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Article: A case of renomedullary interstitial cell tumor: Radiologic-pathologic correlation.

Yamamoto, Kiyohito / Kawabata, Shigeru / Kurisu, Yoshitaka / Inamoto, Teruo / Yamamoto, Kazuhiro / Osuga, Keigo

2023 Volume 18, Issue 12, Page(s) 4574–4579

Abstract: Renomedullary interstitial cell tumor (RMICT), referred to as a medullary fibroma, is almost always asymptomatic and incidentally identified either at autopsy or upon resection of the kidney for other reasons. Although a few cases of RMICTs that are ... ...

Abstract	Renomedullary interstitial cell tumor (RMICT), referred to as a medullary fibroma, is almost always asymptomatic and incidentally identified either at autopsy or upon resection of the kidney for other reasons. Although a few cases of RMICTs that are large in size and clinically symptomatic have been reported, there are few reports of RMICTs contrasting imaging findings with pathological findings. In this report, we describe a relatively large RMICT case of 3 cm in size, focusing on the radiologic-pathologic correlation.
Language	English
Publishing date	2023-10-18
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2023.09.072
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Article ; Online: A case of renomedullary interstitial cell tumor

Kiyohito Yamamoto / Shigeru Kawabata / Yoshitaka Kurisu / Teruo Inamoto / Kazuhiro Yamamoto / Keigo Osuga

Radiology Case Reports, Vol 18, Iss 12, Pp 4574-

Radiologic-pathologic correlation

2023 Volume 4579

Abstract	Renomedullary interstitial cell tumor (RMICT), referred to as a medullary fibroma, is almost always asymptomatic and incidentally identified either at autopsy or upon resection of the kidney for other reasons. Although a few cases of RMICTs that are large in size and clinically symptomatic have been reported, there are few reports of RMICTs contrasting imaging findings with pathological findings. In this report, we describe a relatively large RMICT case of 3 cm in size, focusing on the radiologic-pathologic correlation.
Keywords	Medullary fibroma ; Renal tumor ; Renomedullary interstitial cell tumor ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Conjunctival epithelial hyperplasia in a patient with a nodular lesion in the palpebral conjunctiva: A case report.

Kawabata, Shigeru / Yoshikawa, Yamato / Kurisu, Yoshitaka / Tajiri, Kensuke / Kida, Teruyo / Hirose, Yoshinobu

Biomedical reports

2022 Volume 16, Issue 4, Page(s) 24

Abstract: The conjunctiva is a thin and delicate mucous membrane lining the inner eyelid and the anterior surface of the eyeball. Although hyperplastic changes can occur due to nonspecific chronic inflammation, 'conjunctival epithelial hyperplasia' has not been ... ...

Abstract	The conjunctiva is a thin and delicate mucous membrane lining the inner eyelid and the anterior surface of the eyeball. Although hyperplastic changes can occur due to nonspecific chronic inflammation, 'conjunctival epithelial hyperplasia' has not been sufficiently established as a pathological entity. Additionally, the immunohistochemical (IHC) features of both the intact conjunctiva epithelium and conjunctival epithelial hyperplasia have not been sufficiently evaluated. The present report describes the case of an 86-year-old man who consulted with an ophthalmologist for a 6-month-old nodular lesion on his left eye. Located in the medial aspect of the left lower palpebral conjunctiva, the lesion was slightly erythematous and smooth. An excisional biopsy of the lesion was performed to obtain a pathological diagnosis. The hematoxylin and eosin sections revealed a thickened conjunctival epithelium composed of hyperplastic cuboidal epithelial cells and goblet cells, indicating conjunctival epithelial hyperplasia. Atypia, increased mitosis and a papillomatous architecture, indicative of neoplastic changes, were not observed. This resulted in conjunctival squamous intraepithelial neoplasia and squamous cell papilloma being ruled out. IHC analysis was performed to further characterize the lesion as well as the intact conjunctival epithelium. The thick conjunctival epithelium was composed of epithelial cells that stained positive for cytokeratin [AE1/AE3 (intensity: +), CK5/6 (intensity: ++), and CK7 (intensity: +)] and p63-positive basal cells (intensity: +) whose presence in the conjunctiva has received insufficient recognition. Moreover, squamous metaplasia was found in a segment of the thick conjunctiva, which exhibited IHC features similar to those of hyperplasia. CK5/6 was positive, indicating endogenous squamous differentiation of the conjunctival epithelial hyperplasia. These findings led to the diagnosis of conjunctival epithelial hyperplasia as a pathological entity. Further collection and analysis of several cases of conjunctival epithelial hyperplasia may lead the development of preventative methods and drug treatments for this lesion, and additional prognostic data, such as the recurrence rate.
Language	English
Publishing date	2022-02-14
Publishing country	England
Document type	Case Reports
ZDB-ID	2763624-0
ISSN	2049-9442 ; 2049-9434
ISSN (online)	2049-9442
ISSN	2049-9434
DOI	10.3892/br.2022.1507
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Article ; Online: Carotid Artery Stenting Using Stent-in-Stent Technique with a Closed-Cell Stent and a Dual-Layer Micromesh Stent: A Case Report.

Yamaguchi, Yoshitaka / Takada, Tatsuro / Uchida, Kazuki / Miyata, Kei / Kurisu, Kota / Okuyama, Tomohiro / Tomeoka, Fumiki / Ajiki, Minoru / Hokari, Masaaki / Asaoka, Katsuyuki

Journal of neuroendovascular therapy

2023 Volume 17, Issue 5, Page(s) 101–106

Abstract: Objective: Recent studies evaluating plaque protrusion at carotid artery stenting (CAS) using optical coherence tomography showed not a few cases of plaque protrusion when using double-layer micromesh stents. We report a case of symptomatic internal ... ...

Abstract	Objective: Recent studies evaluating plaque protrusion at carotid artery stenting (CAS) using optical coherence tomography showed not a few cases of plaque protrusion when using double-layer micromesh stents. We report a case of symptomatic internal carotid artery (ICA) stenosis with at-risk unstable plaques in which CAS was successfully performed using a stent-in-stent technique by the combined use of a closed-cell stent and a dual-layer micromesh stent. Case presentation: An 87-year-old Japanese man with dysarthria and right hemiparesis was diagnosed with atheromatous cerebral embolism caused by severe left ICA stenosis on MRI and DSA. MRI with T1-weighted black blood methods showed high intensities in the plaques of the left ICA, suggesting unstable plaque characteristics with intraplaque hemorrhage components. On day 20, CAS was performed. After the pre-stent dilation under proximal and distal protection, a Carotid WALLSTENT was placed to cover the stenotic lesion. Then, a CASPER Rx was placed from the proximal left ICA to the common carotid artery to cover the Carotid WALLSTENT. Although visible plaque debris was recognized in the aspirated blood, the debris became invisible after aspiration of 1300 mL. Postoperative angiography showed enough dilation of the left ICA, with no plaque protrusion or acute stent thrombosis. The patient had an uneventful postoperative course and was discharged without any neurological sequelae. Conclusion: The present case suggests that the combined stent-in-stent technique using a closed-cell stent and a micromesh stent can be considered as one of the treatment strategies for preventing plaque protrusion and procedural ischemic complications in patients with high-risk carotid plaques.
Language	English
Publishing date	2023-04-19
Publishing country	Japan
Document type	Case Reports
ISSN	2186-2494
ISSN (online)	2186-2494
DOI	10.5797/jnet.cr.2023-0003
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Article ; Online: Management and outcome of adenoid cystic carcinoma of the major salivary glands: the 22-year experience of a single institution.

Ozaki, Akiko / Kawata, Ryo / Kinoshita, Ichita / Higashino, Masaaki / Terada, Tetsuya / Haginomori, Shin-Ichi / Kurisu, Yoshitaka / Hirose, Yoshinobu

Acta oto-laryngologica

2023 Volume 143, Issue 6, Page(s) 536–542

Abstract: Background: Prognostic factors and survival rate are difficult to determine for adenoid cystic carcinoma(AdCC) of salivary glands.: Aims/objectives: To clarify the clinical characteristics of AdCC and examine factors associated with recurrence and ... ...

Abstract	Background: Prognostic factors and survival rate are difficult to determine for adenoid cystic carcinoma(AdCC) of salivary glands. Aims/objectives: To clarify the clinical characteristics of AdCC and examine factors associated with recurrence and prognosis by histopathological grade classification. Materials and methods: Twenty-five patients with AdCC of the parotid gland and 10 patients with AdCC of the submandibular gland were included. We classified AdCC histopathologically by the proportion of solid components. Clinical features, fine-needle aspiration cytology (FNAC), and patient outcomes were examined according to grade. Factors associated with local recurrence and distant metastases were examined. Results: Age was significantly higher in the grade III group than in the grade I group. The grade III group had significantly higher proportions of patients with cN+, pN+, and perineural invasion. In FNAC, lower-grade groups showed higher rates of correct histopathological type. Five-year disease-specific survival and disease-free survival rates were significantly lower in the grade III than in the grade I. Distant metastases were more common among patients with high-stage and perineural invasion. Conclusions: Five-year survival is significantly worse in patients with grade III.
MeSH term(s)	Humans ; Carcinoma, Adenoid Cystic/therapy ; Salivary Gland Neoplasms/therapy ; Salivary Gland Neoplasms/pathology ; Salivary Glands/pathology ; Prognosis ; Disease-Free Survival ; Retrospective Studies ; Neoplasm Recurrence, Local
Language	English
Publishing date	2023-06-16
Publishing country	England
Document type	Journal Article
ISSN	1651-2251
ISSN (online)	1651-2251
DOI	10.1080/00016489.2023.2220371
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Article ; Online: Clinicopathological characteristics of four major histological types of high-grade parotid carcinoma.

Kawata, Ryo / Kinoshita, Ichita / Jinnin, Tsuyoshi / Higashino, Masaaki / Terada, Tetsuya / Kurisu, Yoshitaka / Hirose, Yoshinobu / Tochizawa, Takeshi

International journal of clinical oncology

2023 Volume 28, Issue 12, Page(s) 1597–1606

Abstract: Objective: High-grade parotid carcinoma generally has a poor prognosis, and the histological type is mucoepidermoid carcinoma (MEC), salivary duct carcinoma (SDC), carcinoma ex pleomorphic adenoma (CEPA), or adenoid cystic carcinoma (AdCC) in the ... ...

Abstract	Objective: High-grade parotid carcinoma generally has a poor prognosis, and the histological type is mucoepidermoid carcinoma (MEC), salivary duct carcinoma (SDC), carcinoma ex pleomorphic adenoma (CEPA), or adenoid cystic carcinoma (AdCC) in the majority of cases. Methods: During the 23-year period from September 1999 to December 2022, 250 patients with parotid carcinoma underwent initial treatment and had the histopathological type of their carcinoma. Retrospective study evaluated 111 MEC, SDC, CEPA, or AdCC cases among 134 patients with high-grade parotid carcinoma. We examined pathological and clinical features and prognosis, evaluated factors associated with recurrence, and performed immunohistological examinations. Results: Pathological and clinical features and factors associated with recurrence were different for each histological type. The 10-year disease-free survival rates were as follows: MEC, 34.9%; SDC, 22.6%; CEPA, 47.1%; and AdCC, 56.3%. Human epidermal growth factor receptor type-2 and androgen receptor were positive in 48% and 56% of patients with SDC, respectively, 38% and 25% of those with CEPA. Conclusion: Each histological type has its own pathological and clinical features, recurrence types, and tumor activities, suggesting that differentiating between high-grade parotid carcinomas according to histological type will improve diagnosis, and thus prognosis.
MeSH term(s)	Humans ; Retrospective Studies ; Parotid Neoplasms/pathology ; Salivary Gland Neoplasms/pathology ; Adenoma, Pleomorphic/pathology ; Adenocarcinoma ; Carcinoma, Adenoid Cystic/pathology ; Carcinoma ; Carcinoma, Ductal/pathology
Language	English
Publishing date	2023-10-13
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1400227-9
ISSN	1437-7772 ; 1341-9625
ISSN (online)	1437-7772
ISSN	1341-9625
DOI	10.1007/s10147-023-02416-9
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Zs.A 4828: Show issues

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Article ; Online: A huge rapidly-enlarging multicystic biliary hamartoma.

Ogura, Takeshi / Kurisu, Yoshitaka / Miyano, Akira / Higuchi, Kazuhide

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

2018 Volume 50, Issue 7, Page(s) 723

MeSH term(s)	Aged ; Bile Duct Diseases/diagnostic imaging ; Bile Duct Diseases/pathology ; Bile Ducts, Intrahepatic/pathology ; Cholangiopancreatography, Endoscopic Retrograde ; Female ; Hamartoma/diagnostic imaging ; Hamartoma/pathology ; Humans ; Magnetic Resonance Imaging ; Tomography, X-Ray Computed ; Ultrasonography
Language	English
Publishing date	2018-02-05
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	1459373-7
ISSN	1878-3562 ; 1125-8055
ISSN (online)	1878-3562
ISSN	1125-8055
DOI	10.1016/j.dld.2018.01.136
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Article ; Online: Increase in Chymase-Positive Mast Cells in Recurrent Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma of the Parotid Gland.

Kinoshita, Ichita / Jin, Denan / Higashino, Masaaki / Terada, Tetsuya / Kurisu, Yoshitaka / Takai, Shinji / Kawata, Ryo

International journal of molecular sciences

2021 Volume 22, Issue 23

Abstract: Incomplete excision of pleomorphic adenoma (PA) may result in recurrent pleomorphic adenoma (RPA). Furthermore, long-term neglected PA may become carcinoma ex pleomorphic adenoma (CXPA). In the present study, the relationships between mast cell-derived ... ...

Abstract	Incomplete excision of pleomorphic adenoma (PA) may result in recurrent pleomorphic adenoma (RPA). Furthermore, long-term neglected PA may become carcinoma ex pleomorphic adenoma (CXPA). In the present study, the relationships between mast cell-derived chymase and these tumors were examined. The tumor tissues of PA consisted of either or both glandular and fibrotic structures. Histological features of RPA were almost similar to those of PA, except that they showed multinodular structures. CXPA is composed of a mixture of PA and carcinoma. The main stromal cells in PA were myofibroblasts, whereas fibroblasts constituted the main cellular portion in the stromal tissue of RPA. Cancer-associated fibroblasts (CAFs) were present abundantly in CXPA. With increased VEGF expression, neovascularization tended to increase in RPA or CXPA. Compared with PA, chymase-positive mast cells, as well as chymase gene expression, were increased in the tumor tissues from patients with RPA or CXPA. SCF, TGFβ1, and PCNA-positive staining was widely observed in these tumor tissues. The above results suggest that mast cell-derived chymase through its direct or cooperative effects with other mediators may participate in the pathophysiology of RPA and CXPA.
MeSH term(s)	Adenoma, Pleomorphic/metabolism ; Adenoma, Pleomorphic/pathology ; Adult ; Aged ; Aged, 80 and over ; Cancer-Associated Fibroblasts/metabolism ; Cancer-Associated Fibroblasts/pathology ; Chymases/genetics ; Chymases/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mast Cells/metabolism ; Mast Cells/pathology ; Middle Aged ; Neoplasm Recurrence, Local ; Parotid Neoplasms/metabolism ; Parotid Neoplasms/pathology ; Up-Regulation
Chemical Substances	CMA1 protein, human (EC 3.4.21.39) ; Chymases (EC 3.4.21.39)
Language	English
Publishing date	2021-11-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms222312613
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Article ; Online: Successful salvage surgery of the residual tumor after boron neutron capture therapy (BNCT): A case report.

Higashino, Masaaki / Aihara, Teruhito / Ozaki, Akiko / Hu, Naonori / Isohashi, Kayako / Ono, Koji / Nihei, Keiji / Kurisu, Yoshitaka / Kawata, Ryo

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

2022 Volume 189, Page(s) 110420

Abstract: Salvage surgery after radiation therapy is known to be associated with a high incidence of postoperative complications. We describe a case of a successful salvage surgery after BNCT. In our patient with head and neck carcinoma, cervical lymph node ... ...

Abstract	Salvage surgery after radiation therapy is known to be associated with a high incidence of postoperative complications. We describe a case of a successful salvage surgery after BNCT. In our patient with head and neck carcinoma, cervical lymph node recurrence with adhesion to a large vessel occurred after conventional radiotherapy. This lesion responded well to BNCT. Salvage surgery was subsequently performed to remove the residual tumor. Histopathologically, the isolated tissue contained tumor cells in its center and the surrounding tissue showed severe fibrosis. However, the tissue outside of the irradiation area had almost no fibrosis. BNCT may facilitate salvage surgery after radiotherapy because it causes less injury to the surrounding tissue than conventional radiotherapy. Our experience suggests that BNCT may be a feasible preoperative treatment in patients with inoperable lesions or in those who strongly desire preservation of function.
MeSH term(s)	Boron Compounds ; Boron Neutron Capture Therapy/methods ; Head and Neck Neoplasms/radiotherapy ; Humans ; Neoplasm Recurrence, Local/radiotherapy ; Neoplasm, Residual/radiotherapy ; Salvage Therapy
Chemical Substances	Boron Compounds
Language	English
Publishing date	2022-08-18
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1142596-9
ISSN	1872-9800 ; 0883-2889 ; 0969-8043
ISSN (online)	1872-9800
ISSN	0883-2889 ; 0969-8043
DOI	10.1016/j.apradiso.2022.110420
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Article: Management and outcome of parotid mucoepidermoid carcinoma by histological grade: A 21-year review.

Taniuchi, Masataka / Kawata, Ryo / Terada, Tetsuya / Higashino, Masaaki / Nishimura, Hiromi / Kurisu, Yoshitaka / Kuwabara, Hiroko / Hirose, Yoshinobu

Laryngoscope investigative otolaryngology

2022 Volume 7, Issue 3, Page(s) 766–773

Abstract: Objective: Mucoepidermoid carcinoma (MEC) is the most common malignancy of the parotid gland, but the outcome depends on the histological grade. Therefore, the aim of this study was to evaluate MEC on the basis of histological grade.: Study design: ... ...

Abstract	Objective: Mucoepidermoid carcinoma (MEC) is the most common malignancy of the parotid gland, but the outcome depends on the histological grade. Therefore, the aim of this study was to evaluate MEC on the basis of histological grade. Study design: Retrospective analysis. Methods: We performed a retrospective analysis of data from patients whose initial treatment for MEC of the parotid gland was performed at our department between 1999 and 2021. We examined the association between the Armed Forces Institute of Pathology (AFIP) grade and outcome. Results: The AFIP grades were as follows: low, 26 cases; intermediate, 9 cases; and high, 31 cases. About 50% of cases were correctly diagnosed as malignant, and both grade and histology were accurately determined by fine-needle aspiration cytology in 20% of cases. The 5-year disease-free survival rate was 95.5% and 53.8% in the low-/intermediate- and high-grade cases, respectively. In the high-grade group, cases with recurrence were found to have a higher rate of lymph nodes metastasis than cases without recurrence. Furthermore, in this high-grade group, total sacrifice of the facial nerve did not reduce local recurrence. However, radical resection in the cases without tumor invasion to the nerve has decreased the local recurrence rate. The CRTC1-MAML2 fusion gene was expressed in 42.3% of low-/intermediate- and 14.3% of high-grade cases. Conclusions: The survival rate in MEC was quite different between the low-/intermediate- and high-grade cases. However, the rate of correct assessment of the grade by fine-needle aspiration cytology was poor. In high-grade cases, total sacrifice of the facial nerve may improve the rate of local recurrence in cases without invasion of the main trunk of the nerve. Expression of the CRTC1-MAML2 fusion gene could be helpful in not only the assessment of grade but the prediction of recurrence. Level of evidence: 4.
Language	English
Publishing date	2022-05-21
Publishing country	United States
Document type	Journal Article
ISSN	2378-8038
ISSN	2378-8038
DOI	10.1002/lio2.809
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