Article ; Online: Multi-omics data integration shines a light on the renal medulla.
2024 Volume 105, Issue 2, Page(s) 242–244
Abstract: The renal medulla maintains salt and water balance and is prone to dysregulation because of high oxygen demand. Challenges in obtaining high-quality tissue have limited characterization of molecular programs regulating the medulla. Haug et al. leveraged ... ...
Abstract | The renal medulla maintains salt and water balance and is prone to dysregulation because of high oxygen demand. Challenges in obtaining high-quality tissue have limited characterization of molecular programs regulating the medulla. Haug et al. leveraged gene expression, chromatin accessibility, long-range chromosomal interactions, and spatial transcriptomics to build a reference set of medullary tissue marker genes to define the medullary role in kidney function, exemplifying the strength and utility of multi-omic data integration. |
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MeSH term(s) | Multiomics ; Kidney Medulla/metabolism ; Sodium Chloride, Dietary/metabolism ; Sodium Chloride/metabolism ; Water-Electrolyte Balance |
Chemical Substances | Sodium Chloride, Dietary ; Sodium Chloride (451W47IQ8X) |
Language | English |
Publishing date | 2024-01-02 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 120573-0 |
ISSN | 1523-1755 ; 0085-2538 |
ISSN (online) | 1523-1755 |
ISSN | 0085-2538 |
DOI | 10.1016/j.kint.2023.11.014 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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