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Article: Analysis of Protein Cysteine Acylation Using a Modified Suspension Trap (Acyl-Trap).

Forrester, Michael T / Egol, Jacob R / Tata, Aleksandra / Tata, Purushothama Rao / Foster, Matthew W

bioRxiv : the preprint server for biology

2024

Abstract: Protein cysteine thiols undergo ... ...

Abstract	Protein cysteine thiols undergo reversible
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.03.23.586403
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Article ; Online: Person-centred growth-oriented language and care: Fundamental to successful mental health reform.

McLure, James / Forrester-Bowling, Tari / Peeters, Anna / Berk, Michael / Moylan, Steven / Carolin, Renae

Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists

2023 Volume 31, Issue 5, Page(s) 598–600

Abstract: Objective: Person-centred growth-oriented language and care are considered vital for achieving favourable outcomes in mental health care. Personal testimonies detailed in the Final Report of the Royal Commission into Victoria's Mental Health System ( ... ...

Abstract	Objective: Person-centred growth-oriented language and care are considered vital for achieving favourable outcomes in mental health care. Personal testimonies detailed in the Final Report of the Royal Commission into Victoria's Mental Health System (RCVMHS) illustrate the need for a more compassionate and hope filled system, and demonstrate the opportunity to achieve this through embedding best practice person-centred growth-oriented language. A current gap exists in understanding the process and language involved in individuals growing to mental health. Recovery has long been the paradigm for people in the mental health system 'returning to baseline', a stark contrast to our lived experience. We experienced a new beginning post decline, daily personal growth and healing, aiming for constant improvement as we work towards mental health, a status that many may not have even experienced before becoming unwell. Conclusions: Person-centred growth-oriented care includes healing, supportive relationships with the 'caregivers' ideally being transformation specialists; knowing and understanding the process of daily personal growth. While the system is metamorphosing, it is highly recommended to embed person-centred growth-oriented language and care to aid in the transformation of individuals in the service.
MeSH term(s)	Humans ; Mental Health ; Health Care Reform ; Caregivers ; Patient-Centered Care ; Empathy
Language	English
Publishing date	2023-07-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2213198-X
ISSN	1440-1665 ; 1039-8562
ISSN (online)	1440-1665
ISSN	1039-8562
DOI	10.1177/10398562231189437
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Zs.A 6220: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 581: Show issues

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Article ; Online: ERK-dependent proteasome degradation of Txnip regulates thioredoxin oxidoreductase activity.

Kelleher, Zachary T / Wang, Chunbo / Forrester, Michael T / Foster, Matthew W / Marshall, Harvey E

The Journal of biological chemistry

2019 Volume 294, Issue 36, Page(s) 13336–13343

Abstract: Dynamic control of thioredoxin (Trx) oxidoreductase activity is essential for balancing the need of cells to rapidly respond to oxidative/nitrosative stress and to temporally regulate thiol-based redox signaling. We have previously shown that cytokine ... ...

Abstract	Dynamic control of thioredoxin (Trx) oxidoreductase activity is essential for balancing the need of cells to rapidly respond to oxidative/nitrosative stress and to temporally regulate thiol-based redox signaling. We have previously shown that cytokine stimulation of the respiratory epithelium induces a precipitous decline in cell
MeSH term(s)	A549 Cells ; Carrier Proteins/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; Mass Spectrometry ; Proteasome Endopeptidase Complex/metabolism ; Thioredoxin-Disulfide Reductase/metabolism ; Tumor Cells, Cultured
Chemical Substances	Carrier Proteins ; TXNIP protein, human ; Thioredoxin-Disulfide Reductase (EC 1.8.1.9) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
Language	English
Publishing date	2019-07-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.RA119.007733
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Article ; Online: The effect of wasting and stunting during severe acute malnutrition in infancy on insulin sensitivity and insulin clearance in adult life.

Thompson, Debbie S / Francis-Emmanuel, Patrice M / Barnett, Alan T / Osmond, Clive / Hanson, Mark A / Byrne, Christopher D / Gluckman, Peter D / Forrester, Terrence E / Boyne, Michael S

Journal of developmental origins of health and disease

2022 Volume 13, Issue 6, Page(s) 750–756

Abstract: Adults who had non-edematous severe acute malnutrition (SAM) during infancy (i.e., marasmus) have worse glucose tolerance and beta-cell function than survivors of edematous SAM (i.e., kwashiorkor). We hypothesized that wasting and/or stunting in SAM is ... ...

Abstract	Adults who had non-edematous severe acute malnutrition (SAM) during infancy (i.e., marasmus) have worse glucose tolerance and beta-cell function than survivors of edematous SAM (i.e., kwashiorkor). We hypothesized that wasting and/or stunting in SAM is associated with lower glucose disposal rate (M) and insulin clearance (MCR) in adulthood.We recruited 40 nondiabetic adult SAM survivors (20 marasmus survivors (MS) and 20 kwashiorkor survivors (KS)) and 13 matched community controls. We performed 150-minute hyperinsulinaemic, euglycaemic clamps to estimate M and MCR. We also measured serum adiponectin, anthropometry, and body composition. Data on wasting (weight-for-height) and stunting (height-for-age) were abstracted from the hospital records.Children with marasmus had lower weight-for-height
MeSH term(s)	Adult ; Child ; Humans ; Infant ; Kwashiorkor/complications ; Protein-Energy Malnutrition/complications ; Insulin Resistance ; Insulin ; Adiponectin ; Severe Acute Malnutrition/complications ; Growth Disorders ; Glucose
Chemical Substances	Insulin ; Adiponectin ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-03-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2554780-X
ISSN	2040-1752 ; 2040-1744
ISSN (online)	2040-1752
ISSN	2040-1744
DOI	10.1017/S2040174422000034
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Article ; Online: Clinical Factors and Outcomes When Real-World Heart Teams Overruled STS Risk Scores in TAVR Cases.

King, Jackson M / Black, Morgan T / Jin, Ruyun / Grunkemeier, Gary L / Reynolds, Branden R / Curtis, Brydan D / Hodson, Robert W / Strehl, Erika A / Gafoor, Sameer A / Forrester, Matthew D / Cox, Emily J / Ring, Michael E

Journal of interventional cardiology

2022 Volume 2022, Page(s) 9926423

Abstract: Objectives: This study was conducted to determine why heart teams recommended transcatheter aortic valve replacement (TAVR) versus surgical AVR (SAVR) for patients at low predicted risk of mortality (PROM) and describe outcomes of these cases.: ... ...

Abstract	Objectives: This study was conducted to determine why heart teams recommended transcatheter aortic valve replacement (TAVR) versus surgical AVR (SAVR) for patients at low predicted risk of mortality (PROM) and describe outcomes of these cases. Background: Historically, referral to TAVR was based predominately on the Society of Thoracic Surgeons (STS) risk model's PROM >3%. In selected cases, heart teams had latitude to overrule these scores. The clinical reasons and outcomes for these cases are unclear. Methods: Retrospective data were gathered for all TAVR and SAVR cases conducted by 9 hospitals between 2013 and 2017. Results: Cases included TAVR patients with STS PROM >3% ( Conclusions: Heart teams recommended TAVR in patients with STS PROM ≤3% primarily due to frailty, hostile chest, severe lung disease, and/or morbid obesity. Similar postoperative outcomes between these patients and those with STS PROM >3% suggest that decisions to overrule STS PROM ≤3% were merited and may have reduced SAVR 30-day mortality rate.
MeSH term(s)	Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Frailty/etiology ; Frailty/surgery ; Heart Valve Prosthesis Implantation/adverse effects ; Humans ; Lung Diseases/etiology ; Lung Diseases/surgery ; Obesity, Morbid ; Retrospective Studies ; Risk Factors ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
Language	English
Publishing date	2022-06-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1036325-7
ISSN	1540-8183 ; 0896-4327
ISSN (online)	1540-8183
ISSN	0896-4327
DOI	10.1155/2022/9926423
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Zs.A 2719: Show issues

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Article ; Online: Protection from nitrosative stress: a central role for microbial flavohemoglobin.

Forrester, Michael T / Foster, Matthew W

Free radical biology & medicine

2012 Volume 52, Issue 9, Page(s) 1620–1633

Abstract: Nitric oxide (NO) is an inevitable product of life in an oxygen- and nitrogen-rich environment. This reactive diatomic molecule exhibits microbial cytotoxicity, in large part by facilitating nitrosative stress and inhibiting heme-containing proteins ... ...

Abstract	Nitric oxide (NO) is an inevitable product of life in an oxygen- and nitrogen-rich environment. This reactive diatomic molecule exhibits microbial cytotoxicity, in large part by facilitating nitrosative stress and inhibiting heme-containing proteins within the aerobic respiratory chain. Metabolism of NO is therefore essential for microbial life. In many bacteria, fungi, and protozoa, the evolutionarily ancient flavohemoglobin (flavoHb) converts NO and O(2) to inert nitrate (NO(3)(-)) and undergoes catalytic regeneration via flavin-dependent reduction. Since its identification, widespread efforts have characterized roles for flavoHb in microbial nitrosative stress protection. Subsequent genomic studies focused on flavoHb have elucidated the transcriptional machinery necessary for inducible NO protection, such as NsrR in Escherichia coli, as well as additional proteins that constitute a nitrosative stress protection program. As an alternative strategy, flavoHb has been heterologously employed in higher eukaryotic organisms such as plants and human tumors to probe the function(s) of endogenous NO signaling. Such an approach may also provide a therapeutic route to in vivo NO depletion. Here we focus on the molecular features of flavoHb, the hitherto characterized NO-sensitive transcriptional machinery responsible for its induction, the roles of flavoHb in resisting mammalian host defense systems, and heterologous applications of flavoHb in plant/mammalian systems (including human tumors), as well as unresolved questions surrounding this paradigmatic NO-consuming enzyme.
MeSH term(s)	Aerobiosis ; Amino Acid Sequence ; Anaerobiosis ; Dihydropteridine Reductase/chemistry ; Dihydropteridine Reductase/genetics ; Dihydropteridine Reductase/physiology ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/physiology ; Gene Expression Regulation, Bacterial ; Hemeproteins/chemistry ; Hemeproteins/genetics ; Hemeproteins/physiology ; Humans ; Molecular Sequence Data ; NADH, NADPH Oxidoreductases/chemistry ; NADH, NADPH Oxidoreductases/genetics ; NADH, NADPH Oxidoreductases/physiology ; Nitric Oxide/physiology ; Nitrosation ; Oxidative Stress ; Protein Conformation ; Sequence Homology, Amino Acid ; Transcription, Genetic
Chemical Substances	Escherichia coli Proteins ; Hemeproteins ; Nitric Oxide (31C4KY9ESH) ; Dihydropteridine Reductase (EC 1.5.1.34) ; hmp protein, E coli (EC 1.5.1.34) ; NADH, NADPH Oxidoreductases (EC 1.6.-)
Language	English
Publishing date	2012-05-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2012.01.028
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Zs.A 2109: Show issues

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Book ; Online: Background Prompting for Improved Object Depth

Baradad, Manel / Li, Yuanzhen / Cole, Forrester / Rubinstein, Michael / Torralba, Antonio / Freeman, William T. / Jampani, Varun

2023

Abstract: Estimating the depth of objects from a single image is a valuable task for many vision, robotics, and graphics applications. However, current methods often fail to produce accurate depth for objects in diverse scenes. In this work, we propose a simple ... ...

Abstract	Estimating the depth of objects from a single image is a valuable task for many vision, robotics, and graphics applications. However, current methods often fail to produce accurate depth for objects in diverse scenes. In this work, we propose a simple yet effective Background Prompting strategy that adapts the input object image with a learned background. We learn the background prompts only using small-scale synthetic object datasets. To infer object depth on a real image, we place the segmented object into the learned background prompt and run off-the-shelf depth networks. Background Prompting helps the depth networks focus on the foreground object, as they are made invariant to background variations. Moreover, Background Prompting minimizes the domain gap between synthetic and real object images, leading to better sim2real generalization than simple finetuning. Results on multiple synthetic and real datasets demonstrate consistent improvements in real object depths for a variety of existing depth networks. Code and optimized background prompts can be found at: https://mbaradad.github.io/depth_prompt.
Keywords	Computer Science - Computer Vision and Pattern Recognition
Subject code	004
Publishing date	2023-06-08
Publishing country	us
Document type	Book ; Online
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Article ; Online: A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study.

Breslin, Thomas / Paino, Jason / Wegner, Marie / Engels, Elette / Fiedler, Stefan / Forrester, Helen / Rennau, Hannes / Bustillo, John / Cameron, Matthew / Häusermann, Daniel / Hall, Christopher / Krause, Dieter / Hildebrandt, Guido / Lerch, Michael / Schültke, Elisabeth

Biomimetics (Basel, Switzerland)

2023 Volume 8, Issue 2

Abstract: The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the ... ...

Abstract	The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells.
Language	English
Publishing date	2023-05-31
Publishing country	Switzerland
Document type	Journal Article
ISSN	2313-7673
ISSN (online)	2313-7673
DOI	10.3390/biomimetics8020230
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Article ; Online: Chest Wall Injury Society recommendation for surgical stabilization of nonunited rib fractures to decrease pain, reduce opiate use, and improve patient reported outcomes in patients with rib fracture nonunion after trauma.

Forrester, Joseph D / Bauman, Zachary M / Cole, Peter A / Edwards, John G / Knight, Ariel W / LaRoque, Michael / Raffa, Taylor / White, Thomas W / Kartiko, Susan

The journal of trauma and acute care surgery

2023 Volume 95, Issue 6, Page(s) 943–950

Abstract: Background: Rib fractures are common injuries which can be associated with acute pain and chronic disability. While most rib fractures ultimately go on to achieve bony union, a subset of patients may go on to develop non-union. Management of these ... ...

Abstract	Background: Rib fractures are common injuries which can be associated with acute pain and chronic disability. While most rib fractures ultimately go on to achieve bony union, a subset of patients may go on to develop non-union. Management of these nonunited rib fractures can be challenging and variability in management exists. Methods: The Chest Wall Injury Society's Publication Committee convened to develop recommendations for use of surgical stabilization of nonunited rib fractures (SSNURF) to treat traumatic rib fracture nonunions. PubMed, Embase, and the Cochrane database were searched for pertinent studies. Using a process of iterative consensus, all committee members voted to accept or reject the recommendation. Results: No identified studies compared SSNURF to alternative therapy and the overall quality of the body of evidence was rated as low. Risk of bias was identified in all studies. Despite these limitations, there is lower-quality evidence suggesting that SSNURF may be beneficial for decreasing pain, reducing opiate use, and improving patient reported outcomes among patients with symptomatic rib nonunion. However, these benefits should be balanced against risk of symptomatic hardware failure and infection. Conclusion: This guideline document summarizes the current CWIS recommendations regarding use of SSNURF for management of rib nonunion. Level of evidence: Therapeutic/Care Management; Level IV.
MeSH term(s)	Humans ; Rib Fractures/complications ; Rib Fractures/surgery ; Opiate Alkaloids ; Thoracic Wall ; Thoracic Injuries ; Ribs ; Fractures, Ununited/surgery ; Acute Pain
Chemical Substances	Opiate Alkaloids
Language	English
Publishing date	2023-09-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2651070-4
ISSN	2163-0763 ; 2163-0755
ISSN (online)	2163-0763
ISSN	2163-0755
DOI	10.1097/TA.0000000000004083
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Zs.A 127: Show issues

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Book ; Online: Omnimatte

Lu, Erika / Cole, Forrester / Dekel, Tali / Zisserman, Andrew / Freeman, William T. / Rubinstein, Michael

Associating Objects and Their Effects in Video

2021

Abstract: Computer vision is increasingly effective at segmenting objects in images and videos; however, scene effects related to the objects -- shadows, reflections, generated smoke, etc -- are typically overlooked. Identifying such scene effects and associating ... ...

Abstract	Computer vision is increasingly effective at segmenting objects in images and videos; however, scene effects related to the objects -- shadows, reflections, generated smoke, etc -- are typically overlooked. Identifying such scene effects and associating them with the objects producing them is important for improving our fundamental understanding of visual scenes, and can also assist a variety of applications such as removing, duplicating, or enhancing objects in video. In this work, we take a step towards solving this novel problem of automatically associating objects with their effects in video. Given an ordinary video and a rough segmentation mask over time of one or more subjects of interest, we estimate an omnimatte for each subject -- an alpha matte and color image that includes the subject along with all its related time-varying scene elements. Our model is trained only on the input video in a self-supervised manner, without any manual labels, and is generic -- it produces omnimattes automatically for arbitrary objects and a variety of effects. We show results on real-world videos containing interactions between different types of subjects (cars, animals, people) and complex effects, ranging from semi-transparent elements such as smoke and reflections, to fully opaque effects such as objects attached to the subject. Comment: CVPR 2021 Oral. Project webpage: https://omnimatte.github.io/. Added references
Keywords	Computer Science - Computer Vision and Pattern Recognition
Subject code	004
Publishing date	2021-05-14
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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