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Article ; Online: Retinoic Acid Treatment Mitigates PM2.5-Induced Type 2 Inflammation: Insights into Modulation of Innate Immune Responses.

Lee, Hyun-Joo / Kim, Dong-Kyu

International journal of molecular sciences

2024 Volume 25, Issue 7

Abstract: Some studies have demonstrated the effects of particulate matter (PM) on chronic rhinosinusitis with nasal polyps (CRSwNP) development, as well as the therapeutic role of retinoic acid (RA) in nasal polypogenesis. However, the immunologic effect of PM in ...

Abstract	Some studies have demonstrated the effects of particulate matter (PM) on chronic rhinosinusitis with nasal polyps (CRSwNP) development, as well as the therapeutic role of retinoic acid (RA) in nasal polypogenesis. However, the immunologic effect of PM in innate lymphoid cells (ILCs) and the exact mechanism of the therapeutic effect of RA remain unclear. Therefore, the present study investigated the effects of fine-dust-induced inflammation in CRSwNP and the mechanisms of the therapeutic effect of RA. PM2.5 exposure exacerbated pathological damage in the nasal mucosa of mice with nasal polyps (NP) via upregulation of type 2 inflammation. Additionally, PM2.5 exposure increased the expression of type 2 cytokines and epithelial-cell-derived cytokines (IL-33 and IL-25) significantly, as well as the ILC populations in human-NP-derived epithelial cells (HNECs). Moreover, RA supplementation significantly increased the expression of ILCreg in Lin-CD45+CD127+ cells, which in turn increased the levels of the anti-inflammatory cytokine IL-10. The findings suggest that PM2.5 exposures could aggravate the CRSwNP type 2 inflammation, and RA treatment may ameliorate fine-dust-induced inflammation by modulating the innate immune response.
MeSH term(s)	Humans ; Animals ; Mice ; Immunity, Innate ; Nasal Polyps ; Lymphocytes ; Inflammation/drug therapy ; Cytokines ; Dust ; Nasal Mucosa ; Particulate Matter/toxicity
Chemical Substances	Cytokines ; Dust ; Particulate Matter
Language	English
Publishing date	2024-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25073856
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exploring the antecedents of apparel disposal behaviors

Cynthia Goudeau / Hyun-Joo Lee

International Journal of Research In Business and Social Science, Vol 10, Iss 8, Pp 01-

2022 Volume 11

Abstract: To obtain a comprehensive view of the apparel disposal behaviors of young U.S. consumers, this study evaluated antecedents of apparel disposal behaviors using a framework based on the theory of reasoned action (TRA), categorization theory, and prior ... ...

Abstract	To obtain a comprehensive view of the apparel disposal behaviors of young U.S. consumers, this study evaluated antecedents of apparel disposal behaviors using a framework based on the theory of reasoned action (TRA), categorization theory, and prior literature. Data were obtained from a convenience sample of undergraduate students at a large U.S. Midwestern university through a self-administered online survey. A final sample of 358 usable surveys was analyzed through the use of structural equation modeling (SEM) with Amos. The results supported the proposed relationships between environmental apparel knowledge and attitude toward sustainable methods of apparel disposal. In addition, the proposed relationships between attitude and apparel disposal intention (intention to discard, donate, reuse, or resell) were all supported except for intention to resell. While the results showed a significant and positive relationship between subjective norms and intention to resell or donate apparel, no significant relationship was shown between subjective norms and intention to reuse or discard apparel. In addition, subjective norms were a positive and significant antecedent of attitude. Lastly, respondents’ intention to engage in a particular apparel disposal behavior corresponded with the actual apparel disposal behavior.
Keywords	apparel disposal ; theory of reasoned action ; categorization theory ; young consumers ; Social Sciences ; H
Subject code	650
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Center for Strategic Studies in Business & Finance
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The Impact of Consumer Competence in Purchasing Foods on Satisfaction with Food-Related Consumer Policies and Satisfaction with Food-Related Life through Perceptions of Food Safety.

Lee, Hyun-Joo

Foods (Basel, Switzerland)

2020 Volume 9, Issue 8

Abstract: Based on the knowledge-deficit model, this study proposes a relationship between consumer competence in purchasing foods and perceptions of the safety of imported and domestic foods. This study also examines how perceptions of the safety of imported and ... ...

Abstract	Based on the knowledge-deficit model, this study proposes a relationship between consumer competence in purchasing foods and perceptions of the safety of imported and domestic foods. This study also examines how perceptions of the safety of imported and domestic foods affect satisfaction with food-related consumer policy and satisfaction with food-related life. Using data from the "2019 Consumer Behavior Survey for Food," which has been conducted every year since 2013 by the Korea Rural Economic Institute, we analyzed the responses of a final sample of 5869 respondents. The hypothesized conceptual model was assessed through structural equation modeling. All but one of the proposed relationships between consumer competence in purchasing foods and perceptions of food safety were supported. The relationship between perceptions of food safety and satisfaction with food-related consumer policies depends on whether foods are imported or domestic. Food origin also affected the relationship between perceptions of food safety and satisfaction with food-related life. Satisfaction with food-related consumer policies is significantly connected with satisfaction with food-related life. We discuss how the findings of this study can be applied to the development of food-related consumer policies.
Language	English
Publishing date	2020-08-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods9081103
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Article: Priming Behavioral Control Enhances Sharing in Preschoolers.

Lee, Chanmi / Song, Hyun-Joo

Frontiers in psychology

2022 Volume 13, Page(s) 892382

Abstract: Although young children demonstrate knowledge of fairness norms, their actual sharing is often inconsistent with their understanding. A possible explanation for this discrepancy is the failure of behavioral control in young children. Thus, the present ... ...

Abstract	Although young children demonstrate knowledge of fairness norms, their actual sharing is often inconsistent with their understanding. A possible explanation for this discrepancy is the failure of behavioral control in young children. Thus, the present research manipulated behavioral control experimentally and examined its effect on the sharing behavior in 3- to 4-year-olds (
Language	English
Publishing date	2022-07-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.892382
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Article ; Online: Exposure to Foreign Languages through Live Interaction Can Facilitate Children's Acceptance of Multiple Labeling Conventions across Languages.

Lee, Hyuna / Song, Hyun-Joo

Journal of child language

2022 Volume 51, Issue 2, Page(s) 470–484

Abstract: The current research examined whether children's expectations about labeling conventions can be influenced by limited exposure to a foreign language. Three- to four-year-old Korean children were presented with two speakers who each assigned a novel label ...

Abstract	The current research examined whether children's expectations about labeling conventions can be influenced by limited exposure to a foreign language. Three- to four-year-old Korean children were presented with two speakers who each assigned a novel label either in Korean or Spanish to a novel object. Children were asked whether both labels were acceptable for the object. Children who had more exposure to a foreign language through live social interaction, but not through media, were more likely to accept both Korean and Spanish labels. These findings indicate the influence of social interaction in foreign language exposure on children's understanding of different labeling conventions.
MeSH term(s)	Child ; Humans ; Child, Preschool ; Language Development ; Language ; Asian People
Language	English
Publishing date	2022-11-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1466489-6
ISSN	1469-7602 ; 0305-0009
ISSN (online)	1469-7602
ISSN	0305-0009
DOI	10.1017/S0305000922000472
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Article: Comparison of the anti-diabetic effects of various grain and legume extracts in high-fat diet and streptozotocin-nicotinamide-induced diabetic rats.

Jeong, Eunwoo / Baek, Youjin / Kim, Hyun-Joo / Lee, Hyeon Gyu

Heliyon

2024 Volume 10, Issue 3, Page(s) e25279

Abstract: The anti-diabetic properties of whole groats and dietary fibers from various grains and legumes are well known. Nevertheless, studies on the anti-diabetic effects of their extracts are limited, and it is difficult to compare their efficacy. This study ... ...

Abstract	The anti-diabetic properties of whole groats and dietary fibers from various grains and legumes are well known. Nevertheless, studies on the anti-diabetic effects of their extracts are limited, and it is difficult to compare their efficacy. This study investigated the anti-diabetic potential of ethanol extracts from oats (OE), sorghum (SE), foxtail millet (FE), proso millet (PE), adzuki bean (AE), and black soybean (BE) in a high-fat diet and streptozotocin-nicotinamide-induced diabetic rat models. The extracts, obtained using 99.9 % ethanol, were orally administered to diabetic rats for four weeks. Various parameters were evaluated, including fasting blood glucose levels, glucose tolerance, insulin sensitivity, serum insulin levels, and pancreas histological analysis. OE and SE effectively reduced fasting blood glucose levels and the area under the curve (AUC) in the oral glucose tolerance test. Only OE significantly decreased the AUC in the insulin tolerance test and increased insulin concentration and homeostatic model assessment of the β-cell function index, indicating improved insulin sensitivity and β-cell function. Histological and immunohistochemical analysis of the pancreas supported these findings, demonstrating that OE protected against pancreatic cell damage. In contrast, FE, PE, AE, and BE did not have a significant effect on diabetes-related parameters. These findings identify OE as the most promising natural intervention for diabetes management.
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e25279
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Article ; Online: Effect of a 12-Week Multi-Exercise Community Program on Muscle Strength and Lipid Profile in Elderly Women.

Lim, Hee-Sook / Kim, Tae-Hee / Kang, Hyun-Joo / Lee, Hae-Hyeog

Nutrients

2024 Volume 16, Issue 6

Abstract: This study targeted elderly women over 60 years old (109 persons), divided them into an exercise group and a control group, and implemented a 12-week physical activity program for the exercise group. Body composition, muscle, blood tests, depression, ... ...

Abstract	This study targeted elderly women over 60 years old (109 persons), divided them into an exercise group and a control group, and implemented a 12-week physical activity program for the exercise group. Body composition, muscle, blood tests, depression, quality of life (QoL), nutritional status, and physical strength were compared and analyzed. The physical activity program was organized through a consultative body of experts, was performed for about 60 min each time in the type and order of exercise appropriate for elderly women, and consisted of a combination of exercise using a band, gymnastics, and stretching. Changes in the muscle index and muscle mass before and after the program were selected as the primary efficacy evaluations. In the exercise group, waist circumference significantly decreased, and the muscle index significantly increased compared to the control group. The number of subjects who showed sarcopenia with a muscle index of 5.4 or less in the exercise group significantly decreased from 22 (38.6%) before program implementation to 13 (22.8%). According to the results of secondary effectiveness evaluation, high-density lipoprotein cholesterol and apolipoprotein (Apo) A were significantly increased in the exercise group compared to the control group, and Apo B, triglyceride, and c-reactive protein showed a significant decrease. Regular physical activity is very important for improving the health and QoL of elderly women, and as a result of applying a customized program, effects such as increased muscle index, improvement of sarcopenia, and improvement of blood lipid status were confirmed. Therefore, it is believed that the physical activity program developed through this study can be applied as a community program for elderly women.
MeSH term(s)	Humans ; Female ; Aged ; Middle Aged ; Sarcopenia/prevention & control ; Sarcopenia/metabolism ; Quality of Life ; Muscle Strength/physiology ; Exercise/physiology ; Nutritional Status ; Body Composition/physiology ; Muscle, Skeletal/metabolism
Language	English
Publishing date	2024-03-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16060813
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Article ; Online: Effect of Airborne Particulate Matter on the Immunologic Characteristics of Chronic Rhinosinusitis with Nasal Polyps.

Lee, Hyun-Joo / Kim, Dong-Kyu

International journal of molecular sciences

2022 Volume 23, Issue 3

Abstract: The inflammatory mechanisms of environmental pollutants in chronic rhinosinusitis (CRS) have recently been proposed. However, the mechanisms underlying the inflammatory effects of particulate matter (PM) on nasal polyp (NP) tissues remain unknown. Here ... ...

Abstract	The inflammatory mechanisms of environmental pollutants in chronic rhinosinusitis (CRS) have recently been proposed. However, the mechanisms underlying the inflammatory effects of particulate matter (PM) on nasal polyp (NP) tissues remain unknown. Here we investigated the mechanism underlying the inflammatory effects of PM10 on human nasal polyp-derived fibroblasts (NPDFs). We isolated NPDFs from human NP tissues obtained from patients with CRS with NPs (CRSwNP). The NPDFs were exposed to PM10 in vitro. Immunologic characteristics were assessed using real-time polymerase chain reaction, enzyme-linked immunosorbent assay, Western blot, and flow cytometry. Additionally, we investigated the effect of NPDF-conditioned media (CM) on the expression of CD4
MeSH term(s)	CD4-Positive T-Lymphocytes/metabolism ; Cell Culture Techniques ; Culture Media, Conditioned/metabolism ; Cytokines/genetics ; Cytokines/metabolism ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Fibroblasts/immunology ; Gene Expression Regulation/drug effects ; Humans ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Nasal Polyps/genetics ; Nasal Polyps/immunology ; Nasal Polyps/pathology ; Particulate Matter/toxicity ; Primary Cell Culture ; Rhinitis/genetics ; Rhinitis/immunology ; Rhinitis/pathology ; Sinusitis/genetics ; Sinusitis/immunology ; Sinusitis/pathology ; Transcription Factor AP-1/genetics ; Transcription Factor AP-1/metabolism
Chemical Substances	Culture Media, Conditioned ; Cytokines ; NF-kappa B ; Particulate Matter ; Transcription Factor AP-1
Language	English
Publishing date	2022-01-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23031018
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Article ; Online: CD40 ligand stimulation affects the number and memory phenotypes of human peripheral CD8

Choi, Haeyoun / Lee, Hyun-Joo / Sohn, Hyun-Jung / Kim, Tai-Gyu

BMC immunology

2023 Volume 24, Issue 1, Page(s) 15

Abstract: Background: CD40L is primarily expressed on activated CD4: Results: Human peripheral CD8: Conclusions: Our study suggests that CD40L has an effect on the increased number of ... ...

Abstract	Background: CD40L is primarily expressed on activated CD4 Results: Human peripheral CD8 Conclusions: Our study suggests that CD40L has an effect on the increased number of CD8
MeSH term(s)	Humans ; Animals ; Mice ; CD40 Ligand ; CD8-Positive T-Lymphocytes ; CD40 Antigens ; Antigen-Presenting Cells ; Phenotype
Chemical Substances	CD40 Ligand (147205-72-9) ; CD40 Antigens
Language	English
Publishing date	2023-06-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041500-X
ISSN	1471-2172 ; 1471-2172
ISSN (online)	1471-2172
ISSN	1471-2172
DOI	10.1186/s12865-023-00547-2
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Article ; Online: Feasibility study for the automatic surgical planning method based on statistical model.

Nguyen, Hang Phuong / Lee, Hyun-Joo / Kim, Sungmin

Journal of orthopaedic surgery and research

2023 Volume 18, Issue 1, Page(s) 398

Abstract: Purpose: In this study, we proposed establishing an automatic computer-assisted surgical planning approach based on average population models.: Methods: We built the average population models from humerus datasets using the Advanced Normalization ... ...

Abstract	Purpose: In this study, we proposed establishing an automatic computer-assisted surgical planning approach based on average population models. Methods: We built the average population models from humerus datasets using the Advanced Normalization Toolkits (ANTs) and Shapeworks. Experiments include (1) evaluation of the average population models before surgical planning and (2) validation of the average population models in the context of predicting clinical landmarks on the humerus from the new dataset that was not involved in the process of building the average population model. The evaluation experiment consists of explained variation and distance model. The validation experiment calculated the root-mean-square error (RMSE) between the expert-determined clinical ground truths and the landmarks transferred from the average population model to the new dataset. The evaluation results and validation results when using the templates built from ANTs were compared to when using the mean shape generated from Shapeworks. Results: The average population models predicted clinical locations on the new dataset with acceptable errors when compared to the ground truth determined by an expert. However, the templates built from ANTs present better accuracy in landmark prediction when compared to the mean shape built from the Shapeworks. Conclusion: The average population model could be utilized to assist anatomical landmarks checking automatically and following surgical decisions for new patients who are not involved in the dataset used to generate the average population model.
MeSH term(s)	Humans ; Feasibility Studies ; Models, Statistical ; Humerus/surgery
Language	English
Publishing date	2023-06-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2252548-8
ISSN	1749-799X ; 1749-799X
ISSN (online)	1749-799X
ISSN	1749-799X
DOI	10.1186/s13018-023-03870-x
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