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Article ; Online: The Switch/Sucrose Nonfermentable Subunit ARID1A Mediates Neutrophil-Associated Skin Inflammatory Responses.

Batzorig, Uyanga / Chen, Yifang / Liu, Ye / Fernández-Méndez, Celia / Mahapatra, Samiksha / Lim, Sung Ha / Hong, Seung-Phil / Sen, George L

The Journal of investigative dermatology

2024

Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	80136-7
ISSN	1523-1747 ; 0022-202X
ISSN (online)	1523-1747
ISSN	0022-202X
DOI	10.1016/j.jid.2024.03.015
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Article ; Online: RACK1 Prevents the Premature Differentiation of Epidermal Progenitor Cells by Inhibiting IRF6 Expression.

Ling, Ji / Tiwari, Manisha / Chen, Yifang / Sen, George L

The Journal of investigative dermatology

2021 Volume 142, Issue 5, Page(s) 1499–1502.e4

MeSH term(s)	Cell Differentiation ; Epidermal Cells/metabolism ; Interferon Regulatory Factors/metabolism ; Receptors for Activated C Kinase/genetics ; Receptors for Activated C Kinase/metabolism ; Stem Cells
Chemical Substances	Interferon Regulatory Factors ; Receptors for Activated C Kinase
Language	English
Publishing date	2021-11-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80136-7
ISSN	1523-1747 ; 0022-202X
ISSN (online)	1523-1747
ISSN	0022-202X
DOI	10.1016/j.jid.2021.10.017
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Article ; Online: Improved naming in patients with Broca's aphasia with tDCS.

Bonilha, Leonardo / Rorden, Chris / Roth, Rebecca / Sen, Souvik / George, Mark S / Fridriksson, Julius

Journal of neurology, neurosurgery, and psychiatry

2024 Volume 95, Issue 3, Page(s) 273–276

Abstract: Background: Language impairment (aphasia) is a common neurological deficit after strokes. For individuals with chronic aphasia (beyond 6 months after the stroke), language improvements with speech therapy (ST) are often limited. Transcranial direct ... ...

Abstract	Background: Language impairment (aphasia) is a common neurological deficit after strokes. For individuals with chronic aphasia (beyond 6 months after the stroke), language improvements with speech therapy (ST) are often limited. Transcranial direct current stimulation (tDCS) is a promising approach to complement language recovery but interindividual variability in treatment response is common after tDCS, suggesting a possible relationship between tDCS and type of linguistic impairment (aphasia type). Methods: This current study is a subgroup analysis of a randomised controlled phase II futility design clinical trial on tDCS in chronic post-stroke aphasia. All participants received ST coupled with tDCS (n=31) vs sham tDCS (n=39). Confrontation naming was tested at baseline, and 1, 4, and 24 weeks post-treatment. Results: Broca's aphasia was associated with maximal adjunctive benefit of tDCS, with an average improvement of 10 additional named items with tDCS+ST compared with ST alone at 4 weeks post-treatment. In comparison, tDCS was not associated with significant benefits for other aphasia types Conclusions: These results indicate that adjuvant tDCS can enhance ST to treat naming in Broca's aphasia, and this may guide intervention approaches in future studies.
MeSH term(s)	Humans ; Transcranial Direct Current Stimulation/methods ; Aphasia/etiology ; Aphasia/therapy ; Stroke/complications ; Stroke/therapy ; Language ; Speech Therapy
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Randomized Controlled Trial ; Clinical Trial, Phase II ; Journal Article
ZDB-ID	3087-9
ISSN	1468-330X ; 0022-3050
ISSN (online)	1468-330X
ISSN	0022-3050
DOI	10.1136/jnnp-2023-331541
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Article ; Online: Novel presentations associated with a PDHA1 variant - Alternating hemiplegia in Hemizygote proband and Guillain Barre Syndrome in Heterozygote mother.

Sen, Kuntal / Grahame, George / Bedoyan, Jirair K / Gropman, Andrea L

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

2021 Volume 31, Page(s) 27–30

Abstract: We report a 5-year-old male with a PDHA1 variant who presented with alternating hemiplegia of childhood and later developed developmental regression, basal ganglia injury and episodic lactic acidosis. Enzyme assay in lymphocytes confirmed a diagnosis of ... ...

Abstract	We report a 5-year-old male with a PDHA1 variant who presented with alternating hemiplegia of childhood and later developed developmental regression, basal ganglia injury and episodic lactic acidosis. Enzyme assay in lymphocytes confirmed a diagnosis of Pyruvate Dehydrogenase Complex (PDC) deficiency. His mother who was heterozygous for the same variant suffered from ophthalmoplegia, chronic migraine and developed flaccid paralysis at 36 years of age. PDHA1 is the most common genetic cause of PDC deficiency and presents with a myriad of neurological phenotypes including neonatal form with lactic acidosis, non-progressive infantile encephalopathy, Leigh syndrome subtype and intermittent ataxia. The presentations in our 2 patients contribute to the clinical heterogeneity of this neurogenetic condition.
MeSH term(s)	Adult ; Child, Preschool ; Female ; Guillain-Barre Syndrome/genetics ; Hemiplegia/genetics ; Hemizygote ; Heterozygote ; Humans ; Male ; Mothers ; Paraplegia/genetics ; Pedigree ; Phenotype ; Pyruvate Dehydrogenase (Lipoamide)/genetics ; Pyruvate Dehydrogenase Complex Deficiency Disease/diagnosis ; Pyruvate Dehydrogenase Complex Deficiency Disease/genetics
Chemical Substances	Pyruvate Dehydrogenase (Lipoamide) (EC 1.2.4.1)
Language	English
Publishing date	2021-01-22
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1397146-3
ISSN	1532-2130 ; 1090-3798
ISSN (online)	1532-2130
ISSN	1090-3798
DOI	10.1016/j.ejpn.2021.01.006
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Zs.A 4867: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 641: Show issues

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Article ; Online: CDK12 Is Necessary to Promote Epidermal Differentiation Through Transcription Elongation.

Li, Jingting / Tiwari, Manisha / Chen, Yifang / Luanpitpong, Sudjit / Sen, George L

Stem cells (Dayton, Ohio)

2022 Volume 40, Issue 4, Page(s) 435–445

Abstract: Proper differentiation of the epidermis is essential to prevent water loss and to protect the body from the outside environment. Perturbations in this process can lead to a variety of skin diseases that impacts 1 in 5 people. While transcription factors ... ...

Abstract	Proper differentiation of the epidermis is essential to prevent water loss and to protect the body from the outside environment. Perturbations in this process can lead to a variety of skin diseases that impacts 1 in 5 people. While transcription factors that control epidermal differentiation have been well characterized, other aspects of transcription control such as elongation are poorly understood. Here we show that of the two cyclin-dependent kinases (CDK12 and CDK13), that are known to regulate transcription elongation, only CDK12 is necessary for epidermal differentiation. Depletion of CDK12 led to loss of differentiation gene expression and absence of skin barrier formation in regenerated human epidermis. CDK12 binds to genes that code for differentiation promoting transcription factors (GRHL3, KLF4, and OVOL1) and is necessary for their elongation. CDK12 is necessary for elongation by promoting Ser2 phosphorylation on the C-terminal domain of RNA polymerase II and the stabilization of binding of the elongation factor SPT6 to target genes. Our results suggest that control of transcription elongation by CDK12 plays a prominent role in adult cell fate decisions.
MeSH term(s)	Cell Differentiation/genetics ; Cyclin-Dependent Kinases/genetics ; Cyclin-Dependent Kinases/metabolism ; Humans ; Phosphorylation ; RNA Polymerase II/chemistry ; RNA Polymerase II/genetics ; RNA Polymerase II/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemical Substances	Transcription Factors ; CDK12 protein, human (EC 2.7.11.22) ; Cyclin-Dependent Kinases (EC 2.7.11.22) ; RNA Polymerase II (EC 2.7.7.-)
Language	English
Publishing date	2022-03-24
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1143556-2
ISSN	1549-4918 ; 1066-5099
ISSN (online)	1549-4918
ISSN	1066-5099
DOI	10.1093/stmcls/sxac002
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Article ; Online: Enhanc(er)ing Skin Stem Cells.

Wang, Ying / Sen, George L

Cell stem cell

2016 Volume 19, Issue 4, Page(s) 415–417

Abstract: In this issue of Cell Stem Cell, Rinaldi et al. (2016) find an unexpected role for the de novo DNA methyltransferases Dnmt3a and Dnmt3b in the regulation of enhancers. Their findings provide new insight into how regulation of enhancer activity through ... ...

Abstract	In this issue of Cell Stem Cell, Rinaldi et al. (2016) find an unexpected role for the de novo DNA methyltransferases Dnmt3a and Dnmt3b in the regulation of enhancers. Their findings provide new insight into how regulation of enhancer activity through DNA methylation can have dramatic consequences on epidermal stem cell fate decisions.
MeSH term(s)	DNA (Cytosine-5-)-Methyltransferases/genetics ; DNA Methylation ; Stem Cells
Chemical Substances	DNA (Cytosine-5-)-Methyltransferases (EC 2.1.1.37)
Language	English
Publishing date	2016--06
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2375354-7
ISSN	1875-9777 ; 1934-5909
ISSN (online)	1875-9777
ISSN	1934-5909
DOI	10.1016/j.stem.2016.09.003
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Zs.A 6589: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 75: Show issues

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Article ; Online: Regulation of integrin and extracellular matrix genes by HNRNPL is necessary for epidermal renewal.

Li, Jingting / Chen, Yifang / Tiwari, Manisha / Bansal, Varun / Sen, George L

PLoS biology

2021 Volume 19, Issue 9, Page(s) e3001378

Abstract: ... heterogeneous nuclear ribonucleoprotein L (HNRNPL) binds to these genes on chromatin to promote their expression. HNRNPL recruits RNA ...

Abstract	Stratified epithelia such as the epidermis require coordinated regulation of stem and progenitor cell proliferation, survival, and differentiation to maintain homeostasis. Integrin-mediated anchorage of the basal layer stem cells of the epidermis to the underlying dermis through extracellular matrix (ECM) proteins is crucial for this process. It is currently unknown how the expression of these integrins and ECM genes are regulated. Here, we show that the RNA-binding protein (RBP) heterogeneous nuclear ribonucleoprotein L (HNRNPL) binds to these genes on chromatin to promote their expression. HNRNPL recruits RNA polymerase II (Pol II) to integrin/ECM genes and is required for stabilizing Pol II transcription through those genes. In the absence of HNRNPL, the basal layer of the epidermis where the stem cells reside prematurely differentiates and detaches from the underlying dermis due to diminished integrin/ECM expression. Our results demonstrate a critical role for RBPs on chromatin to maintain stem and progenitor cell fate by dictating the expression of specific classes of genes.
MeSH term(s)	Cell Differentiation ; Cells, Cultured ; Chromatin ; Epidermal Cells/metabolism ; Epidermis/growth & development ; Extracellular Matrix/genetics ; Extracellular Matrix/metabolism ; Heterogeneous-Nuclear Ribonucleoprotein L/metabolism ; Humans ; Integrins/genetics ; Integrins/metabolism ; Stem Cells
Chemical Substances	Chromatin ; Heterogeneous-Nuclear Ribonucleoprotein L ; Integrins
Language	English
Publishing date	2021-09-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2126776-5
ISSN	1545-7885 ; 1544-9173
ISSN (online)	1545-7885
ISSN	1544-9173
DOI	10.1371/journal.pbio.3001378
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Zs.A 6193: Show issues

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Article ; Online: Post-Transcriptional Mechanisms Regulating Epidermal Stem and Progenitor Cell Self-Renewal and Differentiation.

Li, Jingting / Sen, George L

The Journal of investigative dermatology

2016 Volume 136, Issue 4, Page(s) 746–752

Abstract: Epidermal stem and progenitor cells exist within the basal layer of the epidermis and serve to replenish the loss of differentiated cells because of normal turnover or injury. Current efforts have focused on elucidating the transcriptional regulation of ... ...

Abstract	Epidermal stem and progenitor cells exist within the basal layer of the epidermis and serve to replenish the loss of differentiated cells because of normal turnover or injury. Current efforts have focused on elucidating the transcriptional regulation of epidermal stem cell self-renewal and differentiation. However, recent studies have pointed to an emerging and prominent role for post-transcriptional regulation of epidermal cell fate decisions. In this review, we will focus on post-transcriptional mechanisms including noncoding RNAs, RNA binding proteins, and mRNA decay-mediated control of epidermal stem and progenitor cell function in the skin.
MeSH term(s)	3' Untranslated Regions ; Animals ; Cell Differentiation ; Cell Proliferation ; Cell Self Renewal ; DEAD-box RNA Helicases/metabolism ; Epidermis/cytology ; Exosomes/metabolism ; Gene Expression Regulation ; Humans ; Mice ; MicroRNAs/genetics ; Mutation ; Proto-Oncogene Proteins/metabolism ; RNA Processing, Post-Transcriptional ; RNA, Long Noncoding/genetics ; Stem Cells/cytology
Chemical Substances	3' Untranslated Regions ; MicroRNAs ; Proto-Oncogene Proteins ; RNA, Long Noncoding ; DDX6 protein, human (EC 3.6.1.-) ; DEAD-box RNA Helicases (EC 3.6.4.13)
Language	English
Publishing date	2016-02-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80136-7
ISSN	1523-1747 ; 0022-202X
ISSN (online)	1523-1747
ISSN	0022-202X
DOI	10.1016/j.jid.2015.12.030
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Article ; Online: Remembering one's identity: the epigenetic basis of stem cell fate decisions.

Sen, George L

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2011 Volume 25, Issue 7, Page(s) 2123–2128

Abstract: Stem cells serve a vital role in multicellular organisms by constantly replenishing tissue with their differentiated progeny during normal homeostasis or damage. How these cells maintain their identities throughout the life of an organism is an area of ... ...

Abstract	Stem cells serve a vital role in multicellular organisms by constantly replenishing tissue with their differentiated progeny during normal homeostasis or damage. How these cells maintain their identities throughout the life of an organism is an area of intense research. In this review, we explore recent emerging evidence that stem cell fate decisions are based on their epigenome and specific epigenetic factors.
MeSH term(s)	Cell Differentiation ; Cell Proliferation ; DNA Methylation ; DNA-Cytosine Methylases/metabolism ; Histone Demethylases/metabolism ; Histone-Lysine N-Methyltransferase/metabolism ; Histones/metabolism ; Humans ; Methylation ; Stem Cells/cytology ; Stem Cells/metabolism
Chemical Substances	Histones ; Histone Demethylases (EC 1.14.11.-) ; DNA-Cytosine Methylases (EC 2.1.1.-) ; histone methyltransferase (EC 2.1.1.-) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43)
Language	English
Publishing date	2011-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.11-182774
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Zs.A 2266: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 296: Show issues

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Article ; Online: ELL Facilitates RNA Polymerase II-Mediated Transcription of Human Epidermal Proliferation Genes.

Li, Jingting / Bansal, Varun / Tiwari, Manisha / Chen, Yifang / Sen, George L

The Journal of investigative dermatology

2020 Volume 141, Issue 5, Page(s) 1352–1356.e3

MeSH term(s)	Cell Proliferation ; Epidermis/growth & development ; Humans ; RNA Polymerase II/physiology ; Transcription, Genetic ; Transcriptional Elongation Factors/physiology
Chemical Substances	ELL protein, human ; Transcriptional Elongation Factors ; RNA Polymerase II (EC 2.7.7.-)
Language	English
Publishing date	2020-11-04
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural
ZDB-ID	80136-7
ISSN	1523-1747 ; 0022-202X
ISSN (online)	1523-1747
ISSN	0022-202X
DOI	10.1016/j.jid.2020.09.024
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