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Article: A case of COVID-19 infection quickly relieved after nasal instillations and gargles with povidone iodine.

Blasi, Claudio

2021 Volume 22, Issue 2, Page(s) 269–270

Abstract: No abstract present. ...

Abstract	No abstract present.
MeSH term(s)	Anti-Infective Agents, Local/adverse effects ; COVID-19 ; Humans ; Mouthwashes ; Povidone-Iodine/adverse effects ; SARS-CoV-2
Chemical Substances	Anti-Infective Agents, Local ; Mouthwashes ; Povidone-Iodine (85H0HZU99M)
Language	English
Publishing date	2021-07-13
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2108910-3
ISSN	1530-6550
ISSN	1530-6550
DOI	10.31083/j.rcm2202033
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Article ; Online: Iodine mouthwashes as deterrents against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Blasi, Claudio

Infection control and hospital epidemiology

2020 Volume 42, Issue 12, Page(s) 1541–1542

MeSH term(s)	COVID-19 ; Humans ; Iodine ; Mouthwashes ; Povidone-Iodine ; SARS-CoV-2
Chemical Substances	Mouthwashes ; Povidone-Iodine (85H0HZU99M) ; Iodine (9679TC07X4)
Language	English
Publishing date	2020-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	639378-0
ISSN	1559-6834 ; 0195-9417 ; 0899-823X
ISSN (online)	1559-6834
ISSN	0195-9417 ; 0899-823X
DOI	10.1017/ice.2020.1356
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Zs.A 1714: Show issues

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Article ; Online: Obesity and Related Type 2 Diabetes

Claudio Blasi

Gastrointestinal Disorders, Vol 2, Iss 39, Pp 423-

A Failure of the Autonomic Nervous System Controlling Gastrointestinal Function?

2020 Volume 447

Abstract: The pandemic spread of obesity and type 2 diabetes is a serious health problem that cannot be contained with common therapies. At present, the most effective therapeutic tool is metabolic surgery, which substantially modifies the gastrointestinal ... ...

Abstract	The pandemic spread of obesity and type 2 diabetes is a serious health problem that cannot be contained with common therapies. At present, the most effective therapeutic tool is metabolic surgery, which substantially modifies the gastrointestinal anatomical structure. This review reflects the state of the art research in obesity and type 2 diabetes, describing the probable reason for their spread, how the various brain sectors are involved (with particular emphasis on the role of the vagal system controlling different digestive functions), and the possible mechanisms for the effectiveness of bariatric surgery. According to the writer’s interpretation, the identification of drugs that can modulate the activity of some receptor subunits of the vagal neurons and energy-controlling structures of the central nervous system (CNS), and/or specific physical treatment of cortical areas, could reproduce, non-surgically, the positive effects of metabolic surgery.
Keywords	GI role in energy homeostasis ; obesity pathogenesis ; obesity therapy ; metabolic surgery mechanism ; vagal control of GI function ; NMDA receptors ; Medicine ; R ; Diseases of the digestive system. Gastroenterology ; RC799-869
Subject code	616
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: The Role of the Vagal Nucleus Tractus Solitarius in the Therapeutic Effects of Obesity Surgery and Other Interventional Therapies on Type 2 Diabetes.

Blasi, Claudio

Obesity surgery

2016 Volume 26, Issue 12, Page(s) 3045–3057

Abstract: The current treatment for obesity-related type 2 diabetes is not able to achieve sufficient metabolic control. New remission prospects have been offered through bariatric surgery and other interventional therapies. The aim of the study is to illustrate ... ...

Abstract	The current treatment for obesity-related type 2 diabetes is not able to achieve sufficient metabolic control. New remission prospects have been offered through bariatric surgery and other interventional therapies. The aim of the study is to illustrate the mechanism by which such therapies affect the autonomic system, in particular the afferent vagal activity. The first and most important terminal of this activity is the brainstem vagal nucleus tractus solitarius. Its function, on which the vagal efferent inputs that control the splanchnic organs depend, is conditioned by the level of synaptic transmission within it. In conclusion, on the basis of such a view, a selective pharmacological modulation of such transmission as the target for future medical treatment of obesity and related type 2 diabetes is proposed.
Language	English
Publishing date	2016-12
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-016-2419-2
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Zs.A 3381: Show issues

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Article ; Online: Can Diabetes Heal?- From Observations to Perspectives.

Blasi, Claudio

Current diabetes reviews

2015 Volume 12, Issue 3, Page(s) 184–198

Abstract: Diabetes, both type 1 and type 2, is considered a chronic incurable disease. Complete cure would bring enormous benefits in terms of both the prevention of complications and reduction of the very high resulting social cost. Recent advances in the study ... ...

Abstract	Diabetes, both type 1 and type 2, is considered a chronic incurable disease. Complete cure would bring enormous benefits in terms of both the prevention of complications and reduction of the very high resulting social cost. Recent advances in the study of autoimmune mechanisms for type 1 and some non-medical therapeutic approaches for type 2 shed light on the pathophysiology and induce optimism concerning a possible cure in the not-too-distant future. This perspective highlights the main mechanisms involved in the pathophysiology of the two forms of diabetes, as the latest research has revealed, and the resulting possible therapeutic strategies that may be involved in obtaining a cure.
MeSH term(s)	Cost of Illness ; Diabetes Complications/prevention & control ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/rehabilitation ; Diabetes Mellitus, Type 1/therapy ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/rehabilitation ; Diabetes Mellitus, Type 2/therapy ; Humans ; Remission Induction ; Therapies, Investigational/methods ; Therapies, Investigational/trends
Language	English
Publishing date	2015-07-02
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ISSN	1875-6417
ISSN (online)	1875-6417
DOI	10.2174/1573399811666150702125702
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Article: Each day is a new beginning.

Blasi, Francesco / Sanguinetti, Claudio M

Multidisciplinary respiratory medicine

2017 Volume 12, Page(s) 4

Language	English
Publishing date	2017-02-15
Publishing country	Italy
Document type	Editorial
ZDB-ID	2677839-7
ISSN	2049-6958 ; 1828-695X
ISSN (online)	2049-6958
ISSN	1828-695X
DOI	10.1186/s40248-017-0085-4
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Article: Impatto del caldo e del freddo sulla mortalità per causa in Italia.

Di Blasi, Chiara / Stafoggia, Massimo / Gariazzo, Claudio / Michelozzi, Paola / De Sario, Manuela / Marinaccio, Alessandro / Maio, Sara / Viegi, Giovanni / De' Donato, Francesca

Epidemiologia e prevenzione

2024 Volume 47, Issue 6, Page(s) 19–26

Abstract: Objectives: to estimate the impact of daily exposure to extreme air temperatures (heat and cold) on cause-specific mortality in Italy and to evaluate the differences in the association between urban, suburban and rural municipalities.: Design: time ... ...

Title translation	Impact of heat and cold on cause -specific mortality in Italy.
Abstract	Objectives: to estimate the impact of daily exposure to extreme air temperatures (heat and cold) on cause-specific mortality in Italy and to evaluate the differences in the association between urban, suburban and rural municipalities. Design: time series analyses with two-stage approach were applied: in the first stage, multiple Poisson regression models and distributed lag non-linear models (DLNM) were used to define the association between temperature and mortality; in the second one, meta-analytic results were obtained by adopting BLUP (Best Linear Unbiased Prediction) coefficients at provincial level, which were then used to estimate the Attributable Fractions of cause-specific deaths. Setting and participants: cause-specific deaths from 2006to 2015 in Italy have been analysed by region and overall. Main outcome measures: 5,648,299 total deaths included. Fractions (and relative 95% empirical confidence interval) of deaths attributable to increases from 75th to 99th percentiles of temperature, for heat, and decreases from 25th to 1st percentile, for cold. Results: the overall impact of air temperature on causespecificmortality is higher for heat than for cold. When considering heat, the attributable fraction is higher for diseases of the central nervous system (3.6% 95% CI 1.9-4.9) and mental health disease (3.1% 95% CI 1.7-4.4), while considering cold, ischemic disease (1.3% 95% CI 1.1-1.6) and diabetes (1.3% 95% CI 0.7-1.8) showed the greater impact. By urbanization level, similar impacts were found for cold temperature, while for heat there was an indication of higher vulnerability in rural areas emerged. Conclusions: results are relevant for the implementation and promotion of preventive measures according to climate change related increase in temperature. The available evidence can provide the basis to identify vulnerable areas and population subgroups to which address current and future heat and cold adaptation plans in Italy.
MeSH term(s)	Humans ; Cold Temperature ; Hot Temperature ; Italy/epidemiology ; Temperature ; Cities ; Mortality
Language	Italian
Publishing date	2024-04-19
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	1038112-0
ISSN	1120-9763
ISSN	1120-9763
DOI	10.19191/EP23.6.S3.004
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Zs.A 2748: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 265: Show issues

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Article ; Online: Minimally invasive versus open radical antegrade modular pancreatosplenectomy for pancreatic ductal adenocarcinoma: an entropy balancing analysis.

Ricci, Claudio / Kauffmann, Emanuele F / Pagnanelli, Michele / Fiorillo, Claudio / Ferrari, Cecilia / De Blasi, Vito / Panaro, Fabrizio / Rosso, Edoardo / Zerbi, Alessandro / Alfieri, Sergio / Boggi, Ugo / Casadei, Riccardo

HPB : the official journal of the International Hepato Pancreato Biliary Association

2023 Volume 26, Issue 1, Page(s) 44–53

Abstract: Background: The safety and efficacy of minimally invasive radical antegrade modular pancreatosplenectomy (MI-RAMPS) remain to be established in pancreatic cancer (PDAC) METHODS: Eighty-five open (O)-RAMPS were compared to 93 MI-RAMPS. The entropy ... ...

Abstract	Background: The safety and efficacy of minimally invasive radical antegrade modular pancreatosplenectomy (MI-RAMPS) remain to be established in pancreatic cancer (PDAC) METHODS: Eighty-five open (O)-RAMPS were compared to 93 MI-RAMPS. The entropy balance matching approach was used to compare the two cohorts, eliminating the selection bias. Three models were created. Model 1 made O-RAMPS equal to the MI-RAMPS cohort (i.e., compared the two procedures for resectable PDAC); model 2 made MI-RAMPS equal to O-RAMPS (i.e., compared the two procedures for borderline-resectable PDAC); model 3, compared robotic and laparoscopic RAMPS. Results: O-RAMPS and MI-RAMPS showed "non-small" differences for BMI, comorbidity, back pain, tumor size, vascular resection, anterior or posterior RAMPS, multi-visceral resection, stump management, grading, and neoadjuvant therapy. Before reweighting, O-RAMPS had fewer clinically relevant postoperative pancreatic fistulae (CR-POPF) (20.0% vs. 40.9%; p = 0.003), while MI-RAMPS had a higher mean of lymph nodes (25.7 vs. 31.7; p = 0.011). In model 1, MI-RAMPS and O-RAMPS achieved similar results. In model 2, O-RAMPS was associated with lower comprehensive complication index scores (MD = 11.2; p = 0.038), and CR-POPF rates (OR = 0.2; p = 0.001). In model 3, robotic-RAMPS had a higher probability of negative resection margins. Conclusion: In patients with anatomically resectable PDAC, MI-RAMPS is feasible and as safe as O-RAMPS.
MeSH term(s)	Humans ; Entropy ; Pancreatectomy/adverse effects ; Pancreatectomy/methods ; Splenectomy ; Pancreatic Neoplasms/surgery ; Pancreatic Neoplasms/pathology ; Carcinoma, Pancreatic Ductal/surgery ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Postoperative Complications/surgery ; Adenocarcinoma/surgery
Language	English
Publishing date	2023-09-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2131251-5
ISSN	1477-2574 ; 1365-182X
ISSN (online)	1477-2574
ISSN	1365-182X
DOI	10.1016/j.hpb.2023.09.013
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Article ; Online: The relationship between the resting state functional connectivity and social cognition in schizophrenia: Results from the Italian Network for Research on Psychoses.

Rocca, Paola / Brasso, Claudio / Montemagni, Cristiana / Del Favero, Elisa / Bellino, Silvio / Bozzatello, Paola / Giordano, Giulia Maria / Caporusso, Edoardo / Fazio, Leonardo / Pergola, Giulio / Blasi, Giuseppe / Amore, Mario / Calcagno, Pietro / Rossi, Rodolfo / Rossi, Alessandro / Bertolino, Alessandro / Galderisi, Silvana / Maj, Mario

Schizophrenia research

2024 Volume 267, Page(s) 330–340

Abstract: Deficits in social cognition (SC) interfere with recovery in schizophrenia (SZ) and may be related to resting state brain connectivity. This study aimed at assessing the alterations in the relationship between resting state functional connectivity and ... ...

Abstract	Deficits in social cognition (SC) interfere with recovery in schizophrenia (SZ) and may be related to resting state brain connectivity. This study aimed at assessing the alterations in the relationship between resting state functional connectivity and the social-cognitive abilities of patients with SZ compared to healthy subjects. We divided the brain into 246 regions of interest (ROI) following the Human Healthy Volunteers Brainnetome Atlas. For each participant, we calculated the resting-state functional connectivity (rsFC) in terms of degree centrality (DC), which evaluates the total strength of the most powerful coactivations of every ROI with all other ROIs during rest. The rs-DC of the ROIs was correlated with five measures of SC assessing emotion processing and mentalizing in 45 healthy volunteers (HVs) chosen as a normative sample. Then, controlling for symptoms severity, we verified whether these significant associations were altered, i.e., absent or of opposite sign, in 55 patients with SZ. We found five significant differences between SZ patients and HVs: in the patients' group, the correlations between emotion recognition tasks and rsFC of the right entorhinal cortex (R-EC), left superior parietal lobule (L-SPL), right caudal hippocampus (R-c-Hipp), and the right caudal (R-c) and left rostral (L-r) middle temporal gyri (MTG) were lost. An altered resting state functional connectivity of the L-SPL, R-EC, R-c-Hipp, and bilateral MTG in patients with SZ may be associated with impaired emotion recognition. If confirmed, these results may enhance the development of non-invasive brain stimulation interventions targeting those cerebral regions to reduce SC deficit in SZ.
Language	English
Publishing date	2024-04-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	639422-x
ISSN	1573-2509 ; 0920-9964
ISSN (online)	1573-2509
ISSN	0920-9964
DOI	10.1016/j.schres.2024.04.009
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Zs.MO 543: Show issues

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Article ; Online: The autoimmune origin of atherosclerosis.

Blasi, Claudio

Atherosclerosis

2008 Volume 201, Issue 1, Page(s) 17–32

Abstract: Atherosclerosis is a chronic inflammatory disease. Many studies and observations suggest that it could be caused by an immune reaction against autoantigens at the endothelial level, the most relevant of which are oxidized LDL and heat shock proteins (HSP) ...

Abstract	Atherosclerosis is a chronic inflammatory disease. Many studies and observations suggest that it could be caused by an immune reaction against autoantigens at the endothelial level, the most relevant of which are oxidized LDL and heat shock proteins (HSP) 60/65. Endothelial dysfunction plays a fundamental role. The first antigen is related to the increased leakage and oxidation of LDL; the second to cellular reaction to stress. Experimental and clinical observations confirm the pathogenetic role of these antigens. Both innate and adaptive immunity and impaired regulatory mechanisms of the autoimmune reaction are involved. Different triggering factors are examined: infectious agents, smoking, air pollution, diabetes and hypercholesterolemia. Analogies and differences between systemic atherosclerosis and transplant-related coronary atherosclerosis help to understand their respective nature. Immune mechanisms might be responsible for the passage from stable plaque to unstable and rupture-prone plaque. Finally, prospects of treatment and prevention are linked to the induction of tolerance to responsible antigens, activation of immune regulatory response and the use of immunomodulatory drugs.
MeSH term(s)	Atherosclerosis/immunology ; Atherosclerosis/pathology ; Atherosclerosis/therapy ; Autoantigens/physiology ; Autoimmunity/physiology ; Heat-Shock Proteins/physiology ; Humans ; Immunomodulation ; Lipoproteins, LDL/physiology ; Oxidative Stress/physiology ; Risk Factors ; Tunica Intima/physiology
Chemical Substances	Autoantigens ; Heat-Shock Proteins ; Lipoproteins, LDL
Language	English
Publishing date	2008-11
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	80061-2
ISSN	1879-1484 ; 0021-9150
ISSN (online)	1879-1484
ISSN	0021-9150
DOI	10.1016/j.atherosclerosis.2008.05.025
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