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Article ; Online: Perspectives on Prediabetes and Aging.

Al-Sofiani, Mohammed E / Asiri, Alanood / Alajmi, Sarah / Alkeridy, Walid

Endocrinology and metabolism clinics of North America

2023 Volume 52, Issue 2, Page(s) 377–388

Abstract: Diabetes prevention programs (DPPs) have been shown to effectively delay, and sometimes prevent, the progression from prediabetes to diabetes; however, labeling someone with prediabetes comes with potential negative psychological, financial, and self- ... ...

Abstract	Diabetes prevention programs (DPPs) have been shown to effectively delay, and sometimes prevent, the progression from prediabetes to diabetes; however, labeling someone with prediabetes comes with potential negative psychological, financial, and self-perception consequences. Many older adults with prediabetes nowadays have a relatively "low-risk" form of prediabetes that rarely progresses to diabetes and may regress to normoglycemia. In this article, we review the impact of aging on glucose metabolism and provide a holistic approach to cases of prediabetes in older adults that maximizes the benefit-risk balance of interventions aimed at addressing prediabetes.
MeSH term(s)	Humans ; Aged ; Prediabetic State/therapy ; Diabetes Mellitus ; Aging ; Risk Assessment ; Blood Glucose/metabolism
Chemical Substances	Blood Glucose
Language	English
Publishing date	2023-02-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	92116-6
ISSN	1558-4410 ; 0889-8529
ISSN (online)	1558-4410
ISSN	0889-8529
DOI	10.1016/j.ecl.2022.10.011
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Article ; Online: Potentially inappropriate prescribing for people with dementia in ambulatory care: a cross-sectional observational study.

Alageel, Nahla A / Hughes, Carmel M / Alwhaibi, Monira / Alkeridy, Walid / Barry, Heather E

BMC geriatrics

2024 Volume 24, Issue 1, Page(s) 328

Abstract: Background: Studies have shown that potentially inappropriate prescribing (PIP) is highly prevalent among people with dementia (PwD) and linked to negative outcomes, such as hospitalisation and mortality. However, there are limited data on prescribing ... ...

Abstract	Background: Studies have shown that potentially inappropriate prescribing (PIP) is highly prevalent among people with dementia (PwD) and linked to negative outcomes, such as hospitalisation and mortality. However, there are limited data on prescribing appropriateness for PwD in Saudi Arabia. Therefore, we aimed to estimate the prevalence of PIP and investigate associations between PIP and other patient characteristics among PwD in an ambulatory care setting. Methods: A cross-sectional, retrospective analysis was conducted at a tertiary hospital in Saudi Arabia. Patients who were ≥ 65 years old, had dementia, and visited ambulatory care clinics between 01/01/2019 and 31/12/2021 were included. Prescribing appropriateness was evaluated by applying the Screening Tool of Older Persons Potentially Inappropriate Prescriptions (STOPP) criteria. Descriptive analyses were used to describe the study population. Prevalence of PIP and the prevalence per each STOPP criterion were calculated as a percentage of all eligible patients. Logistic regression analysis was used to investigate associations between PIP, polypharmacy, age and sex; odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Analyses were conducted using SPSS v27. Results: A total of 287 PwD were identified; 56.0% (n = 161) were female. The mean number of medications prescribed was 9.0 [standard deviation (SD) ± 4.2]. The prevalence of PIP was 61.0% (n = 175). Common instances of PIP were drugs prescribed beyond the recommended duration (n = 90, 31.4%), drugs prescribed without an evidence-based clinical indication (n = 78, 27.2%), proton pump inhibitors (PPIs) for > 8 weeks (n = 75, 26.0%), and acetylcholinesterase inhibitors with concurrent drugs that reduce heart rate (n = 60, 21.0%). Polypharmacy was observed in 82.6% (n = 237) of patients and was strongly associated with PIP (adjusted OR 24.1, 95% CI 9.0-64.5). Conclusions: Findings have revealed a high prevalence of PIP among PwD in Saudi Arabia that is strongly associated with polypharmacy. Future research should aim to explore key stakeholders' experiences and perspectives of medicines management to optimise medication use for this vulnerable patient population.
MeSH term(s)	Humans ; Female ; Aged ; Aged, 80 and over ; Male ; Inappropriate Prescribing/prevention & control ; Retrospective Studies ; Cross-Sectional Studies ; Acetylcholinesterase/therapeutic use ; Potentially Inappropriate Medication List ; Polypharmacy ; Dementia/diagnosis ; Dementia/drug therapy ; Dementia/epidemiology
Chemical Substances	Acetylcholinesterase (EC 3.1.1.7)
Language	English
Publishing date	2024-04-10
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-024-04949-8
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Article: The inadvertent consequences of drug recalls: A case study of a recall of pantoprazole generics from the markets.

Algabbani, Aljoharah M / Alkeridy, Walid A / Alessa, Mohammed A / Alrwisan, Adel A

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

2023 Volume 31, Issue 7, Page(s) 1181–1185

Abstract: Introduction: Drug recalls may impact treatment plans or access to suitable therapies. Thus, they inadvertently affect treatment outcomes.: Objective: We aimed to examine the impact of recalls on patients' safety using pantoprazole-containing ... ...

Abstract	Introduction: Drug recalls may impact treatment plans or access to suitable therapies. Thus, they inadvertently affect treatment outcomes. Objective: We aimed to examine the impact of recalls on patients' safety using pantoprazole-containing products recall as a case study in terms of the occurrence of potential drug-drug interactions (pDDIs). Methods: This retrospective study used de-identified electronic health records of adult patients who had a prescription for oral proton pump inhibitors (PPIs) including pantoprazole, esomeprazole, lansoprazole, or omeprazole from April 2020 through September 2021 from a large tertiary care hospital. The study outcome definition was the prevalence of pDDIs in PPIs users before and after the recall date (March 2021). Changes in the prevalence of pDDIs were modeled using interrupted time-series. The rate ratio of pDDIs in the 12 months before and 6 months after the recall was modeled using negative binomial regression. Results: A total of 1,826 pDDIs were identified, and the median monthly prevalence of pDDI before the recall was 102.5 which increased to 115.5 after the recall. A change in the level of pDDIs occurred immediately after the recall date, followed by a gradual decrease over time. The rate of pDDIs was 69% higher after the recall compared to the baseline (rate ratio 1.69; 95% confidence interval, 0.75-1.91). Discussion: Recall of pantoprazole-containing products was associated with a higher rate of pDDIs. However, the prevalence of pDDIs gradually decreased over time. We highlight the importance of planning of recall process and coordinating all potential stakeholders to avoid potential harms.Word count: 1450.
Language	English
Publishing date	2023-04-15
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	1378024-4
ISSN	1319-0164
ISSN	1319-0164
DOI	10.1016/j.jsps.2023.04.011
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Article ; Online: Reply to: Neurological, Cognitive and Behavioral Disorders During COVID-19: The Nitric Oxide Track.

Alkeridy, Walid A / Almaghlouth, Ibrahim

Journal of the American Geriatrics Society

2020 Volume 68, Issue 9, Page(s) 1923–1924

MeSH term(s)	COVID-19/complications ; Cognition ; Cognition Disorders/virology ; Humans ; Mental Disorders/virology ; Nitric Oxide ; Pandemics ; SARS-CoV-2
Chemical Substances	Nitric Oxide (31C4KY9ESH)
Keywords	covid19
Language	English
Publishing date	2020-06-24
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/jgs.16670
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Article: Reply to: Neurological, Cognitive and Behavioral Disorders During COVID-19: The Nitric Oxide Track

Alkeridy, Walid A / Almaghlouth, Ibrahim

J. am. geriatr. soc

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #613916
Database	COVID19

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Article ; Online: Reply to

Alkeridy, Walid A. / Almaghlouth, Ibrahim

Journal of the American Geriatrics Society

Neurological, Cognitive and Behavioral Disorders During COVID ‐19: The Nitric Oxide Track

2020 Volume 68, Issue 9, Page(s) 1923–1924

Keywords	Geriatrics and Gerontology ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/jgs.16670
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The future of alzheimer disease immunotherapies in Saudi Arabia: Consensus statement of the Saudi Chapter of Cognitive and Behavioral Neurology.

Tayeb, Haythum O / Khallaf, Roaa A / Muayqil, Taim A / Alkeridy, Walid A / Alibrahim, Fawwaz S / Alfaify, Omar A / Qadi, Najeeb / Tarazi, Frank I

Neurosciences (Riyadh, Saudi Arabia)

2023 Volume 28, Issue 2, Page(s) 77–84

Abstract: Alzheimer Disease (AD) constitutes a major global healthcare problem. Standard AD pharmacotherapies offer only modest transient cognitive and behavioral benefits. Aducanumab, an amyloid monoclonal antibody, was the first disease modifying agent to be ... ...

Abstract	Alzheimer Disease (AD) constitutes a major global healthcare problem. Standard AD pharmacotherapies offer only modest transient cognitive and behavioral benefits. Aducanumab, an amyloid monoclonal antibody, was the first disease modifying agent to be approved for AD treatment. However, concerns about its efficacy and side effects led regulatory institutions around the world to restrict its use. Lecanemab was the second amyloid antibody to receive accelerated approval for use in early AD. This review and consensus statement was prepared by the Saudi Chapter of Cognitive and Behavioral Neurology to review the current developments in AD immunotherapies from a Saudi perspective. We outline recommendations with regards to offering aducanumab and other future immunotherapies to Saudi AD patients. We describe resources, infrastructure, research, and clinical practice changes that must be attained to transform the patient journey and clinical pathways of AD in Saudi Arabia to enable offering AD immunotherapies in Saudi Arabia.
MeSH term(s)	Humans ; Alzheimer Disease/therapy ; Saudi Arabia ; Immunotherapy ; Neurology ; Cognition
Language	English
Publishing date	2023-04-10
Publishing country	Saudi Arabia
Document type	Review ; Journal Article
ZDB-ID	2214806-1
ISSN	1319-6138
ISSN	1319-6138
DOI	10.17712/nsj.2023.2.20220133
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Article ; Online: Is COVID-19 associated with self-reported audio-vestibular symptoms?

AlJasser, Arwa / Alkeridy, Walid / Munro, Kevin J / Plack, Christopher J

International journal of audiology

2021 Volume 61, Issue 10, Page(s) 832–840

Abstract: Objective: To determine if a positive test for COVID-19 is associated with self-reported audio-vestibular symptoms.: Design: Self-reported changes in hearing, tinnitus, hyperacusis, and dizziness/rotatory vertigo were assessed in hospitalised and non- ...

Abstract	Objective: To determine if a positive test for COVID-19 is associated with self-reported audio-vestibular symptoms. Design: Self-reported changes in hearing, tinnitus, hyperacusis, and dizziness/rotatory vertigo were assessed in hospitalised and non-hospitalised COVID-19 patients during and after the acute phase of the disease and compared to non-COVID controls. Study sample: There were 150 severe cases of COVID-19 requiring hospital admission and 150 mild cases that were managed at home. Controls were 267 adults, 32 of whom had been hospitalised for a non-COVID-19 condition, and a further 85 who worked in hospital settings. Results: Deterioration in hearing and/or tinnitus was reported in 8% of the COVID-19 cases (tinnitus had resolved in 2% after the acute phase), with no significant difference between severe and mild cases. Deterioration in hearing or tinnitus was not significantly different from controls. However, rotatory vertigo was reported by 5% in the COVID-19 groups and 1.1% in the controls, and this difference was statistically significant. Conclusions: There is no evidence that COVID-19 results in deterioration in hearing or tinnitus during the acute phase or after recovery in mild or severe cases. However, rotatory vertigo, which could be vestibular in origin, may be a clinical manifestation of COVID-19.
MeSH term(s)	Adult ; COVID-19 ; Dizziness/diagnosis ; Dizziness/etiology ; Humans ; Self Report ; Tinnitus/diagnosis ; Tinnitus/etiology ; Vertigo/diagnosis ; Vertigo/etiology
Language	English
Publishing date	2021-08-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2073098-6
ISSN	1708-8186 ; 1499-2027
ISSN (online)	1708-8186
ISSN	1499-2027
DOI	10.1080/14992027.2021.1957161
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Article: Determinants of Vaccine Hesitancy among Home Health Care Service Recipients in Saudi Arabia.

Alkeridy, Walid A / Alquaydheb, Hisham / Almuhaidib, Shadan / Sindi, Nawal A / Aljasser, Arwa / Kushner Kow, Janet / Alqahtani, Amani S

Vaccines

2023 Volume 11, Issue 9

Abstract: Background: Vaccine hesitancy has been identified by the World Health Organization (WHO) as a major worldwide health threat. Home Health Care (HHC) service recipients represent a vulnerable group and were prioritized to receive coronavirus disease ( ... ...

Abstract	Background: Vaccine hesitancy has been identified by the World Health Organization (WHO) as a major worldwide health threat. Home Health Care (HHC) service recipients represent a vulnerable group and were prioritized to receive coronavirus disease (COVID-19) vaccination during the national vaccine campaigns in Saudi Arabia. We aimed to investigate the most frequent reasons for vaccine hesitancy among home health care recipients in Saudi Arabia. Methods: This cross-sectional survey was conducted among home health care (HHC) service recipients in Saudi Arabia from February 2022 to September 2022. The behavioral and social drivers (BeSD) model developed by the WHO was used to understand the factors affecting vaccination decision making in our cohort. Results: Of the 426 HHC service recipients enrolled in the study, a third were hesitant to complete the COVID-19 vaccination series. The most prevalent reported reason for COVID-19 vaccine refusal was concerns about the vaccine side effects (41.6%). Factors independently associated with COVID-19 vaccination hesitancy were: having chronic conditions (odds ratio [OR] = 2.59; 95% confidence interval [CI] = 1.33-5.05, Conclusion: Only one-third of the study participants were hesitant to complete the series of COVID-19 vaccination. Understanding the factors underpinning vaccine hesitancy among this group would help healthcare workers and policymakers in developing personalized health awareness campaigns aimed at improving vaccine acceptance levels.
Language	English
Publishing date	2023-08-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11091436
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Article: Falls and correlations among community-dwelling older adults: A Cross-sectional study in Jeddah, Saudi Arabia.

Alamri, Sultan H / Ghamri, Ranya A / Alshehri, Wejdan H / Alhuthayli, Reema S / Alamoudi, Nouf M / Alnufaei, Ragheed D / Alkeridy, Walid A

Pakistan journal of medical sciences

2023 Volume 39, Issue 1, Page(s) 109–116

Abstract: Objectives: Falls are one of the major health issues faced by older adults, and they can result in physical harm, eventual loss of independence, and even death. Herein, we investigated the prevalence, alongside the main risk factors and resulting ... ...

Abstract	Objectives: Falls are one of the major health issues faced by older adults, and they can result in physical harm, eventual loss of independence, and even death. Herein, we investigated the prevalence, alongside the main risk factors and resulting injuries, of falls among older adults. Methods: We employed a descriptive cross-sectional approach. Data were collected between February and July 2021 from 403 older adults aged 60 years or above via an online self-reported questionnaire. Basic activities of daily living (BADLs) and instrumental activities of daily living (IADLs) were also recorded. Results: The prevalence of falls among community-dwelling older adults was 47.4%. Among those who had experienced a fall, 36.2% incurred injuries, 25.3% had fractures, and 23.1% required walking aids. Age between 95-104 years, female sex, participants on anti-hypertensive medications, history of hip or knee replacement surgery, and presence of a caregiver, were significantly more likely to have had a previous history of falls (p < 0.05). Furthermore, having a previous history of stroke, osteoporosis, lower limb weakness, dizziness, using wheelchairs as walking aids, and living with the fear of stumbling or slipping were significantly associated with history of previous falls (p < 0.05). Conclusions: The prevalence of falls is high among community-dwelling older adults in Jeddah. Physicians should identify older adults with higher falling risk and provide them with appropriate interventions. Public health strategies could significantly reduce falls and fall-related injuries in older adults.
Language	English
Publishing date	2023-01-24
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2032827-8
ISSN	1681-715X ; 1682-024X ; 1017-4699
ISSN (online)	1681-715X
ISSN	1682-024X ; 1017-4699
DOI	10.12669/pjms.39.1.6993
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