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  1. Article: Complex decongestive therapy in hidradenitis suppurativa-related genital lymphoedema: a case report.

    Yaman, Ayşegül / Borman, Pınar / Eşme, Pelin / Çalışkan, Ercan

    Journal of wound care

    2024  Volume 33, Issue Sup2a, Page(s) xxviii–xxxi

    Abstract: Genital lymphoedema is a rare but debilitating and disfiguring complication of longstanding hidradenitis suppurativa (HS). Despite the existence of medical and surgical methods that offer varying success rates in a limited number of cases, no data exist ... ...

    Abstract Genital lymphoedema is a rare but debilitating and disfiguring complication of longstanding hidradenitis suppurativa (HS). Despite the existence of medical and surgical methods that offer varying success rates in a limited number of cases, no data exist about the use of complex decongestive therapy (CDT) in HS-related genital lymphoedema. This case report describes the treatment and outcome of a 56-year-old male patient with severe scrotal lymphoedema due to underlying HS (Hurley stage 3). The patient was unresponsive to various topical and systemic antibiotics and biological agents, including adalimumab and certolizumab pegol. When the patient was assessed, ixekizumab treatment for his HS was planned. He had progressive oedema in the genital area for two years with difficulty in wearing trousers and having sexual intercourse, and painful urination. CDT was recommended for three days a week concurrently with ixekizumab treatment. The patient and his wife were also educated about self-drainage techniques and skincare maintenance. After six sessions of CDT over 14 days, the patient demonstrated a significant reduction in scrotal measurements. He achieved a better scrotal contour, the degree of the buried penis was decreased, and urination was easier and painless. The findings of this case report showed that CDT was an easily applicable, practical and promising method that offered a rapid treatment response for HS-related genital lymphoedema.
    MeSH term(s) Humans ; Male ; Middle Aged ; Hidradenitis Suppurativa/therapy ; Hidradenitis Suppurativa/surgery ; Lymphedema/therapy ; Lymphedema/surgery ; Antibodies, Monoclonal, Humanized ; Genitalia
    Chemical Substances Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1353951-6
    ISSN 0969-0700
    ISSN 0969-0700
    DOI 10.12968/jowc.2024.33.Sup2a.xxviii
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Facial Bier Spots Unresponsive to Botulinum Toxin: A Case Series.

    Esme, Pelin / Beksac, Burcu / Akoglu, Gulsen / Caliskan, Ercan

    Dermatology practical & conceptual

    2023  Volume 13, Issue 1

    Language English
    Publishing date 2023-01-01
    Publishing country Austria
    Document type Letter
    ZDB-ID 2685397-8
    ISSN 2160-9381
    ISSN 2160-9381
    DOI 10.5826/dpc.1301a32
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  3. Article ; Online: The Comparative Dermal Stimulation Potential of Constant-Volume and Constant-Amount Diluted Calcium Hydroxylapatite Injections Versus the Concentrated Form.

    Botsali, Aysenur / Erbil, Hakan / Eşme, Pelin / Gamsızkan, Mehmet / Aksoy, Ali Okan / Caliskan, Ercan

    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

    2023  Volume 49, Issue 9, Page(s) 871–876

    Abstract: Introduction: Biostimulation properties of diluted and hyperdiluted calcium hydroxylapatite (CaHA) injections have become increasingly popular. However, the existing data are insufficient to certify a particular dose-response pattern.: Objective: To ... ...

    Abstract Introduction: Biostimulation properties of diluted and hyperdiluted calcium hydroxylapatite (CaHA) injections have become increasingly popular. However, the existing data are insufficient to certify a particular dose-response pattern.
    Objective: To assess and compare the dermal stimulation potentials of different concentrations of CaHA injections.
    Materials and methods: Two independent experiments (Experiment-1: constant injection volume vs Experiment-2: constant CaHA amount) included 4 study groups each, and these experimental groups were placed consecutively on the abdominal skin of a juvenile Yorkshire pig. Histopathological and immunohistochemical stainings were performed on punch biopsy materials collected 4 months after the injection day.
    Results: The fibroblast count significantly decreased upon dilution from 1:3 to 1:19 in experiment 1 ( p = .000) but still higher than the control group. In experiment 1, the collagen density of the concentrated form was more elevated than the 1:19 dilution and the negative control groups ( p = .034 and .000, respectively) but similar to the 1:3 dilution ( p = .123). No significant difference was observed between the groups regarding collagen density with a standard amount of CaHA (0.2 mL, 30%) ( p > .05).
    Conclusion: Despite the efficacy being more pronounced till 1:3 dilution, hyperdiluted CaHA at any dilution ratio up to 1:19 can provide a higher fibroblast count than the negative control group.
    MeSH term(s) Animals ; Swine ; Durapatite/chemistry ; Calcium ; Skin Aging ; Skin ; Collagen ; Cosmetic Techniques ; Biocompatible Materials
    Chemical Substances Durapatite (91D9GV0Z28) ; Calcium (SY7Q814VUP) ; Collagen (9007-34-5) ; Biocompatible Materials
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1227586-4
    ISSN 1524-4725 ; 1076-0512
    ISSN (online) 1524-4725
    ISSN 1076-0512
    DOI 10.1097/DSS.0000000000003874
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  4. Article ; Online: Commentary on "Surgical and postsurgical wound care in hidradenitis suppurativa".

    Botsali, Ayşenur / Eşme, Pelin / Caliskan, Ercan

    Dermatologic therapy

    2020  Volume 33, Issue 6, Page(s) e14075

    MeSH term(s) Hidradenitis Suppurativa/diagnosis ; Hidradenitis Suppurativa/surgery ; Humans ; Skin Transplantation ; Wound Healing
    Language English
    Publishing date 2020-08-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.14075
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  5. Article: An Anti-Interleukin-17A Monoclonal Antibody, Ixekizumab, in the Treatment of Resistant Hidradenitis Suppurativa: A Case Series.

    Esme, Pelin / Botsali, Aysenur / Akoglu, Gulsen / Caliskan, Ercan

    Skin appendage disorders

    2022  Volume 8, Issue 4, Page(s) 342–345

    Abstract: Introduction: Although adalimumab is the only approved biologic for the treatment of hidradenitis suppurativa (HS), the treatment response may not be satisfactory in all patients. Recently, many other biological agents, including interleukin 17 ... ...

    Abstract Introduction: Although adalimumab is the only approved biologic for the treatment of hidradenitis suppurativa (HS), the treatment response may not be satisfactory in all patients. Recently, many other biological agents, including interleukin 17 inhibitors such as ixekizumab, have shown promise.
    Case presentations: Five severe HS (Hurley stage III) patients resistant to conventional treatments and adalimumab for at least 3 months were recruited. Patients were prescribed ixekizumab with a scheme approved for psoriasis (160 mg once, followed by 80 mg at weeks 2, 4, 6, 8, 10, and 12.) The primary outcome measure was achieving the Hidradenitis Suppurativa Clinical Response (HiSCR) score following 12 weeks. Secondary outcome measures included the patient-reported Dermatology Life Quality Index (DLQI) and visual analog scale (VAS). Four of 5 patients (80%) achieved HiSCR. While improvement was observed in the VAS and DLQI scores of 4 patients, the decline was limited in 1 patient. No adverse event was recorded related to ixekizumab.
    Conclusion: The result of our observation suggests that ixekizumab may be effective for HS, especially in challenging cases.
    Language English
    Publishing date 2022-02-09
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2806972-9
    ISSN 2296-9160 ; 2296-9195
    ISSN (online) 2296-9160
    ISSN 2296-9195
    DOI 10.1159/000521860
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  6. Article ; Online: The role of online consultation requests to personal social media accounts and instant messaging services of dermatologists in occupational burnout: An emerging problem.

    Demirel Öğüt, Neslihan / Öğüt, Çağrı / Eşme, Pelin

    Journal of cosmetic dermatology

    2021  Volume 21, Issue 6, Page(s) 2542–2549

    Abstract: Background: Burnout affects all physicians, including dermatologists. Long working hours, high workload, and work-related activities outside working hours are common risk factors for burnout that disrupt the work-life balance. This study aimed to ... ...

    Abstract Background: Burnout affects all physicians, including dermatologists. Long working hours, high workload, and work-related activities outside working hours are common risk factors for burnout that disrupt the work-life balance. This study aimed to evaluate dermatologists' approach to online consultation requests via social media (SM) and instant messaging services (IMS), the psychological effects of these consultations on dermatologists, and their relationship with burnout syndrome.
    Materials and methods: A cross-sectional, descriptive research was conducted as an online survey using Google Forms. The survey consisted of 55 items and was sent to dermatologists through a closed Facebook group of the Turkish Society of Dermatology. The burnout levels of dermatologists were evaluated using three subscales of the Maslach Burnout Inventory (MBI): emotional exhaustion (EE), depersonalization (DP), and personal achievement (PA).
    Results: Out of the total 270 participants, 268 (99.3%) participants reported using SM and IMS, whereas 263 (98.1%) received personal consultation requests on these applications. Among all IMS, WhatsApp (n=258, 98.1%) was the most common IMS for online consultation requests. Median (IQR) scores for EE, DP, and PA subscales were 18 (11), 6 (5), and 21 (6), respectively. A positive correlation was observed between the frequency of online consultation requests and MBI-EE subscale scores (r = 0.136; 95% CI, 0.013-0.254; p = 0.026). Fatigue (95.1%), anger (66.6%), and unhappiness (45.2%) were among the most common adverse effects of online consultations on dermatologists.
    Conclusion: Online consultation requests to dermatologists' personal IMS and SM accounts can lead to burnout. The current study findings raise the awareness of the risks of burnout among dermatologists. There is an implicit need for further research, mobile apps other than frequently used IMS and SM apps, and regulations to avoid problems related to the consequences of online dermatology consultations through IMS and SM.
    MeSH term(s) Burnout, Professional/diagnosis ; Burnout, Professional/etiology ; Burnout, Professional/psychology ; Cross-Sectional Studies ; Dermatologists ; Humans ; Referral and Consultation ; Social Media ; Surveys and Questionnaires
    Language English
    Publishing date 2021-08-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.14417
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  7. Article ; Online: Psychogenic purpura (Gardner-Diamond syndrome) in a hemodialysis patient.

    Akoglu, Gulsen / Bulut, Mesudiye / Esme, Pelin / Akoglu, Hadim

    Dermatologic therapy

    2021  Volume 34, Issue 2, Page(s) e14789

    MeSH term(s) Autoimmune Diseases ; Factitious Disorders ; Humans ; Psychotic Disorders ; Purpura/diagnosis ; Purpura/etiology ; Renal Dialysis ; Skin Diseases, Vascular
    Language English
    Publishing date 2021-01-28
    Publishing country United States
    Document type Letter
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.14789
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  8. Article ; Online: Comparison of fractional erbium:YAG laser-assisted tranexamic acid delivery alone and in combination with oral tranexamic acid in melasma.

    Botsali, Aysenur / Esme, Pelin / Erbil, Hakan / Caliskan, Ercan

    Lasers in medical science

    2022  Volume 37, Issue 7, Page(s) 2823–2830

    Abstract: Tranexamic acid (TA) emerged as a promising agent for melasma. However, due to its hydrophilic structure, topical TA should be combined with a penetration-enhancing strategy to augment efficacy. To evaluate the efficacy of fractional erbium:YAG laser- ... ...

    Abstract Tranexamic acid (TA) emerged as a promising agent for melasma. However, due to its hydrophilic structure, topical TA should be combined with a penetration-enhancing strategy to augment efficacy. To evaluate the efficacy of fractional erbium:YAG laser-assisted delivery (LAD) of topical TA 5% either with or without oral TA treatment in recalcitrant melasma patients. The authors retrospectively assessed the treatment outcomes of melasma patients treated by fractional erbium:YAG LAD of topical TA 5%. Patients receiving a standard protocol including four biweekly laser sessions were eligible. The study included two groups: group 1 patients received oral TA and LAD of topical TA 5%, and group 2 patients received only LAD of topical TA 5%. Two blinded dermatologists reported pre-treatment and post-treatment modified MASI (mMASI) scores. Mean mMASI scores in both group 1 (n = 15) and group 2 (n = 19) were significantly lower at the end of the treatment than baseline values (p = 0.001; p = 0.022, respectively). The decrease of mMASI scores were higher in group 1 (median = 2.1) (64.7%) than in group 2 (median = 1.2) (41.8%) (p = 0.027). Fractional erbium:YAG LAD of topical TA 5% is an efficient treatment regimen for melasma patients recalcitrant to conventional treatment approaches. The implementation of oral TA to this regimen improves the therapeutic outcomes.
    MeSH term(s) Erbium ; Humans ; Lasers, Solid-State/therapeutic use ; Melanosis/drug therapy ; Retrospective Studies ; Tranexamic Acid ; Treatment Outcome
    Chemical Substances Tranexamic Acid (6T84R30KC1) ; Erbium (77B218D3YE)
    Language English
    Publishing date 2022-03-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 632808-8
    ISSN 1435-604X ; 0268-8921
    ISSN (online) 1435-604X
    ISSN 0268-8921
    DOI 10.1007/s10103-022-03547-7
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  9. Article ; Online: A case report of episcleral artery embolism caused by hyaluronic acid injection into the malar area.

    Akoglu, Gulsen / Ozge, Gokhan / Eşme, Pelin / Erbil, Hakan

    Journal of cosmetic dermatology

    2020  Volume 19, Issue 12, Page(s) 3420–3422

    MeSH term(s) Dermal Fillers/adverse effects ; Embolism/chemically induced ; Humans ; Hyaluronic Acid/adverse effects ; Ophthalmic Artery
    Chemical Substances Dermal Fillers ; Hyaluronic Acid (9004-61-9)
    Language English
    Publishing date 2020-08-26
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.13663
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  10. Article ; Online: Increased prevalence of family history of Alzheimer's disease in hidradenitis suppurativa: Cross-sectional analysis of 192 HS patients.

    Esme, Pelin / Esme, Mert / Caliskan, Ercan

    Dermatologic therapy

    2020  Volume 33, Issue 6, Page(s) e14219

    MeSH term(s) Alzheimer Disease/epidemiology ; Alzheimer Disease/genetics ; Cross-Sectional Studies ; Hidradenitis Suppurativa/diagnosis ; Hidradenitis Suppurativa/epidemiology ; Hidradenitis Suppurativa/genetics ; Humans ; Prevalence ; Risk Factors
    Language English
    Publishing date 2020-09-11
    Publishing country United States
    Document type Letter
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.14219
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