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Book ; Thesis: Role of transcription factor cAMP response element modulator (CREM) in detrimental beta 1 adrenoceptor mediated cardiac effects in mice

Basu, Abhijit

2010

Author's details	vorgelegt von Abhijit Basu
Keywords	Transkriptionsfaktor ; CRE ; Beta-Rezeptor ; Herz
Subject	Adrenergischer Betarezeptor ; Beta-adrenergischer Rezeptor ; Beta-Adrenozeptor ; cAMP-responsive-element ; Cyclic-AMP-responsive-element ; Trans-wirkender Faktor ; Regulatorproteine
Language	English
Size	VIII, 124 Bl. : Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Münster (Westfalen), Univ., Diss., 2010
HBZ-ID	HT016477544
Database	Catalogue ZB MED Medicine, Health

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Article: Sublingual Epidermoid Cyst with Cervical Lymphadenopathy: A Rare Case with Review of Literature.

Rai, Ajay Kumar / Singh, Shalendra / Basu, Abhijit / Prasad, B K

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India

2023 Volume 75, Issue 4, Page(s) 4110–4112

Language	English
Publishing date	2023-07-14
Publishing country	India
Document type	Journal Article
ZDB-ID	1471137-0
ISSN	0973-7707 ; 2231-3796 ; 0019-5421
ISSN (online)	0973-7707
ISSN	2231-3796 ; 0019-5421
DOI	10.1007/s12070-023-04067-8
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Zs.A 5300: Show issues

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Article ; Online: A Comprehensive Review of Yoga Research in 2020.

Dutta, Abhijit / Aruchunan, Mooventhan / Mukherjee, Anindya / Metri, Kashinath G / Ghosh, Kuntal / Basu-Ray, Indranill

Journal of integrative and complementary medicine

2022 Volume 28, Issue 2, Page(s) 114–123

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Anxiety ; Child ; Chronic Pain ; Humans ; Meditation ; Mental Health ; Yoga
Language	English
Publishing date	2022-01-28
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2768-3613
ISSN (online)	2768-3613
DOI	10.1089/jicm.2021.0420
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Article ; Online: Role of methylene blue dye in sentinel node biopsy in N0 oral cavity squamous cell carcinoma.

Upadhyay, Kiran / Gupta, Vikas / Sahu, Pankaj K / Basu, Abhijit / Bhatia, Ritika

Indian journal of cancer

2023

Abstract: Background: Presence of neck nodes in cases of head neck squamous cell cancers is an adverse prognostic factor. Elective neck dissection is traditionally recommended along with primary disease resection. Sentinel lymph node (SLN) is the first draining ... ...

Abstract	Background: Presence of neck nodes in cases of head neck squamous cell cancers is an adverse prognostic factor. Elective neck dissection is traditionally recommended along with primary disease resection. Sentinel lymph node (SLN) is the first draining node. Sentinel lymph node biopsy (SNB) is a minimally invasive technique to identify occult nodal metastasis in early HNSCC. Methods: The objective of this study is to determine the identification rate of SNB using methylene blue dye (MBD) in N0 neck of Oral Squamous cell carcinoma (OSCC) and estimating specificity, sensitivity, negative predictive value and positive predictive value of SNB with frozen section (FS) analysis and in comparison to post-operative histopathological examination (HPE). It is a cross-sectional study conducted at a tertiary care centre, Lucknow, India. 21 patients of N0 OSCC from January 2019 to May 2020, were included. All patients underwent peritumoral injection with MBD. Sentinel nodes were harvested and sent for FS. Depending on FS findings, appropriate neck dissection was performed. Results: SLN was identified at level Ib and II in 19 patients (90.47%). The sensitivity, specificity, PPV and NPV in identifying SLN using MBD versus FS were 100.00%, 11.11%, 15.79% and 100.00% respectively. Whereas, SLN using MBD versus HPE specimens were 100.00%, 10.52%, 10.52% and 100.00% respectively. Conclusion: Despite having 100% sensitivity, MBD alone has poor specificity. With this poor discriminatory power, it is unlikely to be employed as a diagnostic test alone. It is recommended to rely on per-operative FS for taking decision as far as extent of neck dissection in N0 neck is concerned.
Language	English
Publishing date	2023-12-03
Publishing country	India
Document type	Journal Article
ZDB-ID	410194-7
ISSN	1998-4774 ; 0019-509X
ISSN (online)	1998-4774
ISSN	0019-509X
DOI	10.4103/ijc.IJC_862_20
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Article ; Online: Re: Fasting blood glucose predicts response to extended-release metformin in gestational diabetes mellitus by Corbould A, Swinton F, Radford A, Campbell, McBeath S, Dennis A. Aust N Z J Obstet Gynaecol 2013; 53: 125-129.

Basu, Abhijit

The Australian & New Zealand journal of obstetrics & gynaecology

2013 Volume 53, Issue 6, Page(s) 596–597

MeSH term(s)	Diabetes, Gestational/drug therapy ; Female ; Humans ; Hypoglycemic Agents/therapeutic use ; Metformin/therapeutic use ; Pregnancy
Chemical Substances	Hypoglycemic Agents ; Metformin (9100L32L2N)
Language	English
Publishing date	2013-12
Publishing country	Australia
Document type	Comment ; Letter
ZDB-ID	390815-x
ISSN	1479-828X ; 0004-8666
ISSN (online)	1479-828X
ISSN	0004-8666
DOI	10.1111/ajo.12119
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Zs.A 424: Show issues

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Article ; Online: Exome-wide scan identifies significant association of rs4788084 in IL27 promoter with increase in hepatic fat content among Indians.

Chatterjee, Ankita / Basu, Analabha / Das, Kausik / Chowdhury, Abhijit / Basu, Priyadarshi

Gene

2021 Volume 775, Page(s) 145431

Abstract: Background: Non-alcoholic fatty liver disease (NAFLD) is a global epidemic that often progresses to liver cirrhosis and hepatocellular carcinoma. In contrast to most world populations where NAFLD is mostly prevalent among obese, NAFLD among Indians and ... ...

Abstract	Background: Non-alcoholic fatty liver disease (NAFLD) is a global epidemic that often progresses to liver cirrhosis and hepatocellular carcinoma. In contrast to most world populations where NAFLD is mostly prevalent among obese, NAFLD among Indians and generally among South and South-East Asians is unique and highly prevalent among individuals who are lean. Genetics of NAFLD in Indian populations is understudied. In this study, we have used an exome-wide approach to identify genetic determinants of hepatic fat content (HFC) in India. Methods: HFC was measured in 244 participants using Proton magnetic resonance spectroscopy (H1-MRS). Quantitative trait loci (QTL) mapping was done exome-wide, to identify SNPs associated with HFC. The effects of the interaction between adiposity and QTLs on HFC were studied using a regression model. Association of the significant loci with disease severity was studied in 146 NAFLD patients among 244 participants, who underwent liver biopsy. Results: Our study identified 4 significantly associated SNPs (rs738409 and rs2281135 (PNPLA3), rs3761472 (SAMM50), rs17513722 (FAM161A) and rs4788084), with HFC after adjusting for the effects of covariates (p-value < 0.0005). rs738409, rs2281135 (PNPLA3), and rs3761472 (SAMM50) were associated with hepatocyte ballooning, lobular and portal inflammation and non-alcoholic steatohepatitis (NASH) (p-value < 0.05). rs4788048 is an eQTL for IL27 and SULT1A2 genes, both of which are highly expressed in healthy livers and are likely to be involved in NAFLD pathogenesis. Conclusions: Our study identified the novel association of rs4788084 with HFC, which regulates the expression of IL-27, an immune regulatory gene. We further showed that adiposity affected the HFC, irrespective of the genetic predisposition.
MeSH term(s)	Adult ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; India ; Interleukins/genetics ; Intra-Abdominal Fat/diagnostic imaging ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/pathology ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Proton Magnetic Resonance Spectroscopy ; Severity of Illness Index ; Ultrasonography ; Whole Exome Sequencing/methods
Chemical Substances	Interleukins ; MYDGF protein, human
Language	English
Publishing date	2021-01-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2021.145431
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Zs.A 1357: Show issues

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Article ; Online: A Study on Satisfaction Levels among Hearing Aid Users in Gangetic Plains

Bipin Kishore Prasad / Abhijit Basu / Ajay Kumar Rai

Bengal Journal of Otolaryngology and Head Neck Surgery, Vol 28, Iss

2021 Volume 3

Abstract: Introduction Outcome assessments have emerged as an effective method for determining whether or not hearing aids are working to achieve positive results in rehabilitating the hearing impaired. Present study aims to assess the satisfaction level of ... ...

Abstract	Introduction Outcome assessments have emerged as an effective method for determining whether or not hearing aids are working to achieve positive results in rehabilitating the hearing impaired. Present study aims to assess the satisfaction level of clientele using hearing aids. Material and Methods One hundred and fourteen (114) hearing handicapped patients, fitted with government-provided hearing aids at various clinics spread over Gangetic plains were included in this prospective observational study for outcome analysis. Follow up was done at 2 weeks and 45 days when they were further motivated to continue using the aid, comfortable fitting of mould was ensured along with minor trouble shooting. Four and half months later, their satisfaction level was assessed by analysing their response to Clientele Satisfaction Questionnaire. Results Fifty percent of the patients were motivated by their family members to try the aid whereas 50% were self motivated. Better communication with family members and immediate social circle was the common motive. Majority (85%) reported high level of satisfaction in terms of hearing benefit. Patients with severe degree of hearing loss were more satisfied and used the aid for longer duration in a day. Handling the aid was not as much of a problem as tolerating the noise produced by aid itself. Cost of battery was a concern for 80% of our clientele. Conclusion Proper fitting of hearing aid improved the quality of life of majority of our hearing handicapped clientele by overcoming their psychosocial problems.
Keywords	Outcome Assessment ; Hearing Aids ; Personal Satisfaction ; Surveys and Questionnaires ; Quality of Life ; Hearing Loss ; Sensorineural ; Medicine ; R ; Otorhinolaryngology ; RF1-547
Subject code	390
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	The Association of Otolaryngologists of India, West Bengal
Document type	Article ; Online
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Article ; Online: 3, 3'- (3, 5-DCPBC) Down-Regulates Multiple Phosphokinase Dependent Signal Transduction Pathways in Malignant Melanoma Cells through Specific Diminution of EGFR

Qurat-Ul-Ain / Basu, Abhijit / Choudhary, M Iqbal / Scharffetter-Kochanek, Karin

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 4

Abstract: Melanoma is the most dangerous skin malignancy due to its strong metastatic potential with high mortality. Activation of crucial signaling pathways enforcing melanoma progression depends on phosphorylation of distinct tyrosine kinases and oxidative ... ...

Abstract	Melanoma is the most dangerous skin malignancy due to its strong metastatic potential with high mortality. Activation of crucial signaling pathways enforcing melanoma progression depends on phosphorylation of distinct tyrosine kinases and oxidative stress. We here investigated the effect of a
MeSH term(s)	Cell Line, Tumor ; Coumarins/chemistry ; Coumarins/pharmacology ; Down-Regulation/drug effects ; ErbB Receptors/biosynthesis ; ErbB Receptors/genetics ; Gene Expression Regulation, Enzymologic/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Melanoma/drug therapy ; Melanoma/enzymology ; Neoplasm Proteins/biosynthesis ; Neoplasm Proteins/genetics ; Phosphorylation/drug effects ; Phosphotransferases (Alcohol Group Acceptor)/biosynthesis ; Phosphotransferases (Alcohol Group Acceptor)/genetics ; Signal Transduction/drug effects
Chemical Substances	Coumarins ; Neoplasm Proteins ; Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2022-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27041172
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Article ; Online: Long-Term Morbidity and Functional Outcome of Japanese Encephalitis in Children: A Prospective Cohort Study.

Dutta, Abhijit / Nag, Shankha Subhra / Dutta, Manjula / Basu, Sagar

Indian pediatrics

2021 Volume 58, Issue 9, Page(s) 846–849

Abstract: Objective: To describe the long term morbidity and functional outcome of Japanese encephalitis in children.: Methods: Laboratory-confirmed Japanese encephalitis cases were enrolled in the study from January, 2016 to September, 2017 and surviving ... ...

Abstract	Objective: To describe the long term morbidity and functional outcome of Japanese encephalitis in children. Methods: Laboratory-confirmed Japanese encephalitis cases were enrolled in the study from January, 2016 to September, 2017 and surviving cases were prospectively followed up for 2.5 years to document various morbidities. Outcome was functionally graded at discharge and during follow-up using Liverpool outcome score. Results: Out of 56 children enrolled, 10 (17.9%) died during hospital stay; severe sequelae was observed in 17 (30.4%) at discharge. At the end of study, among 37 children under follow-up, 23 (62.2%) recovered fully, 2 (5.4%) showed minor sequelae, 3 (8.1%) had moderate sequelae, and 9 (24.3%) were left with severe sequelae. Common long term morbidities were abnormal behavior (n=10, 27%), post encephalitic epilepsy (n=8, 21.6%), poor scholastic performance (n=8, 21.6%) and residual motor deficit (n=7, 18.9%). Improvement of morbidities was noted mostly within initial 1 year of follow-up. Conclusion: More than half of the Japanese encephalitis survivors recovered fully, most within the first year after discharge.
MeSH term(s)	Child ; Encephalitis ; Encephalitis, Japanese/epidemiology ; Humans ; Infant ; Length of Stay ; Morbidity ; Prospective Studies
Language	English
Publishing date	2021-05-20
Publishing country	India
Document type	Journal Article
ZDB-ID	402594-5
ISSN	0974-7559 ; 0019-6061
ISSN (online)	0974-7559
ISSN	0019-6061
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Article ; Online: Regulation of pancreatic cancer therapy resistance by chemokines.

Gautam, Shailendra K / Basu, Soumi / Aithal, Abhijit / Dwivedi, Nidhi V / Gulati, Mansi / Jain, Maneesh

Seminars in cancer biology

2022 Volume 86, Issue Pt 2, Page(s) 69–80

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy characterized by high resistance and poor response to chemotherapy. In addition, the poorly immunogenic pancreatic tumors constitute an immunosuppressive tumor microenvironment (TME) ... ...

Abstract	Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy characterized by high resistance and poor response to chemotherapy. In addition, the poorly immunogenic pancreatic tumors constitute an immunosuppressive tumor microenvironment (TME) that render immunotherapy-based approaches ineffective. Understanding the mechanisms of therapy resistance, identifying new targets, and developing effective strategies to overcome resistance can significantly impact the management of PDAC patients. Chemokines are small soluble factors that are significantly deregulated during PDAC pathogenesis, contributing to tumor growth, metastasis, immune cell trafficking, and therapy resistance. Thus far, different chemokine pathways have been explored as therapeutic targets in PDAC, with some promising results in recent clinical trials. Particularly, immunotherapies such as immune check point blockade therapies and CAR-T cell therapies have shown promising results when combined with chemokine targeted therapies. Considering the emerging pathological and clinical significance of chemokines in PDAC, we reviewed major chemokine-regulated pathways leading to therapy resistance and the ongoing endeavors to target chemokine signaling in PDAC. This review discusses the role of chemokines in regulating therapy resistance in PDAC and highlights the continuing efforts to target chemokine-regulated pathways to improve the efficacy of various treatment modalities.
MeSH term(s)	Humans ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/immunology ; Chemokines/genetics ; Chemokines/immunology ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/immunology ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology ; Drug Resistance, Neoplasm/genetics ; Drug Resistance, Neoplasm/immunology ; Pancreatic Neoplasms
Chemical Substances	Chemokines
Language	English
Publishing date	2022-09-02
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1033980-2
ISSN	1096-3650 ; 1044-579X
ISSN (online)	1096-3650
ISSN	1044-579X
DOI	10.1016/j.semcancer.2022.08.010
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