastolic ventricle area z-score: -1.48 [1] vs 0.03 [0.9]; P<.001), along with decreased longitudinal motion (tricuspid annular plane systolic excursion z-score: -0.9 [1] vs controls -0.04 [1]; P<.001) and shorter ejection time z-score (-1.5 [0.7] vs controls: 0.0 [0.7]; P<.001). After surgery, an improvement in functional parameters was observed in both fetuses, whereas most morphometric changes prevailed in donors and recipients in the prenatal period. Postnatally, cardiac remodeling persisted in recipients (left relative wall thickness: 0.34 [0.02] vs controls: 0.30 [0.02]; P<.001), whereas donors mainly presented a decreased longitudinal motion in infancy (tricuspid annular plane systolic excursion z-score: -0.72 [0.7] vs controls: 0.23 [0.9]; P<.05). Conclusion: Cardiac remodeling is present in both fetuses at the twin-to-twin transfusion syndrome diagnosis, whereas diastolic dysfunction is only significant in the recipient. Fetal therapy improves most echocardiographic parameters, although postnatally, the echocardiographic changes persist in both fetuses.
MeSH term(s)	Child ; Echocardiography ; Female ; Fetofetal Transfusion/diagnostic imaging ; Fetofetal Transfusion/surgery ; Heart ; Heart Ventricles ; Humans ; Pregnancy ; Ultrasonography, Prenatal ; Ventricular Remodeling
Language	English
Publishing date	2022-03-26
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/j.ajog.2022.03.049
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Article: A Spanish-translated clinical algorithm for management of suspected SARS-CoV-2 infection in pregnant women

Martinez-Portilla, Raigam J / Goncé, Anna / Hawkins-Villarreal, Ameth / Figueras, Francesc

Lancet Infect Dis

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #46598
Database	COVID19

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Article ; Online: Prescriptive standards of echocardiographic morphometric and functional parameters in uncomplicated monochorionic diamniotic fetuses.

Torres, Ximena / Martínez, Josep M / Gómez, Olga / MartÍnez-Portilla, Raigam J / García-Otero, Laura / Crispi, Fátima / Masoller, Narcís / Sepúlveda-Martínez, Álvaro / Marimón, Edda / Gratacós, Eduard / Figueras, Francesc / Bennasar, Mar

Prenatal diagnosis

2021 Volume 41, Issue 12, Page(s) 1486–1497

Abstract: Objective: To create prescriptive standards of cardiac morphometric and functional parameters in a cohort of uncomplicated monochorionic diamniotic (MCDA) twins.: Method: Fetal echocardiography was performed in a cohort of uncomplicated monochorionic ...

Abstract	Objective: To create prescriptive standards of cardiac morphometric and functional parameters in a cohort of uncomplicated monochorionic diamniotic (MCDA) twins. Method: Fetal echocardiography was performed in a cohort of uncomplicated monochorionic twin fetuses scanned longitudinally, including comprehensive morphometric and functional parameters, using 2-D imaging, M-mode and conventional Doppler. A multilevel polynomial hierarchical model adjusted by gestational age and estimated fetal weight was used to fit each cardiac parameter. Results: The global heart dimensions including the atrial and ventricular areas, the ventricles dimensions and myocardial wall thicknesses and most of the functional parameters, such as the longitudinal myocardial motion and the biventricular cardiac output showed a positive quadratic increment throughout pregnancy. On the other hand, the left ejection fraction, shortening fraction and right fractional area change decreased with gestational age. Scatterplots for the main structural and functional parameters and ratios by gestational age, with mean, 5th, 10th, 90th, and 95th percentiles are provided. Regression equations by estimated fetal weight are also created. Conclusion: We provide specific comprehensive echocardiographic prescriptive standards for uncomplicated MCDA twin fetuses following current standardized methodology. The implementation of these charts will potentially help to better identify abnormal cardiovascular parameters associated to monochorionic complications.
MeSH term(s)	Adult ; Blood Flow Velocity/physiology ; Cohort Studies ; Echocardiography/methods ; Echocardiography/standards ; Echocardiography/statistics & numerical data ; Female ; Fetus/diagnostic imaging ; Gestational Age ; Humans ; Pregnancy ; Prospective Studies ; Spain ; Twins, Dizygotic
Language	English
Publishing date	2021-07-08
Publishing country	England
Document type	Journal Article
ZDB-ID	82031-3
ISSN	1097-0223 ; 0197-3851
ISSN (online)	1097-0223
ISSN	0197-3851
DOI	10.1002/pd.5999
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Article ; Online: A Spanish-translated clinical algorithm for management of suspected SARS-CoV-2 infection in pregnant women

Martinez-Portilla, Raigam J / Goncé, Anna / Hawkins-Villarreal, Ameth / Figueras, Francesc

The Lancet Infectious Diseases

2020 Volume 20, Issue 6, Page(s) 655

Keywords	Infectious Diseases ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/s1473-3099(20)30285-1
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