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Article ; Online: Metal-Air Field Emission Devices - Nano Electrode Geometries Comparison of Performance and Stability.

Nirantar, Shruti / Patil, Basanagounda / Tripathi, Durgesh C / Sethu, Nilamani / Narayanan, Ramakrishnan V / Tian, Jie / Bhaskaran, Madhu / Walia, Sumeet / Sriram, Sharath

Small (Weinheim an der Bergstrasse, Germany)

2022 Volume 18, Issue 47, Page(s) e2203234

Abstract: Air-channel devices have a special advantage due to the promise of vacuum-like ballistic transport in air, radiation insensitivity, and nanoscale size. Here, achieving high current at low voltage along with considerable mechanical stability is a primary ... ...

Abstract	Air-channel devices have a special advantage due to the promise of vacuum-like ballistic transport in air, radiation insensitivity, and nanoscale size. Here, achieving high current at low voltage along with considerable mechanical stability is a primary issue. The comparative analysis of four planar and metallic electrode-pair geometries at 10 nm channel length is presented. The impact of nano-electrode-pair geometries on overall device performance is investigated. Air-channel devices are operated at the ultra-low voltage of 5 mV to demonstrate the device dynamics of air-channel devices at low power. Investigations focus on the direct tunneling (DT) mechanism which is dominant in the low-voltage regime. Comparative analysis of different electrode-pair geometries reveals two orders of magnitude increment in the current just by modulating the electrode-pair structure. Theoretical analysis suggests that the emission current is directly related to the active junction area within the metal-air-metal interface at the direct tunneling regime. The geometry-dependent mechanical stability of different electrode pairs is compared by imaging biasing triggered nanoscale structural changes and pulsed biasing stress analysis. The results and claims are confirmed and consolidated with the statistical analysis. Experimental investigations provide strong directions for high-performance and stable devices. In-depth theoretical discussions will enable the accurate modeling of emerging low-power, high-speed, radiation-hardened nanoscale vacuum electronics.
MeSH term(s)	Transistors, Electronic ; Electronics ; Metals/chemistry
Chemical Substances	Metals
Language	English
Publishing date	2022-09-12
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202203234
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Article ; Online: Sensory domain of the cell cycle kinase CckA regulates the differential DNA binding of the master regulator CtrA in Caulobacter crescentus.

Narayanan, Sharath / Kumar, Lokesh / Radhakrishnan, Sunish Kumar

Biochimica et biophysica acta. Gene regulatory mechanisms

2018 Volume 1861, Issue 10, Page(s) 952–961

Abstract: Sophisticated signaling mechanisms allow bacterial cells to cope with environmental and intracellular challenges. Activation of specific pathways ameliorates these challenges and thereby warrants integrity. Here, we demonstrate the pliability of the CckA- ...

Abstract	Sophisticated signaling mechanisms allow bacterial cells to cope with environmental and intracellular challenges. Activation of specific pathways ameliorates these challenges and thereby warrants integrity. Here, we demonstrate the pliability of the CckA-CtrA two-component signaling system in the freshwater bacterium Caulobacter crescentus. Our forward genetic screen to analyze suppressor mutations that can negate the chromosome segregation block induced by the topoisomerase IV inhibitor, NstA, yielded various point mutations in the cell cycle histidine kinase, CckA. Notably, we identified a point mutation in the PAS-B domain of CckA, which resulted in increased levels of phosphorylated CtrA (CtrA~P), the master cell cycle regulator. Surprisingly, this increase in CtrA~P levels did not translate into a genome-wide increase in the DNA occupancy of CtrA, but specifically enriched its affinity for the chromosomal origin of replication, C
MeSH term(s)	Bacterial Proteins/metabolism ; Caulobacter crescentus/cytology ; Caulobacter crescentus/enzymology ; Caulobacter crescentus/genetics ; DNA Replication ; DNA, Bacterial/metabolism ; DNA-Binding Proteins/metabolism ; Histidine Kinase/chemistry ; Histidine Kinase/genetics ; Histidine Kinase/metabolism ; Phenotype ; Promoter Regions, Genetic ; Protein Binding ; Protein Domains ; Suppression, Genetic ; Transcription Factors/metabolism
Chemical Substances	Bacterial Proteins ; CtrA protein, Caulobacter ; DNA, Bacterial ; DNA-Binding Proteins ; Transcription Factors ; Histidine Kinase (EC 2.7.13.1)
Language	English
Publishing date	2018-08-31
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2918786-2
ISSN	1876-4320 ; 1874-9399
ISSN (online)	1876-4320
ISSN	1874-9399
DOI	10.1016/j.bbagrm.2018.08.006
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Article ; Online: Comparative evaluation of modified proximal perineal urethrostomy with direct guided urethral catheterisation and tube cystostomy for the management of obstructive urolithiasis in male goats

Anvitha Hansoge / Sudheesh S Nair / Soumya Ramankutty / B. Lavanya / M.K. Praveen / J. Sharath / J. Deny / M.K. Narayanan / K.D. John Martin

Journal of Veterinary and Animal Sciences, Vol 52, Iss 2, Pp 131-

2021 Volume 134

Abstract: Twelve clinical cases of chronic obstructive urolithiasis in male goats were selected for the study with the objective to evaluate two surgical techniques - modified proximal perineal urethrostomy (MPPU) with direct guided urethral catheterisation (Group ...

Abstract	Twelve clinical cases of chronic obstructive urolithiasis in male goats were selected for the study with the objective to evaluate two surgical techniques - modified proximal perineal urethrostomy (MPPU) with direct guided urethral catheterisation (Group I) and tube cystostomy (Group II) for the surgical management. Ultrasonography was effective in assessing the urinary bladder and detection of uroliths. Functional patency of normal urethra was regained in five out of six animals of each group by third post-operative week. Direct access to the perineal urethra providing quick relief to the turgid bladder was identified as the major advantage of modified proximal perineal urethrostomy technique. Tube cystostomy technique provided direct visual assessment of urinary bladder, precise fixing of Foley’s catheter and retrieval of uroliths. Even though this technique was found to be more invasive, it was identified as an effective approach for correcting cystorrhexis resulted from obstructive urolithiasis
Keywords	modified proximal perineal urethrostomy ; tube cystostomy ; obstructive urolithiasis ; Animal biochemistry ; QP501-801 ; Science (General) ; Q1-390
Subject code	630
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Director of Academics and Research, Kerala Veterinary and Animal Sciences University
Document type	Article ; Online
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Article ; Online: In-phase oscillation of global regulons is orchestrated by a pole-specific organizer.

Janakiraman, Balaganesh / Mignolet, Johann / Narayanan, Sharath / Viollier, Patrick H / Radhakrishnan, Sunish Kumar

Proceedings of the National Academy of Sciences of the United States of America

2016 Volume 113, Issue 44, Page(s) 12550–12555

Abstract: Cell fate determination in the asymmetric bacterium Caulobacter crescentus (Caulobacter) is triggered by the localization of the developmental regulator SpmX to the old (stalked) cell pole during the G1→S transition. Although SpmX is required to localize ...

Abstract	Cell fate determination in the asymmetric bacterium Caulobacter crescentus (Caulobacter) is triggered by the localization of the developmental regulator SpmX to the old (stalked) cell pole during the G1→S transition. Although SpmX is required to localize and activate the cell fate-determining kinase DivJ at the stalked pole in Caulobacter, in cousins such as Asticcacaulis, SpmX directs organelle (stalk) positioning and possibly other functions. We define the conserved σ
MeSH term(s)	Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Caulobacter crescentus/cytology ; Caulobacter crescentus/genetics ; Caulobacter crescentus/metabolism ; Cell Division/genetics ; Gene Expression Regulation, Bacterial ; Phosphorylation ; Regulon/genetics ; Trans-Activators/genetics ; Trans-Activators/metabolism
Chemical Substances	Bacterial Proteins ; Trans-Activators
Language	English
Publishing date	2016-10-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1610723113
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Article ; Online: A cell cycle-controlled redox switch regulates the topoisomerase IV activity.

Narayanan, Sharath / Janakiraman, Balaganesh / Kumar, Lokesh / Radhakrishnan, Sunish Kumar

Genes & development

2015 Volume 29, Issue 11, Page(s) 1175–1187

Abstract: Topoisomerase IV (topo IV), an essential factor during chromosome segregation, resolves the catenated chromosomes at the end of each replication cycle. How the decatenating activity of the topo IV is regulated during the early stages of the chromosome ... ...

Abstract	Topoisomerase IV (topo IV), an essential factor during chromosome segregation, resolves the catenated chromosomes at the end of each replication cycle. How the decatenating activity of the topo IV is regulated during the early stages of the chromosome cycle despite being in continuous association with the chromosome remains poorly understood. Here we report a novel cell cycle-regulated protein in Caulobacter crescentus, NstA (negative switch for topo IV decatenation activity), that inhibits the decatenation activity of the topo IV during early stages of the cell cycle. We demonstrate that in C. crescentus, NstA acts by binding to the ParC DNA-binding subunit of topo IV. Most importantly, we uncover a dynamic oscillation of the intracellular redox state during the cell cycle, which correlates with and controls NstA activity. Thus, we propose that predetermined dynamic intracellular redox fluctuations may act as a global regulatory switch to control cellular development and cell cycle progression and may help retain pathogens in a suitable cell cycle state when encountering redox stress from the host immune response.
MeSH term(s)	Bacterial Proteins/metabolism ; Caulobacter crescentus/enzymology ; Caulobacter crescentus/growth & development ; Cell Cycle/physiology ; DNA Topoisomerase IV/genetics ; DNA Topoisomerase IV/metabolism ; Enzyme Activation/physiology ; Genes, Switch/physiology ; Oxidation-Reduction ; Protein Binding ; Protein Subunits/metabolism
Chemical Substances	Bacterial Proteins ; Protein Subunits ; DNA Topoisomerase IV (EC 5.99.1.-)
Language	English
Publishing date	2015-06-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	806684-x
ISSN	1549-5477 ; 0890-9369
ISSN (online)	1549-5477
ISSN	0890-9369
DOI	10.1101/gad.257030.114
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Zs.A 2292: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Left sided ablation for Atrioventricular Nodal Re-entrant Tachycardia: Frequency, Characteristics and Outcomes.

Narayanan, Kumar / Omer, Mohammed / Arif, Mohammed / Sridhar, Papani / Annarapu, Nitin / Naidu, Shivaprasad / Jariwala, Pankaj / Kavalipati, Narasaraju / Madivada, Mukharjee / Balaji, Ramagiri / M, Premchand / Reddy A, Sharath / Krishna G, Anil / Ea, Padmakumar

Indian pacing and electrophysiology journal

2020 Volume 21, Issue 1, Page(s) 5–10

Abstract: Background: Left-sided ablation, targeting left inferior AV nodal extensions, is thought to be necessary for success in a small proportion of atrioventricular nodal re-entrant tachycardia (AVNRT) ablations; however Indian data are scarce in this regard.! ...

Abstract	Background: Left-sided ablation, targeting left inferior AV nodal extensions, is thought to be necessary for success in a small proportion of atrioventricular nodal re-entrant tachycardia (AVNRT) ablations; however Indian data are scarce in this regard. Methods: Consecutive cases of AVNRT undergoing slow pathway ablation in a single centre over an 18-month period were retrospectively analyzed. Left-sided ablation at the posteroseptal mitral annulus was performed if right-sided ablation failed to abolish AVNRT. Results: From January 2017 to June 2018, out of 215 consecutive supraventricular tachycardia (SVT) cases, 154 (71.6%) were AVNRT (47.1 ± 13.1 years, 46.1% male). Trans-septal ablation was required in 5 (3.2%) cases (mean age 48.8 ± 9.4 years; 4 female, 1 male); all with typical (slow-fast) form of AVNRT. Compared with cases needing only right-sided ablation, radiofrequency time (50.8 ± 16.9 vs. 9.9 ± 8.5 min; p = 0.005) and procedure time (166.0 ± 35.0 vs 79.6 ± 35.9 min; p = 0.004) were significantly longer for trans-septal cases, while baseline intervals and tachycardia cycle length were not significantly different. Junctional ectopy was seen in only 2 of the 5 cases during left-sided ablation, but acute success (non-inducibility) was obtained in 3 cases. There were no instances of AV block. Over mean follow-up of 12.2 ± 4.0 months, clinical recurrence of AVNRT occurred in one case, while others remained arrhythmia-free without medication. Conclusion: Left-sided ablation was required in a small proportion of AVNRT ablations. Trans-septal approach targeting the posteroseptal mitral annulus was safe and yielded good mid-term clinical success.
Language	English
Publishing date	2020-10-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2123606-9
ISSN	0972-6292
ISSN	0972-6292
DOI	10.1016/j.ipej.2020.10.004
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Article: Irrigation protocol among endodontic faculty and post-graduate students in dental colleges of India: A survey.

Gopikrishna, Velayutham / Pare, Sharath / Pradeep Kumar, Ar / Lakshmi Narayanan, L

Journal of conservative dentistry : JCD

2012 Volume 16, Issue 5, Page(s) 394–398

Abstract: Background: Irrigation protocol is the most critical step during the disinfection of an infected root canal system.: Aim: The purpose of this study was to determine the root canal irrigation trends being practiced among the endodontic teaching ... ...

Abstract	Background: Irrigation protocol is the most critical step during the disinfection of an infected root canal system. Aim: The purpose of this study was to determine the root canal irrigation trends being practiced among the endodontic teaching faculty and post-graduate students in the dental colleges present in India. Materials and methods: A postal invitation to participate in this national survey was sent to the Department of Conservative Dentistry and Endodontic of 294 Dental Colleges present in India. A total of 2389 forms were successfully delivered out of which 794 duly filled forms were received back. Survey participants were asked about their irrigant selection, irrigant concentration, smear layer removal protocol, and use of adjuncts during irrigation. Results: This survey elicited a positive response rate of 33.23%. Our data indicated that 92.8% of respondents use sodium hypochlorite (NaOCl) as the primary endodontic irrigant, with 26 gauge needle being most preferred for syringe irrigation, with 49.3% of them using it at a concentration of 2.6-4.0%. 68% of our respondents aim to remove the smear layer during the endodontic treatment while 47% reported using ultrasonic activation as an adjunct during their irrigation protocol. Conclusions: The findings of this survey are that the majority of teaching institutions in India are employing NaOCl (2.6-4.0%) as the primary endodontic irrigant. The concept of smear layer removal is high (68%), and there is a general trend (78%) to modify the irrigation protocol according to the status of the pulp, status of the periapex and in retreatment cases.
Language	English
Publishing date	2012-05-02
Publishing country	India
Document type	Journal Article
ZDB-ID	2064481-4
ISSN	0972-0707
ISSN	0972-0707
DOI	10.4103/0972-0707.117486
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Article ; Online: Irrigation protocol among endodontic faculty and post-graduate students in dental colleges of India

Velayutham Gopikrishna / Sharath Pare / A R Pradeep Kumar / L Lakshmi Narayanan

Journal of Conservative Dentistry, Vol 16, Iss 5, Pp 394-

A survey

2013 Volume 398

Abstract: Background: Irrigation protocol is the most critical step during the disinfection of an infected root canal system. Aim: The purpose of this study was to determine the root canal irrigation trends being practiced among the endodontic teaching faculty and ...

Abstract	Background: Irrigation protocol is the most critical step during the disinfection of an infected root canal system. Aim: The purpose of this study was to determine the root canal irrigation trends being practiced among the endodontic teaching faculty and post-graduate students in the dental colleges present in India. Materials and Methods: A postal invitation to participate in this national survey was sent to the Department of Conservative Dentistry and Endodontic of 294 Dental Colleges present in India. A total of 2389 forms were successfully delivered out of which 794 duly filled forms were received back. Survey participants were asked about their irrigant selection, irrigant concentration, smear layer removal protocol, and use of adjuncts during irrigation. Results: This survey elicited a positive response rate of 33.23%. Our data indicated that 92.8% of respondents use sodium hypochlorite (NaOCl) as the primary endodontic irrigant, with 26 gauge needle being most preferred for syringe irrigation, with 49.3% of them using it at a concentration of 2.6-4.0%. 68% of our respondents aim to remove the smear layer during the endodontic treatment while 47% reported using ultrasonic activation as an adjunct during their irrigation protocol. Conclusions: The findings of this survey are that the majority of teaching institutions in India are employing NaOCl (2.6-4.0%) as the primary endodontic irrigant. The concept of smear layer removal is high (68%), and there is a general trend (78%) to modify the irrigation protocol according to the status of the pulp, status of the periapex and in retreatment cases.
Keywords	Irrigation adjuncts; root canal irrigants; smear layer; sodium hypochlorite; survey ; Dentistry ; RK1-715 ; Medicine ; R
Subject code	571
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Medknow Publications
Document type	Article ; Online
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Article: Contribution of medical colleges to tuberculosis control in India under the Revised National Tuberculosis Control Programme (RNTCP): lessons learnt & challenges ahead.

Sharma, Surendra K / Mohan, Alladi / Chauhan, L S / Narain, J P / Kumar, P / Behera, D / Sachdeva, K S / Kumar, Ashok / Agarwal, Priyanka / Awadh, N T / Bansal, Avi / Baruah, S / Baruwa, Pranab / Balasangameshwara, V H / Balasubramanian, Rani / Bhardwaj, A K / Bhargav, Salil / Chadha, Sarabjit / Chaddha, V K /

Chhatwal, Manpreet / Da Costa, A L / Dash, D P / Dep, Jaydip / Dhingra, Saroj / Dhooria Harmeet, S / Frieden, T R / Garg, Anil / Granich, Reuben / Gulati, Vinay / Gupta, Deepak / Gupta, Dheeraj / Gupta, K B / Gupta, K N / Jaikishan / Janmeja, A K / Jawahar, M S / Jethani, S L / Jindal, S K / John, K R / Kalra, O P / Kalra, V P / Kannan, A T / Kayshap, S / Keshav Chander, G / Khushwa, S S / Kushwaha, R S / Kumar, Vinod / Laskar, B / Leela Itty Amma, K R / Leuva, A T / Maitra Malay, K / Mesquita, A M / Mathew, Thomas / Mundade, Yamuna / Munje, Radha / Nagpal, Somil / Nagaraja, C / Nair, Sanjeev / Narayanan, O R / Paramasivan, C N / Parmar, Malik / Prasad, Rajendra / Phukan, A C / Prasanna, Raj / Purty, Anil / Ramachandran, Ranjani / Ramachandran, Rajeswari / Ravindran, C / Reddy Raveendra, H R / Sahu, S / Santosha / Sarin, Rohit / Sarkar, Soumya / Sarma, K C / Saxena, P / Sehgal, Shruti / Sharath, N / Sharma, Geetanjali / Sharma, Nandini / Shridhar, P K / Shukla, R S / Singh, Om / Singh, N Tombi / Singh, Varinder / Singla, Rupak / Sinha, Neena / Sinha, Pranay / Sinha, Sanjay / Solanki, Rajesh / Sreenivas, A / Srinath, S / Subhakar, Kandi / Suri, J C / Talukdar, Palash / Tonsing, Jamie / Tripathy, S P / Vaidyanathan, Preetish / Vashist, R P / Venu, K

The Indian journal of medical research

2013 Volume 137, Issue 2, Page(s) 283–294

Abstract: Medical college faculty, who are academicians are seldom directly involved in the implementation of national public health programmes. More than a decade ago for the first time in the global history of tuberculosis (TB) control, medical colleges of India ...

Abstract	Medical college faculty, who are academicians are seldom directly involved in the implementation of national public health programmes. More than a decade ago for the first time in the global history of tuberculosis (TB) control, medical colleges of India were involved in the Revised National TB Control Programme (RNTCP) of Government of India (GOI). This report documents the unique and extraordinary course of events that led to the involvement of medical colleges in the RNTCP of GOI. It also reports the contributions made by the medical colleges to TB control in India. For more than a decade, medical colleges have been providing diagnostic services (Designated Microscopy Centres), treatment [Directly Observed Treatment (DOT) Centres] referral for treatment, recording and reporting data, carrying out advocacy for RNTCP and conducting operational research relevant to RNTCP. Medical colleges are contributing to diagnosis and treatment of human immunodeficiency virus (HIV)-TB co-infection and development of laboratory infrastructure for early diagnosis of multidrug-resistant and/or extensively drug-resistant TB (M/XDR-TB) and DOTS-Plus sites for treatment of MDR-TB cases. Overall, at a national level, medical colleges have contributed to 25 per cent of TB suspects referred for diagnosis; 23 per cent of 'new smear-positives' diagnosed; 7 per cent of DOT provision within medical college; and 86 per cent treatment success rate among new smear-positive patients. As the Programme widens its scope, future challenges include sustenance of this contribution and facilitating universal access to quality TB care; greater involvement in operational research relevant to the Programme needs; and better co-ordination mechanisms between district, state, zonal and national level to encourage their involvement.
MeSH term(s)	Antitubercular Agents/therapeutic use ; Coinfection ; Education, Medical ; Extensively Drug-Resistant Tuberculosis/complications ; Extensively Drug-Resistant Tuberculosis/drug therapy ; Extensively Drug-Resistant Tuberculosis/epidemiology ; Extensively Drug-Resistant Tuberculosis/microbiology ; Extensively Drug-Resistant Tuberculosis/physiopathology ; HIV Infections/complications ; HIV Infections/epidemiology ; Humans ; India ; Mycobacterium tuberculosis/pathogenicity
Chemical Substances	Antitubercular Agents
Language	English
Publishing date	2013-04-03
Publishing country	India
Document type	Journal Article
ZDB-ID	390883-5
ISSN	0971-5916 ; 0019-5340
ISSN	0971-5916 ; 0019-5340
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Book ; Online: Contribution of medical colleges to tuberculosis control in India under the Revised National Tuberculosis Control Programme (RNTCP)

Nair, Sanjeev / Jethani, S L / Balasangameshwara, V H / Suri, J C / Kannan, A T / Khushwa, S S / Dhingra, Saroj / Behera, D / Keshav Chander, G / Ramachandran, Rajeswari / Singla, Rupak / Saxena, P / Paramasivan, C N / Tripathy, S P / Awadh, N T / Mundade, Yamuna / Munje, Radha / Prasad, Rajendra / Mohan, Alladi /

Mesquita, A M / Gupta, Deepak / Singh, Om / Maitra Malay, K / Vaidyanathan, Preetish / Kushwaha, R S / Bansal, Avi / Santosha / Frieden, T R / Laskar, B / Sharma, Nandini / Balasubramanian, Rani / Ravindran, C / Dhooria Harmeet, S / Venu, K / Sahu, S / Singh, Varinder / Da Costa, A L / Sinha, Sanjay / Sharma, Geetanjali / Dep, Jaydip / Kalra, V P / Nagpal, Somil / Singh, N Tombi / Agarwal, Priyanka / Chadha, Sarabjit / Ramachandran, Ranjani / Jawahar, M S / Subhakar, Kandi / Baruwa, Pranab / Phukan, A C / Narain, J P / Granich, Reuben / Janmeja, A K / Sarkar, Soumya / Narayanan, O R / Sarin, Rohit / Kumar, P / Shridhar, P K / Vashist, R P / Bhardwaj, A K / Talukdar, Palash / Nagaraja, C / Chaddha, V K / Garg, Anil / Srinath, S / Gulati, Vinay / Sehgal, Shruti / Solanki, Rajesh / Gupta, Dheeraj / Kalra, O P / Shukla, R S / John, K R / Leuva, A T / Sinha, Neena / Sinha, Pranay / Dash, D P / Gupta, K N / Chauhan, L S / Gupta, K B / Prasanna, Raj / Kumar, Ashok / Sreenivas, A / Sarma, K C / Tonsing, Jamie / Kumar, Vinod / Bhargav, Salil / Baruah, S / Kayshap, S / Purty, Anil / Sharma, Surendra K / Parmar, Malik / Reddy Raveendra, H R / Jaikishan / Mathew, Thomas / Chhatwal, Manpreet / Jindal, S K / Sachdeva, K S / Leela Itty Amma, K R / Sharath, N

lessons learnt & challenges ahead

2013

Abstract: Journal Article ... Medical college faculty, who are academicians are seldom directly involved in the implementation of national public health programmes. More than a decade ago for the first time in the global history of tuberculosis (TB) control, medical ...

Abstract	Journal Article Medical college faculty, who are academicians are seldom directly involved in the implementation of national public health programmes. More than a decade ago for the first time in the global history of tuberculosis (TB) control, medical colleges of India were involved in the Revised National TB Control Programme (RNTCP) of Government of India (GOI). This report documents the unique and extraordinary course of events that led to the involvement of medical colleges in the RNTCP of GOI. It also reports the contributions made by the medical colleges to TB control in India. For more than a decade, medical colleges have been providing diagnostic services (Designated Microscopy Centres), treatment [Directly Observed Treatment (DOT) Centres] referral for treatment, recording and reporting data, carrying out advocacy for RNTCP and conducting operational research relevant to RNTCP. Medical colleges are contributing to diagnosis and treatment of human immunodeficiency virus (HIV)-TB co-infection and development of laboratory infrastructure for early diagnosis of multidrug-resistant and/or extensively drug-resistant TB (M/XDR-TB) and DOTS-Plus sites for treatment of MDR-TB cases. Overall, at a national level, medical colleges have contributed to 25 per cent of TB suspects referred for diagnosis; 23 per cent of 'new smear-positives' diagnosed; 7 per cent of DOT provision within medical college; and 86 per cent treatment success rate among new smear-positive patients. As the Programme widens its scope, future challenges include sustenance of this contribution and facilitating universal access to quality TB care; greater involvement in operational research relevant to the Programme needs; and better co-ordination mechanisms between district, state, zonal and national level to encourage their involvement.
Language	English
Publishing date	2013-02-01
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Inter-library loan at ZB MED

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED