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  1. Article ; Online: Richard Hader Visionary Leader Award 2021 International Visionary Leader Hana'a Abd-ul Salam.

    Saad, Hanadi

    Nursing management

    2022  Volume 53, Issue 2, Page(s) 44–46

    Abstract: The following manuscript is the winning international Visionary Leader Award entry submitted to Nursing Management in recognition of Hana'a Abd-ul Salam, MPH, MSN, RN, DESS, TD, director of nursing at Dalla'a General Hospital in Sidon, South Lebanon. ...

    Abstract The following manuscript is the winning international Visionary Leader Award entry submitted to Nursing Management in recognition of Hana'a Abd-ul Salam, MPH, MSN, RN, DESS, TD, director of nursing at Dalla'a General Hospital in Sidon, South Lebanon.
    MeSH term(s) Awards and Prizes ; Humans ; Leadership ; Nurse Administrators ; Nursing Care
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605889-9
    ISSN 1538-8670 ; 0744-6314
    ISSN (online) 1538-8670
    ISSN 0744-6314
    DOI 10.1097/01.NUMA.0000816292.39288.67
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Rezension von: Adams, Richard H., Development and social change in rural Egypt]

    Nagi, Saad Z / Adams, Richard H

    American journal of agricultural economics 70 ,1, S. 201

    1988  

    Author's details Saad Z. Nagi
    Keywords 40;49
    Language English
    Publisher Oxford University Press
    Publishing place Cary, NC
    Document type Article
    ZDB-ID 218188-5
    ISSN 0002-9092
    ISSN 0002-9092
    Database ECONomics Information System

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  3. Article ; Online: Performance of preferentially expressed antigen in melanoma (PRAME) immunohistochemistry for metastatic melanoma in cytology specimens.

    Saad, Mohammed / Cantley, Richard / Hao, Wei / Wang, Zixi / Thomas, Dafydd / Pantanowitz, Liron / Jin, Xiaobing

    Diagnostic cytopathology

    2024  

    Abstract: Background: Preferentially expressed antigen in melanoma (PRAME) has been introduced as a new melanoma marker and potential target for immunotherapy. While PRAME immunohistochemistry (IHC) is well documented in surgical pathology, similar data in ... ...

    Abstract Background: Preferentially expressed antigen in melanoma (PRAME) has been introduced as a new melanoma marker and potential target for immunotherapy. While PRAME immunohistochemistry (IHC) is well documented in surgical pathology, similar data in cytology are limited. Metastatic melanoma is frequently diagnosed via cytology samples in which IHC plays an important role. We aimed to accordingly evaluate the performance of PRAME IHC in diagnosing metastatic melanoma in cytology samples relative to other commonly used melanoma markers.
    Materials and methods: The study included 156 archival cytology cases, of which 93 were melanoma cases and 63 nonmelanoma cases (controls). All cases underwent PRAME IHC staining on cell blocks. Nuclear staining of PRAME was evaluated using a quantitative and qualitative scale. Other melanocytic IHC stain results (SOX10, S-100, Melan-A, and HMB45) were also documented.
    Results: PRAME was detected in tumor cells in 86% of melanoma cases, which was significantly lower than SOX10 (100%) (p < .01), and similar to HMB45 (84%) and Melan-A (82%). S-100 had the lowest sensitivity of 71%. In comparison to other types of melanomas, spindle cell melanoma exhibited higher negativity for PRAME IHC (4/10 = 40%). PRAME was also expressed in some nonmelanocytic malignancies including carcinoma (5/22 = 23%), sarcoma (5/15 = 33%), and hematologic malignancies (1/9 = 11%). Overall, PRAME showed a sensitivity of 86%, specificity of 82%, positive predictive value of 70%, and negative predictive value of 92% for metastatic melanoma.
    Conclusions: PRAME is a useful marker for the diagnosis of melanoma in cytology material, but it is less sensitive than SOX10. PRAME is also expressed in other nonmelanocytic tumors which limits its specificity.
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632710-2
    ISSN 1097-0339 ; 8755-1039
    ISSN (online) 1097-0339
    ISSN 8755-1039
    DOI 10.1002/dc.25313
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  4. Article ; Online: MicroRNAs in inflammasomopathies.

    Saad, Norma / Duroux-Richard, Isabelle / Touitou, Isabelle / Jeziorski, Eric / Apparailly, Florence

    Immunology letters

    2023  Volume 256-257, Page(s) 48–54

    Abstract: microRNAs (miRNAs) are small non-coding RNA sequences that negatively regulate the expression of protein-encoding genes at the post-transcriptional level. They play a role in the regulation of inflammatory responses by controlling the proliferation and ... ...

    Abstract microRNAs (miRNAs) are small non-coding RNA sequences that negatively regulate the expression of protein-encoding genes at the post-transcriptional level. They play a role in the regulation of inflammatory responses by controlling the proliferation and activation of immune cells and their expression is disrupted in several immune-mediated inflammatory disorders. Among these, autoinflammatory diseases (AID) are a group of rare hereditary disorders caused by abnormal activation of the innate immune system and characterized by recurrent fevers. Major groups of AID are inflammasomopathies, which are associated with hereditary defects in the activation of inflammasomes, cytosolic multiprotein signaling complexes regulating IL-1 family cytokine maturation and pyroptosis. The study of the role of miRNAs in AID is only recently emerging and remains scarce in inflammasomopathies. In this review, we describe the AID and inflammasomopathies, and the current knowledge on the role of miRNAs in disease processes.
    MeSH term(s) Humans ; MicroRNAs/genetics ; Immunity, Innate ; Hereditary Autoinflammatory Diseases/genetics ; Inflammasomes/metabolism ; Cytokines
    Chemical Substances MicroRNAs ; Inflammasomes ; Cytokines
    Language English
    Publishing date 2023-04-05
    Publishing country Netherlands
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 445150-8
    ISSN 1879-0542 ; 0165-2478
    ISSN (online) 1879-0542
    ISSN 0165-2478
    DOI 10.1016/j.imlet.2023.04.001
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  5. Article: Dysphagia: A Case Report of an Atypical Presentation of Statin-Induced Necrotizing Myositis.

    Polmann, Michaela B / Suarez, Richard I / Saad, Ali / Bedran, Kebir H

    Cureus

    2023  Volume 15, Issue 8, Page(s) e43587

    Abstract: Statin medications act by inhibiting the enzyme hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGCR), thus decreasing hepatic cholesterol synthesis. They are considered the mainstay treatment of hypercholesterolemia due to their tremendous ... ...

    Abstract Statin medications act by inhibiting the enzyme hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGCR), thus decreasing hepatic cholesterol synthesis. They are considered the mainstay treatment of hypercholesterolemia due to their tremendous efficacy and mortality benefit. Although generally well tolerated, statins may adversely affect skeletal muscle resulting in side effects ranging from mild myalgia to life-threatening necrotizing myositis. Statin-induced necrotizing autoimmune myositis is a rare yet devastating adverse effect that may occur shortly after initiation of therapy or after several years of use. Unfortunately, medication discontinuation has shown no impact on prevention or alleviation of symptoms. Though there is currently no definitive guidance for the treatment of this condition, corticosteroids are generally considered to be first line, via high-dose oral prednisone or intravenous methylprednisolone. In this case report, we discuss the case of a 72-year-old male with an unusual presentation of statin-induced necrotizing autoimmune myositis: dysphagia, weakness, and weight loss. His diagnosis was confirmed by muscle biopsy indicating necrotizing myositis and his serum was found to be strongly positive for anti-HMG-CoA reductase antibodies. This patient had a very brief history of statin use, but his primary care provider discontinued the medication a couple of months prior to symptom onset due to elevated liver function tests. He was treated with aggressive intravenous fluid hydration and intravenous corticosteroids during an extended inpatient hospital stay. He was discharged to a rehabilitation facility. This report demonstrates the importance of creating a wide differential for patients who present with fatigue, generalized weakness, and dysphagia. It is essential to always consider statin-induced necrotizing myositis if a patient has a history of statin use, even if the statin has been discontinued. Necrotizing myositis demands timely diagnosis and management to improve mortality.
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.43587
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  6. Article ; Online: The Wireless Motility Capsule: a One-Stop Shop for the Evaluation of GI Motility Disorders.

    Saad, Richard J

    Current gastroenterology reports

    2016  Volume 18, Issue 3, Page(s) 14

    Abstract: The wireless motility and pH capsule (WMC) provides an office-based test to simultaneously assess both regional and whole gut transit. Ingestion of this non-digestible capsule capable of measuring temperature, pH, and the pressure of its immediate ... ...

    Abstract The wireless motility and pH capsule (WMC) provides an office-based test to simultaneously assess both regional and whole gut transit. Ingestion of this non-digestible capsule capable of measuring temperature, pH, and the pressure of its immediate surroundings allows for the measurement of gastric, small bowel, and colonic transit times in an ambulatory setting. Approved by the US Food and Drug Administration for the evaluation of suspected conditions of delayed gastric emptying and the evaluation of colonic transit in chronic idiopathic constipation, WMC should be considered in suspected gastrointestinal motility disorders as it provides a single study capable of simultaneously assessing for regional, multiregional, or generalized motility disorders. Specific indications for testing with the WMC should include the evaluation of suspect cases of gastroparesis, small bowel dysmotility, and slow transit constipation, as well as symptom syndromes suggestive of a multiregional or generalized gastrointestinal transit delay.
    MeSH term(s) Capsule Endoscopy/adverse effects ; Capsule Endoscopy/instrumentation ; Capsule Endoscopy/methods ; Contraindications ; Gastric Emptying/physiology ; Gastrointestinal Diseases/diagnosis ; Gastrointestinal Diseases/physiopathology ; Gastrointestinal Motility/physiology ; Gastrointestinal Transit/physiology ; Humans
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2041376-2
    ISSN 1534-312X ; 1522-8037
    ISSN (online) 1534-312X
    ISSN 1522-8037
    DOI 10.1007/s11894-016-0489-x
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  7. Article: Correction to: Tranexamic acid lowers transfusion requirements and hospital length of stay following revision total hip or knee arthroplasty.

    Gianakos, Arianna L / Saad, Bishoy N / Haring, Richard / Menken, Luke G / Elkattaway, Sherif / Liporace, Frank A / Yoon, Richard S

    Patient safety in surgery

    2022  Volume 16, Issue 1, Page(s) 1

    Language English
    Publishing date 2022-01-07
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2409244-7
    ISSN 1754-9493
    ISSN 1754-9493
    DOI 10.1186/s13037-021-00313-6
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  8. Article: Transient Complete Atrioventricular Block Associated With Herbal Supplement Use.

    Kucuk, Ugur / Pham, Melissa / Raza Raja, Mohummad Hassan / Saad Shaukat, Muhammad Hamza / Clark, Richard

    South Dakota medicine : the journal of the South Dakota State Medical Association

    2023  Volume 76, Issue 7, Page(s) 311–313

    Abstract: Introduction: Increasing and easy availability of so-called natural/herbal supplements pose the unique challenge of identifying associated side effects, including arrhythmias in otherwise-healthy individuals.: Case presentation: A 25-year-old female ... ...

    Abstract Introduction: Increasing and easy availability of so-called natural/herbal supplements pose the unique challenge of identifying associated side effects, including arrhythmias in otherwise-healthy individuals.
    Case presentation: A 25-year-old female patient presented to the emergency department with fatigue and lightheadedness. The electrocardiogram showed complete AV block with a junctional escape rhythm at 55 beats per minute with QT prolongation (542ms). One week ago, she started to use a herbal medication (Muscle Eze Advanced) for muscle cramps after workouts. Extensive cardiac testing, including complete blood count, complete metabolic panel, TSH, transthoracic echocardiography, urine drug analysis, Lyme antibody were negative. Normal sinus rhythm was restored spontaneously within 1 day of discontinuing the herbal medication. PR and corrected QT intervals returned to baseline over the next two weeks.
    Conclusion: Muscle Eze Advanced consists of seven ingredients, including Melissa officinalis and Valeriana officinalis that have negative chronotropic, negative dromotrophic and QT prolonging effects. Recognizing the association between certain over-the-counter supplements and brady-arrhythmias may circumvent need for permanent pacemakers - an important consideration especially in the young.
    MeSH term(s) Female ; Humans ; Adult ; Atrioventricular Block/chemically induced ; Atrioventricular Block/diagnosis ; Dietary Supplements/adverse effects ; Drug-Related Side Effects and Adverse Reactions ; Echocardiography ; Electrocardiography
    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2278073-7
    ISSN 0038-3317
    ISSN 0038-3317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Unraveling the Complex Interplay of Phase Transitions in Spinel Ferrites: A Comprehensive Quantum Mechanical Vibrational Study of ZnFe

    Almutairi, Tahani Saad

    ACS omega

    2023  Volume 8, Issue 40, Page(s) 36999–37010

    Abstract: The rich phase transition landscape of spinel ferrites and its profound impact ...

    Abstract The rich phase transition landscape of spinel ferrites and its profound impact on their physical properties have garnered significant interest in recent years. The complex interplay of divalent and trivalent cations distributed across A- and B-sites gives rise to a captivating variety of interactions. In this study, we delve into the structural, electronic, magnetic, and vibrational properties of ZnFe
    Language English
    Publishing date 2023-09-25
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c04268
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  10. Article ; Online: Small Intestinal Bacterial Overgrowth: How to Diagnose and Treat (and Then Treat Again).

    Ginnebaugh, Brian / Chey, William D / Saad, Richard

    Gastroenterology clinics of North America

    2020  Volume 49, Issue 3, Page(s) 571–587

    Abstract: Small intestinal bacterial overgrowth (SIBO) is a condition with presentation that can vary from asymptomatic to steatorrhea and malnutrition. Small bowel aspiration and culture is the current gold standard of diagnosis; however, this is invasive and is ... ...

    Abstract Small intestinal bacterial overgrowth (SIBO) is a condition with presentation that can vary from asymptomatic to steatorrhea and malnutrition. Small bowel aspiration and culture is the current gold standard of diagnosis; however, this is invasive and is not without risk to the patient. Breath testing is a noninvasive and less expensive alternative method; however, it lacks diagnostic sensitivity and specificity. Novel diagnostic methods being studied include gas-sensing capsules. The mainstay of treatment is antibiotics; alternative therapies include herbal medications, dietary modifications, and prokinetic agents. Further investigation into less invasive and less harmful diagnostic methods and treatment options is warranted.
    MeSH term(s) Anti-Bacterial Agents/administration & dosage ; Diet Therapy/methods ; Drugs, Chinese Herbal/administration & dosage ; Dysbiosis/diagnosis ; Dysbiosis/microbiology ; Dysbiosis/therapy ; Humans ; Intestinal Diseases/diagnosis ; Intestinal Diseases/microbiology ; Intestinal Diseases/therapy ; Intestine, Small/microbiology ; Kinetics
    Chemical Substances Anti-Bacterial Agents ; Drugs, Chinese Herbal
    Language English
    Publishing date 2020-06-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92114-2
    ISSN 1558-1942 ; 0889-8553
    ISSN (online) 1558-1942
    ISSN 0889-8553
    DOI 10.1016/j.gtc.2020.04.010
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