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Article ; Online: The RhoGEF protein Plekhg5 regulates medioapical and junctional actomyosin dynamics of apical constriction during

Baldwin, Austin / Popov, Ivan K / Keller, Ray / Wallingford, John / Chang, Chenbei

2023 Volume 34, Issue 7, Page(s) ar64

Abstract: Apical constriction results in apical surface reduction in epithelial cells and is a widely used mechanism for epithelial morphogenesis. Both medioapical and junctional actomyosin remodeling are involved in apical constriction, but the deployment of ... ...

Abstract	Apical constriction results in apical surface reduction in epithelial cells and is a widely used mechanism for epithelial morphogenesis. Both medioapical and junctional actomyosin remodeling are involved in apical constriction, but the deployment of medial versus junctional actomyosin and their genetic regulation in vertebrate embryonic development have not been fully described. In this study, we investigate actomyosin dynamics and their regulation by the RhoGEF protein Plekhg5 in
MeSH term(s)	Animals ; Actomyosin/metabolism ; Gastrulation ; Xenopus laevis/metabolism ; Actins/metabolism ; Constriction ; Morphogenesis ; Rho Guanine Nucleotide Exchange Factors
Chemical Substances	Actomyosin (9013-26-7) ; Actins ; Rho Guanine Nucleotide Exchange Factors
Language	English
Publishing date	2023-04-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1098979-1
ISSN	1939-4586 ; 1059-1524
ISSN (online)	1939-4586
ISSN	1059-1524
DOI	10.1091/mbc.E22-09-0411
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Zs.MO 410: Show issues

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Article ; Online: Angiotensin 1-7 increases cardiac tolerance to ischemia/reperfusion and mitigates adverse remodeling of the heart-The signaling mechanism.

Derkachev, Ivan A / Popov, Sergey V / Maslov, Leonid N / Mukhomedzyanov, Alexandr V / Naryzhnaya, Natalia V / Gorbunov, Alexander S / Kan, Artur / Krylatov, Andrey V / Podoksenov, Yuri K / Stepanov, Ivan V / Gusakova, Svetlana V / Fu, Feng / Pei, Jian-Ming

Fundamental & clinical pharmacology

2024

Abstract: ... effect of angiotensin 1-7 has not been elucidated. Perhaps, this end-effector is the sarcolemmal K ...

Abstract	Background: The high mortality rate of patients with acute myocardial infarction (AMI) remains the most pressing issue of modern cardiology. Over the past 10 years, there has been no significant reduction in mortality among patients with AMI. It is quite obvious that there is an urgent need to develop fundamentally new drugs for the treatment of AMI. Angiotensin 1-7 has some promise in this regard. Objective: The objective of this article is analysis of published data on the cardioprotective properties of angiotensin 1-7. Methods: PubMed, Scopus, Science Direct, and Google Scholar were used to search articles for this study. Results: Angiotensin 1-7 increases cardiac tolerance to ischemia/reperfusion and mitigates adverse remodeling of the heart. Angiotensin 1-7 can prevent not only ischemic but also reperfusion cardiac injury. The activation of the Mas receptor plays a key role in these effects of angiotensin 1-7. Angiotensin 1-7 alleviates Ca Conclusion: The molecular nature of the end-effector of the infarct-limiting effect of angiotensin 1-7 has not been elucidated. Perhaps, this end-effector is the sarcolemmal K
Language	English
Publishing date	2024-02-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639134-5
ISSN	1472-8206 ; 0767-3981
ISSN (online)	1472-8206
ISSN	0767-3981
DOI	10.1111/fcp.12983
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Zs.A 2247: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Assays for Apical Constriction Using the Xenopus Model.

Baldwin, Austin T / Popov, Ivan K / Wallingford, John B / Chang, Chenbei

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2438, Page(s) 415–437

Abstract: Apical constriction refers to the active, actomyosin-driven process that reduces apical cell surface area in epithelial cells. Apical constriction is utilized in epithelial morphogenesis during embryonic development in multiple contexts, such as ... ...

Abstract	Apical constriction refers to the active, actomyosin-driven process that reduces apical cell surface area in epithelial cells. Apical constriction is utilized in epithelial morphogenesis during embryonic development in multiple contexts, such as gastrulation, neural tube closure, and organogenesis. Defects in apical constriction can result in congenital birth defects, yet our understanding of the molecular control of apical constriction is relatively limited. To uncover new genetic regulators of apical constriction and gain mechanistic insight into the cell biology of this process, we need reliable assay systems that allow real-time observation and quantification of apical constriction as it occurs and permit gain- and loss-of-function analyses to explore gene function and interaction during apical constriction. In this chapter, we describe using the early Xenopus embryo as an assay system to investigate molecular mechanisms involved in apical constriction during both gastrulation and neurulation.
MeSH term(s)	Animals ; Constriction ; Gastrulation ; Morphogenesis/genetics ; Neurulation ; Xenopus laevis/metabolism
Language	English
Publishing date	2022-01-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2035-9_24
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Article ; Online: The "Affordable Medicines" Reimbursement Program in Ukraine: Framework Assessment and Impact Evaluation.

Dobrova, Viktoriia / Ratushna, Kseniia / Popov, Oleksii / Bezruk, Anna / Loboda, Ivan

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

2023 Volume 26, Issue 3, Page(s) 359–369

Abstract: Objectives: In 2017, the government of Ukraine introduced the new Affordable Medicines Program (AMP) for outpatient prescription medicines reimbursement. Despite the evident program implementation benefits, it is highly important to examine the AMP ... ...

Abstract	Objectives: In 2017, the government of Ukraine introduced the new Affordable Medicines Program (AMP) for outpatient prescription medicines reimbursement. Despite the evident program implementation benefits, it is highly important to examine the AMP framework to reveal its current tendencies, strengths, and shortcomings that might be useful to support further development and improvement of reimbursement models. This study aimed to evaluate how the pricing strategies applied by the AMP framework might affect the potential to provide patients with affordable medicines. Methods: The AMP framework has been evaluated by several parameters characterizing the pricing mechanisms, pharmaceutical manufacturers, the scope of medicines covered by the program, and consumption volumes. The data were collected from official government databases and open sources. The statistics assessment was applied. Results: In 2017 to 2021, the AMP demonstrated extensive growth of the number of medicines covered, consumption volumes, and the scope of international nonproprietary names reimbursed. The pricing limits used by the AMP framework proportionally were correlated with the number of manufacturers involved. At the same time, the number of medicines containing reimbursed international nonproprietary names but not being covered by the program has been decreasing. Conclusions: The AMP framework significantly influences the pharmaceutical market and the potential to provide patients with a wider scope of essential medicines while effectively managing government and patients' healthcare spending. There is a need for the AMP re-evaluation tool enabling timely diagnosing of its shortcomings, assessing the effectiveness and helping to implement its targeted development according to pharmaceutical market tendencies and achievement of desirable patient's health outcomes.
MeSH term(s)	Humans ; Ukraine ; Costs and Cost Analysis ; Delivery of Health Care ; Prescription Drugs ; Drug Costs ; Reimbursement Mechanisms
Chemical Substances	Prescription Drugs
Language	English
Publishing date	2023-01-30
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1471745-1
ISSN	1524-4733 ; 1098-3015
ISSN (online)	1524-4733
ISSN	1098-3015
DOI	10.1016/j.jval.2023.01.014
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Zs.A 5904: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: K

Maslov, Leonid N / Popov, Sergey V / Naryzhnaya, Natalia V / Mukhomedzyanov, Alexandr V / Kurbatov, Boris K / Derkachev, Ivan A / Boshchenko, Alla A / Prasad, N Rajendra / Ma, Huijie / Zhang, Yi / Sufianova, Galina Z / Fu, Feng / Pei, Jian-Ming

Fundamental & clinical pharmacology

2023 Volume 37, Issue 6, Page(s) 1020–1049

Abstract: ... sensitive K: Results: KCOs prevent irreversible ischemia and reperfusion injury of the heart. K ... Conclusion: The cardioprotective effect of KCOs is mediated by the opening of mitochondrial K ...

Abstract	Background: The use of percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) is associated with a mortality rate of 5%-7%. It is clear that there is an urgent need to develop new drugs that can effectively prevent cardiac reperfusion injury. ATP-sensitive K Results: KCOs prevent irreversible ischemia and reperfusion injury of the heart. K Conclusion: The cardioprotective effect of KCOs is mediated by the opening of mitochondrial K
MeSH term(s)	Humans ; Animals ; No-Reflow Phenomenon ; Percutaneous Coronary Intervention ; Myocardial Reperfusion Injury/drug therapy ; Myocardial Reperfusion Injury/prevention & control ; Apoptosis ; Reperfusion ; Adenosine Triphosphate ; KATP Channels
Chemical Substances	Adenosine Triphosphate (8L70Q75FXE) ; KATP Channels
Language	English
Publishing date	2023-06-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639134-5
ISSN	1472-8206 ; 0767-3981
ISSN (online)	1472-8206
ISSN	0767-3981
DOI	10.1111/fcp.12924
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Zs.A 2247: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Heavily Gd-Doped Non-Toxic Cerium Oxide Nanoparticles for MRI Labelling of Stem Cells.

Popov, Anton L / Savintseva, Irina V / Kozlova, Taisiya O / Ivanova, Olga S / Zhukov, Ivan V / Baranchikov, Alexander E / Yurkovskaya, Alexandra V / Savelov, Andrey A / Ermakov, Artem M / Popova, Nelli R / Ivanov, Konstantin L / Ivanov, Vladimir K

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 3

Abstract: Recently, human mesenchymal stem cells (hMSc) have attracted a great deal of attention as potential therapeutic agents in the treatment of socially significant diseases. Despite substantial advances in stem-cell therapy, the biological mechanisms of hMSc ...

Abstract	Recently, human mesenchymal stem cells (hMSc) have attracted a great deal of attention as potential therapeutic agents in the treatment of socially significant diseases. Despite substantial advances in stem-cell therapy, the biological mechanisms of hMSc action after transplantation remain unclear. The use of magnetic resonance imaging (MRI) as a non-invasive method for tracking stem cells in the body is very important for analysing their distribution in tissues and organs, as well as for ensuring control of their lifetime after injection. Herein, detailed experimental data are reported on the biocompatibility towards hMSc of heavily gadolinium-doped cerium oxide nanoparticles (Ce
MeSH term(s)	Humans ; Gadolinium ; Nanoparticles/therapeutic use ; Stem Cells ; Contrast Media ; Magnetic Resonance Imaging/methods
Chemical Substances	gadolinium oxide (5480D0NHLJ) ; Gadolinium (AU0V1LM3JT) ; ceric oxide (619G5K328Y) ; Contrast Media
Language	English
Publishing date	2023-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28031165
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Zs.MO 81: Show issues

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Article ; Online: Spectroscopic and electrochemical characterization of a Pr

Rice, Natalie T / Popov, Ivan A / Carlson, Rebecca K / Greer, Samuel M / Boggiano, Andrew C / Stein, Benjamin W / Bacsa, John / Batista, Enrique R / Yang, Ping / La Pierre, Henry S

Dalton transactions (Cambridge, England : 2003)

2022 Volume 51, Issue 17, Page(s) 6696–6706

Abstract: The molecular tetravalent oxidation state for praseodymium is observed in ... ...

Abstract	The molecular tetravalent oxidation state for praseodymium is observed in solution
Language	English
Publishing date	2022-05-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d2dt00758d
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Article ; Online: Detection of coronaviruses in insectivorous bats of Fore-Caucasus, 2021.

Scientific reports

2023 Volume 13, Issue 1, Page(s) 2306

Abstract: Coronaviruses (CoVs) pose a huge threat to public health as emerging viruses. Bat-borne CoVs are especially unpredictable in their evolution due to some unique features of bat physiology boosting the rate of mutations in CoVs, which is already high by ... ...

Abstract	Coronaviruses (CoVs) pose a huge threat to public health as emerging viruses. Bat-borne CoVs are especially unpredictable in their evolution due to some unique features of bat physiology boosting the rate of mutations in CoVs, which is already high by itself compared to other viruses. Among bats, a meta-analysis of overall CoVs epizootiology identified a nucleic acid observed prevalence of 9.8% (95% CI 8.7-10.9%). The main objectives of our study were to conduct a qPCR screening of CoVs' prevalence in the insectivorous bat population of Fore-Caucasus and perform their characterization based on the metagenomic NGS of samples with detected CoV RNA. According to the qPCR screening, CoV RNA was detected in 5 samples, resulting in a 3.33% (95% CI 1.1-7.6%) prevalence of CoVs in bats from these studied locations. BetaCoVs reads were identified in raw metagenomic NGS data, however, detailed characterization was not possible due to relatively low RNA concentration in samples. Our results correspond to other studies, although a lower prevalence in qPCR studies was observed compared to other regions and countries. Further studies should require deeper metagenomic NGS investigation, as a supplementary method, which will allow detailed CoV characterization.
MeSH term(s)	Animals ; Chiroptera ; Coronavirus/genetics ; Coronavirus Infections/epidemiology ; Coronavirus Infections/veterinary ; Coronavirus Infections/genetics ; Genome, Viral ; Phylogeny ; RNA
Chemical Substances	RNA (63231-63-0)
Language	English
Publishing date	2023-02-09
Publishing country	England
Document type	Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-29099-6
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Article: The Study of Performance of a Nanoribbon Biosensor, Sensitized with Aptamers and Antibodies, upon Detection of Core Antigen of Hepatitis C Virus.

Ivanov, Yuri D / Malsagova, Kristina A / Goldaeva, Kristina V / Pleshakova, Tatyana O / Kozlov, Andrey F / Galiullin, Rafael A / Shumov, Ivan D / Popov, Vladimir P / Abramova, Irina K / Ziborov, Vadim S / Petrov, Oleg F / Dolgoborodov, Alexander Yu / Archakov, Alexander I

Micromachines

2023 Volume 14, Issue 10

Abstract: The development of highly sensitive diagnostic systems for the early revelation of diseases in humans is one of the most important tasks of modern biomedical research, and the detection of the core antigen of the hepatitis C virus (HCVcoreAg)-a protein ... ...

Abstract	The development of highly sensitive diagnostic systems for the early revelation of diseases in humans is one of the most important tasks of modern biomedical research, and the detection of the core antigen of the hepatitis C virus (HCVcoreAg)-a protein marker of the hepatitis C virus-is just the case. Our study is aimed at testing the performance of the nanoribbon biosensor in the case of the use of two different types of molecular probes: the antibodies and the aptamers against HCVcoreAg. The nanoribbon sensor chips employed are based on "silicon-on-insulator structures" (SOI-NR). Two different HCVcoreAg preparations are tested: recombinant β-galactosidase-conjugated HCVcoreAg ("Virogen", Watertown, MA, USA) and recombinant HCVcoreAg ("Vector-Best", Novosibirsk, Russia). Upon the detection of either type of antigen preparation, the lowest concentration of the antigen detectable in buffer with pH 5.1 was found to be approximately equal, amounting to ~10
Language	English
Publishing date	2023-10-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi14101946
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Article ; Online: Older adults and individuals with Parkinson's disease control posture along suborthogonal directions that deviate from the traditional anteroposterior and mediolateral directions.

Mangalam, Madhur / Kelty-Stephen, Damian G / Seleznov, Ivan / Popov, Anton / Likens, Aaron D / Kiyono, Ken / Stergiou, Nick

Scientific reports

2024 Volume 14, Issue 1, Page(s) 4117

Abstract: A rich and complex temporal structure of variability in postural sway characterizes healthy and adaptable postural control. However, neurodegenerative disorders such as Parkinson's disease, which often manifest as tremors, rigidity, and bradykinesia, ... ...

Abstract	A rich and complex temporal structure of variability in postural sway characterizes healthy and adaptable postural control. However, neurodegenerative disorders such as Parkinson's disease, which often manifest as tremors, rigidity, and bradykinesia, disrupt this healthy variability. This study examined postural sway in young and older adults, including individuals with Parkinson's disease, under different upright standing conditions to investigate the potential connection between the temporal structure of variability in postural sway and Parkinsonism. A novel and innovative method called oriented fractal scaling component analysis was employed. This method involves decomposing the two-dimensional center of pressure (CoP) planar trajectories to pinpoint the directions associated with minimal and maximal temporal correlations in postural sway. As a result, it facilitates a comprehensive assessment of the directional characteristics within the temporal structure of sway variability. The results demonstrated that healthy young adults control posture along two orthogonal directions closely aligned with the traditional anatomical anteroposterior (AP) and mediolateral (ML) axes. In contrast, older adults and individuals with Parkinson's disease controlled posture along suborthogonal directions that significantly deviate from the AP and ML axes. These findings suggest that the altered temporal structure of sway variability is evident in individuals with Parkinson's disease and underlies postural deficits, surpassing what can be explained solely by the natural aging process.
MeSH term(s)	Young Adult ; Humans ; Aged ; Parkinson Disease ; Tremor ; Posture ; Standing Position ; Postural Balance
Language	English
Publishing date	2024-02-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54583-y
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