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Article ; Online: Critical evaluation of the questionnaires assessing adherence to the Mediterranean diet that are based on servings.

Chiriacò, Martina / Tubili, Claudio / Bo, Simona / Parillo, Mario / Vetrani, Claudia / Mazzotti, Arianna / Pistis, Danila / Marelli, Giuseppe / Grandone, Ilenia / Natali, Andrea

Nutrition, metabolism, and cardiovascular diseases : NMCD

2023 Volume 33, Issue 4, Page(s) 724–736

Abstract: Background and aims: The Mediterranean Diet (MD) is characterized by a high intake of vegetables, fruit, legumes, nuts, and olive oil, and moderate fish, dairy, and wine intake. A high adherence to MD has been associated with numerous health benefits, ... ...

Abstract	Background and aims: The Mediterranean Diet (MD) is characterized by a high intake of vegetables, fruit, legumes, nuts, and olive oil, and moderate fish, dairy, and wine intake. A high adherence to MD has been associated with numerous health benefits, including reduced risk of chronic diseases such as cardiovascular disease, cancer, and type 2 diabetes. The clinical assessment of MD adherence is complicated by the absence of a univocally accepted tool and by the abundance of questionnaires developed to determine adherence, whose reliability and validity is uncertain. In this inter-associative document, we critically evaluated servings-based questionnaires for the assessment of MD adherence, aiming to identify the most valuable tool for the use in clinical practice. Methods and results: For each questionnaire, we analyzed the structure, evidence on health-related outcomes and agreement with the recommendations of MD. We found that most questionnaires do not accurately reflect the principles of MD in terms of the food groups and their optimal consumption frequency. Additionally, the comparison of questionnaires revealed low agreement and some concerns with regard to the scoring assumptions. Conclusions: Among the available questionnaires, we suggest the use of the 15-Items Pyramid based Mediterranean Diet Score (PyrMDS), which is the one with fewer flaws and a strong supporting body of theoretical and scientific evidence. The use of the PyrMDS may facilitate the assessment of MD adherence in clinical practice, which is instrumental in reducing the risk of non-communicable chronic diseases.
MeSH term(s)	Humans ; Feeding Behavior ; Diet, Mediterranean ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/prevention & control ; Reproducibility of Results ; Surveys and Questionnaires
Language	English
Publishing date	2023-02-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1067704-5
ISSN	1590-3729 ; 0939-4753
ISSN (online)	1590-3729
ISSN	0939-4753
DOI	10.1016/j.numecd.2023.01.024
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Article ; Online: A TGF-beta2 enriched formula as an oral nutritional supplement for hospitalized COVID-19 patients.

Grandone, Ilenia / Cavallo, Massimiliano / Barana, Luisa / Cerasari, Alberto / Luca, Giovanni / Vaudo, Gaetano

Minerva gastroenterology

2021 Volume 69, Issue 3, Page(s) 435–436

MeSH term(s)	Humans ; Transforming Growth Factor beta2 ; COVID-19 ; Food, Formulated ; Dietary Supplements
Chemical Substances	Transforming Growth Factor beta2
Language	English
Publishing date	2021-04-15
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062713-8
ISSN	2724-5365
ISSN (online)	2724-5365
DOI	10.23736/S2724-5985.21.02820-8
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Article ; Online: Critical evaluation of the questionnaires assessing adherence to the Mediterranean diet that are based on servings

Chiriacò, Martina / Tubili, Claudio / Bo, Simona / Parillo, Mario / Vetrani, Claudia / Mazzotti, Arianna / Pistis, Danila / Marelli, Giuseppe / Grandone, Ilenia / Natali, Andrea

Nutrition, Metabolism and Cardiovascular Diseases. 2023 Apr., v. 33, no. 4 p.724-736

2023

Abstract: The Mediterranean Diet (MD) is characterized by a high intake of vegetables, fruit, legumes, nuts, and olive oil, and moderate fish, dairy, and wine intake. A high adherence to MD has been associated with numerous health benefits, including reduced risk ... ...

Institution	Italian Diabetology Society (SID) Italian Association of Diabetologists (AMD) Italian Dietetics Clinical Nutrition Association (ADI) Inter-associative study group of Nutrition in Diabetes
Abstract	The Mediterranean Diet (MD) is characterized by a high intake of vegetables, fruit, legumes, nuts, and olive oil, and moderate fish, dairy, and wine intake. A high adherence to MD has been associated with numerous health benefits, including reduced risk of chronic diseases such as cardiovascular disease, cancer, and type 2 diabetes. The clinical assessment of MD adherence is complicated by the absence of a univocally accepted tool and by the abundance of questionnaires developed to determine adherence, whose reliability and validity is uncertain. In this inter-associative document, we critically evaluated servings-based questionnaires for the assessment of MD adherence, aiming to identify the most valuable tool for the use in clinical practice. For each questionnaire, we analyzed the structure, evidence on health-related outcomes and agreement with the recommendations of MD. We found that most questionnaires do not accurately reflect the principles of MD in terms of the food groups and their optimal consumption frequency. Additionally, the comparison of questionnaires revealed low agreement and some concerns with regard to the scoring assumptions. Among the available questionnaires, we suggest the use of the 15-Items Pyramid based Mediterranean Diet Score (PyrMDS), which is the one with fewer flaws and a strong supporting body of theoretical and scientific evidence. The use of the PyrMDS may facilitate the assessment of MD adherence in clinical practice, which is instrumental in reducing the risk of non-communicable chronic diseases.
Keywords	Mediterranean diet ; cardiovascular diseases ; fish ; fruits ; metabolism ; noninsulin-dependent diabetes mellitus ; olive oil ; questionnaires ; risk ; risk reduction ; wines ; Adherence ; Questionnaire ; Mediterranean diet pyramid ; Non-communicable chronic diseases
Language	English
Dates of publication	2023-04
Size	p. 724-736.
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version ; Use and reproduction
ZDB-ID	1067704-5
ISSN	0939-4753
ISSN	0939-4753
DOI	10.1016/j.numecd.2023.01.024
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Bariatric Surgery for Patients with Overweight/Obesity. A Comprehensive Grading Methodology and Network Metanalysis of Randomized Controlled Trials on Weight Loss Outcomes and Adverse Events.

De Luca, Maurizio / Zese, Monica / Silverii, Giovanni Antonio / Ragghianti, Benedetta / Bandini, Giulia / Forestieri, Pietro / Zappa, Marco Antonio / Navarra, Giuseppe / Foschi, Diego / Musella, Mario / Sarro, Giuliano / Pilone, Vincenzo / Facchiano, Enrico / Foletto, Mirto / Olmi, Stefano / Raffelli, Marco / Bellini, Rosario / Gentileschi, Paolo / Cerbone, Maria Rosaria /

Grandone, Ilenia / Berardi, Giovanna / Di Lorenzo, Nicola / Lucchese, Marcello / Piazza, Luigi / Casella, Giovanni / Manno, Emilio / Zaccaroni, Alberto / Balani, Alessandro / Mannucci, Edoardo / Monami, Matteo

Obesity surgery

2023 Volume 33, Issue 12, Page(s) 4147–4158

Abstract: This study aims to compare different types of metabolic bariatric surgery (MBS) with lifestyle intervention/medical therapy (LSI/MT) for the treatment of overweight/obesity. The present and network meta-analysis (NMA) includes randomized trials. MBS was ... ...

Abstract	This study aims to compare different types of metabolic bariatric surgery (MBS) with lifestyle intervention/medical therapy (LSI/MT) for the treatment of overweight/obesity. The present and network meta-analysis (NMA) includes randomized trials. MBS was associated with a reduction of BMI, body weight, and percent weight loss, when compared to LSI/MT, and also with a significant reduction of HbA1c and a higher remission of diabetes. Meta-regression analyses revealed that BMI, a higher proportion of women, and a longer duration of trial were associated with greater effects of MBS. The NMA showed that all surgical procedures included (except greater curvature plication) were associated with a reduction of BMI. MBS is an effective option for the treatment of obesity. The choice of BMI thresholds for eligibility for surgery of patients with different complications should be performed making an evaluation of risks and benefits in each BMI category.
MeSH term(s)	Humans ; Female ; Overweight/complications ; Overweight/surgery ; Obesity, Morbid/surgery ; Randomized Controlled Trials as Topic ; Obesity/complications ; Obesity/surgery ; Bariatric Surgery/adverse effects ; Bariatric Surgery/methods ; Weight Loss ; Diabetes Mellitus, Type 2/surgery
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Meta-Analysis ; Journal Article ; Review
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-023-06909-4
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Zs.A 3381: Show issues

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Article: Butyrylcholinesterase as a prognostic marker: a review of the literature.

Santarpia, Lidia / Grandone, Ilenia / Contaldo, Franco / Pasanisi, Fabrizio

Journal of cachexia, sarcopenia and muscle

2012 Volume 4, Issue 1, Page(s) 31–39

Abstract: Background: Butyrylcholinesterase (BChE) is an α-glycoprotein synthesized in the liver. Its serum level decreases in many clinical conditions such as acute and chronic liver damage, inflammation, injury and infections, and malnutrition.: Methods and ... ...

Abstract	Background: Butyrylcholinesterase (BChE) is an α-glycoprotein synthesized in the liver. Its serum level decreases in many clinical conditions such as acute and chronic liver damage, inflammation, injury and infections, and malnutrition. Methods and results: This review collects the main evidence on the emerging role of butyrylcholinesterase as a prognostic marker of liver and nonliver diseases as well as a marker of protein-energy malnutrition and obesity. In fact, serum concentrations and BChE activity seem to accurately reflect the availability of amino acidic substrates and/or derangement in protein synthesis due to hepatocellular damage. In cancer, with or without liver impairment, serum BChE levels serve as an accurate functional and prognostic indicator, useful for monitoring clinical and therapeutic interventions according to patients' prognosis. In the absence of inflammation, BChE could also serve as an index of the effectiveness of nutritional support. Conclusions: Serum BChE assessment should be included in routine clinical diagnostic procedures to evaluate patient clinical conditions, in particular in cases of inflammation and/or protein-energy malnutrition.
Language	English
Publishing date	2012-09-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2586864-0
ISSN	2190-6009 ; 2190-5991
ISSN (online)	2190-6009
ISSN	2190-5991
DOI	10.1007/s13539-012-0083-5
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Article ; Online: Impact of Insulin Degludec in Hospitalized Patients With and Without Type 2 Diabetes Requiring Parenteral/Enteral Nutrition: An Observational Study.

Fatati, Giuseppe / Di Donato, Agnese / Grandone, Ilenia / Menicocci, Pina / Mirri, Eva / Prosperini, Giuseppe / Scardapane, Marco / Rossi, Maria Chiara / Palazzi, Mariangela

Advances in therapy

2018 Volume 35, Issue 6, Page(s) 809–816

Abstract: Introduction: Hyperglycemia in inpatients is a major problem, especially when nutritional support is required. This study aims to assess the impact of treatment with insulin degludec (IDeg) on mean blood glucose (BG) and glycemic variability in ... ...

Abstract	Introduction: Hyperglycemia in inpatients is a major problem, especially when nutritional support is required. This study aims to assess the impact of treatment with insulin degludec (IDeg) on mean blood glucose (BG) and glycemic variability in noncritical hospitalized patients with and without type 2 diabetes (T2DM) receiving enteral and/or parenteral nutrition (EN, PN). Methods: Mean BG and glycemic variability from admission up to 7 days of hospitalization were evaluated in consecutive cases with and without T2DM. Percentage of coefficient of variation (CV) for glucose was used to express glycemic variability. Results: Overall, 26 patients (13 with and 13 without T2DM) were admitted to the hospital for any cause. Subjects were 65.4% men and they were mainly elderly (mean age 66.3 ± 13.4 years). PN was administered in 88.5% of patients and EN in 19.2%. At admission, mean HbA1c level was 5.9 ± 0.7% in patients without diabetes and 9.1 ± 2.5% in patients with T2DM. During hospitalization, mean daily BG levels changed from 151 ± 47.3 mg/dl (day 1) to 157 ± 66.7 mg/dl (day 7) in patients without diabetes and from 210 ± 66.5 mg/dl to 192 ± 48.6 mg/dl in patients with T2DM. CV decreased from 14% (day 1) to 11% (day 7) in patients without diabetes and from 20% (day 1) to 9% (day 7) in patients with T2DM. No symptomatic or severe hypoglycemia occurred. Conclusions: Despite the small sample size and the lack of control group, this study represents the first proof-of-concept that IDeg in hospitalized patients with or without T2DM who require nutritional support has the potential to maintain stable levels of BG and reduce glycemic variability. Funding: Novo Nordisk S.p.A. grant.
MeSH term(s)	Aged ; Aged, 80 and over ; Blood Glucose/analysis ; Diabetes Mellitus, Type 2/drug therapy ; Enteral Nutrition ; Female ; Humans ; Hyperglycemia/drug therapy ; Hypoglycemia/drug therapy ; Inpatients ; Insulin, Long-Acting/therapeutic use ; Male ; Middle Aged ; Parenteral Nutrition
Chemical Substances	Blood Glucose ; Insulin, Long-Acting
Language	English
Publishing date	2018-05-17
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	632651-1
ISSN	1865-8652 ; 0741-238X
ISSN (online)	1865-8652
ISSN	0741-238X
DOI	10.1007/s12325-018-0709-x
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Article ; Online: Long-term medical complications after malabsorptive procedures: effects of a late clinical nutritional intervention.

Santarpia, Lidia / Grandone, Ilenia / Alfonsi, Lucia / Sodo, Maurizio / Contaldo, Franco / Pasanisi, Fabrizio

Nutrition (Burbank, Los Angeles County, Calif.)

2014 Volume 30, Issue 11-12, Page(s) 1301–1305

Abstract: Objective: The growing prevalence of severe obesity, combined with the failure of conservative treatments, has led to a significant spread of bariatric surgical procedures. The aim of this study was to emphasize the need of adequate presurgery patient ... ...

Abstract	Objective: The growing prevalence of severe obesity, combined with the failure of conservative treatments, has led to a significant spread of bariatric surgical procedures. The aim of this study was to emphasize the need of adequate presurgery patient selection and close follow-up after malabsorptive procedures for bariatric surgery. Methods: The study retrospectively evaluated 25 (20 F, 5 M; mean age 43 ± 13 y) obese patients (mean weight before intervention 134 ± 30.7 kg, body mass index 50.7 ± 10.1 kg/m(2)) attending our outpatient clinical nutrition unit for severe malabsorption and secondary malnutrition after surgical intervention that had been performed outside the regional area. Results: All patients received personalized dietetic indications; in 12 of 25 (48%) cases integrated by oral protein supplements and in 5 of 25 (20%) by medium chain triglycerides. According to screening exams, patients were prescribed oral/parenteral iron, vitamins A, B group, D, and folate supplementation. In 14 of 25 (56%) patients, parenteral hydration and in 4 of 25 (16%), long-term parenteral nutrition was required. Five patients required hospitalization for severely complicated protein-energy malnutrition. Conclusion: Nutritional deficiencies are common after malabsorptive procedures for bariatric surgery; these can be present or latent before surgery, frequently going unrecognized and/or inadequately treated particularly when patients are not strictly followed up by the operating center. Despite the adequate-even intensive-intervention, clinical nutritional status moderately improved in all patients.
MeSH term(s)	Bariatric Surgery/adverse effects ; Body Mass Index ; Dietary Supplements ; Female ; Health Services Needs and Demand ; Hospitalization ; Humans ; Iron/therapeutic use ; Malabsorption Syndromes/etiology ; Male ; Middle Aged ; Nutritional Status ; Obesity, Morbid/surgery ; Parenteral Nutrition ; Postoperative Complications/diet therapy ; Postoperative Complications/therapy ; Protein-Energy Malnutrition/diet therapy ; Protein-Energy Malnutrition/etiology ; Protein-Energy Malnutrition/therapy ; Retrospective Studies ; Vitamins/therapeutic use
Chemical Substances	Vitamins ; Iron (E1UOL152H7)
Language	English
Publishing date	2014-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2014.03.011
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Article: Dolore cronico nell'obesità: studio osservazionale quali-quantitativo.

Coaccioli, Stefano / Masia, Francesco / Celi, Giorgio / Grandone, Ilenia / Crapa, Mariano E / Fatati, Giuseppe

Recenti progressi in medicina

2014 Volume 105, Issue 4, Page(s) 151–154

Abstract: Introduction: Obesity (Ob) is one of the major issues for the public health care system with a constantly increasing prevalence. Chronic Pain (CP), on the other hand, is a pathological condition as severe and prevalent as the former. Ob and CP are not ... ...

Title translation	Chronic pain in the obese: a quali-quantitative observational study.
Abstract	Introduction: Obesity (Ob) is one of the major issues for the public health care system with a constantly increasing prevalence. Chronic Pain (CP), on the other hand, is a pathological condition as severe and prevalent as the former. Ob and CP are not only pathological conditions, they also are important factors of risk for the onset of a number of morbid conditions. Materials and methods: In our study we have enrolled 182 patients with Ob, to whom we have asked to fill a brief questionnaire with the purpose of evaluating prevalence and characteristics of CP, therapeutic attitude and its results, as well as the knowledge of the Law n. 38 - 15/03/2010. Results: From the analysis of gathered data, CP is present in the 39% of subjects with Ob (73.2% of females and 23.9% of males) and proportionally increases as BMI increases. The majority of patients (48%) shows pain at articular level, and a "pin" and a "gripping" pain are the two types of pain that are mostly described. Almost all the subjects enrolled (90%) suffer of a pain reported at a moderate to intense level. 15% circa of the patients do not take any therapy, while FANS have resulted to be the most used drugs among them (over 50% of the patients) and the 45% of the subjects have currently reported not to have a good control over the pain. The Law n. 38 has been reported unknown by the 8.2% of the investigated sample. Conclusions: The study has demonstrated a substantial association between the Ob and CP, particularly in the female gender, the clinical relevance of pain, its BMI-dependent tendency, the inadequacy of the therapy and the widespread lack of awareness and attention to the themes and issues of pain.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Body Mass Index ; Chronic Pain/drug therapy ; Chronic Pain/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Obesity/physiopathology ; Prevalence ; Sex Factors ; Surveys and Questionnaires
Language	Italian
Publishing date	2014-04
Publishing country	Italy
Document type	English Abstract ; Journal Article ; Observational Study
ZDB-ID	138266-4
ISSN	0034-1193
ISSN	0034-1193
DOI	10.1701/1459.16125
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Article: Dolore e diabete mellito: studio osservazionale quali-quantitativo.

Coaccioli, Stefano / Celi, Giorgio / Masia, Francesco / Grandone, Ilenia / Crapa, Mariano E / Fatati, Giuseppe

Recenti progressi in medicina

2014 Volume 105, Issue 4, Page(s) 155–158

Abstract: Aim: The purpose of this study is to evaluate the prevalence and characteristics of pain in subjects affected by Diabetes Mellitus (DM), to assess approach and therapeutically valid outcomes as well as the knowledge of the Law n. 38/15/03/2010 of the ... ...

Title translation	Chronic pain in the diabetic patient: a quali-quantitative observational study.
Abstract	Aim: The purpose of this study is to evaluate the prevalence and characteristics of pain in subjects affected by Diabetes Mellitus (DM), to assess approach and therapeutically valid outcomes as well as the knowledge of the Law n. 38/15/03/2010 of the Italian Government ("Dispositions to guarantee the access to the Palliative Cares and Pain Therapy"). Materials and methods: We have enrolled 462 patients affected by DM [242 (52.4%) males, 209 (42.5%) females; while in 11 (5.1%) cases the gender has not been specified], with characteristics as follows: 62 patients (13.4%) affected by T1DM (37 males and 25 females) e 400 patients (86.6%) affected by T2DM (224 males e 176 females). The average age was of 65.2 years old (range 20-91). All the patients have been presented with an original questionnaires based on 10 questions. Results: 221 subjects (48%) have claimed to have experienced pain; 60% within the females, 38% within the males (p<0.001). 31% of these are to be included among the patients with T1DM, 50.5% among those with T2DM (p<0.01). The presence of chronic pain has been acknowledged by 162 subjects (35%). As per chronic pain, this has been described as articular pain by 128 patients (80%), while 63 (38%) located the pain through the spine and 29 (18%) throughout the muscles. Chronic pain was described as moderate by 73 subjects (45%), intense by 59 (36%), feeble by 15 (9%), utterly intense by 5 (3%), moderate/intense by 1 (1%). The drugs for treating the chronic pain used by the patients have been enlisted as follows: FANS (41%), paracetamol (30%), glucocorticoids (3%), weak opioids (2%); 27% of subjects have received no therapy. As for the Law 38/2010, only 8% have said they have had news of it. Conclusions: The data gathered in this study have drawn attention on the fact that the presence of pain is higher in female gender, with a prevalence of 60% compared to the 38% of the male gender. It has been observed no relation with the age range, in particular no proportional increase level of pain has been observed, although the higher peak of prevalence has been experienced in the age range between 70-79, both for pain in general and for chronic pain. Speaking about efficacy of the treatment, almost 50% of the subjects have received no improvement from the therapy.
MeSH term(s)	Adult ; Age Factors ; Aged ; Aged, 80 and over ; Analgesics/therapeutic use ; Chronic Pain/drug therapy ; Chronic Pain/epidemiology ; Chronic Pain/physiopathology ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Humans ; Italy/epidemiology ; Legislation, Drug ; Male ; Middle Aged ; Prevalence ; Severity of Illness Index ; Sex Factors ; Surveys and Questionnaires ; Treatment Outcome ; Young Adult
Chemical Substances	Analgesics
Language	Italian
Publishing date	2014-04
Publishing country	Italy
Document type	English Abstract ; Journal Article ; Observational Study
ZDB-ID	138266-4
ISSN	0034-1193
ISSN	0034-1193
DOI	10.1701/1459.16127
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Article ; Online: Rationale and design of the Early Sleeve gastrectomy In New Onset Diabetic Obese Patients (ESINODOP) trial.

Trastulli, Stefano / Desiderio, Jacopo / Grandone, Ilenia / Fontana, Lucia / Paolini, Luisa / Altomare, Maria / D'Angelo, Paola / Palazzi, Mariangela / Cirocchi, Roberto / Leotta, Sergio / Fatati, Giuseppe / Parisi, Amilcare

Endocrine

2017 Volume 55, Issue 3, Page(s) 748–753

Abstract: No randomized clinical trials (RCTs) have yet evaluated the bariatric surgery's efficacy and safety in patients newly diagnosed with type 2 diabetes mellitus (T2DM). The aim of this multicenter RCT is to compare bariatric surgery, particularly ... ...

Abstract	No randomized clinical trials (RCTs) have yet evaluated the bariatric surgery's efficacy and safety in patients newly diagnosed with type 2 diabetes mellitus (T2DM). The aim of this multicenter RCT is to compare bariatric surgery, particularly laparoscopic sleeve gastrectomy (LSG), with conventional medical therapy (CMT) in obese patients (body mass index between 30 and 42 kg/m
MeSH term(s)	Adult ; Aged ; Clinical Protocols ; Diabetes Mellitus, Type 2/surgery ; Gastrectomy/adverse effects ; Gastrectomy/methods ; Humans ; Middle Aged ; Obesity/surgery ; Research Design ; Young Adult
Language	English
Publishing date	2017-03
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	1194484-5
ISSN	1559-0100 ; 1355-008X ; 0969-711X
ISSN (online)	1559-0100
ISSN	1355-008X ; 0969-711X
DOI	10.1007/s12020-016-0996-4
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