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  1. Book ; Thesis: In vitro optical quality measurements of three intraocular lens models having identical platform

    Son, Hyeck Soo

    2017  

    Author's details vorgelegt von Hyeck Soo Son
    Language English
    Size 97 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2017
    HBZ-ID HT019725217
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 E 742 order for loan Magazin

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  2. Book ; Online: The Role of HMGB1 in Immunity

    Shin, Jeon-Soo / Diamond, Betty / Son, Myoungsun / Son, Myoungsun

    2020  

    Keywords Medicine ; Immunology ; HMGB1 ; secretion ; inflammation ; sepsis ; cancer ; immune function ; potential therapeutics
    Size 1 electronic resource (112 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231581
    ISBN 9782889661343 ; 2889661342
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Identification of broad-spectrum neutralizing antibodies against influenza A virus and evaluation of their prophylactic efficacy in mice.

    Son, Sumin / Ahn, Soo Bin / Kim, Geonyeong / Jang, Yejin / Ko, Chunkyu / Kim, Meehyein / Kim, Sang Jick

    Antiviral research

    2023  Volume 213, Page(s) 105591

    Abstract: Influenza A virus continuously infects humans and the antigenic shifts of this respiratory virus enable it to cross the species barrier, threatening public health with the risk of pandemics. Broadly neutralizing antibodies (bnAbs) that target the ... ...

    Abstract Influenza A virus continuously infects humans and the antigenic shifts of this respiratory virus enable it to cross the species barrier, threatening public health with the risk of pandemics. Broadly neutralizing antibodies (bnAbs) that target the antigenic surface glycoprotein, hemagglutinin (HA), of influenza A virus protect against various subtypes of the virus. Here, we screened a human scFv library, through phage display and panning against recombinant HA proteins, to discover human monoclonal antibodies (mAbs) that are broadly active. Consequently, two human mAbs, named G1 and G2, were identified, which target the HA proteins of the H1N1 and H3N2 subtypes, respectively. G1 was shown to have broad binding ability to different HA subtypes of group 1. By contrast, G2 had higher binding affinity but sensed exclusively H3 subtype-derived HAs. In a cell culture-based virus-neutralizing assay, both G1 and G2 efficiently suppressed infection of the parental influenza A viruses of H1N1 and H3N2 subtypes. Mode-of-action studies showed that the G1 antibody blocked HA2-mediated membrane fusion. Meanwhile, G2 inhibited HA1-mediated viral attachment to host cells. It is noteworthy that both antibodies elicited antibody-dependent cellular cytotoxicity (ADCC) activities by recruiting FcγRIIIA-expressing effector cells. In mouse challenge models, single-shot, intraperitoneal administration of chimeric G1 and G2 antibodies with the mouse IgG constant region completely protected mice from viral infections at doses above 10 and 1 mg/kg, respectively. The newly identified bnAbs, G1 and G2, could provide insight into the development of broad-spectrum antivirals against future pandemic influenza A virus involving group 1- or H3-subtyped strains.
    MeSH term(s) Humans ; Animals ; Mice ; Influenza A virus ; Antibodies, Neutralizing ; Broadly Neutralizing Antibodies ; Antibodies, Viral ; Influenza A Virus, H1N1 Subtype ; Influenza A Virus, H3N2 Subtype ; Hemagglutinin Glycoproteins, Influenza Virus ; Antibodies, Monoclonal ; Hemagglutinins ; Influenza Vaccines ; Influenza, Human
    Chemical Substances Antibodies, Neutralizing ; Broadly Neutralizing Antibodies ; Antibodies, Viral ; Hemagglutinin Glycoproteins, Influenza Virus ; Antibodies, Monoclonal ; Hemagglutinins ; Influenza Vaccines
    Language English
    Publishing date 2023-03-31
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2023.105591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Facile preparation of poly(

    Baipaywad, Phornsawat / Ryu, Naeun / Im, Soo-Seok / Lee, Ukjae / Son, Hyung Bin / Kim, Won Jong / Park, Hansoo

    Designed monomers and polymers

    2022  Volume 25, Issue 1, Page(s) 245–253

    Abstract: Carbon-based nanomaterials, such as carbon nanotubes, fullerenes, nanodiamonds, and graphene, have been investigated for various biomedical applications, including biological imaging, photothermal therapy, drug/gene delivery, cancer therapy, biosensors, ... ...

    Abstract Carbon-based nanomaterials, such as carbon nanotubes, fullerenes, nanodiamonds, and graphene, have been investigated for various biomedical applications, including biological imaging, photothermal therapy, drug/gene delivery, cancer therapy, biosensors, and electrochemical sensors. Graphene oxide (GO) has unique physicochemical properties and can be used to restore conductivity through oxidation. In this study, we developed poly(
    Language English
    Publishing date 2022-08-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2045059-X
    ISSN 1568-5551 ; 1385-772X
    ISSN (online) 1568-5551
    ISSN 1385-772X
    DOI 10.1080/15685551.2022.2111854
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Promoting Homogeneous Zinc-Ion Transfer Through Preferential Ion Coordination Effect in Gel Electrolyte for Stable Zinc Metal Batteries.

    Lee, Sangyeop / Han, Im Kyung / Jeon, Na Gyeong / Lee, Yubin / Son, Hye Bin / Han, Dong-Yeob / Nam, Seoha / Chung, Taehun / Kwak, Myung-Jun / Kim, Youn Soo / Park, Soojin

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2023  Volume 10, Issue 34, Page(s) e2304915

    Abstract: Aqueous zinc metal batteries (AZMBs) are emerging energy storage systems that are poised to replace conventional lithium-ion batteries owing to their intrinsic safety, facile manufacturing process, economic benefits, and superior ionic conductivity. ... ...

    Abstract Aqueous zinc metal batteries (AZMBs) are emerging energy storage systems that are poised to replace conventional lithium-ion batteries owing to their intrinsic safety, facile manufacturing process, economic benefits, and superior ionic conductivity. However, the issues of inferior anode reversibility and dendritic plating during operation remain challenging for the practical use of AZMBs. Herein, a gel electrolyte based on zwitterionic poly(sulfobetaine methacrylate) (poly(SBMA)) dissolved with different concentrations of ZnSO
    Language English
    Publishing date 2023-10-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202304915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Weaning Mice and Adult Mice Exhibit Differential Carbon Tetrachloride-Induced Acute Hepatotoxicity.

    Jeong, Tae Bin / Kwon, Doyoung / Son, Seung Won / Kim, Sou Hyun / Lee, Yun-Hee / Seo, Min-Soo / Kim, Kil Soo / Jung, Young-Suk

    Antioxidants (Basel, Switzerland)

    2020  Volume 9, Issue 3

    Abstract: Age is a risk factor for drug-induced liver injury (DILI). However, there is a limited understanding of pediatric DILI. Here, 2-week-old weaning and 8-week-old adult male ICR mice were intraperitoneally injected with ... ...

    Abstract Age is a risk factor for drug-induced liver injury (DILI). However, there is a limited understanding of pediatric DILI. Here, 2-week-old weaning and 8-week-old adult male ICR mice were intraperitoneally injected with CCl
    Language English
    Publishing date 2020-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox9030201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Biomechanical Comparison of Multilevel Lumbar Instrumented Fusions in Adult Spinal Deformity According to the Upper and Lower Fusion Levels: A Finite Element Analysis.

    Son, Dong-Min / Lee, Soo-Bin / Lee, Sung-Jae / Park, Tae-Hyun / Jang, Ji Eun / Jeong, Seung Jo / Kang, Young-Mi / Lee, Byung Ho

    BioMed research international

    2022  Volume 2022, Page(s) 2534350

    Abstract: Multilevel lumbar fusion with posterior pedicle screw fixation is a widely performed surgical procedure for the management of adult spinal deformity. However, there has not been a comprehensive biomechanical study on the different types of fusion levels ... ...

    Abstract Multilevel lumbar fusion with posterior pedicle screw fixation is a widely performed surgical procedure for the management of adult spinal deformity. However, there has not been a comprehensive biomechanical study on the different types of fusion levels in terms of stability and possible complications. We aimed to investigate the biomechanical properties of multilevel lumbar fusion according to different types of upper and lower fusion levels. Six different types of fusions were performed using three-dimensional finite element models. Type A and B referred to the group of which upper fusion level was L1 and T10, respectively. Subtype 1, 2, and 3 referred to the group of which lower fusion level was L5, S1, and ilium, respectively (A1, L1-L5; A2, L1-S1; A3, L1-ilium; B1, T10-L5; B2, T10-S1; B3, T10-ilium). Flexion, extension, axial rotation, and lateral bending moments were applied, and the risk of screw loosening and failure and adjacent segment degeneration (ASD) was analyzed. Stress at the bone-screw interface of type B3 was lowest in overall motions. The risk of screw failure showed increasing pattern as the upper and lower levels extended in all motions. Proximal range of motion (ROM) increased as the lower fusion level changed from L5 to S1 and the ilium. For axial rotation, type B3 showed higher proximal ROM (16.2°) than type A3 (11.8°). In multilevel lumbar fusion surgery for adult spinal deformity, adding iliac screws and increasing the fusion level to T10-ilium may lower the risk of screw loosening. In terms of screw failure and proximal ASD, however, T10-ilium fusion has a higher potential risk compared with other fusion types. These results will contribute for surgeons to provide adequate patient education regarding screw failure and proximal ASD, when performing multilevel lumbar fusion.
    Language English
    Publishing date 2022-11-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2022/2534350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Flash-Induced High-Throughput Porous Graphene via Synergistic Photo-Effects for Electromagnetic Interference Shielding.

    Lee, Jin Soo / Kim, Jeong-Wook / Lee, Jae Hee / Son, Yong Koo / Kim, Young Bin / Woo, Kyoohee / Lee, Chanhee / Kim, Il-Doo / Seok, Jae Young / Yu, Jong Won / Park, Jung Hwan / Lee, Keon Jae

    Nano-micro letters

    2023  Volume 15, Issue 1, Page(s) 191

    Abstract: Porous 2D materials with high conductivity and large surface area have been proposed for potential electromagnetic interference (EMI) shielding materials in future mobility and wearable applications to prevent signal noise, transmission inaccuracy, ... ...

    Abstract Porous 2D materials with high conductivity and large surface area have been proposed for potential electromagnetic interference (EMI) shielding materials in future mobility and wearable applications to prevent signal noise, transmission inaccuracy, system malfunction, and health hazards. Here, we report on the synthesis of lightweight and flexible flash-induced porous graphene (FPG) with excellent EMI shielding performance. The broad spectrum of pulsed flashlight induces photo-chemical and photo-thermal reactions in polyimide films, forming 5 × 10 cm
    Language English
    Publishing date 2023-08-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2642093-4
    ISSN 2150-5551 ; 2150-5551
    ISSN (online) 2150-5551
    ISSN 2150-5551
    DOI 10.1007/s40820-023-01157-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: SscA is required for fungal development, aflatoxin production, and pathogenicity in Aspergillus flavus.

    Son, Ye-Eun / Park, Hee-Soo

    International journal of food microbiology

    2024  Volume 413, Page(s) 110607

    Abstract: Fungal spores are specialized dormant cells that act as primary reproductive biological particles and exhibit strong viability under extremely harsh conditions. They contaminate a variety of crops and foods, causing severe health hazards to humans and ... ...

    Abstract Fungal spores are specialized dormant cells that act as primary reproductive biological particles and exhibit strong viability under extremely harsh conditions. They contaminate a variety of crops and foods, causing severe health hazards to humans and animals. Previous studies demonstrated that a spore-specific transcription factor SscA plays pivotal roles in the conidiogenesis of the model organism Aspergillus nidulans. In this study, we investigated the biological and genetic functions of SscA in the aflatoxin-producing fungus A. flavus. Deletion of sscA showed reduced conidia formation, lost long-term viability, and exhibited more sensitivity to thermal, oxidative, and radiative stresses. The sscA-deficient strain showed increased aflatoxin B
    MeSH term(s) Animals ; Humans ; Aflatoxins ; Aspergillus flavus ; Virulence/genetics ; Fungal Proteins/genetics ; Aflatoxin B1 ; Spores, Fungal
    Chemical Substances Aflatoxins ; Fungal Proteins ; Aflatoxin B1 (9N2N2Y55MH)
    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 87122-9
    ISSN 1879-3460 ; 0168-1605
    ISSN (online) 1879-3460
    ISSN 0168-1605
    DOI 10.1016/j.ijfoodmicro.2024.110607
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4668: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Promoting Homogeneous Zinc‐Ion Transfer Through Preferential Ion Coordination Effect in Gel Electrolyte for Stable Zinc Metal Batteries

    Sangyeop Lee / Im Kyung Han / Na Gyeong Jeon / Yubin Lee / Hye Bin Son / Dong‐Yeob Han / Seoha Nam / Taehun Chung / Myung‐Jun Kwak / Youn Soo Kim / Soojin Park

    Advanced Science, Vol 10, Iss 34, Pp n/a-n/a (2023)

    2023  

    Abstract: Abstract Aqueous zinc metal batteries (AZMBs) are emerging energy storage systems that are poised to replace conventional lithium‐ion batteries owing to their intrinsic safety, facile manufacturing process, economic benefits, and superior ionic ... ...

    Abstract Abstract Aqueous zinc metal batteries (AZMBs) are emerging energy storage systems that are poised to replace conventional lithium‐ion batteries owing to their intrinsic safety, facile manufacturing process, economic benefits, and superior ionic conductivity. However, the issues of inferior anode reversibility and dendritic plating during operation remain challenging for the practical use of AZMBs. Herein, a gel electrolyte based on zwitterionic poly(sulfobetaine methacrylate) (poly(SBMA)) dissolved with different concentrations of ZnSO4 is proposed. Two‐dimensional correlation spectroscopy based on Raman analysis reveals an enhanced interaction priority between the polar groups in SBMA and the dissolved ions as electrolyte concentration increases, which establishes a robust interaction and renders homogeneous ion distribution. Attributable to the modified coordination, zwitterionic gel polymer electrolyte with 5 mol kg−1 of ZnSO4 (ZGPE‐5) facilitates stable zinc deposition and improves anode reversibility. By taking advantage of preferential coordination, a symmetrical cell evaluation employing ZGPE‐5 demonstrates a cycle life over 3600 h, where ZGPE‐5 also exerts a beneficial effect on the full cell cycling when assembled with Zn0.25V2O5 cathode. This study elucidates changes in the internal ion behavior that are dependent on electrolyte concentrations and pave the way for durable AZMBs.
    Keywords aqueous rechargeable batteries ; ion coordination ; preferential coordination ; zinc metal anodes ; zwitterionic gel electrolytes ; Science ; Q
    Subject code 612
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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