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  1. Article ; Online: Correction for Hao et al., Infection and propagation of human rhinovirus C in human airway epithelial cells.

    Hao, Weidong / Bernard, Katie / Patel, Nita / Ulbrandt, Nancy / Feng, Hui / Svabek, Catherine / Wilson, Susan / Stracener, Christina / Wang, Kathy / Suzich, JoAnn / Blair, Wade / Zhu, Qing

    Journal of virology

    2015  Volume 89, Issue 7, Page(s) 4041

    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.00119-15
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    Zs.A 609: Show issues Location:
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  2. Article: The Study of Yin-Chen-Hao-Tang Preventing and Treating Alcoholic Fatty Liver Disease through PPAR Signaling Pathway Based on Network Pharmacology and RNA-Seq Transcriptomics.

    Zhu, Yi-Wei / Li, Du / Ye, Ting-Jie / Qiu, Feng-Jun / Wang, Xiao-Ling / Yan, Xiao-Feng / Lu, Yan-Lin / Xu, Wei / Li, Hua / Hu, Xu-Dong

    Evidence-based complementary and alternative medicine : eCAM

    2021  Volume 2021, Page(s) 8917993

    Abstract: ... course. Yin-Chen-Hao-Tang (YCHT) has a good clinical effect on the treatment of AFLD, but its molecular ...

    Abstract Background: Alcoholic fatty liver disease (AFLD) is the first stage of the alcoholic liver disease course. Yin-Chen-Hao-Tang (YCHT) has a good clinical effect on the treatment of AFLD, but its molecular mechanism has not been elucidated. In this study, we tried to explore the molecular mechanism of YCHT in improving hepatocyte steatosis in AFLD mice through network pharmacology and RNA sequencing (RNA-Seq) transcriptomics.
    Methods: Network pharmacological methods were used to analyze the potential therapeutic signaling pathways and targets of YCHT on AFLD. Then, the AFLD mice model was induced and YCHT was administered concurrently. Liver injury was measured by serum alanine aminotransferase (ALT) activity and liver tissue H&E staining, and liver steatosis was determined by serum triglyceride (TG) level and liver tissue Oil Red staining. The molecular mechanism of YCHT on prevention and treatment of mice AFLD was investigated according to the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the differential expression genes data obtained by liver tissue RNA-Seq. Finally, ethanol-induced AFLD AML12 hepatocyte model was established, YCHT with or without PPAR
    Results: The results of network pharmacology analysis showed that YCHT may exert its pharmacological effect on AFLD through 312 potential targets which are involved in many signaling pathways including the PPAR signaling pathway. AFLD mice experiments results showed that YCHT markedly decreased mice serum ALT activity and serum TG levels. YCHT also significantly improved alcohol-induced hepatic injury and steatosis in mice livers. Furthermore, KEGG pathway enrichment results of RNA-Seq showed that the PPAR signaling pathway should be the most relevant pathway of YCHT in the prevention and treatment of AFLD. AFLD hepatocyte model experiment results showed that YCHT could remarkably reduce hepatocyte steatosis through reducing PPAR
    Conclusions: Our study discovered that PPAR
    Language English
    Publishing date 2021-12-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2021/8917993
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5995: Show issues Location:
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  3. Article ; Online: The Study of Yin-Chen-Hao-Tang Preventing and Treating Alcoholic Fatty Liver Disease through PPAR Signaling Pathway Based on Network Pharmacology and RNA-Seq Transcriptomics

    Yi-Wei Zhu / Du Li / Ting-Jie Ye / Feng-Jun Qiu / Xiao-Ling Wang / Xiao-Feng Yan / Yan-Lin Lu / Wei Xu / Hua Li / Xu-Dong Hu

    Evidence-Based Complementary and Alternative Medicine, Vol

    2021  Volume 2021

    Abstract: ... course. Yin-Chen-Hao-Tang (YCHT) has a good clinical effect on the treatment of AFLD, but its molecular ...

    Abstract Background. Alcoholic fatty liver disease (AFLD) is the first stage of the alcoholic liver disease course. Yin-Chen-Hao-Tang (YCHT) has a good clinical effect on the treatment of AFLD, but its molecular mechanism has not been elucidated. In this study, we tried to explore the molecular mechanism of YCHT in improving hepatocyte steatosis in AFLD mice through network pharmacology and RNA sequencing (RNA-Seq) transcriptomics. Methods. Network pharmacological methods were used to analyze the potential therapeutic signaling pathways and targets of YCHT on AFLD. Then, the AFLD mice model was induced and YCHT was administered concurrently. Liver injury was measured by serum alanine aminotransferase (ALT) activity and liver tissue H&E staining, and liver steatosis was determined by serum triglyceride (TG) level and liver tissue Oil Red staining. The molecular mechanism of YCHT on prevention and treatment of mice AFLD was investigated according to the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the differential expression genes data obtained by liver tissue RNA-Seq. Finally, ethanol-induced AFLD AML12 hepatocyte model was established, YCHT with or without PPARα agonist pemafibrate or PPARγ inhibitor GW9662 was administered, Nile Red fluorescent staining was used to evaluate steatosis levels in AML12 hepatocytes, and qRT-PCR was used to detect PPARα and PPARγ gene expression. Results. The results of network pharmacology analysis showed that YCHT may exert its pharmacological effect on AFLD through 312 potential targets which are involved in many signaling pathways including the PPAR signaling pathway. AFLD mice experiments results showed that YCHT markedly decreased mice serum ALT activity and serum TG levels. YCHT also significantly improved alcohol-induced hepatic injury and steatosis in mice livers. Furthermore, KEGG pathway enrichment results of RNA-Seq showed that the PPAR signaling pathway should be the most relevant pathway of YCHT in the prevention and treatment of AFLD. AFLD ...
    Keywords Other systems of medicine ; RZ201-999
    Subject code 571
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: A strategy for detecting optimal ratio of cardioprotection-dependent three compounds as quality control of guan-xin-er-hao formula.

    Wang, Yang / Huang, Xi / Qin, Feng / Ren, Ping / Zhu, Zhengyan / Fan, Rong / Zhang, Chunhu / Zhang, Hainan / Tang, Tao / He, Juan / Liu, Zhaoqian / Zhou, Honghao

    Journal of ethnopharmacology

    2010  Volume 133, Issue 2, Page(s) 735–742

    Abstract: ... ABCs) as quality control of guan-xin-er-hao (GXEH) formula extracted by various processings.: Methods ...

    Abstract Aims: We aimed to detect optimal ratio of cardioprotection-dependent absorbed bioactive compounds (ABCs) as quality control of guan-xin-er-hao (GXEH) formula extracted by various processings.
    Methods: Ferulic acid (F), tanshinol (T), hydroxysafflor yellow A (A), protocatechualdehyde (P) and paeoniflorin (E) in GXEH formula and FTA in blood from rat with acute myocardial infarction (AMI) were first identified by HPLC-MS/MS, and FTAPE in GXEH formulae with various herbs, extraction times and extraction water volumes were then quantitated only by HPLC.
    Results: FTAPE in various GXEH were determined. FTA were selected as GXEH's ABCs. Ratios of FTA were determined, suggesting the high (1:6.1:15.6), medium (1:1.7:15.2) and low (1:0.2:15.3) ratios. Three FTA ratios and their parent formulae ratio-dependently reduced infarct size, myocardial apoptosis and caspase-3 activity.
    Conclusion: There is the optimal ratio of F:T:A among various formulae, contributing to the best cardioprotection. This FTA ratio was developed as quality control of GXEH formula.
    MeSH term(s) Animals ; Apoptosis/drug effects ; Benzaldehydes/administration & dosage ; Benzoates/administration & dosage ; Bridged-Ring Compounds/administration & dosage ; Cardiotonic Agents/administration & dosage ; Cardiotonic Agents/chemistry ; Cardiotonic Agents/standards ; Caspase 3/metabolism ; Catechols/administration & dosage ; Chalcone/administration & dosage ; Chalcone/analogs & derivatives ; Chemistry, Pharmaceutical ; Coumaric Acids/administration & dosage ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/standards ; Ethnopharmacology ; Glucosides/administration & dosage ; Male ; Monoterpenes ; Myocardial Infarction/drug therapy ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Phytotherapy ; Quality Control ; Quinones/administration & dosage ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Benzaldehydes ; Benzoates ; Bridged-Ring Compounds ; Cardiotonic Agents ; Catechols ; Coumaric Acids ; Drugs, Chinese Herbal ; Glucosides ; Monoterpenes ; Quinones ; guan xin II ; hydroxysafflor yellow A (146087-19-6) ; peoniflorin (21AIQ4EV64) ; protocatechualdehyde (4PVP2HCH4T) ; Chalcone (5S5A2Q39HX) ; ferulic acid (AVM951ZWST) ; Casp3 protein, rat (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-)
    Language English
    Publishing date 2010-11-10
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2010.11.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1494: Show issues Location:
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  5. Book: Hangzhou lao zi hao xi lie cong shu

    Lu, Feng

    (Zhonghua lao zi hao cong shu)

    2008  

    Title variant Yi yao pian
    Author's details Lu Feng, Chen Wanli, Xu Min bian
    Series title Zhonghua lao zi hao cong shu
    MeSH term(s) Medicine, Chinese Traditional/history ; History of Medicine
    Keywords China
    Language Chinese
    Size 335 p. :, ill., ports.
    Edition Di 1 ban.
    Publisher Zhejiang da xue chu ban she
    Publishing place Hangzhou
    Document type Book
    ISBN 9787308058155 ; 7308058158
    Database Catalogue of the US National Library of Medicine (NLM)

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  6. Article ; Online: Antiapoptotic mechanisms of Chinese medicine formula, Guan-Xin-Er-Hao, in the rat ischemic heart.

    Zhao, Hong-Wei / Qin, Feng / Liu, Yi-Xia / Huang, Xi / Ren, Ping

    The Tohoku journal of experimental medicine

    2008  Volume 216, Issue 4, Page(s) 309–316

    Abstract: ... We have previously shown that Guan-Xin-Er-Hao (GXEH), a Chinese medicine formula, attenuates postischemia ...

    Abstract Considerable evidence indicates that apoptosis plays a critical role in acute myocardial infarction. We have previously shown that Guan-Xin-Er-Hao (GXEH), a Chinese medicine formula, attenuates postischemia myocardial apoptosis. The present study was designed to determine the mechanisms by which GXEH exerts its antiapoptotic effect. Adult male Sprague-Dawley rats were randomized to receive vehicle or GXEH (5 or 15 g/kg) orally 30 min before ischemia and subjected to myocardial ischemia of 3 h (apoptosis peak) or 24 h (necrosis peak) for determination of infarct size. Compared with rats receiving vehicle, those rats treated with GXEH (15 g/kg) showed significantly reduced infarct size, the reduced myocardial apoptosis, as judged by the decreases in TUNEL-positive staining (22.40 +/- 5.68% vs. 40.31 +/- 10.58%, p < 0.01), and the decrease in the degree of caspase-3 activation (82.97 +/- 10.54 vs. 159.95 +/- 9.16 mumol cleaved acetyl-Asp-Glu-Val-Asp-p-nitroanilide/mg protein, p < 0.01). Treatment with GXEH (15 g/kg) significantly reduced the release of mitochondrial cytochrome c, a primary mediator of apoptosis, the degree of caspase-9 activation, and the Bax/Bcl-2 ratio. Caspase-9 cleaves and activates caspase-3. Bax promotes apoptosis, while Bcl-2 inhibits apoptosis. Thus, the antiapoptotic mechanisms of GXEH may involve the mitochondrial cytochrome c-mediated caspase-3 activation in cardiomyocytes after acute myocardial infarction. Taken together, GXEH tilted the balance between Bax and Bcl-2 toward an antiapoptotic state, decreased mitochondrial cytochrome c release, reduced caspase-9 activation, and attenuated subsequent caspase-3 activation and postischemic myocardial apoptosis in rats. GXEH may be used as a promising agent for future treatment of cardiovascular diseases.
    MeSH term(s) Animals ; Apoptosis/drug effects ; Caspase 3/metabolism ; Caspase 9/metabolism ; Cell Death/drug effects ; Cytochromes c/metabolism ; Drug Evaluation, Preclinical ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Enzyme Activation/drug effects ; Male ; Medicine, Chinese Traditional ; Mitochondria, Heart/drug effects ; Mitochondria, Heart/metabolism ; Myocardial Infarction/drug therapy ; Myocardial Infarction/pathology ; Myocardial Ischemia/drug therapy ; Myocardial Ischemia/pathology ; Myocardial Ischemia/prevention & control ; Random Allocation ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Drugs, Chinese Herbal ; guan xin II ; Cytochromes c (9007-43-6) ; Casp9 protein, rat (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-) ; Caspase 9 (EC 3.4.22.-)
    Language English
    Publishing date 2008-10-31
    Publishing country Japan
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123477-8
    ISSN 1349-3329 ; 0040-8727
    ISSN (online) 1349-3329
    ISSN 0040-8727
    DOI 10.1620/tjem.216.309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.155: Show issues Location:
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  7. Article ; Online: Anti-inflammatory effect of Guan-Xin-Er-Hao via the nuclear factor-kappa B signaling pathway in rats with acute myocardial infarction.

    Zhang, Xue-Ya / Huang, Xi / Qin, Feng / Ren, Ping

    Experimental animals

    2009  Volume 59, Issue 2, Page(s) 207–214

    Abstract: A traditional Chinese medicine, Guan-Xin-Er-Hao (GXEH), is a famous multiple target therapeutic ...

    Abstract A traditional Chinese medicine, Guan-Xin-Er-Hao (GXEH), is a famous multiple target therapeutic polypharmaceutical. Our aim was to evaluate whether or not oral administration of GXEH has an anti-inflammatory effect associated with blockade of nuclear factor-kappa B (NF-kappaB), and to investigate the NF-kappaB-mediated pro-inflammatory cytokines expression pathway during acute myocardial infarction (AMI) in rats. Sprague-Dawley rats were randomly assigned to four groups: oral GXEH administered at 15 or 5 g/kg, the vehicle control and sham-operated groups. Thirty minutes after giving GXEH or 0.9% NaCl (p.o.) once, coronary arteries were occluded except for the sham-operated rats. We measured 24-h infarct size, 3-h expression of NF-kappaB protein in the myocardial left ventricular tissues and serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and C-reactive protein (CRP). Compared with rats receiving vehicle, rats administered 15 g/kg GXEH had significantly reduced 24-h infarct size, expression of NF-kappaB protein and serum concentrations of TNF-alpha, IL-6, and CRP. GXEH at 5 g/kg did not have a significant effect on these parameters. In conclusion, GXEH exhibited an anti-inflammatory effect through inhibition of the NF-kappaB-mediated signaling pathway leading to downregulation of pro-inflammatory cytokine expression. These findings provide new evidence of the cardioprotective effect of GXEH through reduction of infarct size by mediating lots of endogenous materials via multiple pathways to act on myocardial cells in the treatment of cardiovascular disease.
    MeSH term(s) Administration, Oral ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Chromatography, High Pressure Liquid ; Disease Models, Animal ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Fluorescent Antibody Technique, Indirect ; Heart/drug effects ; Immunoenzyme Techniques ; Male ; Myocardial Infarction/drug therapy ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocardium/metabolism ; Myocardium/pathology ; NF-kappa B/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Drugs, Chinese Herbal ; NF-kappa B ; guan xin II
    Language English
    Publishing date 2009-07-29
    Publishing country Japan
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2088228-2
    ISSN 1881-7122 ; 1341-1357 ; 0007-5124
    ISSN (online) 1881-7122
    ISSN 1341-1357 ; 0007-5124
    DOI 10.1538/expanim.59.207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1653: Show issues Location:
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  8. Article: A strategy for detecting optimal ratio of cardioprotection-dependent three compounds as quality control of Guan-Xin-Er-Hao formula

    Wang, Yang / Huang, Xi / Qin, Feng / Ren, Ping / Zhu, Zhengyan / Fan, Rong / Zhang, Chunhu / Zhang, Hainan / Tang, Tao / He, Juan / Liu, Zhaoqian / Zhou, Honghao

    Journal of ethnopharmacology. 2011 Jan. 27, v. 133, no. 2

    2011  

    Abstract: ... ABCs) as quality control of Guan-Xin-Er-Hao (GXEH) formula extracted by various processings. Methods ...

    Abstract Aims: We aimed to detect optimal ratio of cardioprotection-dependent absorbed bioactive compounds (ABCs) as quality control of Guan-Xin-Er-Hao (GXEH) formula extracted by various processings. Methods: Ferulic acid (F), tanshinol (T), hydroxysafflor yellow A (A), protocatechualdehyde (P) and paeoniflorin (E) in GXEH formula and FTA in blood from rat with acute myocardial infarction (AMI) were first identified by HPLC-MS/MS, and FTAPE in GXEH formulae with various herbs, extraction times and extraction water volumes were then quantitated only by HPLC. Results: FTAPE in various GXEH were determined. FTA were selected as GXEH's ABCs. Ratios of FTA were determined, suggesting the high (1:6.1:15.6), medium (1:1.7:15.2) and low (1:0.2:15.3) ratios. Three FTA ratios and their parent formulae ratio-dependently reduced infarct size, myocardial apoptosis and caspase-3 activity. Conclusion: There is the optimal ratio of F:T:A among various formulae, contributing to the best cardioprotection. This FTA ratio was developed as quality control of GXEH formula.
    Keywords apoptosis ; bioactive properties ; blood ; caspase-3 ; ferulic acid ; herbs ; high performance liquid chromatography ; infarction ; myocardial infarction ; quality control ; rats
    Language English
    Dates of publication 2011-0127
    Size p. 735-742.
    Publishing place Amsterdam; New York: Elsevier
    Document type Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2010.11.006
    Database NAL-Catalogue (AGRICOLA)

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    Z 90/710: Show issues

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  9. Article: Biden's approval, record inflation, economic recovery, COVID-19 mortality, and vaccination rate among Americans-A longitudinal study of state-level data from April 2021 to January 2022.

    Hao, Feng

    Preventive medicine reports

    2023  Volume 36, Page(s) 102454

    Abstract: The COVID-19 pandemic has brought an unprecedented impact on Americans for over three years. One effective strategy to mitigate the pandemic's damage lies in the vaccine. This study aims to investigate the effects of state-level predictors that vary ... ...

    Abstract The COVID-19 pandemic has brought an unprecedented impact on Americans for over three years. One effective strategy to mitigate the pandemic's damage lies in the vaccine. This study aims to investigate the effects of state-level predictors that vary month-by-month on changes in vaccination rates. Panel data of state-level indicators are built for all 50 states from April 2021 to January 2022. The dependent variable is the monthly increase in vaccination rate, and the independent variables include measures of Biden's approval, inflation, economic recovery, and COVID-19 mortality for each month of this study period. Fixed-effects regression is adopted for longitudinal statistical estimation. Findings show that over time Biden's approval and COVID-19 death are positively associated with the growth in the vaccination rate, while inflation and economic recovery are negatively associated with the vaccination rate. Significant interactions are identified among these predictors. The findings from analyzing panel indicators at the state level complement the current literature dominated by examining cross-sectional data and provide public health officials with fresh insights to promote the vaccine rollout.
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2785569-7
    ISSN 2211-3355
    ISSN 2211-3355
    DOI 10.1016/j.pmedr.2023.102454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online ; E-Book: Food Safety Engineering

    Demirci, Ali / Feng, Hao / Krishnamurthy, Kathiravan

    (Food Engineering Series,)

    2020  

    Abstract: Food Safety Engineering is the first reference work to provide up-to-date coverage of the advanced technologies and strategies for the engineering of safe foods. Researchers, laboratory staff and food industry professionals with an interest in food ... ...

    Author's details edited by Ali Demirci, Hao Feng, Kathiravan Krishnamurthy
    Series title Food Engineering Series,
    Abstract Food Safety Engineering is the first reference work to provide up-to-date coverage of the advanced technologies and strategies for the engineering of safe foods. Researchers, laboratory staff and food industry professionals with an interest in food engineering safety will find a singular source containing all of the needed information required to understand this rapidly advancing topic. The text lays a solid foundation for solving microbial food safety problems, developing advanced thermal and non-thermal technologies, designing food safety preventive control processes and sustainable operation of the food safety preventive control processes. The first section of chapters presents a comprehensive overview of food microbiology from foodborne pathogens to detection methods. The next section focuses on preventative practices, detailing all of the major manufacturing processes assuring the safety of foods including Good Manufacturing Practices (GMP), Hazard Analysis and Critical Control Points (HACCP), Hazard Analysis and Risk-Based Preventive Controls (HARPC), food traceability, and recalls. Further sections provide insights into plant layout and equipment design, and maintenance. Modeling and process design are covered in depth. Conventional and novel preventive controls for food safety include the current and emerging food processing technologies. Further sections focus on such important aspects as aseptic packaging and post-packaging technologies. With its comprehensive scope of up-to-date technologies and manufacturing processes, this is a useful and first-of-its kind text for the next generation food safety engineering professionals.
    Keywords Food science ; Food—Microbiology ; Food Science ; Food Microbiology
    Subject code 363.1926
    Language English
    Size 1 online resource (ix, 760 pages).
    Edition 1st ed. 2020.
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-42660-2 ; 3-030-42659-9 ; 978-3-030-42660-6 ; 978-3-030-42659-0
    DOI 10.1007/978-3-030-42660-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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