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  1. Article: Large non-functioning substernal parathyroid cyst: A case report and review of the literature.

    Diaz, Ashley / Chavez, Julia / Hemmrich, Maximilian / Smith, Heather / Donington, Jessica S / Portugal, Louis G

    International journal of surgery case reports

    2022  Volume 93, Page(s) 106989

    Abstract: Objectives: Parathyroid cysts are rare benign lesions of the head and neck that account for less than 1% of cystic neck masses. We present a rare case of a large 6 cm substernal parathyroid cyst.: Presentation of case: An otherwise healthy 65 year- ... ...

    Abstract Objectives: Parathyroid cysts are rare benign lesions of the head and neck that account for less than 1% of cystic neck masses. We present a rare case of a large 6 cm substernal parathyroid cyst.
    Presentation of case: An otherwise healthy 65 year-old female presented to the otolaryngology clinic for evaluation of an anterior, midline neck mass. On physical exam, she was noted to have a fullness in the anterior neck extending to the sternal notch. CT demonstrated an enlarged thyroid with a cyst extending to the aortic arch. Initial evaluation suggested a bilateral goiter with substernal extension. The cyst was managed with drainage and observation. After two years of continued growth, the patient underwent a left thyroid lobectomy and mediastinal mass resection via the cervical approach. Final pathology was consistent with a parathyroid cyst.
    Conclusions: Parathyroid cysts are a rare cause of neck mass in an adult, and a 6 cm substernal parathyroid cyst represents an unusual site and size for these cysts. Parathyroid cysts are not often considered on the differential of neck and mediastinal cystic lesions. However, appropriate steps should be taken to ensure a proper diagnosis for any cystic lesion in the neck.
    Language English
    Publishing date 2022-03-29
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2022.106989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Surgical Safety Checklist for Performing Tracheotomy in Patients with Coronavirus Disease 19.

    Portugal, Louis G / Adams, Dara R / Baroody, Fuad M / Agrawal, Nishant

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2020  Volume 163, Issue 1, Page(s) 42–46

    Abstract: Performance of tracheotomy is a potential necessary step in the patient with coronavirus disease 19 (COVID-19) and prolonged mechanical ventilation. Due to viral aerosolization, tracheotomy carries a high risk of transmission of COVID-19 to the health ... ...

    Abstract Performance of tracheotomy is a potential necessary step in the patient with coronavirus disease 19 (COVID-19) and prolonged mechanical ventilation. Due to viral aerosolization, tracheotomy carries a high risk of transmission of COVID-19 to the health care team performing the procedure. We share our institution's surgical safety checklist for performing tracheotomy in patients with COVID-19, including key modifications intended to mitigate risk to the surgical team.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Checklist ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Disease Transmission, Infectious/prevention & control ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Respiration, Artificial/methods ; Respiration, Artificial/standards ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy ; SARS-CoV-2 ; Tracheotomy/standards ; Treatment Outcome
    Keywords covid19
    Language English
    Publishing date 2020-04-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1177/0194599820922981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A Surgical Safety Checklist for Performing Tracheotomy in Patients with Coronavirus Disease 19

    Portugal, Louis G / Adams, Dara R / Baroody, Fuad M / Agrawal, Nishant

    Otolaryngol Head Neck Surg

    Abstract: Performance of tracheotomy is a potential necessary step in the patient with coronavirus disease 19 (COVID-19) and prolonged mechanical ventilation. Due to viral aerosolization, tracheotomy carries a high risk of transmission of COVID-19 to the health ... ...

    Abstract Performance of tracheotomy is a potential necessary step in the patient with coronavirus disease 19 (COVID-19) and prolonged mechanical ventilation. Due to viral aerosolization, tracheotomy carries a high risk of transmission of COVID-19 to the health care team performing the procedure. We share our institution's surgical safety checklist for performing tracheotomy in patients with COVID-19, including key modifications intended to mitigate risk to the surgical team.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #133489
    Database COVID19

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  4. Article ; Online: A Surgical Safety Checklist for Performing Tracheotomy in Patients with Coronavirus Disease 19

    Portugal, Louis G. / Adams, Dara R. / Baroody, Fuad M. / Agrawal, Nishant

    Otolaryngology–Head and Neck Surgery

    2020  Volume 163, Issue 1, Page(s) 42–46

    Abstract: Performance of tracheotomy is a potential necessary step in the patient with coronavirus disease 19 (COVID-19) and prolonged mechanical ventilation. Due to viral aerosolization, tracheotomy carries a high risk of transmission of COVID-19 to the health ... ...

    Abstract Performance of tracheotomy is a potential necessary step in the patient with coronavirus disease 19 (COVID-19) and prolonged mechanical ventilation. Due to viral aerosolization, tracheotomy carries a high risk of transmission of COVID-19 to the health care team performing the procedure. We share our institution’s surgical safety checklist for performing tracheotomy in patients with COVID-19, including key modifications intended to mitigate risk to the surgical team.
    Keywords Surgery ; Otorhinolaryngology ; covid19
    Language English
    Publisher SAGE Publications
    Publishing country us
    Document type Article ; Online
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1177/0194599820922981
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Treatment of rhinosinusitis in the outpatient setting.

    Poole, Michael D / Portugal, Louis G

    The American journal of medicine

    2005  Volume 118 Suppl 7A, Page(s) 45S–50S

    Abstract: Rhinosinusitis is one of the most common respiratory tract conditions seen by primary care physicians. Each year approximately 20 million cases of acute bacterial rhinosinusitis (ABRS) occur in the United States. Since diagnosis of ABRS relies on ... ...

    Abstract Rhinosinusitis is one of the most common respiratory tract conditions seen by primary care physicians. Each year approximately 20 million cases of acute bacterial rhinosinusitis (ABRS) occur in the United States. Since diagnosis of ABRS relies on clinical evaluation, treatments are usually empirical and include an antibiotic treatment that covers the common bacteria associated with ABRS infection, Streptococcus pneumoniae and Haemophilus influenzae. The Council for Appropriate and Rational Antibiotic Therapy (CARAT) recommends that antimicrobial therapy for rhinosinusitis should combine high susceptibility, clinical effectiveness, safety, and tolerability. The most efficacious antibiotics for ABRS include the respiratory fluoroquinolones gatifloxacin, levofloxacin, and moxifloxacin, as well as ceftriaxone and amoxicillin-clavulanate. The use of fluoroquinolones or high-dose amoxicillin-clavulanate is recommended for patients with mild disease who have had recent antimicrobial therapy or for patients with moderate disease. These drugs are generally well tolerated with mild adverse effects. Resistance to fluoroquinolones in S pneumoniae and H influenzae has remained low in spite of their increased use. Recent studies indicate that short-course, high-dose treatment regimens may reduce total drug use, improve tolerability and adherence, prevent increases in resistance, and increase efficacy. The use of fluoroquinolones or amoxicillin-clavulanate in a short-course, high-dose regimen may represent an exciting new protocol in the treatment of rhinosinusitis.
    MeSH term(s) Ambulatory Care ; Anti-Bacterial Agents/economics ; Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/drug therapy ; Humans ; Practice Guidelines as Topic ; Rhinitis/complications ; Rhinitis/drug therapy ; Rhinitis/microbiology ; Sinusitis/complications ; Sinusitis/drug therapy ; Sinusitis/microbiology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2005-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2005.05.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Role of dental hardware in oral cavity squamous cell carcinoma in the low-risk nonsmoker nondrinker population.

    Yesensky, Jessica A / Hasina, Rifat / Wroblewski, Kristen E / Bellairs, Joseph / Gooi, Zhen / Saloura, Vassiliki / Cipriani, Nicole A / Vokes, Everett E / Portugal, Louis G / Seiwert, Tanguy Y / Blair, Elizabeth D / Agrawal, Nishant

    Head & neck

    2018  Volume 40, Issue 4, Page(s) 784–792

    Abstract: Background: Oral cavity squamous cell carcinoma (SCC) arising in nonsmokers and nondrinkers remains poorly characterized. We hypothesized that these patients had prior exposure to metallic dental hardware.: Methods: We utilized a questionnaire ... ...

    Abstract Background: Oral cavity squamous cell carcinoma (SCC) arising in nonsmokers and nondrinkers remains poorly characterized. We hypothesized that these patients had prior exposure to metallic dental hardware.
    Methods: We utilized a questionnaire querying the lifetime oral health status of 54 patients. Demographics and extensive oral health history were collected.
    Results: The majority of patients (74%) had prior exposure to metallic dental hardware. The younger population with almost exclusively oral tongue cancer had a high prevalence of metallic orthodontic braces (40%) within 15 years before diagnosis. In the 51+ year age group, 82% had crowns, dental implants, and/or dentures with metallic elements.
    Conclusion: Exposure to metallic dental hardware has increased in the past few decades given the rise of orthodontic braces and older adults retaining more teeth. Although this study does not prove a causal relationship between oral cavity SCC and dental hardware, this is a step toward identifying and investigating their role.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Alcohol Drinking ; Cohort Studies ; Confidence Intervals ; Dental Alloys/adverse effects ; Female ; Humans ; Incidence ; Life Style ; Male ; Metals/adverse effects ; Middle Aged ; Mouth Neoplasms/epidemiology ; Mouth Neoplasms/etiology ; Mouth Neoplasms/physiopathology ; Non-Smokers ; Oral Health ; Orthodontic Appliances/adverse effects ; Prognosis ; Retrospective Studies ; Risk Factors ; Sex Factors ; Squamous Cell Carcinoma of Head and Neck/epidemiology ; Squamous Cell Carcinoma of Head and Neck/etiology ; Squamous Cell Carcinoma of Head and Neck/physiopathology ; Surveys and Questionnaires ; Tongue Neoplasms/epidemiology ; Tongue Neoplasms/etiology ; Tongue Neoplasms/physiopathology ; United States ; Young Adult
    Chemical Substances Dental Alloys ; Metals
    Language English
    Publishing date 2018-01-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.25059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Genomic epidemiology of SARS-CoV-2 transmission lineages in Ecuador.

    Gutierrez, Bernardo / Márquez, Sully / Prado-Vivar, Belén / Becerra-Wong, Mónica / Guadalupe, Juan José / da Silva Candido, Darlan / Fernandez-Cadena, Juan Carlos / Morey-Leon, Gabriel / Armas-Gonzalez, Rubén / Andrade-Molina, Derly Madeleiny / Bruno, Alfredo / de Mora, Domenica / Olmedo, Maritza / Portugal, Denisse / Gonzalez, Manuel / Orlando, Alberto / Drexler, Jan Felix / Moreira-Soto, Andres / Sander, Anna-Lena /
    Brünink, Sebastian / Kühne, Arne / Patiño, Leandro / Carrazco-Montalvo, Andrés / Mestanza, Orson / Zurita, Jeannete / Sevillano, Gabriela / du Plessis, Louis / McCrone, John T / Coloma, Josefina / Trueba, Gabriel / Barragán, Verónica / Rojas-Silva, Patricio / Grunauer, Michelle / Kraemer, Moritz U G / Faria, Nuno R / Escalera-Zamudio, Marina / Pybus, Oliver G / Cárdenas, Paúl

    medRxiv : the preprint server for health sciences

    2021  

    Abstract: Characterisation of SARS-CoV-2 genetic diversity through space and time can reveal trends in virus importation and domestic circulation, and permit the exploration of questions regarding the early transmission dynamics. Here we present a detailed ... ...

    Abstract Characterisation of SARS-CoV-2 genetic diversity through space and time can reveal trends in virus importation and domestic circulation, and permit the exploration of questions regarding the early transmission dynamics. Here we present a detailed description of SARS-CoV-2 genomic epidemiology in Ecuador, one of the hardest hit countries during the early stages of the COVID-19 pandemic. We generate and analyse 160 whole genome sequences sampled from all provinces of Ecuador in 2020. Molecular clock and phylgeographic analysis of these sequences in the context of global SARS-CoV-2 diversity enable us to identify and characterise individual transmission lineages within Ecuador, explore their spatiotemporal distributions, and consider their introduction and domestic circulation. Our results reveal a pattern of multiple international importations across the country, with apparent differences between key provinces. Transmission lineages were mostly introduced before the implementation of non-pharmaceutical interventions (NPIs), with differential degrees of persistence and national dissemination.
    Language English
    Publishing date 2021-04-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2021.03.31.21254685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Genomic epidemiology of SARS-CoV-2 transmission lineages in Ecuador.

    Gutierrez, Bernardo / Márquez, Sully / Prado-Vivar, Belén / Becerra-Wong, Mónica / Guadalupe, Juan José / Candido, Darlan Da Silva / Fernandez-Cadena, Juan Carlos / Morey-Leon, Gabriel / Armas-Gonzalez, Rubén / Andrade-Molina, Derly Madeleiny / Bruno, Alfredo / De Mora, Domenica / Olmedo, Maritza / Portugal, Denisse / Gonzalez, Manuel / Orlando, Alberto / Drexler, Jan Felix / Moreira-Soto, Andres / Sander, Anna-Lena /
    Brünink, Sebastian / Kühne, Arne / Patiño, Leandro / Carrazco-Montalvo, Andrés / Mestanza, Orson / Zurita, Jeannete / Sevillano, Gabriela / Du Plessis, Louis / McCrone, John T / Coloma, Josefina / Trueba, Gabriel / Barragán, Verónica / Rojas-Silva, Patricio / Grunauer, Michelle / Kraemer, Moritz U G / Faria, Nuno R / Escalera-Zamudio, Marina / Pybus, Oliver G / Cárdenas, Paúl

    Virus evolution

    2021  Volume 7, Issue 2, Page(s) veab051

    Abstract: Characterisation of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic diversity through space and time can reveal trends in virus importation and domestic circulation and permit the exploration of questions regarding the early ... ...

    Abstract Characterisation of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic diversity through space and time can reveal trends in virus importation and domestic circulation and permit the exploration of questions regarding the early transmission dynamics. Here, we present a detailed description of SARS-CoV-2 genomic epidemiology in Ecuador, one of the hardest hit countries during the early stages of the coronavirus-19 pandemic. We generated and analysed 160 whole genome sequences sampled from all provinces of Ecuador in 2020. Molecular clock and phylogeographic analysis of these sequences in the context of global SARS-CoV-2 diversity enable us to identify and characterise individual transmission lineages within Ecuador, explore their spatiotemporal distributions, and consider their introduction and domestic circulation. Our results reveal a pattern of multiple international importations across the country, with apparent differences between key provinces. Transmission lineages were mostly introduced before the implementation of non-pharmaceutical interventions, with differential degrees of persistence and national dissemination.
    Language English
    Publishing date 2021-06-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2818949-8
    ISSN 2057-1577
    ISSN 2057-1577
    DOI 10.1093/ve/veab051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Different phenotypic plastic responses to predators observed among aphid lineages specialized on different host plants.

    Sentis, Arnaud / Bertram, Raphaël / Dardenne, Nathalie / Ramon-Portugal, Felipe / Louit, Ines / Le Trionnaire, Gaël / Simon, Jean-Christophe / Magro, Alexandra / Pujol, Benoit / Hemptinne, Jean-Louis / Danchin, Etienne

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 9017

    Abstract: The role of intraspecific variation in the magnitude and direction of plastic responses in ecology and evolution is increasingly recognized. However, the factors underlying intraspecific variation in plastic responses remain largely unexplored, ... ...

    Abstract The role of intraspecific variation in the magnitude and direction of plastic responses in ecology and evolution is increasingly recognized. However, the factors underlying intraspecific variation in plastic responses remain largely unexplored, particularly for the hypothesis that the herbivores' phenotypic response to predators might vary amongst lineages associated with different host plants. Here, we tested whether plant-specialized lineages of the pea aphid, Acyrthosiphon pisum, differed in their transgenerational phenotypic response to ladybird predators (i.e., the asexual production of winged offspring by wingless mothers). In a full factorial laboratory experiment, we found that six aphid clonal lineages each specialized either on alfalfa or clover significantly differed in their transgenerational phenotypic response to predators. Some lineages produced an increased number of winged aphids in predator presence while others did not respond. Aphid lineages specialized on alfalfa had stronger phenotypic responses to predators than those specialized on clover. Although we tested only six aphid lineages from two biotypes, our results imply that intraspecific variation in prey phenotypic response of herbivores to predators differs amongst lineages specialized on different host plants. Our findings therefore raise the question of the influence of plant specialization in shaping herbivore phenotypic responses, and highlight the need to consider multi-trophic interactions to understand the causes and consequences of intraspecific variation in complex phenotypic traits.
    MeSH term(s) Animals ; Aphids/classification ; Aphids/genetics ; Aphids/physiology ; Biological Evolution ; Herbivory/physiology ; Host-Parasite Interactions ; Medicago/parasitology ; Medicago sativa/parasitology ; Phenotype ; Plants/classification ; Plants/parasitology ; Plastics ; Predatory Behavior/physiology ; Wings, Animal/physiology
    Chemical Substances Plastics
    Language English
    Publishing date 2019-06-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-45220-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The smell of change: warming affects species interactions mediated by chemical information.

    Sentis, Arnaud / Ramon-Portugal, Felipe / Brodeur, Jacques / Hemptinne, Jean-Louis

    Global change biology

    2015  Volume 21, Issue 10, Page(s) 3586–3594

    Abstract: ... system boundaries (e.g. immigration and emigration) and thus alter the dynamics and stability ...

    Abstract Knowledge of how temperature influences an organism's physiology and behaviour is of paramount importance for understanding and predicting the impacts of climate change on species' interactions. While the behaviour of many organisms is driven by chemical information on which they rely on to detect resources, conspecifics, natural enemies and competitors, the effects of temperature on infochemical-mediated interactions remain largely unexplored. Here, we experimentally show that temperature strongly influences the emission of infochemicals by ladybeetle larvae, which, in turn, modifies the oviposition behaviour of conspecific females. Temperature also directly affects female perception of infochemicals and their oviposition behaviour. Our results suggest that temperature-mediated effects on chemical communication can influence flows across system boundaries (e.g. immigration and emigration) and thus alter the dynamics and stability of ecological networks. We therefore argue that investigating the effects of temperature on chemical communication is a crucial step towards a better understanding of the functioning of ecological communities facing rapid environmental changes.
    MeSH term(s) Animal Migration ; Animals ; Biodiversity ; Chemotaxis ; Coleoptera/growth & development ; Coleoptera/physiology ; Female ; Global Warming ; Larva/physiology ; Oviposition ; Pheromones/metabolism
    Chemical Substances Pheromones
    Language English
    Publishing date 2015-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1281439-8
    ISSN 1365-2486 ; 1354-1013
    ISSN (online) 1365-2486
    ISSN 1354-1013
    DOI 10.1111/gcb.12932
    Database MEDical Literature Analysis and Retrieval System OnLINE

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