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Book ; Online ; E-Book: Re-visioning psychiatry

Lemelson, Robert / Cummings, Constance A. / Kirmayer, Laurence J.

cultural phenomenology, critical neuroscience, and global mental health

2015

Title variant	Revisioning psychiatry
Author's details	Edited by Laurence J. Kirmeyer, Robert Lemelson, Constance A. Cummings
Keywords	Psychiatry / trends ; Mental Disorders / etiology ; Neuropsychiatry / trends ; Sociological Factors
Language	English
Size	1 Online-Ressource (xxx, 693 Seiten), Illustrationen, Karten
Publisher	Cambridge University Press
Publishing place	New York, NY
Publishing country	United States
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019123283
ISBN	978-1-316-36001-9 ; 9781107032200 ; 1-316-36001-6 ; 1107032202
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: A Study of Defective Pupils in the Public Schools of Tacoma, Wash.

Cummings, Robert A

The Psychological clinic

2017 Volume 8, Issue 6, Page(s) 153–169

Language	English
Publishing date	2017-09-14
Publishing country	United States
Document type	Journal Article
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Delivery of re-irradiation and complex palliative radiotherapy using proton therapy in pediatric cancer patients.

Berlin, Eva / Eisenberg, Rachel / Hill-Kayser, Christine / Lustig, Robert A / Kurtz, Goldie / Cummings, Elizabeth / LaRiviere, Michael

Pediatric blood & cancer

2023 Volume 70, Issue 12, Page(s) e30708

Abstract: Background: The intent of this study is to characterize indications for pediatric palliative-intent proton radiation therapy (PIPRT).: Procedure: We retrospectively reviewed patients 21 years and younger who received PIPRT. We defined PIPRT as ... ...

Abstract	Background: The intent of this study is to characterize indications for pediatric palliative-intent proton radiation therapy (PIPRT). Procedure: We retrospectively reviewed patients 21 years and younger who received PIPRT. We defined PIPRT as radiotherapy (RT) aimed to improve cancer-related symptoms/provide durable local control in the non-curative setting. Mixed proton/photon plans were included. Adjacent re-irradiation (reRT) was defined as a reRT volume within the incidental dose cloud of a prior RT target, whereas direct reRT was defined as in-field overlap with prior RT target. Acute toxicity during RT until first inspection visit was graded according to the Common Terminology Criteria for Adverse Events. The Kaplan-Meier method, measured from last PIPRT fraction, was used to assess progression-free survival (PFS) and overall survival (OS). Results: Eighteen patients underwent PIPRT between 2014 and 2020. Median age at treatment start was 10 years [2-21]. Median follow-up was 8.2 months [0-48]. Treatment sites included: brain/spine [10], abdomen/pelvis [3], thorax [3], and head/neck [2]. Indications for palliation included: durable tumor control [18], neurologic symptoms [4], pain [3], airway compromise [2], and great vessel compression [1]. Indications for protons included: reRT [15] (three adjacent, 12 direct), craniospinal irradiation [4], reduction of dose to normal tissues [3]. Sixteen experienced grade (G) 1-2 toxicity; two G3. There were no reports of radionecrosis. Median PFS was 5.3 months [95% confidence interval (CI): 2.7-16.3]. Median OS was 8.3 months [95% CI: 5.5-26.3]. Conclusions: The most common indication for PIPRT was reRT to provide durable tumor control. PIPRT appears to be safe, with no cases of high-grade toxicity.
MeSH term(s)	Humans ; Child ; Re-Irradiation/adverse effects ; Re-Irradiation/methods ; Proton Therapy/adverse effects ; Proton Therapy/methods ; Retrospective Studies ; Protons ; Radiotherapy Dosage ; Neoplasms/radiotherapy ; Neoplasms/etiology ; Neoplasm Recurrence, Local/pathology
Chemical Substances	Protons
Language	English
Publishing date	2023-10-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.30708
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Article ; Online: Integration of population-level data sources into an individual-level clinical prediction model for dengue virus test positivity.

Williams, Robert J / Brintz, Ben J / Ribeiro Dos Santos, Gabriel / Huang, Angkana T / Buddhari, Darunee / Kaewhiran, Surachai / Iamsirithaworn, Sopon / Rothman, Alan L / Thomas, Stephen / Farmer, Aaron / Fernandez, Stefan / Cummings, Derek A T / Anderson, Kathryn B / Salje, Henrik / Leung, Daniel T

Science advances

2024 Volume 10, Issue 7, Page(s) eadj9786

Abstract: The differentiation of dengue virus (DENV) infection, a major cause of acute febrile illness in tropical regions, from other etiologies, may help prioritize laboratory testing and limit the inappropriate use of antibiotics. While traditional clinical ... ...

Abstract	The differentiation of dengue virus (DENV) infection, a major cause of acute febrile illness in tropical regions, from other etiologies, may help prioritize laboratory testing and limit the inappropriate use of antibiotics. While traditional clinical prediction models focus on individual patient-level parameters, we hypothesize that for infectious diseases, population-level data sources may improve predictive ability. To create a clinical prediction model that integrates patient-extrinsic data for identifying DENV among febrile patients presenting to a hospital in Thailand, we fit random forest classifiers combining clinical data with climate and population-level epidemiologic data. In cross-validation, compared to a parsimonious model with the top clinical predictors, a model with the addition of climate data, reconstructed susceptibility estimates, force of infection estimates, and a recent case clustering metric significantly improved model performance.
MeSH term(s)	Humans ; Dengue Virus ; Dengue/diagnosis ; Dengue/epidemiology ; Models, Statistical ; Prognosis ; Climate ; Fever
Language	English
Publishing date	2024-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adj9786
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Article: Understanding COVID-19 Vaccine Uptake and Hesitancy among People with HIV in Freetown, Sierra Leone: A Cross-Sectional Study.

Cummings, Peterlyn E / Lakoh, Sulaiman / Yendewa, Sahr A / Massaquoi, Samuel P E / James, Peter B / Sahr, Foday / Deen, Gibrilla F / Salata, Robert A / Gevao, Pelema / Yendewa, George A

Vaccines

2023 Volume 11, Issue 11

Abstract: People with HIV (PWH) incur a higher risk of COVID-19-related morbidity and mortality rates, yet less is known about COVID-19 vaccine uptake and hesitancy in this group. We conducted a cross-sectional study in Freetown, Sierra Leone, from April to June ... ...

Abstract	People with HIV (PWH) incur a higher risk of COVID-19-related morbidity and mortality rates, yet less is known about COVID-19 vaccine uptake and hesitancy in this group. We conducted a cross-sectional study in Freetown, Sierra Leone, from April to June 2022, using the VAX scale, a validated instrument, to assess attitudes towards COVID-19 vaccination and calculate the hesitancy (VAX) scores. We used generalized linear models to identify the factors associated with vaccine hesitancy. Overall, 490 PWH were enrolled (71.4% female, median age: 38 years, median CD4 count: 412 cells/mm
Language	English
Publishing date	2023-11-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11111685
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Article ; Online: Correction to: Comparison of fracture risk assessment tools in older men without prior hip or spine fracture: the MrOS study.

Gourlay, Margaret L / Ritter, Victor S / Fine, Jason P / Overman, Robert A / Schousboe, John T / Cawthon, Peggy M / Orwoll, Eric S / Nguyen, Tuan V / Lane, Nancy E / Cummings, Steven R / Kado, Deborah M / Lapidus, Jodi A / Diem, Susan J / Ensrud, Kristine E

Archives of osteoporosis

2023 Volume 18, Issue 1, Page(s) 34

Language	English
Publishing date	2023-02-22
Publishing country	England
Document type	Published Erratum
ZDB-ID	2253231-6
ISSN	1862-3514 ; 1862-3522
ISSN (online)	1862-3514
ISSN	1862-3522
DOI	10.1007/s11657-023-01223-z
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Article ; Online: A widespread methylotroph acyl-homoserine lactone synthase produces a new quorum sensing signal that regulates swarming in

Wallace, Mike / Cummings, Dale A / Roberts, Andrew G / Puri, Aaron W

mBio

2023 Volume 15, Issue 1, Page(s) e0199923

Abstract: Importance: Bacteria known as pink-pigmented facultative methylotrophs colonize many diverse environments on earth, play an important role in the carbon cycle, and in some cases promote plant growth. However, little is known about how these organisms ... ...

Abstract	Importance: Bacteria known as pink-pigmented facultative methylotrophs colonize many diverse environments on earth, play an important role in the carbon cycle, and in some cases promote plant growth. However, little is known about how these organisms interact with each other and their environment. In this work, we identify one of the chemical signals commonly used by these bacteria and discover that this signal controls swarming motility in the pink-pigmented facultative methylotroph
MeSH term(s)	Quorum Sensing ; Acyl-Butyrolactones ; Methylobacterium/genetics
Chemical Substances	Acyl-Butyrolactones
Language	English
Publishing date	2023-12-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.01999-23
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Article ; Online: Glycoproteomics Landscape of Asymptomatic and Symptomatic Human Alzheimer's Disease Brain.

Suttapitugsakul, Suttipong / Stavenhagen, Kathrin / Donskaya, Sofia / Bennett, David A / Mealer, Robert G / Seyfried, Nicholas T / Cummings, Richard D

Molecular & cellular proteomics : MCP

2022 Volume 21, Issue 12, Page(s) 100433

Abstract: Molecular changes in the brain of individuals afflicted with Alzheimer's disease (AD) are an intense area of study. Little is known about the role of protein abundance and posttranslational modifications in AD progression and treatment, in particular ... ...

Abstract	Molecular changes in the brain of individuals afflicted with Alzheimer's disease (AD) are an intense area of study. Little is known about the role of protein abundance and posttranslational modifications in AD progression and treatment, in particular large-scale intact N-linked glycoproteomics analysis. To elucidate the N-glycoproteome landscape, we developed an approach based on multi-lectin affinity enrichment, hydrophilic interaction chromatography, and LC-MS-based glycoproteomics. We analyzed brain tissue from 10 persons with no cognitive impairment or AD, 10 with asymptomatic AD, and 10 with symptomatic AD, detecting over 300 glycoproteins and 1900 glycoforms across the samples. The majority of glycoproteins have N-glycans that are high-mannosidic or complex chains that are fucosylated and bisected. The Man5 N-glycan was found to occur most frequently at >20% of the total glycoforms. Unlike the glycoproteomes of other tissues, sialylation is a minor feature of the brain N-glycoproteome, occurring at <9% among the glycoforms. We observed AD-associated differences in the number of antennae, frequency of fucosylation, bisection, and other monosaccharides at individual glycosylation sites among samples from our three groups. Further analysis revealed glycosylation differences in subcellular compartments across disease stage, including glycoproteins in the lysosome frequently modified with paucimannosidic glycans. These results illustrate the N-glycoproteomics landscape across the spectrum of AD clinical and pathologic severity and will facilitate a deeper understanding of progression and treatment development.
MeSH term(s)	Humans ; Alzheimer Disease/metabolism ; Glycoproteins/metabolism ; Glycosylation ; Brain/metabolism ; Proteome/metabolism ; Polysaccharides/metabolism
Chemical Substances	Glycoproteins ; Proteome ; Polysaccharides
Language	English
Publishing date	2022-10-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2075924-1
ISSN	1535-9484 ; 1535-9476
ISSN (online)	1535-9484
ISSN	1535-9476
DOI	10.1016/j.mcpro.2022.100433
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Article ; Online: Impact of COVID-19 on hepatitis B screening in Sierra Leone: insights from a community pharmacy model of care.

Ghazzawi, Manal / Babawo, Lawrence S / Mohareb, Amir M / James, Peter B / Yendewa, Sahr A / Massaquoi, Samuel P E / Cummings, Peterlyn E / Lakoh, Sulaiman / Salata, Robert A / Yendewa, George A

IJID regions

2023 Volume 9, Page(s) 7–13

Abstract: Objectives: To assess the impact of COVID-19-related interruptions and seasonal patterns on hepatitis B virus (HBV) screening in a hyperendemic setting in Sierra Leone.: Methods: We conducted a retrospective study of HBV testing in a community ... ...

Abstract	Objectives: To assess the impact of COVID-19-related interruptions and seasonal patterns on hepatitis B virus (HBV) screening in a hyperendemic setting in Sierra Leone. Methods: We conducted a retrospective study of HBV testing in a community pharmacy in Freetown, Sierra Leone, from October 01, 2019, through September 30, 2022. We compared participant characteristics using Pearson's chi-square test. We evaluated trends in HBV screening and diagnosis using one-way analysis of variance with Tukey's or Dunnett's post-test. Results: Of 920 individuals screened, 161 had detectable HBV surface antigen (seroprevalence 17.5% [95% CI 14.9-20.4]). There was a 100% decrease in HBV screening during January-June of 2020; however, screening increased by 27% and 23% in the first and second years after COVID-19, respectively. Mean quarterly tests showed a significant upward trend: 55 ± 6 tests during January-March (baseline), 74 ± 16 tests during April-June, 101 ± 3 tests during July-September, and 107 ± 17 tests during October-December (one-way analysis of variance test for trend, F = 7.7, Conclusion: Community-based HBV screening dramatically improved following temporary disruptions related to COVID-19. Seasonal variation in HBV screening, but not HBV diagnosis, may have implications for HBV elimination efforts in Sierra Leone and other West African countries.
Language	English
Publishing date	2023-08-15
Publishing country	England
Document type	Journal Article
ISSN	2772-7076
ISSN (online)	2772-7076
DOI	10.1016/j.ijregi.2023.08.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Measuring Stigma Associated with Hepatitis B Virus Infection in Sierra Leone: Validation of an Abridged Berger HIV Stigma Scale.

Yendewa, George A / Sellu, Edmond J / Kpaka, Rashid A / James, Peter B / Yendewa, Sahr A / Cummings, Peterlyn E / Babawo, Lawrence M / Massaquoi, Samuel P / Ghazawi, Manal / Ocama, Ponsiano / Lakoh, Sulaiman / Babawo, Lawrence S / Salata, Robert A

medRxiv : the preprint server for health sciences

2023

Abstract: Stigma associated with hepatitis B virus (HBV) is common in endemic countries; however; instruments are lacking to accurately measure HBV-related stigma. We therefore aimed to develop and validate a concise instrument for measuring perceived HBV-related ... ...

Abstract	Stigma associated with hepatitis B virus (HBV) is common in endemic countries; however; instruments are lacking to accurately measure HBV-related stigma. We therefore aimed to develop and validate a concise instrument for measuring perceived HBV-related stigma in Sierra Leone. We enrolled 220 people living with HBV (PWHB) aged ≥ 18 years from August to November 2022. The initial Likert-scale instrument entailed 12 items adapted from Berger's HIV Stigma Scale. We included 4 additional items adapted from the USAID indicators for enacted stigma. The proposed scale's psychometric properties were assessed. After item reduction, the final HBV Stigma Scale consisted of 10 items and had good internal consistency (overall Cronbach's α = 0.74), discriminant and construct validity. Exploratory factor analysis produced a 3-dimensional structure accounting for 59.3% of variance: personalized stigma driven by public attitudes (6 items), negative self-image (2 items), and disclosure concerns (2 items). Overall, 72.8% of respondents reported perceived HBV stigma (mean score 29.11 ± 4.14) and a similar a proportion (73.6%) reported at least one instance of enacted stigma. In assessing criterion-related validity, perceived HBV-related stigma correlated strongly with enacted stigma (r = 0.556) and inversely with having family/friends with HBV (r = -0.059). The 10-item HBV Stigma Scale demonstrated good internal consistency and validity and is suitable for screening for HBV-related stigma in Sierra Leone. The psychometric properties of the scale can be optimized with item additions/modifications and confirmatory factor analysis. The scale may help in combating stigma as a barrier to achieving HBV global elimination goals.
Language	English
Publishing date	2023-02-18
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.02.17.23286086
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