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Article: Effectiveness and Safety of Linezolid Versus Vancomycin, Teicoplanin, or Daptomycin against Methicillin-Resistant

Kawasuji, Hitoshi / Nagaoka, Kentaro / Tsuji, Yasuhiro / Kimoto, Kou / Takegoshi, Yusuke / Kaneda, Makito / Murai, Yushi / Karaushi, Haruka / Mitsutake, Kotaro / Yamamoto, Yoshihiro

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 4

Abstract: Vancomycin (VCM) and daptomycin (DAP) are standard therapies for methicillin- ... ...

Abstract	Vancomycin (VCM) and daptomycin (DAP) are standard therapies for methicillin-resistant
Language	English
Publishing date	2023-04-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12040697
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reduction of mycophenolate mofetil dosage to limit prolonged viral shedding in solid organ transplant recipients with COVID-19: Two case reports.

Murai, Yushi / Sakao, Seiichiro / Kure, Fujihiro / Kawasaki, Takeshi / Maruyama, Michihiro / Suzuki, Hidemi / Yoshino, Ichiro / Suzuki, Takuji

Respiratory investigation

2023 Volume 62, Issue 1, Page(s) 98–101

Abstract: Solid organ transplant (SOT) recipients with coronavirus disease-2019 (COVID-19) experience prolonged viral shedding, and they are forced to stay in the hospital because of the requirement for COVID-19 isolation. Here, we present two cases (lung and ... ...

Abstract	Solid organ transplant (SOT) recipients with coronavirus disease-2019 (COVID-19) experience prolonged viral shedding, and they are forced to stay in the hospital because of the requirement for COVID-19 isolation. Here, we present two cases (lung and renal transplant recipients), wherein the isolation period was shortened by reducing the dosage of mycophenolate mofetil (MMF). Both patients recovered well from COVID-19 pneumonia. This case study suggests that a reduction in MMF dosage may lead to a shorter hospitalization period in SOT recipients with COVID-19.
MeSH term(s)	Humans ; Mycophenolic Acid ; COVID-19 ; Immunosuppressive Agents ; Virus Shedding ; Kidney Transplantation
Chemical Substances	Mycophenolic Acid (HU9DX48N0T) ; Immunosuppressive Agents
Language	English
Publishing date	2023-11-28
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2660821-2
ISSN	2212-5353 ; 2212-5345
ISSN (online)	2212-5353
ISSN	2212-5345
DOI	10.1016/j.resinv.2023.10.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: High Incidence of Metastatic Infections in Panton-Valentine Leucocidin-Negative, Community-Acquired Methicillin-Resistant

Kawasuji, Hitoshi / Ikezawa, Yoshihiro / Morita, Mika / Sugie, Kazushige / Somekawa, Mayu / Ezaki, Masayoshi / Koshiyama, Yuki / Takegoshi, Yusuke / Murai, Yushi / Kaneda, Makito / Kimoto, Kou / Nagaoka, Kentaro / Niimi, Hideki / Morinaga, Yoshitomo / Yamamoto, Yoshihiro

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 10

Abstract: Panton-Valentine leucocidin (PVL)-negative community-associated methicillin- ... ...

Abstract	Panton-Valentine leucocidin (PVL)-negative community-associated methicillin-resistant
Language	English
Publishing date	2023-10-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12101516
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Article ; Online: Short-Term Corticosteroid Therapy for Early Exacerbation of COVID-19 Pneumonia: A Case Report.

Urano, Akira / Kasai, Hajime / Murai, Yushi / Ikeda, Hideki / Urushibara, Takashi

The American journal of case reports

2020 Volume 21, Page(s) e924476

Abstract: BACKGROUND The effect of corticosteroids in the management of patients with coronavirus disease 2019 (COVID-19) is unclear. CASE REPORT A 67-year-old man who tested positive for COVID-19 by reverse-transcription PCR (RT-PCR) analysis was admitted to our ... ...

Abstract	BACKGROUND The effect of corticosteroids in the management of patients with coronavirus disease 2019 (COVID-19) is unclear. CASE REPORT A 67-year-old man who tested positive for COVID-19 by reverse-transcription PCR (RT-PCR) analysis was admitted to our hospital. On admission, he had no dyspnea and his oxygen saturation (SpO₂) level was normal. Chest imaging revealed ground-glass opacities (GGO) distributed in both lung fields. Four days after admission, bilateral lung shadows worsened, with a slight reduction in SpO₂ levels. Short-term corticosteroid therapy was initiated, and SpO₂ and radiographic findings promptly improved without use of antiviral agents. CONCLUSIONS More data are required to ascertain the role of corticosteroids in the management of COVID-19 pneumonia.
MeSH term(s)	Aged ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Drug Administration Schedule ; Glucocorticoids/administration & dosage ; Humans ; Lung/diagnostic imaging ; Male ; Methylprednisolone/administration & dosage ; Oxygen/blood ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; SARS-CoV-2 ; Tomography, X-Ray Computed
Chemical Substances	Glucocorticoids ; Oxygen (S88TT14065) ; Methylprednisolone (X4W7ZR7023)
Keywords	covid19
Language	English
Publishing date	2020-08-14
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/AJCR.924476
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Article ; Online: Effect of Casirivimab/Imdevimab Treatment on Serum Type I Interferon Levels in SARS-CoV-2 Infection.

Nagaoka, Kentaro / Kawasuji, Hitoshi / Takegoshi, Yusuke / Murai, Yushi / Kaneda, Makito / Ueno, Akitoshi / Miyajima, Yuki / Niimi, Hideki / Morinaga, Yoshitomo / Yamamoto, Yoshihiro

Viruses

2022 Volume 14, Issue 7

Abstract: The effects of casirivimab and imdevimab (C/I) on the innate immune response against SARS-CoV-2 infection remain unclear. We evaluated the effect of C/I on type I interferon (IFN-I) and cytokines in patients with SARS-CoV-2 infection. This prospective ... ...

Abstract	The effects of casirivimab and imdevimab (C/I) on the innate immune response against SARS-CoV-2 infection remain unclear. We evaluated the effect of C/I on type I interferon (IFN-I) and cytokines in patients with SARS-CoV-2 infection. This prospective observational study recruited consecutive patients hospitalized with SARS-CoV-2 infection. Blood levels of IFN-I and cytokines before and after C/I administration were assessed using enzyme-linked immunoassay. The study enrolled 29 patients in the C/I group. In addition, 11 patients who received remdesivir and dexamethasone (R/D group) during the early phase (≤5 days after the onset of symptoms) were included as a comparator group. After treatment, IFN-α and IFN-β levels decreased significantly in both the C/I group and R/D group, whilst the post-treatment neutrophil-to-lymphoid ratio increased in the early C/I group but not the R/D group. In the C/I group, temporal temperature elevation and hypoxemia were observed after treatment in 58.6% and 41.4% of the cohort, respectively. However, most patients recovered by 5 days after treatment. This study could demonstrate the high therapeutic effect of C/I with an antibody-dependent enhancement-like response and decreased IFN-I production, which was likely due to the immediate induction of an antibody-dependent immune response against SARS-CoV-2.
MeSH term(s)	Antibodies, Monoclonal, Humanized ; COVID-19/drug therapy ; Cytokines ; Humans ; Interferon Type I/pharmacology ; Interferon Type I/therapeutic use ; SARS-CoV-2
Chemical Substances	Antibodies, Monoclonal, Humanized ; Cytokines ; Interferon Type I ; imdevimab (2Z3DQD2JHM) ; casirivimab (J0FI6WE1QN)
Language	English
Publishing date	2022-06-27
Publishing country	Switzerland
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14071399
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Article ; Online: Circulating Type I Interferon Levels in the Early Phase of COVID-19 Are Associated With the Development of Respiratory Failure.

Nagaoka, Kentaro / Kawasuji, Hitoshi / Murai, Yushi / Kaneda, Makito / Ueno, Akitoshi / Miyajima, Yuki / Fukui, Yasutaka / Morinaga, Yoshitomo / Yamamoto, Yoshihiro

Frontiers in immunology

2022 Volume 13, Page(s) 844304

Abstract: Background: The role of type I interferons (IFNs) in the early phase of COVID-19 remains unclear.: Objectives: To evaluate the relationship between IFN-I levels in patients with COVID-19 and clinical presentation, SARS-CoV-2 viral load, and other ... ...

Abstract	Background: The role of type I interferons (IFNs) in the early phase of COVID-19 remains unclear. Objectives: To evaluate the relationship between IFN-I levels in patients with COVID-19 and clinical presentation, SARS-CoV-2 viral load, and other major pro-inflammatory cytokines. Methods: This prospective observational study recruited patients hospitalized with COVID-19. The levels of interferon-alpha (IFN-α), interferon-beta (IFN-β), interleukin-6 (IL-6), and C-X-C motif chemokine ligand (CXCL10) within 5 days after symptom onset were measured using an ELISA, in serum from blood collected within 5 days after the onset of symptoms. The SARS-CoV-2 viral load was determined Results: The study enrolled 50 patients with COVID-19. IFN-α levels were significantly higher in patients who presented with pneumonia or developed hypoxemic respiratory failure (p < 0.001). Furthermore, IFN-α levels were associated with viral load in nasal-swab specimens and RNAemia (p < 0.05). In contrast, there was no significant association between IFN-β levels and the presence of pneumonia or RNAemia, despite showing a stronger association with nasal-swab viral load (p < 0.001). Correlation analysis showed that the serum levels of IFN-α significantly correlated with those of IFN-β, IL-6, and CXCL10, while the levels of IFN-β did not correlate with those of IL-6 or CXCL10. Conclusions: Serum IFN-I levels in the early phase of SARS-CoV-2 infection were higher in patients who developed hypoxemic respiratory failure. The association between IFN-α, IL-6, and CXCL10 may reflect the systemic immune response against SARS-CoV-2 invasion into pulmonary circulation, which might be an early predictor of respiratory failure due to COVID-19.
MeSH term(s)	Adult ; COVID-19/blood ; COVID-19/complications ; COVID-19/virology ; Cytokines/blood ; Female ; Hospitalization ; Humans ; Inflammation ; Interferon Type I/blood ; Male ; Middle Aged ; Prospective Studies ; Respiratory Insufficiency/blood ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/virology ; SARS-CoV-2/pathogenicity ; Viral Load
Chemical Substances	Cytokines ; Interferon Type I
Language	English
Publishing date	2022-02-14
Publishing country	Switzerland
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.844304
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Article ; Online: Dominant CT Patterns and Immune Responses during the Early Infection Phases of Different SARS-CoV-2 Variants.

Nagaoka, Kentaro / Kawasuji, Hitoshi / Takegoshi, Yusuke / Murai, Yushi / Kaneda, Makito / Kimoto, Kou / Tani, Hideki / Niimi, Hideki / Morinaga, Yoshitomo / Noguchi, Kyo / Yamamoto, Yoshihiro

Viruses

2023 Volume 15, Issue 6

Abstract: Ground-glass opacity (GGO) and organizing pneumonia (OP) are dominant pulmonary CT lesions associated with COVID-19. However, the role of different immune responses in these CT patterns remains unclear, particularly following the emergence of the Omicron ...

Abstract	Ground-glass opacity (GGO) and organizing pneumonia (OP) are dominant pulmonary CT lesions associated with COVID-19. However, the role of different immune responses in these CT patterns remains unclear, particularly following the emergence of the Omicron variant. In this prospective observational study, we recruited patients hospitalized with COVID-19, before and after the emergence of Omicron variants. Semi-quantitative CT scores and dominant CT patterns were retrospectively determined for all patients within five days of symptom onset. Serum levels of IFN-α, IL-6, CXCL10, and VEGF were assessed using ELISA. Serum-neutralizing activity was measured using a pseudovirus assay. We enrolled 48 patients with Omicron variants and 137 with precedent variants. While the frequency of GGO patterns was similar between the two groups, the OP pattern was significantly more frequent in patients with precedent variants. In patients with precedent variants, IFN-α and CXCL10 levels were strongly correlated with GGO, whereas neutralizing activity and VEGF were correlated with OP. The correlation between IFN-α levels and CT scores was lower in patients with Omicron than in those with precedent variants. Compared to preceding variants, infection with the Omicron variant is characterized by a less frequent OP pattern and a weaker correlation between serum IFN-α and CT scores.
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; COVID-19 ; Retrospective Studies ; Vascular Endothelial Growth Factor A ; Interferon-alpha ; Tomography, X-Ray Computed
Chemical Substances	Vascular Endothelial Growth Factor A ; Interferon-alpha
Language	English
Publishing date	2023-05-31
Publishing country	Switzerland
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15061304
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Article ; Online: Comparative Study of Three Commercial Blood (1→3)-β-D-glucan Detection Reagents for Invasive Mycosis.

Miyajima, Yuki / Nagaoka, Kentaro / Takegoshi, Yusuke / Kaneda, Makito / Murai, Yushi / Kimoto, Kou / Kawamura, Takayuki / Ueno, Akitoshi / Kawasuji, Hitoshi / Kawago, Koyomi / Fukui, Yasutaka / Sakamaki, Ippei / Yamamoto, Yoshihiro

Medical mycology journal

2023 Volume 64, Issue 1, Page(s) 1–6

Abstract: Background: β-D-glucan detection is a useful diagnostic indicator of invasive mycosis. However, the differences among the commercial β-D-glucan assays are unclear. Herein, we explored the diagnostic value of various β-D-glucan assay reagents.: Methods! ...

Abstract	Background: β-D-glucan detection is a useful diagnostic indicator of invasive mycosis. However, the differences among the commercial β-D-glucan assays are unclear. Herein, we explored the diagnostic value of various β-D-glucan assay reagents. Methods: This prospective observational study involved 175 eligible patients suspected to have fungal infections. For all participants, culture examinations were conducted with specimens obtained from the infected site (or blood culture), and β-D-glucan was measured using three commercial kits: Wako β-glucan test (Wako), Fungitech G-test MKII "Nissui" (MKII), and Fungitech G-test ES "Nissui" (ES). Results: A total of 163 participants were included. Among them, 32 cases of invasive mycosis, 34 cases with mycotic colonization infection, and 97 cases with non-fungal infections were confirmed. Regarding the diagnostic value of the commercial kits for invasive mycosis, the areas under the receiver operating characteristic curves were > 0.8 for all the agents. However, on the basis of the cut-off value set by the manufacturer, the sensitivity and specificity of the three kits for definitive invasive infection were 80.0% and 90.6% with Wako, 80.0% and 80.7% with MKII, and 86.7% and 71.8% with ES, respectively. Moreover, the rate of false-positive β-D-glucan elevation detection in patients with negative fungal culture was 9.3% with Wako, 18.6% with MKII, and 23.7% with ES. Conclusion: Despite the high diagnostic value of β-D-glucan detection in invasive fungal infections, caution should be exercised in interpreting the value of the assay reagents.
MeSH term(s)	Humans ; Glucans ; Invasive Fungal Infections ; Blood Culture ; beta-Glucans ; Biological Assay
Chemical Substances	Glucans ; beta-Glucans
Language	English
Publishing date	2023-03-01
Publishing country	Japan
Document type	Observational Study ; Journal Article
ZDB-ID	2628906-4
ISSN	1882-0476 ; 2186-165X ; 2185-6486 ; 0916-4804
ISSN (online)	1882-0476 ; 2186-165X
ISSN	2185-6486 ; 0916-4804
DOI	10.3314/mmj.22-00016
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Article ; Online: Neutralizing Antibody Response of the Wild-Type/Omicron BA.1 Bivalent Vaccine as the Second Booster Dose against Omicron BA.2 and BA.5.

Kawasuji, Hitoshi / Morinaga, Yoshitomo / Tani, Hideki / Saga, Yumiko / Yamada, Hiroshi / Yoshida, Yoshihiro / Takegoshi, Yusuke / Kaneda, Makito / Murai, Yushi / Kimoto, Kou / Ueno, Akitoshi / Miyajima, Yuki / Nagaoka, Kentaro / Ono, Chikako / Matsuura, Yoshiharu / Niimi, Hideki / Yamamoto, Yoshihiro

Microbiology spectrum

2023 , Page(s) e0513122

Abstract: In addition to the original monovalent vaccines available for SARS-CoV-2, bivalent vaccines covering wild-type (WT) and Omicron BA.1 are also available. However, there is a lack of real-world data on the immunogenicity of bivalent vaccines as second ... ...

Abstract	In addition to the original monovalent vaccines available for SARS-CoV-2, bivalent vaccines covering wild-type (WT) and Omicron BA.1 are also available. However, there is a lack of real-world data on the immunogenicity of bivalent vaccines as second boosters against the dominant Omicron sublineages, including BA.2 and BA.5. Healthcare workers (
Language	English
Publishing date	2023-03-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.05131-22
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Article: Short-Term Corticosteroid Therapy for Early Exacerbation of COVID-19 Pneumonia: A Case Report

Urano, Akira / Kasai, Hajime / Murai, Yushi / Ikeda, Hideki / Urushibara, Takashi

Am J Case Rep

Abstract	BACKGROUND The effect of corticosteroids in the management of patients with coronavirus disease 2019 (COVID-19) is unclear. CASE REPORT A 67-year-old man who tested positive for COVID-19 by reverse-transcription PCR (RT-PCR) analysis was admitted to our hospital. On admission, he had no dyspnea and his oxygen saturation (SpO2) level was normal. Chest imaging revealed ground-glass opacities (GGO) distributed in both lung fields. Four days after admission, bilateral lung shadows worsened, with a slight reduction in SpO2 levels. Short-term corticosteroid therapy was initiated, and SpO2 and radiographic findings promptly improved without use of antiviral agents. CONCLUSIONS More data are required to ascertain the role of corticosteroids in the management of COVID-19 pneumonia.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #717813
Database	COVID19

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