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  1. Article ; Online: The essential role of

    Yagasaki, Lisa / Chiba, Tomoki / Kurimoto, Ryota / Nakajima, Mitsuyo / Iwata, Takanori / Asahara, Hiroshi

    Regenerative therapy

    2023  Volume 25, Page(s) 186–193

    Abstract: Introduction: The periodontium is a connective tissue which consists of periodontal ligament, alveolar bone, cementum and gingiva. Periodontal ligament (PDL) is a specialized connective tissue that connects the cementum - coating the surface of the ... ...

    Abstract Introduction: The periodontium is a connective tissue which consists of periodontal ligament, alveolar bone, cementum and gingiva. Periodontal ligament (PDL) is a specialized connective tissue that connects the cementum - coating the surface of the tooth - to the alveolar bone. Mohawk homeobox
    Materials and methods: Alveolar bone height, bone mineral density (BMD) and bone volume fractions (Bone volume/Total volume: BV/TV) were measured and analyzed using micro-computed tomography (Micro-CT) and 3DBon on 7-week-old male wild-type (WT) (
    Results: The level of alveolar bone height was significantly higher in
    Conclusion: Our findings further reveal the essential roles of
    Language English
    Publishing date 2023-12-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2835333-X
    ISSN 2352-3204 ; 2352-3204
    ISSN (online) 2352-3204
    ISSN 2352-3204
    DOI 10.1016/j.reth.2023.12.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Effect of the Addition of the Fifth Amino Acid to [GADV]-Protein on the Three-Dimensional Structure.

    Kato, Koichi / Nakayoshi, Tomoki / Oyaizu, Ryota / Noda, Natsuko / Kurimoto, Eiji / Oda, Akifumi

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 1

    Abstract: The [GADV]-protein, consisting only of glycine (G), alanine (A), aspartic acid (D), and valine (V), is frequently studied as a candidate for a primitive protein that existed at the beginning of life on Earth. The number of proteogenic amino acids ... ...

    Abstract The [GADV]-protein, consisting only of glycine (G), alanine (A), aspartic acid (D), and valine (V), is frequently studied as a candidate for a primitive protein that existed at the beginning of life on Earth. The number of proteogenic amino acids increased during evolution, and glutamic acid may have been added as the fifth amino acid. In this study, we used molecular dynamics simulations to estimate the conformation of random peptides when glutamate is added to G, A, D, and V ([GADVE]), when leucine is added ([GADVL]), and when the frequency of alanine is doubled ([GADVA]). The results showed that the secondary structure contents of the [GADVE]-peptide and [GADVL]-peptide were higher than that of the [GADVA]-peptide. Although the [GADVL]-peptide had a higher secondary structure formation ability than the [GADVE]-peptide, it was less water soluble, suggesting that it may not be a primitive protein. The [GA(D/E)V]-peptide with G:A:D:V:E = 2:2:1:2:1 according to the occurrence ratio in the codon table also increased the secondary structure contents compared to the [GADV]-peptide, indicating that the addition of glutamic acid increased the structure formation ability of the primitive protein candidates.
    Language English
    Publishing date 2023-01-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13010246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A case of COVID-19 with the atypical CT finding.

    Kurimoto, Ryota / Sakurai, Kenji / Motoori, Ken / Suda, Akira

    Clinical case reports

    2020  Volume 8, Issue 11, Page(s) 2306–2307

    Abstract: COVID-19 usually demonstrates the specific pattern of chest CT findings (GGO, inverted-halo sign, etc). However, some COVID-19 cases show atypical CT findings. Physicians should make comprehensive judgments. ...

    Abstract COVID-19 usually demonstrates the specific pattern of chest CT findings (GGO, inverted-halo sign, etc). However, some COVID-19 cases show atypical CT findings. Physicians should make comprehensive judgments.
    Keywords covid19
    Language English
    Publishing date 2020-07-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.3115
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  4. Article ; Online: Transcriptional, epigenetic and microRNA regulation of growth plate.

    Nakamichi, Ryo / Kurimoto, Ryota / Tabata, Yusuke / Asahara, Hirosi

    Bone

    2020  Volume 137, Page(s) 115434

    Abstract: Endochondral ossification is a critical event in bone formation, particularly in long shaft bones. Many cellular differentiation processes work in concert to facilitate the generation of cartilage primordium to formation of trabecular structures, all of ... ...

    Abstract Endochondral ossification is a critical event in bone formation, particularly in long shaft bones. Many cellular differentiation processes work in concert to facilitate the generation of cartilage primordium to formation of trabecular structures, all of which occur within the growth plate. Previous studies have revealed that the growth plate is tightly regulated by various transcription factors, epigenetic systems, and microRNAs. Hence, understanding these mechanisms that regulate the growth plate is crucial to furthering the current understanding on skeletal diseases, and in formulating effective treatment strategies. In this review, we focus on describing the function and mechanisms of the transcription factors, epigenetic systems, and microRNAs known to regulate the growth plate.
    MeSH term(s) Animals ; Cartilage ; Chondrocytes ; Chondrogenesis ; Epigenesis, Genetic ; Gene Expression Regulation, Developmental ; Growth Plate ; Humans ; MicroRNAs/genetics ; Osteogenesis
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2020-05-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 632515-4
    ISSN 1873-2763 ; 8756-3282
    ISSN (online) 1873-2763
    ISSN 8756-3282
    DOI 10.1016/j.bone.2020.115434
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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: One-step generation of mice with gene editing by Tol2 transposon-dependent gRNA delivery.

    Inotsume, Maiko / Chiba, Tomoki / Matsushima, Takahide / Kurimoto, Ryota / Nakajima, Mitsuyo / Kato, Tomomi / Shishido, Kana / Liu, Lin / Kawakami, Koichi / Asahara, Hiroshi

    FEBS letters

    2023  Volume 597, Issue 7, Page(s) 975–984

    Abstract: Conditional knockout mice are valuable tools for examining the functions of targeted genes in a time- and space-specific manner. Here, we generated gene-edited mice by using the Tol2 transposon to introduce guide RNA (gRNA) into fertilized eggs obtained ... ...

    Abstract Conditional knockout mice are valuable tools for examining the functions of targeted genes in a time- and space-specific manner. Here, we generated gene-edited mice by using the Tol2 transposon to introduce guide RNA (gRNA) into fertilized eggs obtained by crossing LSL (loxP-stop-loxP)-CRISPR-associated 9 (Cas9) mice, which express Cas9 in a Cre-dependent manner, with CAG-CreER mice. Transposase mRNA and plasmid DNA, which contained a gRNA sequence for the gene encoding tyrosinase flanked by the transposase recognition sequence, were injected together into fertilized eggs. As a result, the transcribed gRNA cleaved the target genome in a Cas9-dependent manner. Using this method, it is possible to generate conditional genome-edited mice more easily in a shorter period of time.
    MeSH term(s) Mice ; Animals ; Gene Editing ; CRISPR-Cas Systems ; Plasmids ; Mice, Knockout ; Transposases/genetics
    Chemical Substances Transposases (EC 2.7.7.-)
    Language English
    Publishing date 2023-03-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 282: Show issues Location:
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  6. Article ; Online: A case of COVID‐19 with the atypical CT finding

    Ryota Kurimoto / Kenji Sakurai / Ken Motoori / Akira Suda

    Clinical Case Reports, Vol 8, Iss 11, Pp 2306-

    2020  Volume 2307

    Abstract: Abstract COVID‐19 usually demonstrates the specific pattern of chest CT findings (GGO, inverted‐halo sign, etc). However, some COVID‐19 cases show atypical CT findings. Physicians should make comprehensive judgments. ...

    Abstract Abstract COVID‐19 usually demonstrates the specific pattern of chest CT findings (GGO, inverted‐halo sign, etc). However, some COVID‐19 cases show atypical CT findings. Physicians should make comprehensive judgments.
    Keywords COVID‐19 ; CT ; pneumonia ; Respiratory medicine ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: A case of COVID‐19 with the atypical CT finding

    Kurimoto, Ryota / Sakurai, Kenji / Motoori, Ken / Suda, Akira

    Clinical Case Reports ; ISSN 2050-0904 2050-0904

    2020  

    Keywords covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/ccr3.3115
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Post-transcriptional regulation of inflammation by RNA-binding proteins via cis-elements of mRNAs.

    Uchida, Yutaro / Chiba, Tomoki / Kurimoto, Ryota / Asahara, Hiroshi

    Journal of biochemistry

    2019  Volume 166, Issue 5, Page(s) 375–382

    Abstract: In human genome, there are approximately 1,500 RNA-binding proteins (RBPs). They can regulate mRNA stability or translational efficiency via ribosomes and these processes are known as 'post-transcriptional regulation'. Accumulating evidences indicate ... ...

    Abstract In human genome, there are approximately 1,500 RNA-binding proteins (RBPs). They can regulate mRNA stability or translational efficiency via ribosomes and these processes are known as 'post-transcriptional regulation'. Accumulating evidences indicate that post-transcriptional regulation is the determinant of the accurate levels of cytokines mRNAs. While transcriptional regulation of cytokines mRNAs has been well studied and found to be important for the rapid induction of mRNA and regulation of the acute phase of inflammation, post-transcriptional regulation by RBPs is essential for resolving inflammation in the later phase, and their dysfunction may lead to severe autoimmune diseases such as rheumatoid arthritis or systemic lupus erythematosus. For post-transcriptional regulation, RBPs recognize and directly bind to cis-regulatory elements in 3' untranslated region of mRNAs such as AU-rich or constitutive decay elements and play various roles. In this review, we summarize the recent findings regarding the role of RBPs in the regulation of inflammation.
    MeSH term(s) Animals ; Humans ; Inflammation/genetics ; Inflammation/immunology ; RNA, Messenger/genetics ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/immunology ; RNA-Binding Proteins/metabolism ; Transcription, Genetic/genetics
    Chemical Substances RNA, Messenger ; RNA-Binding Proteins
    Language English
    Publishing date 2019-09-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 218073-x
    ISSN 1756-2651 ; 0021-924X
    ISSN (online) 1756-2651
    ISSN 0021-924X
    DOI 10.1093/jb/mvz067
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  9. Article ; Online: Identification of chemical compounds regulating PD-L1 by introducing HiBiT-tagged cells.

    Uchida, Yutaro / Matsushima, Takahide / Kurimoto, Ryota / Chiba, Tomoki / Inutani, Yuki / Asahara, Hiroshi

    FEBS letters

    2021  Volume 595, Issue 5, Page(s) 563–576

    Abstract: Programmed death-ligand 1 (PD-L1) is a co-inhibitory molecule expressed on tumor cells. Immune checkpoint inhibitors focusing on the PD-L1 mechanism are now being studied for the treatment of various cancer types. However, the regulatory mechanism of PD- ... ...

    Abstract Programmed death-ligand 1 (PD-L1) is a co-inhibitory molecule expressed on tumor cells. Immune checkpoint inhibitors focusing on the PD-L1 mechanism are now being studied for the treatment of various cancer types. However, the regulatory mechanism of PD-L1 is yet to be fully clarified, and a high-throughput system for comparing the abilities of small compounds in regulating PD-L1 has not yet been established. Therefore, we created a HiBiT-tagged lung adenocarcinoma cell line, PC9-KI, for easier and faster detection of changes in PD-L1 protein expression. Using PC9-KI cells, we screened 1280 chemical compounds from the Library of Pharmacologically Active Compounds and identified microtubule polymerization inhibitors and thapsigargin as PD-L1 upregulators and a p97 inhibitor as a PD-L1 downregulator.
    MeSH term(s) Antineoplastic Agents/pharmacology ; B7-H1 Antigen/agonists ; B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/genetics ; B7-H1 Antigen/metabolism ; Benzimidazoles/pharmacology ; Cell Line, Tumor ; Founder Effect ; Gene Expression ; Genes, Reporter ; High-Throughput Screening Assays ; Humans ; Luminescent Measurements ; Oligopeptides/genetics ; Oligopeptides/metabolism ; Protein Engineering/methods ; Quinazolines/pharmacology ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Respiratory Mucosa/drug effects ; Respiratory Mucosa/metabolism ; Respiratory Mucosa/pathology ; Small Molecule Libraries/pharmacology ; Thapsigargin/pharmacology ; Tubulin Modulators/pharmacology ; Valosin Containing Protein/antagonists & inhibitors ; Valosin Containing Protein/genetics ; Valosin Containing Protein/metabolism
    Chemical Substances Antineoplastic Agents ; B7-H1 Antigen ; Benzimidazoles ; CD274 protein, human ; ML240 compound ; Oligopeptides ; Quinazolines ; Recombinant Fusion Proteins ; Small Molecule Libraries ; Tubulin Modulators ; Thapsigargin (67526-95-8) ; VCP protein, human (EC 3.6.4.6) ; Valosin Containing Protein (EC 3.6.4.6)
    Language English
    Publishing date 2021-01-20
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14032
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  10. Article: [Monitoring the side effects of cancer chemotherapy].

    Kurimoto, Ryota / Takiguchi, Yuichi

    Nihon rinsho. Japanese journal of clinical medicine

    2015  Volume 73 Suppl 2, Page(s) 102–106

    MeSH term(s) Administration, Oral ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Drug Monitoring ; Humans ; Neoplasms/drug therapy ; Outpatients ; Patient Care Team
    Chemical Substances Antineoplastic Agents
    Language Japanese
    Publishing date 2015-02
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
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    Zs.A 429: Show issues Location:
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