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  1. Article ; Online: The combination of Ling Jiao Gou Teng decoction and ischemic preconditioning protect against cerebral ischemic reperfusion injury in rats by protecting the blood brain barrier

    Zhen-zhen Chen / Xin Gong / Jianfeng Lei

    Pharmacological Research - Modern Chinese Medicine, Vol 3, Iss , Pp 100073- (2022)

    2022  

    Abstract: Ling Jiao Gou Teng decoction (LJGT) is a famous traditional Chinese medicine formula for treating ...

    Abstract Ling Jiao Gou Teng decoction (LJGT) is a famous traditional Chinese medicine formula for treating ischemic stroke. It is not known whether the combination of LJGT and ischemic preconditioning can enhance the neuroprotective effect of cerebral ischemia and thus alleviate the neurological damage caused by subsequent ischemic attacks. In this article, we used middle cerebral artery occlusion (MCAO) rats model to evaluate the effects of LJGT associate to remote ischemic preconditioning (RIPC) on cerebral ischemic reperfusion (I/R) injury and its underlying molecular mechanisms. The results showed that LJGT and RIPC pretreatment significantly reduced the cerebral edema, cerebral infarct volume and the neurological deficit scores. Meanwhile, LJGT and RIPC could protect the blood brain barrier (BBB) and improve the morphology and ultrastructure of ischemic penumbra brain tissue. In addition, LJGT and RIPC pretreatment significantly inhibited the expressions of mRNA and protein of MMP-2 and MMP-9, while it strengthened the expressions of occlusion, ZO-1 and TIMP-1. Moreover, the effects of LJGT and RIPC pretreatment on the expression of these genes were better than that in the group treated with LJGT or RIPC alone. The results suggested that LJGT and RIPC preconditioning had a neuroprotective effect on cerebral ischemia/reperfusion injury, and the underlying mechanism was related to protecting BBB integrity through inhibiting the production of MMP-2 and MMP-9 and activating the expressions of occlusion, ZO-1, and TIMP-1.
    Keywords Cerebral edema ; BBB ; Cerebral ischemia reperfusion ; Ling Jiao Gou Teng decoction ; Remote ischemic preconditioning ; Other systems of medicine ; RZ201-999 ; Therapeutics. Pharmacology ; RM1-950
    Subject code 610
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: The combination of Ling Jiao Gou Teng decoction and ischemic preconditioning protect against cerebral ischemic reperfusion injury in rats by protecting the blood brain barrier

    Chen, Zhen-zhen / Gong, Xin / Lei, Jianfeng

    Pharmacological research. 2022 June, v. 3

    2022  

    Abstract: Ling Jiao Gou Teng decoction (LJGT) is a famous traditional Chinese medicine formula for treating ...

    Abstract Ling Jiao Gou Teng decoction (LJGT) is a famous traditional Chinese medicine formula for treating ischemic stroke. It is not known whether the combination of LJGT and ischemic preconditioning can enhance the neuroprotective effect of cerebral ischemia and thus alleviate the neurological damage caused by subsequent ischemic attacks. In this article, we used middle cerebral artery occlusion (MCAO) rats model to evaluate the effects of LJGT associate to remote ischemic preconditioning (RIPC) on cerebral ischemic reperfusion (I/R) injury and its underlying molecular mechanisms. The results showed that LJGT and RIPC pretreatment significantly reduced the cerebral edema, cerebral infarct volume and the neurological deficit scores. Meanwhile, LJGT and RIPC could protect the blood brain barrier (BBB) and improve the morphology and ultrastructure of ischemic penumbra brain tissue. In addition, LJGT and RIPC pretreatment significantly inhibited the expressions of mRNA and protein of MMP-2 and MMP-9, while it strengthened the expressions of occlusion, ZO-1 and TIMP-1. Moreover, the effects of LJGT and RIPC pretreatment on the expression of these genes were better than that in the group treated with LJGT or RIPC alone. The results suggested that LJGT and RIPC preconditioning had a neuroprotective effect on cerebral ischemia/reperfusion injury, and the underlying mechanism was related to protecting BBB integrity through inhibiting the production of MMP-2 and MMP-9 and activating the expressions of occlusion, ZO-1, and TIMP-1.
    Keywords Oriental traditional medicine ; blood-brain barrier ; brain ; edema ; infarction ; ischemia ; neuroprotective effect ; reperfusion injury ; research ; stroke ; ultrastructure
    Language English
    Dates of publication 2022-06
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 2667-1425
    DOI 10.1016/j.prmcm.2022.100073
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Correction: Zhang, G.; Cheng, G.; Jia, P.; Jiao, S.; Feng, C.; Hu, T.; Liu, H.; Du, Y. The Positive Correlation of the Enhanced Immune Response to PCV2 Subunit Vaccine by Conjugation of Chitosan Oligosaccharide with the Deacetylation Degree. Marine Drugs 2017, 15, 236.

    Zhang, Guiqiang / Cheng, Gong / Jia, Peiyuan / Jiao, Siming / Feng, Cui / Hu, Tao / Liu, Hongtao / Du, Yuguang

    Marine drugs

    2017  Volume 15, Issue 9

    Abstract: The authors wish to correct Figure 1 in this paper [1] to be as follows:[ ... ]. ...

    Abstract The authors wish to correct Figure 1 in this paper [1] to be as follows:[...].
    Language English
    Publishing date 2017-09-20
    Publishing country Switzerland
    Document type Journal Article ; Published Erratum
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md15090292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Beetroot (

    Gong, Shaoying / Jiao, Chaoqin / Guo, Ling / Jiang, Yujun

    International journal of molecular sciences

    2023  Volume 24, Issue 18

    Abstract: ... ...

    Abstract Salmonella
    MeSH term(s) Swine ; Animals ; Beta vulgaris ; Salmonella typhimurium ; Pork Meat ; Red Meat ; Apoptosis ; Anti-Bacterial Agents/pharmacology ; Vegetables ; Plant Extracts/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Plant Extracts
    Language English
    Publishing date 2023-09-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241814217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Data standards and standardization: The shortest plank of bucket for the COVID-19 containment.

    Gong, Mengchun / Jiao, Yuanshi / Gong, Yang / Liu, Li

    The Lancet regional health. Western Pacific

    2022  , Page(s) 100565

    Language English
    Publishing date 2022-08-11
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2666-6065
    ISSN (online) 2666-6065
    DOI 10.1016/j.lanwpc.2022.100565
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Zhongguo li dai wei sheng zu zhi ji yi xue jiao yu

    Gong, Chun

    (She hui yi xue yu wei sheng shi ye guan li jiao xue yan jiu can kao zi liao)

    1983  

    Title translation A history of the organization of public health services and medical education in China.
    Author's details Kong Chun bian zhu
    Series title She hui yi xue yu wei sheng shi ye guan li jiao xue yan jiu can kao zi liao
    MeSH term(s) Health Services/history ; Education, Medical/history
    Keywords China
    Language Chinese
    Size ii, 164 p. :, ill.
    Edition Di 1 ban.
    Publisher Wei sheng bu ke jiao si ; Di 4 jun yi da xue
    Publishing place Beijing
    Document type Book
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Article ; Online: The SphK1/S1P Axis Regulates Synaptic Vesicle Endocytosis via TRPC5 Channels.

    Jiang, Zhong-Jiao / Gong, Liang-Wei

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2023  Volume 43, Issue 21, Page(s) 3807–3824

    Abstract: Sphingosine-1-phosphate (S1P), a bioactive sphingolipid concentrated in the brain, is essential for normal brain functions, such as learning and memory and feeding behaviors. Sphingosine kinase 1 (SphK1), the primary kinase responsible for S1P production ...

    Abstract Sphingosine-1-phosphate (S1P), a bioactive sphingolipid concentrated in the brain, is essential for normal brain functions, such as learning and memory and feeding behaviors. Sphingosine kinase 1 (SphK1), the primary kinase responsible for S1P production in the brain, is abundant within presynaptic terminals, indicating a potential role of the SphK1/S1P axis in presynaptic physiology. Altered S1P levels have been highlighted in many neurologic diseases with endocytic malfunctions. However, it remains unknown whether the SphK1/S1P axis may regulate synaptic vesicle endocytosis in neurons. The present study evaluates potential functions of the SphK1/S1P axis in synaptic vesicle endocytosis by determining effects of a dominant negative catalytically inactive SphK1. Our data for the first time identify a critical role of the SphK1/S1P axis in endocytosis in both neuroendocrine chromaffin cells and neurons from mice of both sexes. Furthermore, our Ca
    MeSH term(s) Male ; Female ; Mice ; Animals ; Synaptic Vesicles/metabolism ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Sphingosine/metabolism ; Endocytosis ; Lysophospholipids/metabolism ; TRPC Cation Channels
    Chemical Substances sphingosine kinase (EC 2.7.1.-) ; sphingosine 1-phosphate (26993-30-6) ; Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) ; Sphingosine (NGZ37HRE42) ; Lysophospholipids ; TRPC Cation Channels ; Trpc5 protein, mouse
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.1494-22.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1668: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Accurate Complementarity Learning for Graph-Based Multiview Clustering.

    Xiao, Xiaolin / Gong, Yue-Jiao

    IEEE transactions on neural networks and learning systems

    2023  Volume PP

    Abstract: In real scenarios, graph-based multiview clustering has clearly shown popularity owing to the high efficiency in fusing the information from multiple views. Practically, the multiview graphs offer both consistent and inconsistent cues as they usually ... ...

    Abstract In real scenarios, graph-based multiview clustering has clearly shown popularity owing to the high efficiency in fusing the information from multiple views. Practically, the multiview graphs offer both consistent and inconsistent cues as they usually come from heterogeneous sources. Previous methods illustrated the importance of leveraging the multiview consistency and inconsistency for accurate modeling. However, when fusing the graphs, the inconsistent parts are generally ignored and hence the valued view-specific attributes are lost. To solve this problem, we propose an accurate complementarity learning (ACL) model for graph-based multiview clustering. ACL clearly distinguishes the consistent, complementary, and noise and corruption terms from the initial multiview graphs. In contrast to existing models that overlooked the complementary information, we argue that the view-specific characteristics extracted from the complementary terms are beneficial for affinity learning. In addition, ACL exploits only the positive parts of the complementary information for preserving the evidence on the positive sample relationship, and ignores the negative cues to avoid the vanishing of effective affinity strengths. This way, the learned affinity matrix is able to properly balance the consistent and complementary information. To solve the ACL model, we introduce an efficient alternating optimization algorithm with a varying penalty parameter. Experiments on synthetic and real-world databases clearly demonstrated the superiority of ACL.
    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2023.3292057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Exome-Based Amino Acid Optimization: A Dietary Strategy to Satisfy Human Nutritional Demands and Enhance Muscle Strength in Breast Tumor Mice Undergoing Chemotherapy.

    Gong, Congcong / Jiao, Chunwei / Liang, Huijia / Ma, Yuxin / Wu, Qingping / Xie, Yizhen

    Journal of agricultural and food chemistry

    2024  Volume 72, Issue 13, Page(s) 7089–7099

    Abstract: Breast cancer patients undergoing chemotherapy often experience muscle wasting and weakness, which impact their quality of life. A potential solution lies in customizing amino acid compositions based on exome-derived formulations (ExAAs). The study ... ...

    Abstract Breast cancer patients undergoing chemotherapy often experience muscle wasting and weakness, which impact their quality of life. A potential solution lies in customizing amino acid compositions based on exome-derived formulations (ExAAs). The study hypothesized that tailoring dietary amino acids using ExAAs could enhance muscle health. Theoretical amino acid requirements were calculated from the genome's exome region, and a breast cancer mouse model undergoing paclitaxel treatment was established. The mice were supplemented with a cancer-specific nutritional formula (QJS), and the effects of QJS and amino acid-adjusted QJS (adjQJS) were compared. Both formulations improved the nutritional status without compromising tumor growth. Notably, adjQJS significantly enhanced muscle strength compared to QJS (1.51 ± 0.25
    MeSH term(s) Humans ; Animals ; Mice ; Female ; Exome/genetics ; Quality of Life ; Amino Acids/metabolism ; Diet ; Muscle Strength ; Muscle, Skeletal/metabolism ; Dietary Supplements ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism
    Chemical Substances Amino Acids
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c07256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1172: Show issues Location:
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  10. Article: The effects of ultrasonic processing on the antioxidant activity of

    Jiao, Fengping / Cui, Xianping / Gong, Xiaodi / Jiang, Guozheng / Wang, Jinbiao / Meng, Ling

    Frontiers in nutrition

    2024  Volume 11, Page(s) 1334956

    Abstract: Introduction: Extraction techniques that influence cell wall polysaccharides (EPS) is crucial for maximizing their bioactivity. This study evaluates ultrasound technology for extracting antioxidant polysaccharides from : Methods: Ultrasound ... ...

    Abstract Introduction: Extraction techniques that influence cell wall polysaccharides (EPS) is crucial for maximizing their bioactivity. This study evaluates ultrasound technology for extracting antioxidant polysaccharides from
    Methods: Ultrasound extraction of EPS from
    Results: The Results showed that ultrasonic treatment markedly increased the ABTS radical scavenging efficiency of LG-8 cells by 47%. At a concentration of 1 mg/mL, the ultrasonically extracted LG-EPS1 and LG-EPS3 polysaccharides exhibited significant ABTS radical scavenging efficiencies of 26% and 51%, respectively. Monosaccharide composition analysis identified mannose and glucose in LG-EPS1, while LG-EPS3 was primarily composed of mannose. FTIR spectra verified the polysaccharides' presence, and SEM provided visual confirmation of the nanoparticle structures characteristic of LG-EPS1 and LG-EPS3.
    Discussion: This research not only underscores the technological merits of ultrasound in polysaccharide extraction but also highlights the potential of
    Language English
    Publishing date 2024-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2024.1334956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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