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  1. Article ; Online: An unusual case of tetralogy of Fallot with an absent pulmonary valve associated with a retro-aortic innominate vein in a patient with a 16p12.2 microdeletion.

    Linnane, Niall / Green, Andrew / McMahon, Colin J

    Cardiology in the young

    2021  Volume 31, Issue 5, Page(s) 836–837

    Abstract: 16p12.2 microdeletion has been associated with congenital heart defects and developmental delay. In this case, we describe the rare association between tetralogy of Fallot with an absent pulmonary valve a right-sided aortic arch and a retro-aortic ... ...

    Abstract 16p12.2 microdeletion has been associated with congenital heart defects and developmental delay. In this case, we describe the rare association between tetralogy of Fallot with an absent pulmonary valve a right-sided aortic arch and a retro-aortic innominate vein associated with a 16p12.2 microdeletion and epilepsy.
    MeSH term(s) Brachiocephalic Veins/diagnostic imaging ; Heart Defects, Congenital ; Humans ; Pulmonary Atresia ; Pulmonary Valve/diagnostic imaging ; Tetralogy of Fallot/complications ; Tetralogy of Fallot/diagnosis ; Tetralogy of Fallot/genetics
    Language English
    Publishing date 2021-01-18
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951120004667
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  2. Article ; Online: A case of COVID-19 in a patient with a univentricular heart post total cavopulmonary connection (Fontan) surgery.

    Linnane, Niall / Cox, Des W / James, Adam

    Cardiology in the young

    2020  Volume 30, Issue 9, Page(s) 1350–1352

    Abstract: Coronavirus disease 2019 (COVID-19) has caused a global pandemic which has affected patients and healthcare systems around the world. Patients with underlying health conditions seem to be more severely affected. There are limited reports of patients with ...

    Abstract Coronavirus disease 2019 (COVID-19) has caused a global pandemic which has affected patients and healthcare systems around the world. Patients with underlying health conditions seem to be more severely affected. There are limited reports of patients with univentricular circulations and COVID 19; thus, we report a case of COVID-19 in a patient with a univentricular circulation.
    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Child ; Comorbidity ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/physiopathology ; Coronavirus Infections/therapy ; Fontan Procedure/methods ; Heart Septal Defects, Atrial/diagnosis ; Heart Septal Defects, Atrial/surgery ; Humans ; Lung/diagnostic imaging ; Male ; Oximetry/methods ; Oxygen Inhalation Therapy/methods ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/therapy ; Pulmonary Atresia/diagnosis ; Pulmonary Atresia/surgery ; Radiography, Thoracic/methods ; SARS-CoV-2 ; Treatment Outcome ; Univentricular Heart/diagnosis ; Univentricular Heart/epidemiology ; Univentricular Heart/physiopathology ; Univentricular Heart/surgery ; COVID-19 Drug Treatment
    Keywords covid19
    Language English
    Publishing date 2020-06-25
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951120001882
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  3. Article ; Online: Transfemoral Perimembranous Ventricular Septal Defect Device Closure in Infants Weighing ≤ 10 kg.

    Alshahrani, Dhafer / Linnane, Niall / McCrossan, Brian / Oslizlok, Paul / McMahon, Colin J / Walsh, Kevin P / Kenny, Damien P

    Pediatric cardiology

    2023  Volume 44, Issue 5, Page(s) 1176–1182

    Abstract: Transcatheter closure of Perimembranous VSDs (PMVSD) remains challenging particularly in infants. The aim of this study is to evaluate the efficacy and safety of transfemoral PMVSD device closure in infants weighing ≤ 10 kg in a single centre. ... ...

    Abstract Transcatheter closure of Perimembranous VSDs (PMVSD) remains challenging particularly in infants. The aim of this study is to evaluate the efficacy and safety of transfemoral PMVSD device closure in infants weighing ≤ 10 kg in a single centre. Retrospective review of departmental databases and medical charts to define patient cohort and collect demographic, procedural and follow-up data. Between July 2014 and March 2021, 16 patients underwent attempted transfemoral PMVSD device closure (12 retrograde) at a median age of 11 months (interquartile range [IQR] 9-15.5) and a median weight of 8.3 kg (IQR 7.2-9.5). All patients were either symptomatic, had progressive left heart dilation or had VSD associated valve regurgitation. Median defect size on pre-procedural transoesophageal echocardiography was 6.8 mm (IQR 6-8.5). Median device waist size was 6 mm (IQR 4.5-8). Successful device placement was achieved in 14 patients (88%). One patient developed moderate aortic and tricuspid valve regurgitation upon retrograde and antegrade device deployment, respectively, and subsequently underwent surgical closure. The second patient developed progressive aortic regurgitation (AR) 2 days post procedure, and also underwent surgical removal with no residual AR. There was no cases of device embolization and no femoral arterial compromise. On median follow-up of 40.5 months (IQR 25-64), none of the patients developed complete heart block. Three patients (18.75%) had small residual shunts at latest follow-up which have not required any further intervention. Device closure of PMVSD's in children weighing ≤ 10 kg is feasible and safe with good procedural success rates. Use of both the antegrade and retrograde approaches may be necessary depending on anatomical variances.
    MeSH term(s) Child ; Humans ; Infant ; Cardiac Catheterization/methods ; Echocardiography, Transesophageal ; Heart Septal Defects, Ventricular/diagnostic imaging ; Heart Septal Defects, Ventricular/surgery ; Aortic Valve Insufficiency ; Septal Occluder Device ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 800857-7
    ISSN 1432-1971 ; 0172-0643
    ISSN (online) 1432-1971
    ISSN 0172-0643
    DOI 10.1007/s00246-023-03100-5
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  4. Article: A case of COVID-19 in a patient with a univentricular heart post total cavopulmonary connection (Fontan) surgery

    Linnane, Niall / Cox, Des W / James, Adam

    Cardiol Young

    Abstract: Coronavirus disease 2019 (COVID-19) has caused a global pandemic which has affected patients and healthcare systems around the world. Patients with underlying health conditions seem to be more severely affected. There are limited reports of patients with ...

    Abstract Coronavirus disease 2019 (COVID-19) has caused a global pandemic which has affected patients and healthcare systems around the world. Patients with underlying health conditions seem to be more severely affected. There are limited reports of patients with univentricular circulations and COVID 19; thus, we report a case of COVID-19 in a patient with a univentricular circulation.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #605993
    Database COVID19

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  5. Article ; Online: A case of COVID-19 in a patient with a univentricular heart post total cavopulmonary connection (Fontan) surgery

    Linnane, Niall / Cox, Des W. / James, Adam

    Cardiology in the Young

    2020  Volume 30, Issue 9, Page(s) 1350–1352

    Abstract: Abstract Coronavirus disease 2019 (COVID-19) has caused a global pandemic which has affected patients and healthcare systems around the world. Patients with underlying health conditions seem to be more severely affected. There are limited reports of ... ...

    Abstract Abstract Coronavirus disease 2019 (COVID-19) has caused a global pandemic which has affected patients and healthcare systems around the world. Patients with underlying health conditions seem to be more severely affected. There are limited reports of patients with univentricular circulations and COVID 19; thus, we report a case of COVID-19 in a patient with a univentricular circulation.
    Keywords Pediatrics, Perinatology, and Child Health ; Cardiology and Cardiovascular Medicine ; General Medicine ; covid19
    Language English
    Publisher Cambridge University Press (CUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/s1047951120001882
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  6. Article: Cleaning up the paper trail - our clinical notes in open view.

    Lambe, Gerard / Linnane, Niall / Callanan, Ian / Butler, Marcus W

    International journal of health care quality assurance

    2018  Volume 31, Issue 3, Page(s) 228–236

    Abstract: Purpose Ireland's physicians have a legal and an ethical duty to protect confidential patient information. Most healthcare records in Ireland remain paper based, so the purpose of this paper is to: assess the protection afforded to paper records; log ... ...

    Abstract Purpose Ireland's physicians have a legal and an ethical duty to protect confidential patient information. Most healthcare records in Ireland remain paper based, so the purpose of this paper is to: assess the protection afforded to paper records; log highest risk records; note the variations that occurred during the working week; and observe the varying protection that occurred when staff, students and public members were present. Design/methodology/approach A customised audit tool was created using Sphinx software. Data were collected for three months. All wards included in the study were visited once during four discrete time periods across the working week. The medical records trolley's location was noted and total unattended medical records, total unattended nursing records, total unattended patient lists and when nursing personnel, medical students, public and a ward secretary were visibly present were recorded. Findings During 84 occasions when the authors visited wards, unattended medical records were identified on 33 per cent of occasions, 49 per cent were found during weekend visiting hours and just 4 per cent were found during morning rounds. The unattended medical records belonged to patients admitted to a medical specialty in 73 per cent of cases and a surgical specialty in 27 per cent. Medical records were found unattended in the nurses' station with much greater frequency when the ward secretary was off duty. Unattended nursing records were identified on 67 per cent of occasions the authors visited the ward and were most commonly found unattended in groups of six or more. Practical implications This study is a timely reminder that confidential patient information is at risk from inappropriate disclosure in the hospital. There are few context-specific standards for data protection to guide healthcare professionals, particularly paper records. Nursing records are left unattended with twice the frequency of medical records and are found unattended in greater numbers than medical records. Protection is strongest when ward secretaries are on duty. Over-reliance on vigilant ward secretaries could represent a threat to confidential patient information. Originality/value While other studies identified data protection as an issue, this study assesses how data security varies inside and outside conventional working hours. It provides a rationale and an impetus for specific changes across the whole working week. By identifying the on-duty ward secretary's favourable effect on medical record security, it highlights the need for alternative arrangements when the ward secretary is off duty. Data were collected prospectively in real time, giving a more accurate healthcare record security snapshot in each data collection point.
    MeSH term(s) Confidentiality/standards ; Health Records, Personal ; Humans ; Ireland ; Medical Secretaries ; Nursing Staff, Hospital ; Personnel, Hospital/standards ; Personnel, Hospital/statistics & numerical data ; Students, Medical
    Language English
    Publishing date 2018-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 645125-1
    ISSN 0952-6862 ; 1366-0756
    ISSN 0952-6862 ; 1366-0756
    DOI 10.1108/IJHCQA-09-2016-0126
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    Zs.A 2499: Show issues Location:
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  7. Article ; Online: Incidence and outcome of retained Port-A-Cath fragments during removal.

    Aworanti, Olugbenga Michael / Linnane, Niall / Tareen, Farhan / Mortell, Alan

    Pediatric surgery international

    2017  Volume 33, Issue 7, Page(s) 777–781

    Abstract: Purpose: Port-A-Cath devices are frequently used for long-term venous access. We postulate that long-term use predisposes them to getting stuck and retained in a central vein at the time of removal. We aim to report the incidence and outcome of this ... ...

    Abstract Purpose: Port-A-Cath devices are frequently used for long-term venous access. We postulate that long-term use predisposes them to getting stuck and retained in a central vein at the time of removal. We aim to report the incidence and outcome of this complication.
    Methods: Between January 2006 and July 2016, a retrospective review of all Port-A-Cath removals that were performed at our centre was conducted. At the time of removal, catheters that could not be removed from the vein were considered retained.
    Results: During the study period, 107 children had 174 episodes of silicone Sitimplant (Vygon, Ecouen, France) Port-A-Cath insertions. These children required 135 removal episodes and there were 3 (2.2%) instances whereby the catheter fragment was retained. These episodes of retained catheters only occurred in children with factor VIII deficiency (4.1% incidence in this cohort). For each episode of catheter insertion and removal, the catheters had been left in situ for a mean duration of 43 months in children with factor deficiency and no retained fragments, and the mean duration was 91 months in children with factor deficiency and retained catheter fragments (p = 0.0011).
    Conclusions: Port-A-Caths that are retained after attempted removal is a complication encountered predominantly in catheters that have been in use for a prolonged duration. Furthermore, factor replacement therapy in haemophiliacs may be a risk factor for this complication.
    Language English
    Publishing date 2017-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 632773-4
    ISSN 1437-9813 ; 0179-0358
    ISSN (online) 1437-9813
    ISSN 0179-0358
    DOI 10.1007/s00383-017-4103-6
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    Zs.A 2138: Show issues Location:
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  8. Article ; Online: Multisystem inflammatory syndrome in the context of paediatric COVID-19 infection in the Republic of Ireland April 2020 to April 2021.

    Treston, Bryony / Petty-Saphon, Naomi / Collins, Abigail / Murray, Sarah / Colgan, Aoife / Fitzgerald, Eoin / Hassan, Mahmoud / Forde, Karina / O'Farrell, Anne / Sayers, Gerardine / Linnane, Niall / Franklin, Orla / McMahon, Colin / Leahy, Timothy R / Gavin, Patrick

    Acta paediatrica (Oslo, Norway : 1992)

    2022  Volume 111, Issue 12, Page(s) 2344–2351

    Abstract: Aim: Our aim was to describe the epidemiology of multisystem inflammatory syndrome in children (MIS-C) in the Republic of Ireland, in the context of all cases of COVID-19 in children, during the first year of the SARS-CoV-2 pandemic.: Methods: Cases ... ...

    Abstract Aim: Our aim was to describe the epidemiology of multisystem inflammatory syndrome in children (MIS-C) in the Republic of Ireland, in the context of all cases of COVID-19 in children, during the first year of the SARS-CoV-2 pandemic.
    Methods: Cases of MIS-C were identified by prospective surveillance in Irish hospitals from April 2020 to April 2021. Paediatric COVID-19 cases and outbreaks in schools or childcare facilities were notified to and routinely investigated by Public Health. Univariate and bivariate analyses were carried out in Excel, Stata and JMP statistical package.
    Results: Fifty-four MIS-C cases (median age 7.58 years; males 57%) were identified over the study period. MIS-C incidence was higher in certain ethnicities ('black' 21.3/100,000 [95% CI 4.3-38.4]; and 'Irish Traveller' 14.7/100,000 [95% CI -5.7-35.1]) than those of 'white' ethnicity (3.4 /100,000). MIS-C cases occurred in three temporal clusters, which followed three distinct waves of community COVID-19 infection, irrespective of school closures. Formal contact tracing identified an epidemiological link with a COVID-19-infected family member in the majority of MIS-C cases (77%). In contrast, investigation of COVID-19 school outbreaks demonstrated no epidemiological link with MIS-C cases during the study period.
    Conclusion: Efforts at controlling SARS-CoV-2 transmission in the community may be a more effective means to reduce MIS-C incidence than school closures. Establishing a mandatory reporting structure for MIS-C will help delineate the role of risk factors such as ethnicity and obesity and the effect of vaccination on MIS-C incidence.
    MeSH term(s) Male ; Child ; Humans ; COVID-19/epidemiology ; SARS-CoV-2 ; Prospective Studies ; Ireland/epidemiology ; Systemic Inflammatory Response Syndrome/epidemiology
    Language English
    Publishing date 2022-09-06
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.16531
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  9. Article ; Online: Transcarotid Approach to Ventricular Septal Defect Closure in Small Infants.

    Breatnach, Colm R / Kenny, Damien / Linnane, Niall / Al Nasef, Mohamed / Ng, Li Yen / McGuinness, Jonathan / McCrossan, Brian / Nölke, Lars / Oslizlok, Paul / Redmond, Mark / Walsh, Kevin

    Pediatric cardiology

    2021  Volume 42, Issue 7, Page(s) 1539–1545

    Abstract: Perimembranous ventricular septal defect closure in small infants has traditionally been a surgically treated defect, although alternative hybrid strategies are emerging. We aim to describe a novel approach to retrograde device closure of clinically ... ...

    Abstract Perimembranous ventricular septal defect closure in small infants has traditionally been a surgically treated defect, although alternative hybrid strategies are emerging. We aim to describe a novel approach to retrograde device closure of clinically relevant perimembranous ventricular septal defects in small infants via carotid cutdown. A retrospective review of all patients managed with attempted carotid cutdown for device closure of a perimembranous ventricular septal defect was recorded at a single tertiary cardiac centre. We summarized data on successful device deployment, conversion to open repair, complications, and length of stay. Eighteen infants with median (IQR) age of 7 months (5-9 months) and weight of 7.1 kg (6.5-7.8 kg) with clinically relevant PMVSD underwent attempted retrograde closure via carotid cutdown. Median (IQR) defect size was 8 mm (7-9 mm). Successful device deployment without significant aortic or tricuspid valve interference occurred in 15 (83%) patients. Three patients were converted to open repair, one following damage to the tricuspid valve apparatus. Median (IQR) hospital stay was 1 day (1-3 days). There were no complications related to carotid cutdown. Retrograde device closure of hemodynamically significant PMVSD is feasible and effective in small infants. Decision to convert to surgical repair should be made early if suboptimal device placement occurs. Carotid evaluation should be performed to rule out any access-related complications.
    MeSH term(s) Cardiac Catheterization ; Heart Septal Defects, Ventricular/surgery ; Humans ; Infant ; Retrospective Studies ; Septal Occluder Device ; Treatment Outcome ; Tricuspid Valve
    Language English
    Publishing date 2021-06-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 800857-7
    ISSN 1432-1971 ; 0172-0643
    ISSN (online) 1432-1971
    ISSN 0172-0643
    DOI 10.1007/s00246-021-02638-6
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  10. Article ; Online: Right ventricular outflow tract stenting in symptomatic infants without the use of a long delivery sheath.

    Linnane, Niall / Nasef, Mohamed Al / McMahon, Colin J / McGuinness, Jonathan / McCrossan, Brian / Oslizlok, Paul / Walsh, Kevin P / Kenny, Damien

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2021  Volume 98, Issue 2, Page(s) E275–E281

    Abstract: Background and objectives: Right ventricular outflow tract (RVOT) stenting improves systemic oxygenation and facilitates pulmonary arterial growth in symptomatic infants prior to repair of tetralogy of Fallot. The aim of this study was to evaluate the ... ...

    Abstract Background and objectives: Right ventricular outflow tract (RVOT) stenting improves systemic oxygenation and facilitates pulmonary arterial growth in symptomatic infants prior to repair of tetralogy of Fallot. The aim of this study was to evaluate the safety and efficacy of RVOT stenting without the use of a long delivery sheath.
    Methods: Retrospective data analysis of patients under 1 year of age undergoing RVOT stenting from January 2010 to January 2020 at a single tertiary pediatric cardiology center.
    Results: Sixty-three RVOT stents were deployed during 53 procedures into 44 patients. The median age and weight at insertion were 41 days (range 2-204) and 3.6 kg (range 1.59-7) respectively. Thirty-one procedures were semi-elective and 22 were emergencies. Stent positioning was guided by transthoracic echocardiogram and/or RV angiography from a pigtail micro-catheter placed via the aorta. The median total procedure and fluoroscopy times were 67.5 (range 15-145) and 19 min (1-107), respectively. The median length of hospital stay was 7 days (range 1-258). Twenty-one patients were admitted to ICU post-procedure with a median ICU length of stay of 3 days (range 3-11). There were three major complications including two deaths within 30 days of the procedure. A patient with Cornelia de Lange Syndrome (1.8 kg) died following stent migration and inability to wean from emergency cardiopulmonary bypass and the second infant had an unexplained asystolic arrest post-procedure while awaiting transfer to ICU.
    Conclusions: RVOT stenting is technically possible with minimal complications without the need for a long delivery sheath. Additional imaging with transthoracic echocardiography can facilitate the safe deployment of the stent.
    MeSH term(s) Child ; Heart Ventricles ; Humans ; Infant ; Retrospective Studies ; Stents ; Tetralogy of Fallot ; Treatment Outcome
    Language English
    Publishing date 2021-04-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.29708
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