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  1. Article ; Online: Accessory posterior cerebral artery.

    Endo, Hideki / Ono, Hidetoshi / Nakamura, Hirohiko

    Acta neurologica Belgica

    2024  

    Language English
    Publishing date 2024-02-29
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-024-02489-x
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  2. Article: Fenestration of the posterior cerebral artery P1-P2 junction: A case report.

    Endo, Hideki / Nakamura, Hirohiko

    Radiology case reports

    2024  Volume 19, Issue 6, Page(s) 2192–2195

    Abstract: Fenestration is a rare anatomical variation in the posterior cerebral artery. To the best of our knowledge, there are few reports of fenestrations at the posterior cerebral artery P1-P2 junction. Herein, we report a case of fenestration of the posterior ... ...

    Abstract Fenestration is a rare anatomical variation in the posterior cerebral artery. To the best of our knowledge, there are few reports of fenestrations at the posterior cerebral artery P1-P2 junction. Herein, we report a case of fenestration of the posterior cerebral artery P1-P2 junction diagnosed by 3-T magnetic resonance imaging and magnetic resonance angiography. A 75-year-old woman visited our hospital because of headaches. Magnetic resonance imaging incidentally showed fenestration around the P1-P2 segment of the right posterior cerebral artery. Magnetic resonance angiography revealed a small fenestration at the right posterior cerebral artery P1-P2 junction. The vessel diameter of both limbs forming the fenestration was nearly equal. Careful imaging assessment is important to identify fenestration of the posterior cerebral artery P1-P2 junction. Both magnetic resonance angiography and magnetic resonance imaging were useful for diagnosis in this case.
    Language English
    Publishing date 2024-03-14
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2024.02.088
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  3. Article ; Online: Higher prevalence of nail psoriasis in patients with psoriatic arthritis receiving biologic therapy: A single center cross sectional study.

    Ikumi, Natsumi / Hayama, Koremasa / Kitamura, Noboru / Terui, Tadashi / Takei, Masami / Nakamura, Hideki / Fujita, Hideki

    The Journal of dermatology

    2024  

    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.17196
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  4. Article ; Online: Engineering Hydrogel Production in Mammalian Cells to Synthetically Mimic RNA Granules.

    Nakamura, Hideki

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2312, Page(s) 253–276

    Abstract: Recent studies revealed the biological significance of dynamic multicomponent assemblies of biomolecules inside living cells. Protein and nucleic acid assemblies are biomolecular condensates or non-membrane-bound organelles that have attracted increasing ...

    Abstract Recent studies revealed the biological significance of dynamic multicomponent assemblies of biomolecules inside living cells. Protein and nucleic acid assemblies are biomolecular condensates or non-membrane-bound organelles that have attracted increasing attention. Synthetic tools that manipulate the dynamic assembly/disassembly process of the structures are useful in elucidating both biophysical mechanisms of their assembly/disassembly and physiological roles of the condensates. In this report, general protocols to form and observe synthetic polymer-based condensates in living cells are described using the tool iPOLYMER. Taking advantage of the modular design of the tool, both chemical and light stimuli can induce formation of synthetic condensates inside living cells, which are observed by laser-scanning confocal microscopy. The experimental design described herein should help those who conduct experiments on synthetic manipulation of biomolecular condensates using iPOLYMER and other tools for synthetic manipulation of condensates. Technical notes for using iPOLYMER, including basic protocols of chemical- or light-inducible dimerization techniques (CID/LID), choice of proper control experiments, and advantages/disadvantages are also presented.
    MeSH term(s) Animals ; COS Cells ; Cell Culture Techniques ; Cell Engineering ; Chlorocebus aethiops ; Cytoplasmic Granules/genetics ; Cytoplasmic Granules/metabolism ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/radiation effects ; HEK293 Cells ; Humans ; Hydrogels ; Light ; Microscopy, Confocal ; Microscopy, Fluorescence ; Molecular Mimicry ; Optogenetics ; Peptides/genetics ; Peptides/metabolism ; Protein Domains ; RNA/genetics ; RNA/metabolism ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Sirolimus/pharmacology ; Synthetic Biology ; T-Cell Intracellular Antigen-1/genetics ; T-Cell Intracellular Antigen-1/metabolism ; Transfection
    Chemical Substances Hydrogels ; Peptides ; Recombinant Fusion Proteins ; T-Cell Intracellular Antigen-1 ; RNA (63231-63-0) ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2021-07-06
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1441-9_15
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  5. Article ; Online: Special Issue 'Viral Infection and Autoimmune Diseases'.

    Nakamura, Hideki / Takei, Masami

    Viruses

    2022  Volume 14, Issue 11

    Abstract: Viral infection, which is one of the environmental factors, and human autoimmune diseases are often associated with each other [ ... ]. ...

    Abstract Viral infection, which is one of the environmental factors, and human autoimmune diseases are often associated with each other [...].
    MeSH term(s) Humans ; Virus Diseases ; Autoimmune Diseases
    Language English
    Publishing date 2022-11-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14112491
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  6. Article ; Online: Randomised controlled trial on the effect of video-conference cognitive behavioural therapy for patients with schizophrenia: a study protocol.

    Katsushima, Masayuki / Nakamura, Hideki / Hanaoka, Hideki / Shiko, Yuki / Komatsu, Hideki / Shimizu, Eiji

    BMJ open

    2023  Volume 13, Issue 9, Page(s) e069734

    Abstract: Introduction: Cognitive behavioural therapy for psychosis (CBTp) has demonstrated effectiveness in reducing positive symptoms, improving depression, enhancing coping skills and increasing awareness of illness. However, compared with cognitive ... ...

    Abstract Introduction: Cognitive behavioural therapy for psychosis (CBTp) has demonstrated effectiveness in reducing positive symptoms, improving depression, enhancing coping skills and increasing awareness of illness. However, compared with cognitive behavioural therapy for depression and anxiety, the spread of CBTp in clinical practice is minimal. The present study designed a randomised controlled trial (RCT) research protocol to evaluate whether real-time remote video-conference CBTp (vCBTp) could facilitate access to psychosocial interventions and effectively improve symptoms compared with usual care (UC) for patients with schizophrenia.
    Methods and analysis: This exploratory RCT will consist of two parallel groups (vCBTp+UC and UC alone) of 12 participants (n=24) diagnosed with schizophrenia, schizoaffective disorder or paranoid disorder, who remain symptomatic following pharmacotherapy. Seven 50-min weekly vCBTp interventions will be administered to test efficacy. The primary outcome will be the positive and negative syndrome scale score at week 8. The secondary outcome will be the Beck Cognitive Insight Scale to assess insight, the Patient Health Questionnaire-9 to assess depression, the Generalised Anxiety Disorder-7 to assess anxiety, the 5-level EuroQol 5-dimensional questionnaire to assess quality of life and the Impact of Event Scale-Revised to assess subjective distress about a specific stressful life event. We will take all measurements at 0 weeks (baseline) and at 8 weeks (post-intervention), and apply intention-to-treat analysis.
    Ethics and dissemination: We will conduct this study in the outpatient department of Cognitive Behavioral Therapy Center at Chiba University Hospital. Further, all participants will be informed of the study and will be asked to sign consent forms. We will report according to the Consolidated Standards of Reporting Trials.
    Trial registration number: UMIN000043396.
    MeSH term(s) Humans ; Schizophrenia/therapy ; Outpatients ; Psychotic Disorders/therapy ; Anxiety/therapy ; Cognitive Behavioral Therapy ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2023-09-11
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-069734
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  7. Article ; Online: Randomised controlled trial on the effect of video-conference cognitive behavioural therapy for patients with schizophrenia

    Hideki Hanaoka / Eiji Shimizu / Hideki Nakamura / Hideki Komatsu / Yuki Shiko / Masayuki Katsushima

    BMJ Open, Vol 13, Iss

    a study protocol

    2023  Volume 9

    Abstract: Introduction Cognitive behavioural therapy for psychosis (CBTp) has demonstrated effectiveness in reducing positive symptoms, improving depression, enhancing coping skills and increasing awareness of illness. However, compared with cognitive behavioural ... ...

    Abstract Introduction Cognitive behavioural therapy for psychosis (CBTp) has demonstrated effectiveness in reducing positive symptoms, improving depression, enhancing coping skills and increasing awareness of illness. However, compared with cognitive behavioural therapy for depression and anxiety, the spread of CBTp in clinical practice is minimal. The present study designed a randomised controlled trial (RCT) research protocol to evaluate whether real-time remote video-conference CBTp (vCBTp) could facilitate access to psychosocial interventions and effectively improve symptoms compared with usual care (UC) for patients with schizophrenia.Methods and analysis This exploratory RCT will consist of two parallel groups (vCBTp+UC and UC alone) of 12 participants (n=24) diagnosed with schizophrenia, schizoaffective disorder or paranoid disorder, who remain symptomatic following pharmacotherapy. Seven 50-min weekly vCBTp interventions will be administered to test efficacy. The primary outcome will be the positive and negative syndrome scale score at week 8. The secondary outcome will be the Beck Cognitive Insight Scale to assess insight, the Patient Health Questionnaire-9 to assess depression, the Generalised Anxiety Disorder-7 to assess anxiety, the 5-level EuroQol 5-dimensional questionnaire to assess quality of life and the Impact of Event Scale-Revised to assess subjective distress about a specific stressful life event. We will take all measurements at 0 weeks (baseline) and at 8 weeks (post-intervention), and apply intention-to-treat analysis.Ethics and dissemination We will conduct this study in the outpatient department of Cognitive Behavioral Therapy Center at Chiba University Hospital. Further, all participants will be informed of the study and will be asked to sign consent forms. We will report according to the Consolidated Standards of Reporting Trials.Trial registration number UMIN000043396.
    Keywords Medicine ; R
    Subject code 150
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Thoracic spinal cord injury after surgical removal of a ruptured cerebellar arteriovenous malformation in a patient in the Concorde position: illustrative case.

    Ishikawa, Kohei / Endo, Hideki / Ohtake, Yasufumi / Watanabe, Toshiichi / Nakamura, Hirohiko

    Journal of neurosurgery. Case lessons

    2024  Volume 7, Issue 16

    Abstract: Background: Thoracic spinal cord injury after posterior cranial fossa surgery in younger patients is a rare complication. There have been reports of this complication in tumor and spine fields but not in vascular surgery.: Observations: A 22-year-old- ...

    Abstract Background: Thoracic spinal cord injury after posterior cranial fossa surgery in younger patients is a rare complication. There have been reports of this complication in tumor and spine fields but not in vascular surgery.
    Observations: A 22-year-old-man experienced cerebellar arteriovenous malformation rupture, and the malformation was surgically removed with the man in the Concorde position. After surgery, the man had severe paraplegia, and a thoracic spinal cord injury was diagnosed.
    Lessons: In younger patients, cervical hyperflexion in the Concorde position can cause thoracic spinal cord injury even in surgery for cerebrovascular disease.
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ISSN 2694-1902
    ISSN (online) 2694-1902
    DOI 10.3171/CASE249
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  9. Article ; Online: Dysplastic aberrant left subclavian artery originating from a thoracic intersegmental artery associated with a right aortic arch.

    Ishikawa, Kohei / Ohtake, Yasufumi / Fukuda, Mamoru / Endo, Hideki / Nakamura, Hirohiko

    Surgical and radiologic anatomy : SRA

    2024  Volume 46, Issue 4, Page(s) 519–522

    Abstract: Purpose: A right aortic arch (RAA) is a rare vascular anomaly that often coexists with an aberrant left subclavian artery (ALSA). Due to the rarity of RAA, the development of an ALSA is not well understood.: Method: We describe a case in which a 58- ... ...

    Abstract Purpose: A right aortic arch (RAA) is a rare vascular anomaly that often coexists with an aberrant left subclavian artery (ALSA). Due to the rarity of RAA, the development of an ALSA is not well understood.
    Method: We describe a case in which a 58-year-old man who was scheduled to undergo posterior decompression and fusion surgery for thoracic ossification of the posterior longitudinal ligament from Th1 to Th3 was found to have a RAA and an ALSA.
    Results: Preoperative computed tomography angiography demonstrated a RAA and an ALSA. The ALSA was extremely tortuous and ran in the paraspinal muscles behind the thoracic laminae, which meant it was in the surgical field. The ALSA arose from the descending aorta and bifurcated into the left segmental arteries of Th1 and Th2, and also bifurcated into the left vertebral artery, which had a normal subsequent course. The dysplastic ALSA was considered to have developed from the thoracic intersegmental artery. Based on preoperative examination findings, we performed spinal surgery without vessel injury.
    Conclusion: We report a rare case of a dysplastic ALSA that developed from the thoracic intersegmental artery with a RAA. The knowledge of this anomaly provides safety in spinal surgery of the cervicothoracic junction.
    MeSH term(s) Male ; Humans ; Middle Aged ; Aorta, Thoracic/diagnostic imaging ; Aorta, Thoracic/surgery ; Aorta, Thoracic/abnormalities ; Cardiovascular Abnormalities/diagnostic imaging ; Cardiovascular Abnormalities/surgery ; Cardiovascular Abnormalities/complications ; Subclavian Artery/diagnostic imaging ; Subclavian Artery/abnormalities ; Vascular Malformations/complications
    Language English
    Publishing date 2024-03-13
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 632839-8
    ISSN 1279-8517 ; 0930-312X ; 0930-1038
    ISSN (online) 1279-8517
    ISSN 0930-312X ; 0930-1038
    DOI 10.1007/s00276-024-03333-w
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  10. Article ; Online: Replaced posterior cerebral artery.

    Endo, Hideki / Ishikawa, Kohei / Ono, Hidetoshi / Honjo, Kaori / Nakamura, Hirohiko

    Surgical and radiologic anatomy : SRA

    2024  Volume 46, Issue 3, Page(s) 299–302

    Abstract: Purpose: Replaced posterior cerebral artery (PCA), defined as a hyperplastic anterior choroidal artery (AChA) supplying all branches of the PCA, is an extremely rare anatomical variation. To the best of our knowledge, there are only a few reports of ... ...

    Abstract Purpose: Replaced posterior cerebral artery (PCA), defined as a hyperplastic anterior choroidal artery (AChA) supplying all branches of the PCA, is an extremely rare anatomical variation. To the best of our knowledge, there are only a few reports of replaced PCA.
    Methods: Herein, we report a case of replaced PCA diagnosed by digital subtraction angiography.
    Results: A 76-year-old woman visited a neurosurgical clinic because of headache and vertigo. Magnetic resonance imaging and magnetic resonance angiography incidentally revealed a left internal carotid artery aneurysm. She was referred to our hospital for further examination and treatment of the unruptured intracranial aneurysm. Left internal carotid angiography revealed a paraclinoid aneurysm. We also incidentally found an anomalous hyperplastic AChA distal to the aneurysm. This hyperplastic AChA supplied not only the AChA territory but also the entire PCA territory. No vessels that could be a normal AChA or posterior communicating artery were identified along the left internal carotid artery. Vertebral angiography demonstrated that the left PCA was not visualized. With these findings, we diagnosed anomalous hyperplastic AChoA in this case as replaced PCA.
    Conclusion: Careful imaging assessment is important to identify replaced PCA. Both direct findings of a hyperplastic AChA course and perfusion territory and indirect findings of the absence of the original PCA are useful in the diagnosis of replaced PCA.
    MeSH term(s) Female ; Humans ; Aged ; Posterior Cerebral Artery/diagnostic imaging ; Posterior Cerebral Artery/abnormalities ; Intracranial Aneurysm/diagnostic imaging ; Cerebral Arteries ; Carotid Artery, Internal/abnormalities ; Magnetic Resonance Angiography ; Cerebral Angiography
    Language English
    Publishing date 2024-02-05
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 632839-8
    ISSN 1279-8517 ; 0930-312X ; 0930-1038
    ISSN (online) 1279-8517
    ISSN 0930-312X ; 0930-1038
    DOI 10.1007/s00276-023-03294-6
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