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Article ; Online: A Pulmonary

Journal of immunology (Baltimore, Md. : 1950)

2021 Volume 207, Issue 7, Page(s) 1857–1870

Abstract: The lungs harbor multiple resident microbial communities, otherwise known as the microbiota. There is an emerging interest in deciphering whether the pulmonary microbiota modulate local immunity, and whether this knowledge could shed light on mechanisms ... ...

Abstract	The lungs harbor multiple resident microbial communities, otherwise known as the microbiota. There is an emerging interest in deciphering whether the pulmonary microbiota modulate local immunity, and whether this knowledge could shed light on mechanisms operating in the response to respiratory pathogens. In this study, we investigate the capacity of a pulmonary
MeSH term(s)	Animals ; Cells, Cultured ; Disease Models, Animal ; Humans ; Lactobacillus/physiology ; Lung/immunology ; Lung/microbiology ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mycobacterium tuberculosis/physiology ; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism ; Pneumonia ; T-Lymphocytes, Regulatory/immunology ; Th17 Cells/immunology ; Tuberculosis, Pulmonary/immunology
Chemical Substances	Nuclear Receptor Subfamily 1, Group F, Member 3 ; Rorc protein, mouse
Language	English
Publishing date	2021-09-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.2001044
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Book ; Online: Raisins in a Hydrogen Pie

Zhou, Di / Semenok, Dmitrii V. / Galasso, Michele / Alabarse, Frederico Gil / Sannikov, Denis A. / Troyan, Ivan A. / Nakamoto, Yuki / Shimizu, Katsuya / Oganov, Artem R.

Ultrastable Cesium and Rubidium Polyhydrides

2024

Abstract: We proposed a new method for synthesis of metal polyhydrides via high-pressure thermal decomposition of corresponding amidoboranes in diamond anvil cells. Within this approach, we synthesized molecular semiconducting cesium ($\textit P4/nmm$-CsH$_7$, $\ ... ...

Abstract	We proposed a new method for synthesis of metal polyhydrides via high-pressure thermal decomposition of corresponding amidoboranes in diamond anvil cells. Within this approach, we synthesized molecular semiconducting cesium ($\textit P4/nmm$-CsH$_7$, $\textit P$1-CsH$_{15+x}$) and rubidium (RbH$_{9-x}$) polyhydrides with a very high hydrogen content reaching 93 at%. Preservation of CsH$_7$ at near ambient conditions, confirmed both experimentally and theoretically, represents a significant advance in the stabilization of hydrogen-rich compounds. In addition, we synthesized two crystal modifications of RbH$_{9-x}$ with pseudo hexagonal and pseudo tetragonal structures identified by synchrotron X-ray diffraction and Raman measurements. Both phases are stable at 8-10 GPa. This is an unprecedented low stabilization pressure for polyhydrides. These discoveries open up possibilities for modifying existing hydrogen storage materials to increase their efficiency.
Keywords	Condensed Matter - Materials Science ; Condensed Matter - Soft Condensed Matter
Subject code	540
Publishing date	2024-01-01
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Ruthenophosphanorcaradiene as a Synthon for an Ambiphilic Metallophosphinidene.

Saint-Denis, Tyler G / Wheeler, T Alexander / Chen, Qingchuan / Balázs, Gábor / Settineri, Nicholas S / Scheer, Manfred / Tilley, T Don

Journal of the American Chemical Society

2024 Volume 146, Issue 7, Page(s) 4369–4374

Abstract: Reaction of the ruthenium carbene complex Cp*(IPr)RuCl ( ...

Abstract	Reaction of the ruthenium carbene complex Cp*(IPr)RuCl (
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c14779
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Article ; Online: A sensitive zinc probe operating

Kumar, G Dinesh / Banasiewicz, Marzena / Wrzosek, Antoni / O'Mari, Omar / Zochowska, Monika / Vullev, Valentine I / Jacquemin, Denis / Szewczyk, Adam / Gryko, Daniel T

Organic & biomolecular chemistry

2022 Volume 20, Issue 37, Page(s) 7439–7447

Abstract: Novel highly sensitive fluorescent probes for zinc cations based on the diketopyrrolopyrrole scaffold were designed and synthesized. Large bathochromic shifts (≈80 nm) of fluorescence are observed when the ... ...

Abstract	Novel highly sensitive fluorescent probes for zinc cations based on the diketopyrrolopyrrole scaffold were designed and synthesized. Large bathochromic shifts (≈80 nm) of fluorescence are observed when the Zn
MeSH term(s)	Amines ; Cations, Divalent ; Fluorescent Dyes/chemistry ; Ketones ; Morpholines ; Pyridines ; Pyrroles ; Spectrometry, Fluorescence ; Zinc/chemistry
Chemical Substances	Amines ; Cations, Divalent ; Fluorescent Dyes ; Ketones ; Morpholines ; Pyridines ; Pyrroles ; diketopyrrolopyrrole dye ; Zinc (J41CSQ7QDS)
Language	English
Publishing date	2022-09-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d2ob01296k
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Book ; Online: ViT-A*

Liu, Jianwei / Lyu, Shirui / Hadjivelichkov, Denis / Modugno, Valerio / Kanoulas, Dimitrios

Legged Robot Path Planning using Vision Transformer A*

2023

Abstract: Legged robots, particularly quadrupeds, offer promising navigation capabilities, especially in scenarios requiring traversal over diverse terrains and obstacle avoidance. This paper addresses the challenge of enabling legged robots to navigate complex ... ...

Abstract	Legged robots, particularly quadrupeds, offer promising navigation capabilities, especially in scenarios requiring traversal over diverse terrains and obstacle avoidance. This paper addresses the challenge of enabling legged robots to navigate complex environments effectively through the integration of data-driven path-planning methods. We propose an approach that utilizes differentiable planners, allowing the learning of end-to-end global plans via a neural network for commanding quadruped robots. The approach leverages 2D maps and obstacle specifications as inputs to generate a global path. To enhance the functionality of the developed neural network-based path planner, we use Vision Transformers (ViT) for map pre-processing, to enable the effective handling of larger maps. Experimental evaluations on two real robotic quadrupeds (Boston Dynamics Spot and Unitree Go1) demonstrate the effectiveness and versatility of the proposed approach in generating reliable path plans. Comment: 6 pages, 6 figures, conference
Keywords	Computer Science - Robotics
Subject code	629
Publishing date	2023-10-11
Publishing country	us
Document type	Book ; Online
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Article: Drug switching in axial spondyloarthritis patients in Germany - a social listening analysis.

Kahn, Maria / Papukchieva, Steffeni / Fehr, Axel / Eberl, Markus / Rösler, Berenice / Veit, Justyna / Friedrich, Benjamin / Poddubnyy, Denis

Therapeutic advances in musculoskeletal disease

2023 Volume 15, Page(s) 1759720X231187189

Abstract: Background: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease which primarily affects the axial skeleton resulting in chronic back pain and stiffness. According to the guideline, the first-line treatment includes non-steroidal anti- ... ...

Abstract	Background: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease which primarily affects the axial skeleton resulting in chronic back pain and stiffness. According to the guideline, the first-line treatment includes non-steroidal anti-inflammatory drugs (NSAIDs), conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and non-pharmacological treatment. Second line treatment involves biological disease-modifying antirheumatic drugs (bDMARDs) such as tumour necrosis factor and interleukin-17 inhibitors. Objectives: The aim of this social media listening research project was to analyse switches of medication and the reasons thereof to gain valuable insights into real-life journeys of patients suffering from axSpA. Methods: Publicly available posts in German-speaking disease-specific forums were scanned for disease-specific keywords and commonly used drugs by axSpA patients on the Permea platform. Posts containing at least two key words were selected and switches between medications were manually labelled. A total of 287 scraped posts between 01 July 2010 and 04 Feb 2022 were analysed. Results: The largest group of described medication switches was initially using bDMARDs. Switches to a different bDMARD, termination of medication and switches to glucocorticoids were most frequently named. Patients on NSAIDs switched to glucocorticoids, a different NSAID or bDMARD, whereas patients on csDMARDs most frequently changed to bDMARDs. In all medication groups the main reason for switching was insufficient efficacy and side effects. Additionally, for the medication groups bDMARDs, csDMARDs and corticosteroids, pregnancy and lactation were given as a reason for switching, whereas patients in the NSAID group never mentioned pregnancy and breastfeeding as a reason for switching treatment. Conclusion: Our analysis shows medication switches based on real-life patient experiences shared with peers in a social listening setting. We also show medication switches differing from advised guidelines. Gathering real-life insights into patients' journey dealing with chronic diseases allows us to understand, and thereby improve patient care and treatment.
Language	English
Publishing date	2023-08-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2516075-8
ISSN	1759-7218 ; 1759-720X
ISSN (online)	1759-7218
ISSN	1759-720X
DOI	10.1177/1759720X231187189
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Article ; Online: A lentiviral vector expressing a dendritic cell-targeting multimer induces mucosal anti-mycobacterial CD4

Anna, François / Lopez, Jodie / Moncoq, Fanny / Blanc, Catherine / Authié, Pierre / Noirat, Amandine / Fert, Ingrid / Souque, Philippe / Nevo, Fabien / Pawlik, Alexandre / Hardy, David / Goyard, Sophie / Hudrisier, Denis / Brosch, Roland / Guinet, Françoise / Neyrolles, Olivier / Charneau, Pierre / Majlessi, Laleh

Mucosal immunology

2022 Volume 15, Issue 6, Page(s) 1389–1404

Abstract: Most viral vectors, including the potently immunogenic lentiviral vectors (LVs), only poorly direct antigens to the MHC-II endosomal pathway and elicit ... ...

Abstract	Most viral vectors, including the potently immunogenic lentiviral vectors (LVs), only poorly direct antigens to the MHC-II endosomal pathway and elicit CD4
MeSH term(s)	Mice ; Animals ; CD8-Positive T-Lymphocytes ; CD4-Positive T-Lymphocytes ; Dendritic Cells ; Mice, Inbred C57BL ; Genetic Vectors/genetics
Language	English
Publishing date	2022-09-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2411370-0
ISSN	1935-3456 ; 1933-0219
ISSN (online)	1935-3456
ISSN	1933-0219
DOI	10.1038/s41385-022-00566-z
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Article: Hormone Receptor Expression in Meningiomas: A Systematic Review.

Agopiantz, Mikaël / Carnot, Mélanie / Denis, Constance / Martin, Elena / Gauchotte, Guillaume

Cancers

2023 Volume 15, Issue 3

Abstract: Meningiomas are, in most cases, low grade intracranial tumors. However, relapses are frequent. To date, only a few prognostic markers are described in the literature. Several studies have discussed the expression of progesterone, estrogen, androgen, and ... ...

Abstract	Meningiomas are, in most cases, low grade intracranial tumors. However, relapses are frequent. To date, only a few prognostic markers are described in the literature. Several studies have discussed the expression of progesterone, estrogen, androgen, and somatostatin receptors. The utility of analyzing these expressions for prognostic, theragnostic, and therapeutic purposes remains unclear. The aim of this study was to report the expression of these receptors, based on immunohistochemistry. Cochrane Collaboration guidelines and PRISMA statements were followed. We did an online search in PubMed using the MeSH database. References were selected if the investigations occurred from 1990 to 2022. 61 references were included (34 descriptive observational studies, 26 analytical observational studies, and one case report). In this review, we describe the expression of these receptors in function of age, sex, hormonal context, localization, histological subtype, grade, and recurrence.
Language	English
Publishing date	2023-02-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15030980
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Article ; Online: Pain Perception in Contact Sport Athletes: A Scoping Review.

O'Farrell, Amanda / Sauvé, William / Bergevin, Maxime / Cimadoro, Giuseppe / Arvisais, Denis / Rainville, Pierre / Pageaux, Benjamin

Sports medicine (Auckland, N.Z.)

2022 Volume 52, Issue 11, Page(s) 2593–2604

Abstract: Contact sports athletes are regularly facing acute physical pain in part of their sport; however, the literature investigating pain perception in these athletes remains scarce. This scoping review aimed to explore the literature surrounding pain ... ...

Abstract	Contact sports athletes are regularly facing acute physical pain in part of their sport; however, the literature investigating pain perception in these athletes remains scarce. This scoping review aimed to explore the literature surrounding pain perception in contact sport athletes and to compile and understand how it is studied. The search strategy consisted of using index terms and keywords in the MEDLINE, EMBASE, SPORTDiscus, Web of Science, PsycINFO, CINAHL and ProQuest Dissertations & Theses Global search engines. Results from 11 studies revealed that a mix of team contact sports and combat sports are studied and are included under the umbrella of contact sports. These athletes are being compared with non-athletes as well as athletes from non-contact sports. The cold pressor test and the pain pressure test are the two predominant methods used to investigate physical pain. This review highlights the need to clearly define sports based on contact levels expected in play to better define the types of pain athletes are facing in their practice. Athletes' level of play as well as years of experience should also be more rigorously reported. While contact sport athletes seem to have a higher level of pain tolerance than both active controls and non-contact athletes, the methods of pain testing are not always justified and appropriate in relation to the pain induced during contact sports. Future experimental studies should use pain testing methods relevant to the pain experienced during contact sports and to better justify the rationale for the choice of these methods.
MeSH term(s)	Humans ; Sports ; Athletes ; Pain Perception ; Pain Threshold ; Pain
Language	English
Publishing date	2022-07-22
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	605911-9
ISSN	1179-2035 ; 0112-1642
ISSN (online)	1179-2035
ISSN	0112-1642
DOI	10.1007/s40279-022-01721-z
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Article ; Online: A single N

Sharma, Sunny / Hartmann, Johannes David / Watzinger, Peter / Klepper, Arvid / Peifer, Christian / Kötter, Peter / Lafontaine, Denis L J / Entian, Karl-Dieter

Scientific reports

2018 Volume 8, Issue 1, Page(s) 11904

Abstract: The entire chemical modification repertoire of yeast ribosomal RNAs and the enzymes responsible for it have recently been identified. Nonetheless, in most cases the precise roles played by these chemical modifications in ribosome structure, function and ... ...

Abstract	The entire chemical modification repertoire of yeast ribosomal RNAs and the enzymes responsible for it have recently been identified. Nonetheless, in most cases the precise roles played by these chemical modifications in ribosome structure, function and regulation remain totally unclear. Previously, we demonstrated that yeast Rrp8 methylates m
MeSH term(s)	Adenosine/analogs & derivatives ; Adenosine/metabolism ; Base Sequence ; Electrophoresis, Gel, Two-Dimensional ; HCT116 Cells ; Humans ; Methylation ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Mutation ; Nuclear Proteins/chemistry ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Nucleic Acid Conformation ; Protein Domains ; Protein O-Methyltransferase ; Proteomics/methods ; RNA, Ribosomal/chemistry ; RNA, Ribosomal/genetics ; RNA, Ribosomal/metabolism ; RNA-Binding Proteins ; Ribosomal Proteins/chemistry ; Ribosomal Proteins/genetics ; Ribosomal Proteins/metabolism ; Ribosome Subunits, Large/chemistry ; Ribosome Subunits, Large/genetics ; Ribosome Subunits, Large/metabolism ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
Chemical Substances	Nuclear Proteins ; RNA, Ribosomal ; RNA-Binding Proteins ; Ribosomal Proteins ; Saccharomyces cerevisiae Proteins ; RNA, ribosomal, 25S (130527-23-0) ; 1-methyladenosine (15763-06-1) ; Methyltransferases (EC 2.1.1.-) ; Protein O-Methyltransferase (EC 2.1.1.-) ; RRP8 protein, S cerevisiae (EC 2.1.1.-) ; RRP8 protein, human (EC 2.1.1.-) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2018-08-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-30383-z
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