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Article ; Online: Denosumab in the treatment of osteoporosis associated with chronic kidney disease.

Covic, Adrian / Apetrii, Mugurel

The lancet. Diabetes & endocrinology

2024 Volume 12, Issue 4, Page(s) 225–227

MeSH term(s)	Humans ; Denosumab/therapeutic use ; Osteoporosis/complications ; Osteoporosis/drug therapy ; Bone Density Conservation Agents/therapeutic use ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Bone Density
Chemical Substances	Denosumab (4EQZ6YO2HI) ; Bone Density Conservation Agents
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article
ISSN	2213-8595
ISSN (online)	2213-8595
DOI	10.1016/S2213-8587(24)00057-3
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Article ; Online: Targeting NaPi-IIb for Hyperphosphatemia in Chronic Kidney Disease Patients - The Dead End?

Apetrii, Mugurel / Covic, Adrian

Kidney international reports

2021 Volume 6, Issue 3, Page(s) 557–558

Language	English
Publishing date	2021-02-03
Publishing country	United States
Document type	Editorial ; Comment
ISSN	2468-0249
ISSN (online)	2468-0249
DOI	10.1016/j.ekir.2021.01.017
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Article ; Online: Nutrition in Chronic Kidney Disease-The Role of Proteins and Specific Diets.

Apetrii, Mugurel / Timofte, Daniel / Voroneanu, Luminita / Covic, Adrian

Nutrients

2021 Volume 13, Issue 3

Abstract: Chronic kidney disease (CKD) is a global public health burden, needing comprehensive management for preventing and delaying the progression to advanced CKD. The role of nutritional therapy as a strategy to slow CKD progression and uremia has been ... ...

Abstract	Chronic kidney disease (CKD) is a global public health burden, needing comprehensive management for preventing and delaying the progression to advanced CKD. The role of nutritional therapy as a strategy to slow CKD progression and uremia has been recommended for more than a century. Although a consistent body of evidence suggest a benefit of protein restriction therapy, patients' adherence and compliance have to be considered when prescribing nutritional therapy in advanced CKD patients. Therefore, these prescriptions need to be individualized since some patients may prefer to enjoy their food without restriction, despite knowing the potential importance of dietary therapy in reducing uremic manifestations, maintaining protein-energy status.
MeSH term(s)	Diet, Protein-Restricted/methods ; Dietary Proteins/administration & dosage ; Humans ; Renal Insufficiency, Chronic/diet therapy
Chemical Substances	Dietary Proteins
Language	English
Publishing date	2021-03-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13030956
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Article ; Online: Health-related quality of life in patients with chronic kidney disease.

Hussien, Hani / Apetrii, Mugurel / Covic, Adrian

Expert review of pharmacoeconomics & outcomes research

2020 Volume 21, Issue 1, Page(s) 43–54

Abstract: ... ...

Abstract	Introduction
MeSH term(s)	Delivery of Health Care/organization & administration ; Humans ; Kidney Transplantation ; Quality of Life ; Renal Dialysis ; Renal Insufficiency, Chronic/physiopathology ; Renal Insufficiency, Chronic/psychology ; Renal Insufficiency, Chronic/therapy ; Social Support
Language	English
Publishing date	2020-12-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2208481-2
ISSN	1744-8379 ; 1473-7167
ISSN (online)	1744-8379
ISSN	1473-7167
DOI	10.1080/14737167.2021.1854091
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Zs.A 6194: Show issues

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Article ; Online: Different aspects of frailty and COVID-19: points to consider in the current pandemic and future ones.

Hussien, Hani / Nastasa, Andra / Apetrii, Mugurel / Nistor, Ionut / Petrovic, Mirko / Covic, Adrian

BMC geriatrics

2021 Volume 21, Issue 1, Page(s) 389

Abstract: Background: Older adults at a higher risk of adverse outcomes and mortality if they get infected with Severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2). These undesired outcomes are because ageing is associated with other conditions like ... ...

Abstract	Background: Older adults at a higher risk of adverse outcomes and mortality if they get infected with Severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2). These undesired outcomes are because ageing is associated with other conditions like multimorbidity, frailty and disability. This paper describes the impact of frailty on coronavirus disease 2019 (COVID-19) management and outcomes. We also try to point out the role of inflamm-ageing, immunosenescence and reduced microbiota diversity in developing a severe form of COVID-19 and a different response to COVID-19 vaccination among older frail adults. Additionally, we attempt to highlight the impact of frailty on intensive care unit (ICU) outcomes, and hence, the rationale behind using frailty as an exclusion criterion for critical care admission. Similarly, the importance of using a time-saving, validated, sensitive, and user-friendly tool for frailty screening in an acute setting as COVID-19 triage. We performed a narrative review. Publications from 1990 to March 2021 were identified by searching the electronic databases MEDLINE, CINAHL and SCOPUS. Based on this search, we have found that in older frail adults, many mechanisms contribute to the severity of COVID-19, particularly cytokine storm; those mechanisms include lower immunological capacity and status of ongoing chronic inflammation and reduced gut microbiota diversity. Higher degrees of frailty were associated with poor outcomes and higher mortality rates during and after ICU admission. Also, the response to COVID-19 vaccination among frail older adults might differ from the general population regarding effectiveness and side effects. Researches also had shown that there are many tools for identifying frailty in an acute setting that could be used in COVID-19 triage, and before ICU admission, the clinical frailty scale (CFS) was the most recommended tool. Conclusion: Older frail adults have a pre-existing immunopathological base that puts them at a higher risk of undesired outcomes and mortality due to COVID-19 and poor response to COVID-19 vaccination. Also, their admission in ICU should depend on their degree of frailty rather than their chronological age, which is better to be screened using the CFS.
MeSH term(s)	Aged ; COVID-19 ; COVID-19 Vaccines ; Frail Elderly ; Frailty/diagnosis ; Frailty/epidemiology ; Humans ; Pandemics ; SARS-CoV-2
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2021-06-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-021-02316-5
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Article ; Online: Cisplatin and AKI: an ongoing battle with new perspectives-a narrative review.

Volovat, Simona / Apetrii, Mugurel / Stefan, Anca / Vlad, Cristiana / Voroneanu, Luminita / Hogas, Mihai / Haisan, Anca / Volovat, Constantin / Hogas, Simona

International urology and nephrology

2022 Volume 55, Issue 5, Page(s) 1205–1209

Abstract: Acute kidney injury (AKI) is a growing global health problem with increased mortality and morbidity. Cisplatin is achemotherapy drug first introduced in 1978, and since then, it became one of the most widely used and successful anti-cancer medication. ... ...

Abstract	Acute kidney injury (AKI) is a growing global health problem with increased mortality and morbidity. Cisplatin is achemotherapy drug first introduced in 1978, and since then, it became one of the most widely used and successful anti-cancer medication. However, there are risks associated with cisplatin administration, such as nephrotoxicity. Mechanisms of nephrotoxicity include proximal tubular injury, DNA damage, apoptosis, inflammation, oxidative stress, and vascular injury. Although various protocols are being used in clinical practice in nephrotoxicity prevention due to cisplatin, there are no clear guidelines regarding this approach. Most recommendations include hydration and avoiding additional nephrotoxic drugs. To prevent nephrotoxicity, future perspectives could rely on natural products, such as flavonoids or saponins or pharmacological products, such as aprepitant, but data are scarce in this direction. Repetitive administration of cisplatin could cause subclinical kidney injury, which over time, leads to chronic kidney disease (CKD). Therefore, more studies are needed to determine possible ways to prevent nephrotoxicity and avoid the burden of CKD worldwide.
MeSH term(s)	Humans ; Cisplatin/adverse effects ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/prevention & control ; Acute Kidney Injury/drug therapy ; Kidney ; Renal Insufficiency, Chronic/drug therapy ; Neoplasms ; Apoptosis
Chemical Substances	Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2022-12-12
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	204048-7
ISSN	1573-2584 ; 0301-1623 ; 0042-1162
ISSN (online)	1573-2584
ISSN	0301-1623 ; 0042-1162
DOI	10.1007/s11255-022-03418-8
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Zs.A 733: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Long-term cardio-vascular risk assessment in chronic kidney disease and kidney transplanted patients following SARS-COV-2 disease: protocol for multi-center observational match controlled trial.

Tapoi, Laura / Apetrii, Mugurel / Dodi, Gianina / Nistor, Ionut / Voroneanu, Luminita / Siriteanu, Lucian / Onofriescu, Mihai / Kanbay, Mehmet / Covic, Adrian

BMC nephrology

2022 Volume 23, Issue 1, Page(s) 176

Abstract: Background: The coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produced a pandemic since March 2020 by affecting more than 243 million people with more than 5 million deaths globally. SARS-CoV-2 ...

Abstract	Background: The coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produced a pandemic since March 2020 by affecting more than 243 million people with more than 5 million deaths globally. SARS-CoV-2 infection is produced by binding to angiotensin-converting enzyme, which among other sites is highly expressed in the endothelial cells of the blood vessels, pericytes and the heart, as well as in renal podocytes and proximal tubular epithelial cells. SARS-CoV-2 and cardiovascular disease (CVD) are interconnected by risk factors association with an increased incidence of the disease and by determining de novo cardiac complications. At the same time, COVID-19 disease can lead to acute kidney injury directly, or due to sepsis, multi-organ failure and shock. Therefore, the pre-existence of both CVD and chronic kidney disease (CKD) is linked with a higher risk of severe disease and worse prognosis. Methods: The main aim of this study is to assess the CV risk in a CKD (stage 3 to 5), dialysis and kidney transplanted population, following SARS-CoV-2 infection, with focus on the endothelial dysfunction as compared to a control group of matched patients. By using clinical evaluation, flow-mediated dilatation, carotid-femoral pulse wave velocity, intima-media thickness, echocardiographic parameters, lung ultrasound, bioimpedance spectroscopy and a series of novel biomarkers, the investigators will determine the long-term impact of this disease on CV and renal outcomes. Discussion: This study will address the challenges and implications in long-term CV sequeale of COVID-19 and focus on a better understanding of the underlying mechanisms and possible therapeutic options. Trial registration: Patient enrolment in the trial started in January 2021 and is expected to finish at the end of 2022. The study can be found on ClinicalTrials.gov database with NCT05125913 identifier. Registered on 18 November 2021 - Retrospectively registered.
MeSH term(s)	COVID-19/epidemiology ; Cardiovascular Diseases/epidemiology ; Carotid Intima-Media Thickness ; Controlled Clinical Trials as Topic ; Endothelial Cells ; Female ; Humans ; Kidney ; Male ; Multicenter Studies as Topic ; Observational Studies as Topic ; Pulse Wave Analysis ; Renal Insufficiency, Chronic/epidemiology ; Risk Assessment ; SARS-CoV-2
Language	English
Publishing date	2022-05-06
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-022-02809-4
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Article ; Online: Revisiting risk prediction tools for death and end-stage renal disease in older patients with advanced chronic kidney disease: a prospective study.

Nastasa, Andra / Hussien, Hani / Apetrii, Mugurel / Nistor, Ionut / Onofriescu, Mihai / Voroneanu, Luminita / Hogas, Simona / Covic, Adrian

International urology and nephrology

2022 Volume 54, Issue 8, Page(s) 1969–1976

Abstract: Background: Risk assessment tools for predicting mortality and end-stage renal disease (ESRD) in the elderly with CKD have received growing attention. However, integrating risk equations into a multidimensional approach of elderly with CKD stage 3b-4 is ...

Abstract	Background: Risk assessment tools for predicting mortality and end-stage renal disease (ESRD) in the elderly with CKD have received growing attention. However, integrating risk equations into a multidimensional approach of elderly with CKD stage 3b-4 is lacking. Methods: In this prospective observational study, we enrolled CKD stage 3b-4 patients aged ≥ 65 years. Bansal score for predicting mortality risk and Kidney Failure Risk Equation (KFRE) for estimating progression to ESRD were applied. Predicted outcome was compared with actual clinical end-points. All patients underwent comprehensive geriatric assessment (CGA), which is an interdisciplinary multidimensional process for geriatric evaluation and management. Results: Participants (N = 184) were divided into two groups, according to Bansal score: Group 1 (low-risk of death, Bansal score < 7, N = 69) and Group 2 (high-risk of death, Bansal score ≥ 7, N = 115). Group 2 displayed a substantially higher cardiovascular disease burden than Group 1 and was significantly more likely to be depressed and at risk of malnutrition, according to CGA. Thirty-seven patients died, and 16 started dialysis. Group 2 displayed significantly higher all-cause mortality. In the univariable Cox regression, Group 2 had a fourfold increase in the risk of all-cause mortality, as compared with Group 1 (HR = 4.29, 95% CI 1.88-10.26, P < 0.001). Multivariable stepwise Cox analysis showed that Bansal score above 7 remained significantly associated with all-cause mortality (HR = 3.96, 95% CI 1.68-9.29, P < 0.001). Group 2 also displayed higher event rates for dialysis initiation. In Group 1, only four patients started dialysis, and three out of them had a high-risk of progression at baseline, according to KFRE. Conclusions: Using risk stratification tools and CGA in a population of elderly with advanced CKD, we found that two-thirds of the patients were at high risk of death, malnutrition and depression, with multimorbidity and four times worse probability of survival than those at lower risk of death.
MeSH term(s)	Aged ; Disease Progression ; Humans ; Kidney Failure, Chronic/epidemiology ; Malnutrition/complications ; Prospective Studies ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/therapy ; Risk Factors
Language	English
Publishing date	2022-01-07
Publishing country	Netherlands
Document type	Journal Article ; Observational Study
ZDB-ID	204048-7
ISSN	1573-2584 ; 0301-1623 ; 0042-1162
ISSN (online)	1573-2584
ISSN	0301-1623 ; 0042-1162
DOI	10.1007/s11255-021-03082-4
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Zs.A 733: Show issues

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Article ; Online: Magnesium supplementation: A consideration in dialysis patients.

Apetrii, Mugurel / Covic, Adrian / Massy, Ziad A

Seminars in dialysis

2017 Volume 31, Issue 1, Page(s) 11–14

Abstract: Even though disorders of magnesium (Mg) balance are common in dialyzed patients, this cation is often neglected. Many factors interfere with serum magnesium including diet, medications (eg, antacids or phosphate binders), and the dialysis prescription. ... ...

Abstract	Even though disorders of magnesium (Mg) balance are common in dialyzed patients, this cation is often neglected. Many factors interfere with serum magnesium including diet, medications (eg, antacids or phosphate binders), and the dialysis prescription. Mg supplementation may help reduce serum phosphate concentration, PTH, and interfere with vascular calcification and bone mineralization. It could also decrease the all-cause and cardiovascular mortalities, although the results of current studies are conflicting. As with many other variables that influence hard endpoints in nephrology, additional research directly targeting the role of Mg supplementation in dialyzed patients are required. Nevertheless, a current risk/benefit assessment suggests that supplementation of Mg targeting high normal serum levels may represent a plausible option to improve the outcome of dialysis patients.
MeSH term(s)	Dietary Supplements ; Female ; Humans ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/mortality ; Kidney Failure, Chronic/therapy ; Magnesium/administration & dosage ; Magnesium/blood ; Male ; Prognosis ; Renal Dialysis/adverse effects ; Renal Dialysis/methods ; Renal Tubular Transport, Inborn Errors/drug therapy ; Renal Tubular Transport, Inborn Errors/etiology ; Renal Tubular Transport, Inborn Errors/physiopathology ; Risk Assessment ; Survival Analysis ; Treatment Outcome
Chemical Substances	Magnesium (I38ZP9992A)
Language	English
Publishing date	2017-10-23
Publishing country	United States
Document type	Editorial ; Review
ZDB-ID	1028193-9
ISSN	1525-139X ; 0894-0959
ISSN (online)	1525-139X
ISSN	0894-0959
DOI	10.1111/sdi.12653
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Zs.A 2879: Show issues

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Article ; Online: PTH and/or Bone Histology: Are We Still Waiting for a Verdict From the CKD-MBD Grand Jury?

Covic, Adrian / Voroneanu, Luminita / Apetrii, Mugurel

American journal of kidney diseases : the official journal of the National Kidney Foundation

2016 Volume 67, Issue 4, Page(s) 535–538

MeSH term(s)	Bone Remodeling/physiology ; Bone and Bones/pathology ; Female ; Humans ; Male ; Renal Dialysis ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/physiopathology
Language	English
Publishing date	2016-04
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	604539-x
ISSN	1523-6838 ; 0272-6386
ISSN (online)	1523-6838
ISSN	0272-6386
DOI	10.1053/j.ajkd.2015.11.028
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Zs.A 1669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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