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Article: YKL-40 promotes chemokine expression following drug-induced liver injury via TF-PAR1 pathway in mice.

Jing-Lun, Zhan / Shuang, Chai / Li-Mei, Zhao / Xiao-Dong, Liu

2023 Volume 14, Page(s) 1205062

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-08-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1205062
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Systematic Review of the Immune-Regulating and Anticancer Activities of Pseudolaric Acid B.

Liu, Mei-Lun / Sun, Dan / Li, Tan / Chen, Hong

Frontiers in pharmacology

2017 Volume 8, Page(s) 394

Abstract: ... Cortex ... ...

Abstract	Cortex pseudolaricis
Language	English
Publishing date	2017-06-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2017.00394
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Article ; Online: A Systematic Review of the Immune-Regulating and Anticancer Activities of Pseudolaric Acid B

Mei-lun Liu / Dan Sun / Tan Li / Hong Chen

Frontiers in Pharmacology, Vol

2017 Volume 8

Abstract: Cortex pseudolaricis, the root bark of Pseudolarix kaempferi Gord, has been used to treat tinea and other skin diseases for the antimicrobial activities in Traditional Chinese Medicine (TCM). Pseudolaric acid B (PAB) has been identified as the major ... ...

Abstract	Cortex pseudolaricis, the root bark of Pseudolarix kaempferi Gord, has been used to treat tinea and other skin diseases for the antimicrobial activities in Traditional Chinese Medicine (TCM). Pseudolaric acid B (PAB) has been identified as the major component responsible for the action of C. pseudolaricis. Recently, PAB has been demonstrated to be used as novel treatments for cancer, immune disorders, inflammatory diseases, and immunosuppression. However, the mechanisms through which PAB exerts its properties are not understood well, and little attention in the literature has been given to review its pharmacological activities before. In this review, we performed a systematic summary of the literature with respect to the anticancer, immunosuppressive and anti-inflammatory properties of PAB and its derivatives. Currently available data suggest that PAB is a promising immunosuppressive and anti-inflammatory agent candidate and should be explored further in cancer treatment and prevention.
Keywords	traditional chinese medicine ; pseudolaric acid B ; cancer ; inflammation ; immunoregulation ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2017-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Application of furazolidone in Helicobacter pylori infection eradication.

Han, Ying Ying / Li, Ji Yan / Guan, Jia Lun / Liu, Mei / Li, Pei Yuan

Journal of digestive diseases

2024 Volume 25, Issue 3, Page(s) 148–155

Abstract: Increasing antibiotic resistance is the primary reason for treatment failure of Helicobacter pylori (H. pylori) infection. To enhance the eradication rate, minimize the development of secondary resistance, and alleviate the socioeconomic burden, it is ... ...

Abstract	Increasing antibiotic resistance is the primary reason for treatment failure of Helicobacter pylori (H. pylori) infection. To enhance the eradication rate, minimize the development of secondary resistance, and alleviate the socioeconomic burden, it is crucial to select H. pylori-sensitive antibiotics carefully. Furazolidone has been used for H. pylori eradication in developing countries for decades due to its affordability and low resistance rate. Numerous studies have demonstrated that furazolidone-containing regimens are more efficacious than those containing other antibiotics, as both first- and second-line therapies, and are also well tolerated. However, utility of furazolidone is restricted or not optimal in certain countries due to its infrequent but potentially severe adverse effects. The decision to discontinue usage of furazolidone because of concerns regarding adverse effects may be misguided. Here we comprehensively reviewed the studies on furazolidone at different dosages and treatment durations for H. pylori eradication. Further research on the mechanisms of action and clinical trials of furazolidone are of great practical importance.
MeSH term(s)	Furazolidone/therapeutic use ; Furazolidone/administration & dosage ; Helicobacter Infections/drug therapy ; Humans ; Helicobacter pylori/drug effects ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/administration & dosage ; Drug Therapy, Combination ; Drug Resistance, Bacterial ; Treatment Outcome
Chemical Substances	Furazolidone (5J9CPU3RE0) ; Anti-Bacterial Agents
Language	English
Publishing date	2024-04-16
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2317117-0
ISSN	1751-2980 ; 1751-2972
ISSN (online)	1751-2980
ISSN	1751-2972
DOI	10.1111/1751-2980.13265
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Article ; Online: Dihydroartemisinin eliminates senescent cells by promoting autophagy-dependent ferroptosis via AMPK/mTOR signaling pathway.

Wan, Xing / Li, Can / Tan, Yue Hao / Zuo, Shi Qi / Deng, Feng Mei / Sun, Jing / Liu, Yi Lun

Cell biology international

2024 Volume 48, Issue 5, Page(s) 726–736

Abstract: Cellular senescence is an irreversible cell-cycle arrest in response to a variety of cellular stresses, which contribute to the pathogenesis of a variety of age-related degenerative diseases. However, effective antisenescence strategies are still lacking. ...

Abstract	Cellular senescence is an irreversible cell-cycle arrest in response to a variety of cellular stresses, which contribute to the pathogenesis of a variety of age-related degenerative diseases. However, effective antisenescence strategies are still lacking. Drugs that selectively target senescent cells represent an intriguing therapeutic strategy to delay aging and age-related diseases. Thus, we thought to investigate the effects of dihydroartemisinin (DHA) on senescent cells and elucidated its mechanisms underlying aging. Stress-induced premature senescence (SIPS) model was built in NIH3T3 cells using H
MeSH term(s)	Animals ; Mice ; AMP-Activated Protein Kinases/metabolism ; Artemisinins ; Autophagy ; Cellular Senescence ; Ferroptosis ; Hydrogen Peroxide/pharmacology ; Iron ; NIH 3T3 Cells ; Reactive Oxygen Species/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
Chemical Substances	AMP-Activated Protein Kinases (EC 2.7.11.31) ; Artemisinins ; artenimol (6A9O50735X) ; Hydrogen Peroxide (BBX060AN9V) ; Iron (E1UOL152H7) ; Reactive Oxygen Species ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1143453-3
ISSN	1095-8355 ; 1065-6995
ISSN (online)	1095-8355
ISSN	1065-6995
DOI	10.1002/cbin.12143
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Zs.A 1451: Show issues

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Article ; Online: Defect Detection of MEMS Based on Data Augmentation, WGAN-DIV-DC, and a YOLOv5 Model.

Shi, Zhenman / Sang, Mei / Huang, Yaokang / Xing, Lun / Liu, Tiegen

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 23

Abstract: Surface defect detection of micro-electromechanical system (MEMS) acoustic thin film plays a crucial role in MEMS device inspection and quality control. The performances of deep learning object detection models are significantly affected by the number of ...

Abstract	Surface defect detection of micro-electromechanical system (MEMS) acoustic thin film plays a crucial role in MEMS device inspection and quality control. The performances of deep learning object detection models are significantly affected by the number of samples in the training dataset. However, it is difficult to collect enough defect samples during production. In this paper, an improved YOLOv5 model was used to detect MEMS defects in real time. Mosaic and one more prediction head were added into the YOLOv5 baseline model to improve the feature extraction capability. Moreover, Wasserstein divergence for generative adversarial networks with deep convolutional structure (WGAN-DIV-DC) was proposed to expand the number of defect samples and to make the training samples more diverse, which improved the detection accuracy of the YOLOv5 model. The optimal detection model achieved 0.901
Language	English
Publishing date	2022-12-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22239400
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Article ; Online: Optimization of Mother-to-Child Hepatitis B Virus Prevention Program: Integration of Maternal Screening and Infant Post-vaccination Serologic Testing.

Su, Wei-Ju / Chen, Huey-Ling / Chen, Shu-Fong / Liu, Yu-Lun / Wang, Ting-Ann / Ho, Yee-Chuan / Chang, Mei-Hwei

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2024

Abstract: Background: Evaluation of the impact on mother-to-child transmission (MTCT) of a HBV-prevention program that incorporates maternal antiviral prophylaxis is hindered by the limited availability of real-world data.: Methods: This study analyzed data on ...

Abstract	Background: Evaluation of the impact on mother-to-child transmission (MTCT) of a HBV-prevention program that incorporates maternal antiviral prophylaxis is hindered by the limited availability of real-world data. Methods: This study analyzed data on maternal HBV screening, neonatal immunization, and post-vaccination serologic testing (PVST) for HBsAg among at-risk infants born to HBV carrier mothers from the National Immunization Information System during 01/01/2008-31/12/2022. Through linkage with the National Health Insurance Database, information of maternal antiviral therapy was obtained. Multivariate logistic regression was performed to explore MTCT risk in relation to infant-mother characteristics and prevention strategies. Results: Totally, 2,460,218 deliveries with maternal HBV status were screened. Between 2008 and 2022, the annual HBsAg and HBeAg seropositivity rates among native pregnant women aged 15-49 years decreased from 12.2% to 2.6% and from 2.7% to 0.4%, respectively (p for both trends < 0.0001). Among the 22,859 at-risk infants undergoing PVST, the MTCT rates differed between infants born to HBsAg-positive/HBeAg-negative and HBeAg-positive mothers (0.75% and 6.33%, respectively; p < 0.001). The MTCT rate was 1.72% (11/641) for infants born to HBeAg-positive mothers with antiviral prophylaxis. MTCT risk increased with maternal HBeAg-positivity (OR 9.29, 6.79-12.73) and decreased with maternal antiviral prophylaxis (OR 0.28, 0.16-0.49). For infants with maternal HBeAg-positivity, MTCT risk was associated with mothers born in the immunization era (OR 1.40, 1.17-1.67). Conclusions: MTCT was related to maternal HBeAg-positivity and effectively prevented by maternal prophylaxis in the immunized population. At-risk infants born to maternal vaccinated cohorts might possibly pose further risk.
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciae176
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Review of electrospun microtube array membrane (MTAM)-a novel new class of hollow fiber for encapsulated cell therapy (ECT) in clinical applications.

Chew, Chee Ho / Lee, Hsin-Lun / Chen, Amanda Lin / Huang, Wan-Ting / Chen, Shu-Mei / Liu, Yen-Lin / Chen, Chien-Chung

Journal of biomedical materials research. Part B, Applied biomaterials

2024 Volume 112, Issue 1, Page(s) e35348

Abstract: Encapsulated cell therapy (ECT) shows significant potential for treating neurodegenerative disorders including Alzheimer's and Parkinson's, which currently lack curative medicines and must be managed symptomatically. This novel technique encapsulates ... ...

Abstract	Encapsulated cell therapy (ECT) shows significant potential for treating neurodegenerative disorders including Alzheimer's and Parkinson's, which currently lack curative medicines and must be managed symptomatically. This novel technique encapsulates functional cells with a semi-permeable membrane, providing protection while enabling critical nutrients and therapeutic substances to pass through. Traditional ECT procedures, on the other hand, pose difficulties in terms of cell survival and retrieval. We introduce the Microtube Array Membrane (MTAM), a revolutionary technology that solves these constraints, in this comprehensive overview. Microtube Array Membrane has distinct microstructures that improve encapsulated cells' long-term viability by combining the advantages of macro and micron scales. Importantly, the MTAM platform improves biosafety by allowing the entire encapsulated unit to be retrieved in the event of an adverse reaction. Our findings show that MTAM-based ECT has a great potential in a variety of illness situations. For cancer treatment, hybridoma cells secreting anti-CEACAM 6 antibodies inhibit triple-negative breast cancer cell lines for an extended period of time. In animal brain models of Alzheimer's disease, hybridoma cells secreting anti-pTau antibodies successfully reduce pTau buildup, accompanied by improvements in memory performance. In mouse models, MTAM-encapsulated primary cardiac mesenchymal stem cells dramatically improve overall survival and heart function. These findings illustrate the efficacy and adaptability of MTAM-based ECT in addressing major issues such as immunological isolation, cell viability, and patient safety. We provide new possibilities for the treatment of neurodegenerative illnesses and other conditions by combining the potential of ECT with MTAM. Continued research and development in this subject has a lot of promise for developing cell therapy and giving hope to people suffering from chronic diseases.
MeSH term(s)	Animals ; Mice ; Humans ; Biological Transport ; Brain ; Cell Line ; Cell- and Tissue-Based Therapy ; Disease Models, Animal
Language	English
Publishing date	2024-01-21
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2099992-6
ISSN	1552-4981 ; 1552-4973 ; 0021-9304
ISSN (online)	1552-4981
ISSN	1552-4973 ; 0021-9304
DOI	10.1002/jbm.b.35348
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Article ; Online: Pseudolaric acid B extracted from the Chinese medicinal herb Cortex Pseudolaricis ameliorates DNFB-induced atopic dermatitis-like skin lesions in BALB/c mice

Yi-Teng Wang / Min Zhang / Mei-Lun Liu / Li-Ming Zhang / Hong Chen / Tan Li

Traditional Medicine Research, Vol 2, Iss 4, Pp 169-

2017 Volume 175

Abstract: Objective: Pseudolaric acid B (PB) is a newly identified diterpenoid isolated from Tujinpi (Cortex Pseudolaricis). In the present study, we aimed to explore the anti-inflammatory effects of PB on atopic dermatitis (AD), as well as the molecular ... ...

Abstract	Objective: Pseudolaric acid B (PB) is a newly identified diterpenoid isolated from Tujinpi (Cortex Pseudolaricis). In the present study, we aimed to explore the anti-inflammatory effects of PB on atopic dermatitis (AD), as well as the molecular mechanisms underlying its effects. Methods: BALB/c mice treated with 2,4-dinitrofluorobenzene were orally administered with PB (10 mg∙kg-1∙d-1). After evaluating the AD score, serum levels of IgE and the mRNA expression of NLRP3 inflammasome and IL-1β were measured by ELISA and qRT-PCR respectively. Results: The results showed that PB treatment significantly ameliorated the development of AD-like clinical symptoms and effectively suppressed the infiltration of inflammatory cells. Furthermore, PB inhibited the expression of NLRP3 inﬂammasome and IL-1β in skin lesions, and downregulated serum IgE levels. Conclusion: The anti-inflammatory properties of PB were demonstrated using the 2,4-dinitrofluorobenzene-induced mouse model of AD-like skin lesions. Our study highlighted the potential use of PB as a novel therapeutic agent for the treatment of inflammation-associated skin diseases.
Keywords	Pseudolaric acid B ; Atopic dermatitis ; Inflammation ; NLRP3 inflammasome ; Medicine ; R ; Miscellaneous systems and treatments ; RZ409.7-999
Subject code	616
Language	English
Publishing date	2017-10-01T00:00:00Z
Publisher	Hong Kong Gold Orchid Science and Technology Co., Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Green tea consumption and risk for esophageal cancer: A systematic review and dose-response meta-analysis.

Zhao, Huilei / Mei, Kaibo / Yang, Lun / Liu, Xiao / Xie, Lixia

Nutrition (Burbank, Los Angeles County, Calif.)

2021 Volume 87-88, Page(s) 111197

Abstract: Objective: Controversial results of the association between green tea consumption and risk for esophageal cancer (EC) were reported by previous meta-analysis. Thus, the aim of this study was to quantitatively investigate the association.: Methods: ... ...

Abstract	Objective: Controversial results of the association between green tea consumption and risk for esophageal cancer (EC) were reported by previous meta-analysis. Thus, the aim of this study was to quantitatively investigate the association. Methods: The Cochrane Library, PubMed, and EMBASE databases were searched for relevant studies. We used a "one-stage approach" with a restricted cubic spline model to summarize the dose-specific relationships between green tea and risk for EC. Odds ratios (ORs) were used to measure the effects. Fourteen studies were included with a total of 5057 ECs among 493 332 participants. Results: In the dose-response analysis, the summary OR for a 1 cup/d increase in green tea was 1.00 (95% confidence interval [CI], 0.95-1.04; I Conclusion: Contrary to previous studies, based on current evidence, the present dose-response study suggested no association between green tea and risk for EC. However, there might be a protective effect of green tea in women. Notably, our conclusion might be influenced by limited studies and potential bias, such as dose of green tea assessment and select bias of case-control studies. Further larger number, prospective, and well-designed larger-scale studies are needed to provide more precise evidence, especially in women and more regions (United States and Europe).
MeSH term(s)	Esophageal Neoplasms/epidemiology ; Esophageal Neoplasms/etiology ; Esophageal Neoplasms/prevention & control ; Europe ; Female ; Humans ; Male ; Odds Ratio ; Prospective Studies ; Risk Factors ; Tea
Chemical Substances	Tea
Language	English
Publishing date	2021-02-12
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2021.111197
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Zs.A 2290: Show issues

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