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Article ; Online: Sars-Cov-2 virus and vaccination; biological and statistical framework.

Arslan, Ferhat / Ankaralı, Handan

2021 Volume 20, Issue 9, Page(s) 1059–1063

Abstract: Introduction: The Development of the SARS-CoV-2 virus vaccine and its update on an ongoing pandemic is the first subject of the world health agenda.: Areas covered: First, we will scrutinize the biological features of the measles virus (MV), variola ... ...

Abstract	Introduction: The Development of the SARS-CoV-2 virus vaccine and its update on an ongoing pandemic is the first subject of the world health agenda. Areas covered: First, we will scrutinize the biological features of the measles virus (MV), variola virus (smallpox virus), influenza virus, and their vaccines to compare them with the SARS-CoV-2 virus and vaccine. Next, we will discuss the statistical details of measuring the effectiveness of an improved vaccine. Expert opinion: Amidst the pandemic, we ought to acknowledge our prior experiences with respiratory viruses and vaccines. In the planning stage of observational Phase-III vaccine effectiveness studies, the sample size, sampling method, statistical model, and selection of variables are crucial in obtaining high-quality and valid results.
MeSH term(s)	COVID-19/pathology ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; Humans ; Immunity, Cellular/immunology ; Influenza Vaccines/immunology ; Mass Vaccination/methods ; Measles virus/immunology ; Measles-Mumps-Rubella Vaccine/immunology ; Orthomyxoviridae/immunology ; SARS-CoV-2/immunology ; Smallpox Vaccine/immunology ; Vaccination ; Vaccines, Attenuated/immunology ; Variola virus/immunology
Chemical Substances	COVID-19 Vaccines ; Influenza Vaccines ; Measles-Mumps-Rubella Vaccine ; Smallpox Vaccine ; Vaccines, Attenuated
Language	English
Publishing date	2021-08-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2181284-6
ISSN	1744-8395 ; 1476-0584
ISSN (online)	1744-8395
ISSN	1476-0584
DOI	10.1080/14760584.2021.1965884
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Article ; Online: Indirect Forecasting of the Number of Intensive Care Beds and Hospital Capacity for the COVID-19 Outbreak in Turkey Until the End of April

Handan Ankaralı / Seyit Ankaralı

Türk Yoğun Bakım Dergisi, Vol 18, Iss 1, Pp 22-

2020 Volume 30

Abstract: Objective:The COVID-19 outbreak has been threatening the entire world for approximately 4 months. Healthcare management is one of the most important precautions to be taken for the successful management of this epidemic. Evidence-based estimates are of ... ...

Abstract	Objective:The COVID-19 outbreak has been threatening the entire world for approximately 4 months. Healthcare management is one of the most important precautions to be taken for the successful management of this epidemic. Evidence-based estimates are of great importance in solving these problems. In this study, as of the first week of April, we provide a description of Turkey according to the indicators of the COVID-19 outbreak in each city and an evaluation of the relationship between the population density of each province and the number of cases. Additionally, we calculate the change in the new case rate and aim to estimate the number of intensive care beds and the number of intubations needed on a day-to-day basis.Materials and Methods:The outbreak indicators and number of tests announced by the Ministry of Health of the Turkish Republic day-by-day were used. A Poisson regression model was used for data analysis. In addition, a new algorithm was proposed to estimate healthcare needs.Results:The relationship between urban density and the total number of cases was found to be statistically significant (r=0.464, p<0.001). When the density increased by one person, the total number of cases was estimated to increase by one. Minor changes were observed in the rate of new cases within the daily tests between March 29 and April 5. The total numbers of intensive care patients, intubated patients, patients quarantined at home or hospitalized in the normal service, and recovered patients, as well as the total case numbers were used in the calculations. By using the total forecasted cases, the service infrastructure requirements to be provided in hospitals, such as the number of beds and the number of intubations, were estimated and given in tables.Conclusion:When priorities are questioned in the coming days, it should not be forgotten that these types of studies will be helpful to solve important health problems.
Keywords	intensive care ; intubation ; covid-19 ; time series ; poisson regression ; Medicine ; R ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; covid19
Subject code	360
Language	Turkish
Publishing date	2020-10-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
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Article ; Online: Examination of posture and balance in children with primary monosymptomatic nocturnal enuresis.

Inal, Busra / Ozengin, Nuriye / Bakar, Yesim / Ankaralı, Handan / Ozturk, Yusuf

Journal of pediatric rehabilitation medicine

2023 Volume 16, Issue 3, Page(s) 529–537

Abstract: Purpose: This study aimed to examine symptom severity, posture, and balance of children with primary monosymptomatic nocturnal enuresis (PMNE) and compare to a healthy control group.: Methods: Thirty-five children with PMNE and 34 healthy children ... ...

Abstract	Purpose: This study aimed to examine symptom severity, posture, and balance of children with primary monosymptomatic nocturnal enuresis (PMNE) and compare to a healthy control group. Methods: Thirty-five children with PMNE and 34 healthy children were included in this study. Physical and sociodemographic characteristics of the children were recorded. Symptom severity was assessed with a Vancouver Non-Neurogenic Lower Urinary Tract Dysfunction/Dysfunctional Elimination Syndrome Questionnaire (NLUTD/DES), a four-day bladder diary and a seven-day bowel diary. Standing postural alignment was assessed with the Spinal Mouse device, and the sensory integration of static balance and dynamic standing balance was assessed with the Biodex Balance System SD. Results: Compared to healthy controls, children with PMNE demonstrated increased symptom severity (p = 0.001), increased upright lumbar lordosis (p = 0.018) and sacral-hip angles (p = 0.029), decreased static balance in the sensory condition of unstable surface with eyes closed (p = 0.001), and decreased mediolateral dynamic balance (p = 0.049). Conclusion: Children with PMNE demonstrate altered postural alignment, static and dynamic postural instability, and greater symptom severity on the Vancouver NLUTD/DES than age-matched controls.
MeSH term(s)	Humans ; Child ; Animals ; Mice ; Nocturnal Enuresis/diagnosis ; Urinary Bladder ; Physical Examination ; Posture ; Standing Position
Language	English
Publishing date	2023-01-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2403637-7
ISSN	1875-8894 ; 1874-5393
ISSN (online)	1875-8894
ISSN	1874-5393
DOI	10.3233/PRM-210105
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Article ; Online: Assessment of the dissimilarities of totally 186 countries and regions according to COVID-19 indicators at the end of March 2020.

Ankarali, Handan / Uslu, Unal / Ankarali, Seyit / Cangur, Sengul

Malawi medical journal : the journal of Medical Association of Malawi

2022 Volume 34, Issue 2, Page(s) 73–86

Abstract: Background: This study is aimed at evaluating the relationship between the number of days elapsed since a country's first case(s) of coronavirus disease 2019 (COVID-19), the total number of tests conducted, and outbreak indicators such as the total ... ...

Abstract	Background: This study is aimed at evaluating the relationship between the number of days elapsed since a country's first case(s) of coronavirus disease 2019 (COVID-19), the total number of tests conducted, and outbreak indicators such as the total numbers of cases, deaths, and patients who recovered. The study compares COVID-19 indicators among countries and clusters them according to similarities in the indicators. Methods: Descriptive statistics of the indicators were computed and the results were presented in figures and tables. A fuzzy Results: The highest numbers of COVID-19 cases were found in Gibraltar, Spain, Switzerland, Liechtenstein and Italy were also of that order with about 1500 cases per million population. Spain and Italy had the highest total number of deaths, which were about 140 and 165 per million population, respectively. In Japan, where exposure to the causative virus was longer than in most other countries, the total number of deaths per million population was less than 0.5. According to cluster analysis, the total numbers of deaths, patients who recovered, and active cases were higher in Western countries, especially in central and southern European countries, which had the highest numbers when compared with other countries. Conclusion: There may be various reasons for the differences between the clusters obtained by fuzzy
MeSH term(s)	COVID-19/epidemiology ; Health Policy ; Humans ; Quarantine
Language	English
Publishing date	2022-01-18
Publishing country	Malawi
Document type	Journal Article
ZDB-ID	2491952-4
ISSN	1995-7270 ; 1995-7270
ISSN (online)	1995-7270
ISSN	1995-7270
DOI	10.4314/mmj.v34i2.2
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Article: The relationship between aerobic capacity and cognitive/academic performance in medical students.

Bayramlar, Zeynep / Ankarali, Seyit / Ankarali, Handan

General physiology and biophysics

2022 Volume 41, Issue 6, Page(s) 579–590

Abstract: The positive relationship between aerobic capacity and cognitive performance is well known, but there is little information regarding young adults. Therefore, we aimed to test the hypothesis that aerobic capacity (VO2max) correlates with cognitive and ... ...

Abstract	The positive relationship between aerobic capacity and cognitive performance is well known, but there is little information regarding young adults. Therefore, we aimed to test the hypothesis that aerobic capacity (VO2max) correlates with cognitive and academic performance in medical students who have higher academic achievement with academic performance. We included 65 volunteer medical students who were in term 2/6 in this descriptive, cross-sectional study. Body composition and the International Physical Activity Questionnaire and cardiopulmonary exercise test results of all participants were analyzed. Lumosity application with 6 categories of cognitive tests was applied to evaluate cognitive performance. The university entrance exam scores of the students were taken into consideration to assess their academic performance. We observed a significant "positive" relationship between aerobic capacity and some domains of cognitive performance, especially problem solving (p < 0.05), but we did not find a significant relationship between aerobic capacity and academic performance. Consequently, although we confirmed the existence of a positive effect of high aerobic capacity on cognitive performance stated in the literature, we couldn't confirm this for all cognitive domains or academic performance. These results suggest that more comprehensive studies on this subject are needed.
MeSH term(s)	Young Adult ; Humans ; Students, Medical ; Cross-Sectional Studies ; Academic Performance ; Cognition
Language	English
Publishing date	2022-11-08
Publishing country	Slovakia
Document type	Journal Article
ZDB-ID	791184-1
ISSN	0231-5882
ISSN	0231-5882
DOI	10.4149/gpb_2022031
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Article ; Online: Does Pilates effect on depression status, pain, functionality, and quality of life in university students? A randomized controlled study.

Saltan, Asuman / Ankaralı, Handan

Perspectives in psychiatric care

2020 Volume 57, Issue 1, Page(s) 198–205

Abstract: Purpose: The aim of this study is to investigate the effects of Pilates exercise program on health-related quality of life, pain, functional level, and depression status in university students.: Design and methods: The exercise programs were carried ... ...

Abstract	Purpose: The aim of this study is to investigate the effects of Pilates exercise program on health-related quality of life, pain, functional level, and depression status in university students. Design and methods: The exercise programs were carried out for 12 weeks. The scales of Nottingham Health Profile, Visual Analog Scale, Oswestry Disability Index, and Beck Depression Inventory were used at the baseline and after training. Findings: Exercise should be encouraged to reduce pain and depression and improve the quality of life in healthy university students. Both Pilates and therapeutic exercises approach can be preferred. Practice implications: The results of this study show the inability to identify clear different effects from therapeutic exercises on university students for Pilates exercises.
MeSH term(s)	Adolescent ; Adult ; Depression/psychology ; Depression/therapy ; Exercise Movement Techniques ; Female ; Humans ; Male ; Pain/psychology ; Pain Management ; Quality of Life ; Students/psychology ; Universities ; Young Adult
Language	English
Publishing date	2020-06-02
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	391097-0
ISSN	1744-6163 ; 0031-5990
ISSN (online)	1744-6163
ISSN	0031-5990
DOI	10.1111/ppc.12547
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Article ; Online: Direct Prediction of the Number of Intensive Care Beds and Ventilators it Will be Needed for COVID-19 Outbreak in Turkey ; Türkiye’de COVID-19 Salgın Sürecinde İhtiyaç Duyulacak Yoğun Bakım Yatak ve Solunum Cihazı Sayılarının Direkt Tahmini

ANKARALI, Handan

Issue: Special Issue on COVID 19 59-62 ; 2149-5254 ; 2458-8849 ; Anatolian Clinic the Journal of Medical Sciences

2020

Abstract: Introduction and Aim: Because the number of coronavirus cases has increased day by day in Turkey, , evidence-based prediction of the needs in the provision of health services and particularly critical/seriously patient needs is of paramount importance. ... ...

Abstract	Introduction and Aim: Because the number of coronavirus cases has increased day by day in Turkey, , evidence-based prediction of the needs in the provision of health services and particularly critical/seriously patient needs is of paramount importance. In this study, it was aimed to predict the number of intensive care beds and breathing apparatus with the help of two different models.Materials and Methods: Data were analyzed with Gompertz and Time series models.Results: The forecasting of the models used in the study were found similar. Since a few data are used in model development (13 days), only 1 week forecasts were given. While the total number of intensive care beds according to the Gompertz model on April 6 was 1474, this number was forecast as 1485 in the time series model. The number of ventilators that will be needed on the same date was 1000 according to the Gompertz model and 1004 according to the time series model.Conclusion: When the number of data (days) exceeds 30, the mathematical models used will increase the success in the future long-term forecasts as they will better catch the trend. Giriş ve Amaç: COVID-19 salgın sürecinde, Türkiye’ de vaka sayısının hızlı artış periyoduna girdiği bu günlerde, sunulan sağlık hizmetlerindeki ihtiyaçların ve özellikle hayati önem taşıyan hasta ihtiyaçlarının kanıta dayalı öngörüsü büyük önem taşımaktadır. Bu çalışmada, karşılaştırmalı olarak iki farklı model yardımıyla yoğun bakım yatak ve solunum cihazı sayılarının öngörülmesi amaçlandı. Gereç ve Yöntemler: Veriler, Gompertz ve Zaman serileri modelleri ile incelendi. Bulgular: Çalışmada kullanılan modellerin öngörü başarıları benzer bulundu. Ancak modellemede kullanılan veri sayısının az olması nedeniyle (13 gün) sadece 1 haftalık öngörüler verildi. Gompertz modeline göre 6 Nisan’ da öngörülen toplam yoğun bakım yatak sayısı 1474 iken zaman serisi modelinde 1485 bulundu. Aynı tarihte ihtiyaç duyulacak solunum cihazı sayısı Gompertz modeline göre 1000, zaman serisi modeline göre 1004 olarak hesaplandı.Sonuç: Veri sayısı (gün sayısı) 30’ un üzerine çıktığı zaman kullanılan matematiksel modeller, eğilimi daha iyi yakalayacağı için ileriye dönük uzun süreli tahminlerdeki başarıları artacaktır.
Keywords	COVID-19,intensive care unit,ventilator,Gomperz model,Time series ; COVID-19,Yoğun bakım ünitesi,ventilatör,Gomperz modeli,Zaman serileri ; covid19
Language	Turkish
Publishing date	2020-03-20T00:00:00Z
Publisher	Hayat Sağlık ve Sosyal Hizmetler Vakfı
Publishing country	tr
Document type	Article ; Online
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Article: Anxiety and Depression among People Living with HIV During the COVID-19 Pandemic: A Face-to-Face Survey from Turkey.

Ergen, Pınar / Görmez, Aynur / Ankaralı, Handan / Aydın, Özlem / Baysal, Naciye Betül / Çağ, Yasemin

Psychiatria Danubina

2023 Volume 35, Issue 1, Page(s) 103–111

Abstract: Background: During the COVID-19 pandemic, there have been some difficulties in the routine care of people living with HIV (PLWH).: Subjects and methods: We aimed to evaluate the impact of COVID-19 on mental health of PLWH and their use of health ... ...

Abstract	Background: During the COVID-19 pandemic, there have been some difficulties in the routine care of people living with HIV (PLWH). Subjects and methods: We aimed to evaluate the impact of COVID-19 on mental health of PLWH and their use of health services. This study was conducted using the face-to-face interview method in the outpatient clinic of a university hospital, between 01.09.2020 and 30.11.2020. Hospital Anxiety and Depression Scale and survey instrument designed by the researchers investigating socio-demographic data and access to health services were used. Results: The study included 217 patients, 91.7% (n=199) of whom were male. All of the patients were postponed their hospital appointments, 60.8% were concerned about not being able to contact their physician and 53% had concerned about being stigmatized if they went to the hospital. Of the participants, 27.6% had depression, 12.9% had anxiety and 8.3% had both depression and anxiety. Low income, job loss, and fear of being stigmatized were associated with depression and anxiety. Lower level of education, discontinuation of medications and lack of opportunity to work remotely were associated with depression, while history of psychiatric illness, worry about not being able to contact their physician and cessation of antiretroviral therapy were associated with higher anxiety levels. Conclusion: It is important to develop strategies ensuring the continuity of care for PWLH and identify and support those with a higher mental health impact.
MeSH term(s)	Humans ; Male ; Female ; COVID-19/epidemiology ; COVID-19/complications ; Depression/epidemiology ; Depression/psychology ; Turkey/epidemiology ; Pandemics ; Anxiety/epidemiology ; Anxiety/psychology ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV Infections/complications
Language	English
Publishing date	2023-04-15
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	1067580-2
ISSN	0353-5053
ISSN	0353-5053
DOI	10.24869/psyd.2023.103
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Article ; Online: The evaluation of risk factors related to reduced bone mineral density in young people living with HIV.

Aydın, Özlem / Ankaralı, Handan / Ergen, Pınar / Baysal, Naciye Betül / Çağ, Yasemin

African health sciences

2023 Volume 22, Issue 4, Page(s) 461–469

Abstract: Background: Low bone mineral density (BMD) is one of the comorbidities that develop in people living with HIV (PLWHIV).: Objective: This study was conducted to review the frequency and risk factors of reduced BMD according to age in HIV-infected ... ...

Abstract	Background: Low bone mineral density (BMD) is one of the comorbidities that develop in people living with HIV (PLWHIV). Objective: This study was conducted to review the frequency and risk factors of reduced BMD according to age in HIV-infected patients in Turkey. Material and method: This retrospective cohort study included HIV-infected patients aged 18-50. Bone density was analysed using dual-energy X-ray absorptiometry (DXA) according to the Z-score in three different regions including the lumbar, total-hip and femoral-neck. Results: The study included 224 PLWHIV with a mean age of 35.84-7.54, and 59.8% were ART naive. Of the patients, 40.6% had lower BMD than expected at least in one of the three examined regions including the lumbar, total hip and femoral neck. The low BMD ratios were found respectively as 11.6%, 11.6% and 28.6% in the femoral neck, total hip and lumbar regions. According to the logistic regression model, a high body mass index (p=0.003) and HIV-RNA level of ≥100.000IU/ml during the diagnosis in the ART-naive group (p=0.008) were associated with reduced bone demineralization. The low BMD frequency was high in the group that received ART for <24 months (p=0.001). Conclusion: Performing bone demineralization screening in the naive and young patient group, independently from ART status prior to making the diagnosis of HIV is important for organizing the bone health improvement methods.
MeSH term(s)	Adolescent ; Adult ; Humans ; Bone Density ; Bone Diseases, Metabolic/etiology ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Retrospective Studies ; Risk Factors ; Young Adult ; Middle Aged
Language	English
Publishing date	2023-04-25
Publishing country	Uganda
Document type	Journal Article
ZDB-ID	2240308-5
ISSN	1729-0503 ; 1680-6905
ISSN (online)	1729-0503
ISSN	1680-6905
DOI	10.4314/ahs.v22i4.52
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Article ; Online: Comparison of decision-making under ambiguity in patients with temporal lobe and frontal lobe epilepsy.

Simsekoglu, Ruken / Tombul, Temel / Demirci, Hasan / Özdemir, Mehtap / Ankaralı, Handan

Epilepsy & behavior : E&B

2022 Volume 129, Page(s) 108636

Abstract: Objective: The effect of the frontal lobe on cognitive functions is a subject that has been studied frequently. However, cognitive impairments that can be seen in frontal lobe epilepsy are less addressed. In previous studies on decision-making disorders ...

Abstract	Objective: The effect of the frontal lobe on cognitive functions is a subject that has been studied frequently. However, cognitive impairments that can be seen in frontal lobe epilepsy are less addressed. In previous studies on decision-making disorders in patients with epilepsy, patients with temporal lobe epilepsy (TLE) were frequently studied, and it was reported that decision-making disorders could be encountered in this patient group. In this study, we aimed to compare the decision-making performance of patients with cryptogenic frontal lobe epilepsy (FLE) and TLE in ambiguous situations. Methods: Twenty patients with TLE (mean age: 34.10 ± 11.71 years) and 20 patients with FLE (mean age: 32.25 ± 11.92 years) were enrolled in the study and their cognitive performance was compared with 20 healthy controls (mean age: 33.15 ± 13.66 years). Neuropsychological tests were performed on the participants for sleep, depression, anxiety, impulsivity, intelligence, attention, language functions, memory and learning, and frontal axis functions. Decision-making performance in ambiguous situations was studied using the Iowa Gambling Task (IGT). Results: Iowa Gambling Task performances of patients with FLE and TLE were found to be worse than in healthy controls (p = 0.049). Although there was no statistically significant difference when the decision-making of patients with TLE and FLE was compared, it was observed that patients with FLE chose higher risk cards compared with those with TLE. The performances of the neuropsychological subgroup tests of patients with TLE and FLE in attention, language functions, memory and learning, and frontal axis functions were found to be significantly worse than in healthy subjects. Conclusion: Decision-making in patients with TLE and FLE in ambiguous situations is similarly impaired compared with healthy controls.
MeSH term(s)	Adult ; Cognition ; Epilepsy, Frontal Lobe/psychology ; Epilepsy, Temporal Lobe/complications ; Epilepsy, Temporal Lobe/psychology ; Humans ; Middle Aged ; Neuropsychological Tests ; Temporal Lobe ; Young Adult
Language	English
Publishing date	2022-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010587-3
ISSN	1525-5069 ; 1525-5050
ISSN (online)	1525-5069
ISSN	1525-5050
DOI	10.1016/j.yebeh.2022.108636
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