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  1. Article ; Online: Recognition of facial expression of fetuses by artificial intelligence (AI).

    Miyagi, Yasunari / Hata, Toshiyuki / Bouno, Saori / Koyanagi, Aya / Miyake, Takahito

    Journal of perinatal medicine

    2021  Volume 49, Issue 5, Page(s) 596–603

    Abstract: Objectives: The development of the artificial intelligence (AI) classifier to recognize fetal ... eliminated before preparation. Next, we created a deep learning AI classifier with the data. Statistical ... values such as accuracy for the test dataset and the AI confidence score profiles for each category ...

    Abstract Objectives: The development of the artificial intelligence (AI) classifier to recognize fetal facial expressions that are considered as being related to the brain development of fetuses as a retrospective, non-interventional pilot study.
    Methods: Images of fetal faces with sonography obtained from outpatient pregnant women with a singleton fetus were enrolled in routine conventional practice from 19 to 38 weeks of gestation from January 1, 2020, to September 30, 2020, with completely de-identified data. The images were classified into seven categories, such as eye blinking, mouthing, face without any expression, scowling, smiling, tongue expulsion, and yawning. The category in which the number of fetuses was less than 10 was eliminated before preparation. Next, we created a deep learning AI classifier with the data. Statistical values such as accuracy for the test dataset and the AI confidence score profiles for each category per image for all data were obtained.
    Results: The number of fetuses/images in the rated categories were 14/147, 23/302, 33/320, 8/55, and 10/72 for eye blinking, mouthing, face without any expression, scowling, and yawning, respectively. The accuracy of the AI fetal facial expression for the entire test data set was 0.985. The accuracy/sensitivity/specificity values were 0.996/0.993/1.000, 0.992/0.986/1.000, 0.985/1.000/0.979, 0.996/0.888/1.000, and 1.000/1.000/1.000 for the eye blinking, mouthing, face without any expression, scowling categories, and yawning, respectively.
    Conclusions: The AI classifier has the potential to objectively classify fetal facial expressions. AI can advance fetal brain development research using ultrasound.
    MeSH term(s) Artificial Intelligence ; Brain/growth & development ; Face/diagnostic imaging ; Facial Expression ; Female ; Fetal Development ; Fetal Movement/physiology ; Fetus/diagnostic imaging ; Humans ; Pregnancy ; Ultrasonography, Prenatal/methods
    Language English
    Publishing date 2021-02-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 123512-6
    ISSN 1619-3997 ; 0300-5577 ; 0936-174X
    ISSN (online) 1619-3997
    ISSN 0300-5577 ; 0936-174X
    DOI 10.1515/jpm-2020-0537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Ai to nikushimi

    Miyagi, Otoya

    sono shinri to byori. [Love and hatred; its psychology and pathology]

    1967  

    MeSH term(s) Hate ; Love
    Language Japanese
    Size ix, 192, 12 p. :, illus.
    Publisher Iwanami
    Publishing place Tokyo
    Document type Book
    Note First published 1963.
    Database Catalogue of the US National Library of Medicine (NLM)

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  3. Article ; Online: Long-term Health-related Quality of Life and Physical Function of COVID-19 Survivors with ICU-acquired Weakness.

    Taketa, Tomoyo / Uchiyama, Yuki / Miyagi, Yohei / Yamakawa, Seiya / Seo, Tetsu / Yanagida, Ai / Sasanuma, Naoki / Kodama, Norihiko / Domen, Kazuhisa

    Progress in rehabilitation medicine

    2024  Volume 9, Page(s) 20240012

    Abstract: Objectives: This study examined the long-term health-related quality of life (HRQOL) and physical function of coronavirus 2019 (COVID-19) survivors diagnosed with intensive care unit-acquired weakness (ICU-AW). The correlation between muscle weakness at ...

    Abstract Objectives: This study examined the long-term health-related quality of life (HRQOL) and physical function of coronavirus 2019 (COVID-19) survivors diagnosed with intensive care unit-acquired weakness (ICU-AW). The correlation between muscle weakness at ICU discharge and HRQOL was assessed.
    Methods: A retrospective study was conducted on COVID-19 patients admitted to the ICU at Hyogo Medical University Hospital between January 2021 and November 2021. The HRQOL was evaluated using the SF-36 questionnaire, and physical function, including muscle strength assessed by the Medical Research Council Sum Score (MRC-SS), grip strength, and the 6-min walk distance (6MWD), were assessed 18 months after the onset. ICU-AW was diagnosed in patients with an MRC-SS of less than 48 at ICU discharge. We investigated the correlations between the MRC-SS at ICU discharge and the long-term clinical outcomes.
    Results: We included 26 patients, with 13 having ICU-AW. In the long-term follow-up, the ICU-AW group had significantly lower scores than the no ICU-AW group in the SF-36 subscales such as Physical Functioning (PF), Role Limitation-Physical (RP), Bodily Pain (BP), Vitality (VT), Social Functioning (SF), and Role Limitation-Emotional (RE), as well as in the Physical Component Summary Score (PCS). The muscle strength was also decreased in the ICU-AW group. The MRC-SS at ICU discharge was positively correlated with PF, RP, BP, SF, RE, and PCS in SF-36 at the 18-month follow-up.
    Conclusions: COVID-19 survivors with ICU-AW experienced a long-term decline in HRQOL, and muscle weakness at ICU discharge was correlated with the long-term HRQOL.
    Language English
    Publishing date 2024-04-03
    Publishing country Japan
    Document type Journal Article
    ISSN 2432-1354
    ISSN (online) 2432-1354
    DOI 10.2490/prm.20240012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A rare case of fibrohistiocytic hepatic inflammatory pseudotumor with cholecystocholangitis showing positive IgG4 staining.

    Miyagi, Ai / Fujimoto, Daisaku / Yoshikawa, Akina / Okushi, Seiko / Miyagi, Junko / Matsumoto, Ryosuke / Ogata, Shinya / Bando, Yoshiaki / Ogawa, Hirohisa / Tanahashi, Toshihito

    Clinical journal of gastroenterology

    2022  Volume 15, Issue 5, Page(s) 975–980

    Abstract: Inflammatory pseudotumor (IPT) is a rare benign mass characterized by infiltration of inflammatory cells and proliferation of fibrous tissues. Consistent with increasing knowledge about IgG4-related disease (RD), it has been implicated in the etiology of ...

    Abstract Inflammatory pseudotumor (IPT) is a rare benign mass characterized by infiltration of inflammatory cells and proliferation of fibrous tissues. Consistent with increasing knowledge about IgG4-related disease (RD), it has been implicated in the etiology of hepatic IPT, which is pathologically classified into two categories with respect to the proportion of IgG4-positive plasma cells: fibrohistiocytic- and lymphoplasmacytic-type. A 66-year-old man was admitted for treatment of cholecystocholangitis. Incidentally, abdominal computed tomography (CT) revealed an ambiguous low-density mass within segment 4 (S4) of the liver. Magnetic resonance imaging (MRI) showed the typical images of hepatic IPT within S4. Together with CT and MRI imaging, we suspected hepatic IPT, and had the opportunity to biopsy the S4 lesion during surgery for cholecystitis. Histopathological examination of liver tissue showed diffuse fibrous tissues, dense lymphoplasmacytic infiltration, and obliterative phlebitis with no evidence of malignancy. Despite infiltration of IgG4-positive plasma cells, these histological findings corresponded with fibrohistiocytic-type hepatic IPT. Similarly, in the resected gallbladder, relatively abundant IgG4-positive cells were observed, but not entirely consistent with IgG4-RD criteria. Although IgG4 immunostaining can be useful for the classification of hepatic IPT, the present histological tissues were borderline condition defined by IgG4-RD criteria. This rare case of hepatic IPT suggests a future focus on the borderline histological features of IgG4-RD.
    MeSH term(s) Aged ; Granuloma, Plasma Cell/diagnosis ; Granuloma, Plasma Cell/diagnostic imaging ; Humans ; Immunoglobulin G ; Immunoglobulin G4-Related Disease ; Immunohistochemistry ; Male ; Staining and Labeling
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2022-06-30
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 2429411-1
    ISSN 1865-7265 ; 1865-7257
    ISSN (online) 1865-7265
    ISSN 1865-7257
    DOI 10.1007/s12328-022-01663-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effect of Optimizing Medical Rehabilitation System for Patients with Coronavirus Disease 2019 Using the Functional Resonance Analysis Method.

    Sasanuma, Naoki / Takahashi, Keiko / Yanagida, Ai / Miyagi, Yohei / Yamakawa, Seiya / Seo, Tetsu / Uchiyama, Yuki / Kodama, Norihiko / Domen, Kazuhisa

    Progress in rehabilitation medicine

    2023  Volume 8, Page(s) 20230032

    Abstract: Objectives: Coronavirus infection 2019 (COVID-19) is an indication for rehabilitation medicine, especially in severe cases. However, there has been no system analysis of safe and continuous provision of medical rehabilitation for COVID-19 patients. The ... ...

    Abstract Objectives: Coronavirus infection 2019 (COVID-19) is an indication for rehabilitation medicine, especially in severe cases. However, there has been no system analysis of safe and continuous provision of medical rehabilitation for COVID-19 patients. The aim of this study was to confirm the effectiveness of rehabilitation for severe COVID-19 and to analyze the optimization of the medical rehabilitation system using the Functional Resonance Analysis Method (FRAM).
    Methods: The subject of the analysis was the medical rehabilitation system itself, which had been implemented by the Rehabilitation Center of our hospital in response to the increased number of COVID-19 patients. In the FRAM analysis, Functions were identified, and their relationships were examined. Functions were established using a hierarchical cross-check by the authors. Patient outcomes resulting from optimization of the rehabilitation system were length of hospital stay, patient independence in daily living, and rehabilitation-related medical costs, and these were statistically validated.
    Results: In repeated optimizations of the rehabilitation system, the main issues were "handling of infected patients and isolation of usual clinical practice," "staff rotation," and "remote consultation". The modification of the medical rehabilitation system was associated with shorter hospital stays, shorter periods of time without prescription, faster improvement in independence of daily living, and lower rehabilitation-related medical costs.
    Conclusions: Optimization at each stage of medical rehabilitation resulted in positive effects on patient outcomes. FRAM is useful for identifying and the optimization of key functions.
    Language English
    Publishing date 2023-09-26
    Publishing country Japan
    Document type Journal Article
    ISSN 2432-1354
    ISSN (online) 2432-1354
    DOI 10.2490/prm.20230032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Mitochondrial DNA mutations can influence the post-implantation development of human mosaic embryos.

    Ijuin, Akifumi / Ueno, Hiroe / Hayama, Tomonari / Miyai, Shunsuke / Miyakoshi, Ai / Hamada, Haru / Sueyoshi, Sumiko / Tochihara, Shiori / Saito, Marina / Hamanoue, Haruka / Takeshima, Teppei / Yumura, Yasushi / Miyagi, Etsuko / Kurahashi, Hiroki / Sakakibara, Hideya / Murase, Mariko

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1215626

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-08-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1215626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Early gastric cancer with lanthanum deposition mucosa by endoscopic submucosal dissection: a case report and literature review.

    Fujimoto, Daisaku / Miyagi, Ai / Tamura, Ushio / Takahashi, Sayo / Okushi, Seiko / Miyagi, Junko / Ogawa, Hirohisa / Tanahashi, Toshihito

    Clinical journal of gastroenterology

    2021  Volume 14, Issue 5, Page(s) 1344–1349

    Abstract: Lanthanum carbonate is used to prevent hyperphosphatemia in dialysis patients with chronic renal failure and generally recognized as poorly absorbed by the gastrointestinal tract. However, some clinical cases of lanthanum deposition in the stomach have ... ...

    Abstract Lanthanum carbonate is used to prevent hyperphosphatemia in dialysis patients with chronic renal failure and generally recognized as poorly absorbed by the gastrointestinal tract. However, some clinical cases of lanthanum deposition in the stomach have been shown. In addition, few endoscopic images of lanthanum deposition have been reported, particularly with respect to early-stage gastric cancer. A 64-year-old man with 22 years history of dialysis was treated with lanthanum carbonate for 3 years. With screening esophagogastroduodenoscopy, he was diagnosed with intramucosal gastric cancer, surrounded by the specific endoscopic images of the lanthanum deposition, and underwent endoscopic submucosal dissection. Histopathologically, massive accumulations of macrophages containing fine, granular, eosinophilic materials were observed in the lamina propria. These eosinophilic depositions were present in the lamina propria of the non-tumor region, but not in that of the tumor region. The histological features were further identified as lanthanum phosphate deposition by scanning electron microscopy. This case indicates the clinical significance of lanthanum deposition associated with gastric cancer. It is further required to evaluate more endoscopic images of the gastric mucosa, especially intramucosal cancer, with lanthanum deposition.
    MeSH term(s) Endoscopic Mucosal Resection ; Gastric Mucosa ; Humans ; Hyperphosphatemia/etiology ; Lanthanum/adverse effects ; Male ; Middle Aged ; Stomach Neoplasms/surgery
    Chemical Substances Lanthanum (6I3K30563S)
    Language English
    Publishing date 2021-06-01
    Publishing country Japan
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2429411-1
    ISSN 1865-7265 ; 1865-7257
    ISSN (online) 1865-7265
    ISSN 1865-7257
    DOI 10.1007/s12328-021-01453-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Potential of Artificial Intelligence for Estimating Japanese Fetal Weights.

    Miyagi, Yasunari / Miyake, Takahito

    Acta medica Okayama

    2020  Volume 74, Issue 6, Page(s) 483–493

    Abstract: We developed an artificial intelligence (AI) method for estimating fetal weights of Japanese ... length. The AI comprised of neural network architecture was trained by deep learning with a dataset ... the fetal weights of Japanese fetuses by t-test and Bland-Altman analyses, respectively. The residuals of the AI ...

    Abstract We developed an artificial intelligence (AI) method for estimating fetal weights of Japanese fetuses based on the gestational weeks and the bi-parietal diameter, abdominal circumference, and femur length. The AI comprised of neural network architecture was trained by deep learning with a dataset that consists of ± 2 standard devia-tion (SD), ± 1.5SD, and ± 0SD categories of the approved standard values of ultrasonic measurements of the fetal weights of Japanese fetuses (Japan Society of Ultrasonics in Medicine [JSUM] data). We investigated the residuals and compared 2 other regression formulae for estimating the fetal weights of Japanese fetuses by t-test and Bland-Altman analyses, respectively. The residuals of the AI for the test dataset that was 12.5% of the JSUM data were 6.4 ± 2.6, -3.8 ± 8.6, and -0.32 ± 6.3 (g) at -2SD, +2SD, and all categories, respectively. The residu-als of another AI method created with all of the JSUM data, of which 20% were randomized validation data, were -1.5 ± 9.4, -2.5 ± 7.3, and -1.1 ± 6.7 (g) for -2SD, +2SD, and all categories, respectively. The residuals of this AI were not different from zero, whereas those of the published formulae differed from zero. Though vali-dation is required, the AI demonstrated potential for generating fetal weights accurately, especially for extreme fetal weights.
    MeSH term(s) Asian Continental Ancestry Group ; Datasets as Topic ; Deep Learning/standards ; Female ; Fetal Weight ; Gestational Age ; Humans ; Japan ; Pregnancy ; Ultrasonography, Prenatal
    Language English
    Publishing date 2020-12-23
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 188415-3
    ISSN 0386-300X ; 0001-6152
    ISSN 0386-300X ; 0001-6152
    DOI 10.18926/AMO/61207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Intentions for catch-up HPV vaccination in Japan: an internet survey.

    Nakagawa, Satoshi / Yagi, Asami / Ueda, Yutaka / Ikeda, Sayaka / Kakuda, Mamoru / Hiramatsu, Kosuke / Miyoshi, Ai / Kimura, Toshihiro / Hirai, Kei / Sekine, Masayuki / Nakayama, Tomio / Kobayashi, Eiji / Miyagi, Etsuko / Enomoto, Takayuki / Kimura, Tadashi

    International journal of clinical oncology

    2023  Volume 28, Issue 12, Page(s) 1667–1679

    Abstract: Purpose: In Japan, Japan's Ministry of Health, Labor, and Welfare decided to suspend govermental recommendation for HPV vaccination in FY 2013. The HPV vaccination rate for those born in FY 2000 or thereafter declined dramatically. In 2021, the " ... ...

    Abstract Purpose: In Japan, Japan's Ministry of Health, Labor, and Welfare decided to suspend govermental recommendation for HPV vaccination in FY 2013. The HPV vaccination rate for those born in FY 2000 or thereafter declined dramatically. In 2021, the "suspension of recommendation" ended. The catch-up vaccinations for the unvaccinated have been offered nationwide from FY 2022 to FY 2024. We aimed to quantify the vaccination intentions and characteristics of those young women now eligible for catch-up vaccination.  METHODS: In February of 2022, we conducted an internet survey targeted women who were born in 1997-2004 but who had not yet been HPV vaccinated.
    Results: We received 1,648 valid responses. 41.6% of the respondents wanted to uptake the catch-up HPV vaccination, 29.7% were undecided, and 28.7% did not want to be vaccinated. The intention to uptake catch-up HPV vaccination was associated with a good history of gynecological visits, intention to receive cervical cancer screening, sexual activity, degree of anxiety about cervical cancer, familiarity with problems associated with cervical cancer, experience with vaccination recommendations, and knowledge about cervical cancer (p < 0.05, respectively). In the vaccinated generation, the proportion of the group that did not want to be vaccinated was significantly higher (p < 0.05). In the vaccine-suspended generation, the proportion of the group that wanted to be vaccinated was significantly higher (p < 0.05).
    Conclusion: Our survey revealed that catch-up vaccination intentions differed depending on the vaccination environment. It is necessary for all organizations involved with HPV vaccination, such as government, medical institutions, and educational institutions, to make recommendations based on an understanding of the characteristics of the "vaccinated generation" and the "vaccine-suspended generation".
    MeSH term(s) Female ; Humans ; Uterine Cervical Neoplasms/prevention & control ; Intention ; Japan ; Papillomavirus Infections/prevention & control ; Early Detection of Cancer ; Surveys and Questionnaires ; Vaccination ; Internet ; Papillomavirus Vaccines/therapeutic use
    Chemical Substances Papillomavirus Vaccines
    Language English
    Publishing date 2023-09-30
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1400227-9
    ISSN 1437-7772 ; 1341-9625
    ISSN (online) 1437-7772
    ISSN 1341-9625
    DOI 10.1007/s10147-023-02411-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: TROP-2, Nectin-4, GPNMB, and B7-H3 Are Potentially Therapeutic Targets for Anaplastic Thyroid Carcinoma.

    Toda, Soji / Sato, Shinya / Saito, Nao / Sekihara, Kazumasa / Matsui, Ai / Murayama, Daisuke / Nakayama, Hirotaka / Suganuma, Nobuyasu / Okubo, Yoichiro / Hayashi, Hiroyuki / Iwasaki, Hiroyuki / Miyagi, Yohei / Hoshino, Daisuke

    Cancers

    2022  Volume 14, Issue 3

    Abstract: Background: Anaplastic thyroid carcinoma (ATC) is a highly aggressive thyroid tumor with a poor prognosis. However, there are limited choices for ATC treatment. Recently, the effectiveness of antibody-drug conjugates has been demonstrated in various ... ...

    Abstract Background: Anaplastic thyroid carcinoma (ATC) is a highly aggressive thyroid tumor with a poor prognosis. However, there are limited choices for ATC treatment. Recently, the effectiveness of antibody-drug conjugates has been demonstrated in various carcinomas. Whether the targets of antibody-drug conjugates are expressed in anaplastic thyroid carcinoma remains unclear.
    Methods: Fifty-four patients with ATC were enrolled in this study. Tissue microarrays were constructed using the archives of formalin-fixed paraffin-embedded tissue blocks. All sections were stained with the following antibody-drug conjugate targets:
    Results: HER2
    Conclusions: TROP-2
    Language English
    Publishing date 2022-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14030579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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