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  1. Article ; Online: Viral targets for vaccines against COVID-19.

    Dai, Lianpan / Gao, George F

    Nature reviews. Immunology

    2020  Volume 21, Issue 2, Page(s) 73–82

    Abstract: Vaccines are urgently needed to control the coronavirus disease 2019 (COVID-19) pandemic and to help the return to pre-pandemic normalcy. A great many vaccine candidates are being developed, several of which have completed late-stage clinical trials and ... ...

    Abstract Vaccines are urgently needed to control the coronavirus disease 2019 (COVID-19) pandemic and to help the return to pre-pandemic normalcy. A great many vaccine candidates are being developed, several of which have completed late-stage clinical trials and are reporting positive results. In this Progress article, we discuss which viral elements are used in COVID-19 vaccine candidates, why they might act as good targets for the immune system and the implications for protective immunity.
    MeSH term(s) Antigens, Viral/immunology ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/classification ; COVID-19 Vaccines/immunology ; Host-Pathogen Interactions/immunology ; Humans ; Pandemics/prevention & control ; SARS-CoV-2/immunology ; Viral Proteins/immunology
    Chemical Substances Antigens, Viral ; COVID-19 Vaccines ; Viral Proteins
    Language English
    Publishing date 2020-12-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-020-00480-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5565: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 34: Show issues

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  2. Article ; Online: Correction: Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine.

    Guo, Mengyu / Cao, Mingjing / Sun, Jiufeng / Chen, Ziwei / Wang, Xin / Dai, Lianpan / Gao, George F / Zhao, Yuliang / Wang, Yaling / Chen, Chunying

    Signal transduction and targeted therapy

    2024  Volume 9, Issue 1, Page(s) 22

    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-024-01739-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Humoral and cellular immunity and the safety of COVID-19 vaccines: a summary of data published by 21 May 2021.

    Xu, Kun / Dai, Lianpan / Gao, George F

    International immunology

    2021  Volume 33, Issue 10, Page(s) 529–540

    Abstract: Coronavirus disease 2019 (COVID-19) has caused millions of deaths, and serious consequences to public health, economies and societies. Rapid responses in vaccine development have taken place since the isolation of severe acute respiratory syndrome ... ...

    Abstract Coronavirus disease 2019 (COVID-19) has caused millions of deaths, and serious consequences to public health, economies and societies. Rapid responses in vaccine development have taken place since the isolation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the release of the viral genome sequence. By 21 May 2021, 101 vaccines were under clinical trials, and published data were available for 18 of them. Clinical study results from some vaccines indicated good immunogenicity and acceptable reactogenicity. Here, we focus on these 18 vaccines that had published clinical data to dissect the induced humoral and cellular immune responses as well as their safety profiles and protection efficacy.
    MeSH term(s) Animals ; COVID-19/immunology ; COVID-19 Vaccines/immunology ; Humans ; Immunity, Cellular/immunology ; Immunity, Humoral/immunology ; Immunogenicity, Vaccine/immunology ; SARS-CoV-2/immunology
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-09-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1013745-2
    ISSN 1460-2377 ; 0953-8178
    ISSN (online) 1460-2377
    ISSN 0953-8178
    DOI 10.1093/intimm/dxab061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2619: Show issues Location:
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  4. Article ; Online: Inside-out assembly of viral antigens for the enhanced vaccination.

    Cao, Fengqiang / Peng, Sha / An, Yaling / Xu, Kun / Zheng, Tianyi / Dai, Lianpan / Ogino, Kenji / Ngai, To / Xia, Yufei / Ma, Guanghui

    Signal transduction and targeted therapy

    2023  Volume 8, Issue 1, Page(s) 189

    Abstract: Current attempts in vaccine delivery systems concentrate on replicating the natural dissemination of live pathogens, but neglect that pathogens evolve to evade the immune system rather than to provoke it. In the case of enveloped RNA viruses, it is the ... ...

    Abstract Current attempts in vaccine delivery systems concentrate on replicating the natural dissemination of live pathogens, but neglect that pathogens evolve to evade the immune system rather than to provoke it. In the case of enveloped RNA viruses, it is the natural dissemination of nucleocapsid protein (NP, core antigen) and surface antigen that delays NP exposure to immune surveillance. Here, we report a multi-layered aluminum hydroxide-stabilized emulsion (MASE) to dictate the delivery sequence of the antigens. In this manner, the receptor-binding domain (RBD, surface antigen) of the spike protein was trapped inside the nanocavity, while NP was absorbed on the outside of the droplets, enabling the burst release of NP before RBD. Compared with the natural packaging strategy, the inside-out strategy induced potent type I interferon-mediated innate immune responses and triggered an immune-potentiated environment in advance, which subsequently boosted CD40
    MeSH term(s) Humans ; Antigens, Viral ; COVID-19 Vaccines ; Influenza A Virus, H1N1 Subtype ; COVID-19 ; SARS-CoV-2 ; Vaccination ; Antigens, Surface ; Antibodies
    Chemical Substances Antigens, Viral ; COVID-19 Vaccines ; Antigens, Surface ; Antibodies
    Language English
    Publishing date 2023-05-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-023-01414-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Spatially resolved transcriptomics reveals distinct pulmonary immune responses during influenza virus and SARS-CoV-2 infections.

    Zhao, Min / Shao, Fei / Liu, Zhen / Ma, Jiangwen / Yu, Dou / Zhang, Hangjie / Dai, Lianpan / Xu, Kun / Zhao, Xin / Zheng, Mengli / Gao, George Fu / Wang, Shuo

    Science bulletin

    2023  Volume 68, Issue 24, Page(s) 3137–3141

    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2/genetics ; Gene Expression Profiling ; Orthomyxoviridae
    Language English
    Publishing date 2023-11-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2023.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine.

    Guo, Mengyu / Cao, Mingjing / Sun, Jiufeng / Chen, Ziwei / Wang, Xin / Dai, Lianpan / Gao, George F / Zhao, Yuliang / Wang, Yaling / Chen, Chunying

    Signal transduction and targeted therapy

    2023  Volume 8, Issue 1, Page(s) 462

    MeSH term(s) Humans ; SARS-CoV-2 ; Manganese ; COVID-19/prevention & control
    Chemical Substances Manganese (42Z2K6ZL8P)
    Language English
    Publishing date 2023-12-16
    Publishing country England
    Document type Letter
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-023-01718-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Omicron neutralisation: RBD-dimer booster versus BF.7 and BA.5.2 breakthrough infection.

    Dai, Lianpan / Duan, Huixin / Liu, Xueyuan / Zhou, Huan / Duan, Minrun / An, Yaling / Yuan, Linfeng / Zhao, Xin / Xu, Kun / Wu, Qiang / Gao, George F

    Lancet (London, England)

    2023  Volume 402, Issue 10403, Page(s) 687–689

    MeSH term(s) Humans ; Breakthrough Infections ; COVID-19/prevention & control ; COVID-19 Vaccines
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)01367-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.5: Show issues Location:
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  8. Article ; Online: Immunogenicity, efficacy and safety of COVID-19 vaccines: an update of data published by 31 December 2021.

    Xu, Kun / Fan, Chunxiang / Han, Yuxuan / Dai, Lianpan / Gao, George F

    International immunology

    2022  Volume 34, Issue 12, Page(s) 595–607

    Abstract: The unprecedented coronavirus disease 2019 (COVID-19) pandemic has caused a disaster for public health in the last 2 years, without any sign of an ending. Various vaccines were developed rapidly as soon as the outbreak occurred. Clinical trials ... ...

    Abstract The unprecedented coronavirus disease 2019 (COVID-19) pandemic has caused a disaster for public health in the last 2 years, without any sign of an ending. Various vaccines were developed rapidly as soon as the outbreak occurred. Clinical trials demonstrated the reactogenicity, immunogenicity and protection efficacy in humans, and some of the vaccines have been approved for clinical use. However, waves of infections such as the recently circulating Omicron variant still occur. Newly emerging variants, especially the variants of concern, and waning humoral responses pose serious challenges to the control of the COVID-19 pandemic. Previously, we summarized the humoral and cellular immunity, safety profiles and protection efficacy of COVID-19 vaccines with clinical data published by 21 May 2021. In this review, we summarize and update the published clinical data of COVID-19 vaccines and candidates up to 31 December 2021.
    MeSH term(s) Humans ; COVID-19 Vaccines/adverse effects ; COVID-19/prevention & control ; Pandemics ; SARS-CoV-2 ; Antibodies, Viral
    Chemical Substances COVID-19 Vaccines ; Antibodies, Viral
    Language English
    Publishing date 2022-07-01
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1013745-2
    ISSN 1460-2377 ; 0953-8178
    ISSN (online) 1460-2377
    ISSN 0953-8178
    DOI 10.1093/intimm/dxac031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online ; Thesis: Generation, characterization and application of a novel BAC system for MVA mutagenesis to investigate the function of vaccinia virus immune modulatory gene N1L

    Dai, Lianpan

    2014  

    Author's details Lianpan Dai
    Language English
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Techn. Univ., Diss.--München, 2014
    Database Former special subject collection: coastal and deep sea fishing

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  10. Article ; Online: Inside-out assembly of viral antigens for the enhanced vaccination

    Fengqiang Cao / Sha Peng / Yaling An / Kun Xu / Tianyi Zheng / Lianpan Dai / Kenji Ogino / To Ngai / Yufei Xia / Guanghui Ma

    Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-

    2023  Volume 14

    Abstract: Abstract Current attempts in vaccine delivery systems concentrate on replicating the natural dissemination of live pathogens, but neglect that pathogens evolve to evade the immune system rather than to provoke it. In the case of enveloped RNA viruses, it ...

    Abstract Abstract Current attempts in vaccine delivery systems concentrate on replicating the natural dissemination of live pathogens, but neglect that pathogens evolve to evade the immune system rather than to provoke it. In the case of enveloped RNA viruses, it is the natural dissemination of nucleocapsid protein (NP, core antigen) and surface antigen that delays NP exposure to immune surveillance. Here, we report a multi-layered aluminum hydroxide-stabilized emulsion (MASE) to dictate the delivery sequence of the antigens. In this manner, the receptor-binding domain (RBD, surface antigen) of the spike protein was trapped inside the nanocavity, while NP was absorbed on the outside of the droplets, enabling the burst release of NP before RBD. Compared with the natural packaging strategy, the inside-out strategy induced potent type I interferon-mediated innate immune responses and triggered an immune-potentiated environment in advance, which subsequently boosted CD40+ DC activations and the engagement of the lymph nodes. In both H1N1 influenza and SARS-CoV-2 vaccines, rMASE significantly increased antigen-specific antibody secretion, memory T cell engagement, and Th1-biased immune response, which diminished viral loads after lethal challenge. By simply reversing the delivery sequence of the surface antigen and core antigen, the inside-out strategy may offer major implications for enhanced vaccinations against the enveloped RNA virus.
    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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