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  1. Article ; Online: Considerations for rapid development and licencing of conventional and platform technology veterinary vaccines.

    Francis, Michael James

    Avian pathology : journal of the W.V.P.A

    2022  Volume 51, Issue 2, Page(s) 107–112

    Abstract: The threat posed by zoonotic diseases and other livestock pathogens has never been greater, and thus we must do all we can to learn from experience in order to tackle emerging disease threats. The process of developing a new veterinary vaccine involves ... ...

    Abstract The threat posed by zoonotic diseases and other livestock pathogens has never been greater, and thus we must do all we can to learn from experience in order to tackle emerging disease threats. The process of developing a new veterinary vaccine involves the generation of a specific set of data in order to meet the strict product licencing requirements of regulatory approval bodies around the globe. As a result, it is important that those embarking on the development of a vaccine using either conventional or novel platform technologies understand these regulations. In addition, there are a number of specific requirements that one needs to take into consideration when developing a product specifically for the commercial poultry market. This paper briefly outlines the veterinary vaccine development process in general and then explores how this process can be accelerated. It also recognizes the "One Health" lessons that can be learnt from the recent rapid development of vaccines to tackle the COVID-19 pandemic and acknowledges the important measures that regulatory authorities have taken in the creation of an environment to facilitate the licencing of new vaccine platform technologies.
    MeSH term(s) Animals ; COVID-19/prevention & control ; COVID-19/veterinary ; Pandemics ; Poultry Diseases ; Technology ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2022-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476380-1
    ISSN 1465-3338 ; 0307-9457
    ISSN (online) 1465-3338
    ISSN 0307-9457
    DOI 10.1080/03079457.2022.2046703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: How has Covid-19 changed our views of the One Health agenda?

    Francis, Michael James

    The Veterinary record

    2021  Volume 188, Issue 9, Page(s) 361

    MeSH term(s) Animals ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; One Health ; Zoonoses/prevention & control
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-05-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 390015-0
    ISSN 2042-7670 ; 0042-4900
    ISSN (online) 2042-7670
    ISSN 0042-4900
    DOI 10.1002/vetr.487
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 645: Show issues Location:
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  3. Article ; Online: Spotlight on avian pathology: the importance of recombinant vector platform technologies in poultry vaccination.

    Francis, Michael James

    Avian pathology : journal of the W.V.P.A

    2021  Volume 50, Issue 2, Page(s) 109–111

    Abstract: The use of novel vector vaccines (viral, bacterial and apicomplexan) can have a significant impact on the control of poultry disease. They offer a cost effective, convenient and effective means of mass vaccine delivery combined with the ability to switch ...

    Abstract The use of novel vector vaccines (viral, bacterial and apicomplexan) can have a significant impact on the control of poultry disease. They offer a cost effective, convenient and effective means of mass vaccine delivery combined with the ability to switch on both antibody and cell-mediated immunity. In addition, recent viral vector constructs have enabled farmers to vaccinate against up to three important pathogens with a single
    MeSH term(s) Animals ; Communicable Diseases, Emerging/pathology ; Communicable Diseases, Emerging/prevention & control ; Eimeria/immunology ; Fowlpox virus/genetics ; Fowlpox virus/immunology ; Genetic Vectors ; Immunity, Cellular ; Immunity, Humoral ; Poultry ; Poultry Diseases/pathology ; Poultry Diseases/prevention & control ; Salmonella/immunology ; Vaccination/veterinary ; Vaccines/administration & dosage ; Vaccines, Synthetic
    Chemical Substances Vaccines ; Vaccines, Synthetic
    Language English
    Publishing date 2021-02-08
    Publishing country England
    Document type Editorial
    ZDB-ID 1476380-1
    ISSN 1465-3338 ; 0307-9457
    ISSN (online) 1465-3338
    ISSN 0307-9457
    DOI 10.1080/03079457.2021.1875624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Considerations for rapid development and licencing of conventional and platform technology veterinary vaccines

    Francis, Michael James

    Avian pathology. 2022 Mar. 04, v. 51, no. 2

    2022  

    Abstract: The threat posed by zoonotic diseases and other livestock pathogens has never been greater, and thus we must do all we can to learn from experience in order to tackle emerging disease threats. The process of developing a new veterinary vaccine involves ... ...

    Abstract The threat posed by zoonotic diseases and other livestock pathogens has never been greater, and thus we must do all we can to learn from experience in order to tackle emerging disease threats. The process of developing a new veterinary vaccine involves the generation of a specific set of data in order to meet the strict product licencing requirements of regulatory approval bodies around the globe. As a result, it is important that those embarking on the development of a vaccine using either conventional or novel platform technologies understand these regulations. In addition, there are a number of specific requirements that one needs to take into consideration when developing a product specifically for the commercial poultry market. This paper briefly outlines the veterinary vaccine development process in general and then explores how this process can be accelerated. It also recognizes the “One Health” lessons that can be learnt from the recent rapid development of vaccines to tackle the COVID-19 pandemic and acknowledges the important measures that regulatory authorities have taken in the creation of an environment to facilitate the licencing of new vaccine platform technologies.
    Keywords COVID-19 infection ; birds ; markets ; poultry ; vaccine development ; vaccines
    Language English
    Dates of publication 2022-0304
    Size p. 107-112.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 1476380-1
    ISSN 1465-3338 ; 0307-9457
    ISSN (online) 1465-3338
    ISSN 0307-9457
    DOI 10.1080/03079457.2022.2046703
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: A Veterinary Vaccine Development Process Map to assist in the development of new vaccines.

    Francis, Michael James

    Vaccine

    2020  Volume 38, Issue 29, Page(s) 4512–4515

    Abstract: The UK Government recognised the importance of vaccines in the control of new emerging disease threats and in 2015 established the UK Vaccine Network to focus on specific areas of need. One of these was the understanding of what is involved in the ... ...

    Abstract The UK Government recognised the importance of vaccines in the control of new emerging disease threats and in 2015 established the UK Vaccine Network to focus on specific areas of need. One of these was the understanding of what is involved in the development of a new vaccine and what are the potential bottlenecks to a rapid response in the face of an epidemic such as Ebola, MERS and more recently COVID-19. A Working Group was established to initially produce a Vaccine Development Process Map for a Human Vaccine. However, in view of the importance of animal wellbeing and the significant impact of diseases with Zoonotic potential, a similar Map has been created outlining the Veterinary Vaccine Development Process. This paper describes the production of that Map and covers the process from the generation of a Target Product Profile (TPP) through Discovery and Feasibility, and on to Product Development and Registration.
    MeSH term(s) Animals ; Betacoronavirus/immunology ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/veterinary ; Humans ; Pandemics/prevention & control ; Pandemics/veterinary ; Pneumonia, Viral/immunology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/veterinary ; SARS-CoV-2 ; Vaccination/veterinary ; Vaccines/immunology
    Chemical Substances Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-05-06
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2020.05.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1930: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 458: Show issues

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  6. Article ; Online: Applications of platform technologies in veterinary vaccinology and the benefits for one health.

    Entrican, Gary / Francis, Michael James

    Vaccine

    2022  Volume 40, Issue 20, Page(s) 2833–2840

    Abstract: The animal-human interface has played a central role in advances made in vaccinology for the past two centuries. Many traditional veterinary vaccines were developed by growing, attenuating, inactivating and fractioning the pathogen of interest. While ... ...

    Abstract The animal-human interface has played a central role in advances made in vaccinology for the past two centuries. Many traditional veterinary vaccines were developed by growing, attenuating, inactivating and fractioning the pathogen of interest. While such approaches have been very successful, we have reached a point where they have largely been exhausted and alternative approaches are required. Furthermore, although subunit vaccines have enhanced safety profiles and created opportunities for combined discrimination between vaccinated and infected animal (DIVA) approaches, their functionality has largely been limited to diseases that can be controlled by humoral immunity until very recently. We now have a new generation of adjuvants and delivery systems that can elicit CD4 + T cells and/or CD8 +  T cell responses in addition to high-titre antibody responses. We review the current vaccine platform technologies, describe their roles in veterinary vaccinology and discuss how knowledge of their mode of action allows informed decisions on their deployment with wider benefits for One Health.
    MeSH term(s) Adjuvants, Immunologic ; Animals ; Antibody Formation ; One Health ; Vaccines, Subunit ; Vaccinology
    Chemical Substances Adjuvants, Immunologic ; Vaccines, Subunit
    Language English
    Publishing date 2022-04-02
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2022.03.059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1930: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 458: Show issues

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  7. Article: Spotlight on avian pathology: the importance of recombinant vector platform technologies in poultry vaccination

    Francis, Michael James

    Avian pathology. 2021 Mar. 04, v. 50, no. 2

    2021  

    Abstract: The use of novel vector vaccines (viral, bacterial and apicomplexan) can have a significant impact on the control of poultry disease. They offer a cost effective, convenient and effective means of mass vaccine delivery combined with the ability to switch ...

    Abstract The use of novel vector vaccines (viral, bacterial and apicomplexan) can have a significant impact on the control of poultry disease. They offer a cost effective, convenient and effective means of mass vaccine delivery combined with the ability to switch on both antibody and cell-mediated immunity. In addition, recent viral vector constructs have enabled farmers to vaccinate against up to three important pathogens with a single in ovo administration. As the technology develops, it is likely that this means of vaccine administration will be utilized further and it will play a key role in the control of both existing and new emerging diseases of poultry in the future.
    Keywords Miozoa ; antibodies ; birds ; cell-mediated immunity ; cost effectiveness ; poultry ; poultry diseases ; vaccination
    Language English
    Dates of publication 2021-0304
    Size p. 109-111.
    Publishing place Taylor & Francis
    Document type Article
    Note NAL-light
    ZDB-ID 1476380-1
    ISSN 1465-3338 ; 0307-9457
    ISSN (online) 1465-3338
    ISSN 0307-9457
    DOI 10.1080/03079457.2021.1875624
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: A Veterinary Vaccine Development Process Map to assist in the development of new vaccines

    Francis, Michael James

    Vaccine

    Abstract: The UK Government recognised the importance of vaccines in the control of new emerging disease threats and in 2015 established the UK Vaccine Network to focus on specific areas of need. One of these was the understanding of what is involved in the ... ...

    Abstract The UK Government recognised the importance of vaccines in the control of new emerging disease threats and in 2015 established the UK Vaccine Network to focus on specific areas of need. One of these was the understanding of what is involved in the development of a new vaccine and what are the potential bottlenecks to a rapid response in the face of an epidemic such as Ebola, MERS and more recently COVID-19. A Working Group was established to initially produce a Vaccine Development Process Map for a Human Vaccine. However, in view of the importance of animal wellbeing and the significant impact of diseases with Zoonotic potential, a similar Map has been created outlining the Veterinary Vaccine Development Process. This paper describes the production of that Map and covers the process from the generation of a Target Product Profile (TPP) through Discovery and Feasibility, and on to Product Development and Registration.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #186281
    Database COVID19

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  9. Article: Applications of platform technologies in veterinary vaccinology and the benefits for one health

    Entrican, Gary / Francis, Michael James

    Vaccine. 2022 May 03, v. 40, no. 20

    2022  

    Abstract: The animal-human interface has played a central role in advances made in vaccinology for the past two centuries. Many traditional veterinary vaccines were developed by growing, attenuating, inactivating and fractioning the pathogen of interest. While ... ...

    Abstract The animal-human interface has played a central role in advances made in vaccinology for the past two centuries. Many traditional veterinary vaccines were developed by growing, attenuating, inactivating and fractioning the pathogen of interest. While such approaches have been very successful, we have reached a point where they have largely been exhausted and alternative approaches are required. Furthermore, although subunit vaccines have enhanced safety profiles and created opportunities for combined discrimination between vaccinated and infected animal (DIVA) approaches, their functionality has largely been limited to diseases that can be controlled by humoral immunity until very recently. We now have a new generation of adjuvants and delivery systems that can elicit CD4 + T cells and/or CD8 + T cell responses in addition to high-titre antibody responses. We review the current vaccine platform technologies, describe their roles in veterinary vaccinology and discuss how knowledge of their mode of action allows informed decisions on their deployment with wider benefits for One Health.
    Keywords T-lymphocytes ; animals ; antibodies ; humoral immunity ; mechanism of action ; pathogens ; vaccine development
    Language English
    Dates of publication 2022-0503
    Size p. 2833-2840.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2022.03.059
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

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    Zs.MO 458: Show issues

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  10. Article ; Online: Recent Advances in Vaccine Technologies.

    Francis, Michael James

    The Veterinary clinics of North America. Small animal practice

    2017  Volume 48, Issue 2, Page(s) 231–241

    Abstract: This brief review discusses some recent advances in vaccine technologies with particular reference to their application within veterinary medicine. It highlights some of the key inactivated/killed approaches to vaccination, including natural split- ... ...

    Abstract This brief review discusses some recent advances in vaccine technologies with particular reference to their application within veterinary medicine. It highlights some of the key inactivated/killed approaches to vaccination, including natural split-product and subunit vaccines, recombinant subunit and protein vaccines, and peptide vaccines. It also covers live/attenuated vaccine strategies, including modified live marker/differentiating infected from vaccinated animals vaccines, live vector vaccines, and nucleic acid vaccines.
    MeSH term(s) Animals ; Bacteria ; Eimeria/immunology ; Plant Cells ; Vaccination/methods ; Vaccination/veterinary ; Vaccines/pharmacology ; Vaccines, DNA/pharmacology ; Yeasts
    Chemical Substances Vaccines ; Vaccines, DNA
    Keywords covid19
    Language English
    Publishing date 2017-12-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 757662-6
    ISSN 1878-1306 ; 0195-5616
    ISSN (online) 1878-1306
    ISSN 0195-5616
    DOI 10.1016/j.cvsm.2017.10.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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