LIVIVO - Search results -

Search results

Result 1 - 10 of total 522

Search options

Article ; Online: A close shave: How SARS-CoV-2 induces the loss of cilia.

Fonseca, Barbara F / Chakrabarti, Lisa A

2022 Volume 221, Issue 7

Abstract: Wang et al. report in this issue (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202108015) that the SARS-CoV-2 protein ORF10 increases the activity of the E3 ligase CUL2ZYG11B, leading to the degradation of multiple ciliary proteins. The resulting loss ... ...

Abstract	Wang et al. report in this issue (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202108015) that the SARS-CoV-2 protein ORF10 increases the activity of the E3 ligase CUL2ZYG11B, leading to the degradation of multiple ciliary proteins. The resulting loss of cilia may facilitate the spread of SARS-CoV-2 in the respiratory tree.
MeSH term(s)	COVID-19/pathology ; Cell Cycle Proteins ; Cilia/pathology ; Cullin Proteins ; Genes, Viral ; Humans ; Proteins/metabolism ; SARS-CoV-2 ; Ubiquitin-Protein Ligases/metabolism
Chemical Substances	CUL2 protein, human ; Cell Cycle Proteins ; Cullin Proteins ; Proteins ; ZYG11A protein, human ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2022-06-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	218154-x
ISSN	1540-8140 ; 0021-9525
ISSN (online)	1540-8140
ISSN	0021-9525
DOI	10.1083/jcb.202206023
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ub I Zs.190: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Editorial

Bernardo Duarte / Célia M. Teixeira / Irene Martins / Aschwin H. Engelen / Raquel L. Costa / Janine Barbara Adams / Maria João Bebianno / Ricardo A. Melo / Vanessa F. Fonseca

Frontiers in Marine Science, Vol

Emerging Topics in Coastal and Transitional Ecosystems: Science, Literacy, and Innovation

2022 Volume 9

Keywords	emerging pollutants ; marine governance ; ecosystem-based approach (EBA) ; blue economy ; ocean literacy ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Larry Parsons: Researcher, mentor, and friend.

Frantz, Kyle / Roberto, Marisa / Mason, Barbara / Koob, George F / Volkow, Nora / Rodriguez de Fonseca, Fernando

Addiction biology

2018 Volume 23, Issue 6, Page(s) 1204–1206

Language	English
Publishing date	2018-11-28
Publishing country	United States
Document type	Editorial
ZDB-ID	1324314-7
ISSN	1369-1600 ; 1355-6215
ISSN (online)	1369-1600
ISSN	1355-6215
DOI	10.1111/adb.12686
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4586: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Global loss of cellular m

Vaid, Roshan / Mendez, Akram / Thombare, Ketan / Burgos-Panadero, Rebeca / Robinot, Rémy / Fonseca, Barbara F / Gandasi, Nikhil R / Ringlander, Johan / Hassan Baig, Mohammad / Dong, Jae-June / Cho, Jae Yong / Reinius, Björn / Chakrabarti, Lisa A / Nystrom, Kristina / Mondal, Tanmoy

Genome research

2023 Volume 33, Issue 3, Page(s) 299–313

Abstract: Insights into host-virus interactions during SARS-CoV-2 infection are needed to understand COVID-19 pathogenesis and may help to guide the design of novel antiviral therapeutics. ...

Abstract	Insights into host-virus interactions during SARS-CoV-2 infection are needed to understand COVID-19 pathogenesis and may help to guide the design of novel antiviral therapeutics.
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; COVID-19/genetics ; Methylation ; RNA ; RNA, Viral/genetics ; Methyltransferases/genetics
Chemical Substances	RNA (63231-63-0) ; RNA, Viral ; METTL3 protein, human (EC 2.1.1.62) ; Methyltransferases (EC 2.1.1.-)
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1284872-4
ISSN	1549-5469 ; 1088-9051 ; 1054-9803
ISSN (online)	1549-5469
ISSN	1088-9051 ; 1054-9803
DOI	10.1101/gr.276407.121
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3729: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 8: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Recapitulating memory B cell responses in a Lymphoid Organ-Chip to evaluate mRNA vaccine boosting strategies

Jeger-Madiot, Raphaël / Planas, Delphine / Staropoli, Isabelle / Kervevan, Jérôme / Mary, Héloïse / Collina, Camilla / Fonseca, Barbara F. / Debarnot, Hippolyte / Robinot, Rémy / Gellenoncourt, Stacy / Schwartz, Olivier / Ewart, Lorna / Bscheider, Michael / Gobaa, Samy / Chakrabarti, Lisa A.

bioRxiv

Abstract: Predicting the immunogenicity of candidate vaccines in humans remains a challenge. To address this issue, we developed a Lymphoid Organ-Chip (LO chip) model based on a microfluidic chip seeded with human PBMC at high density within a 3D collagen matrix. ... ...

Abstract	Predicting the immunogenicity of candidate vaccines in humans remains a challenge. To address this issue, we developed a Lymphoid Organ-Chip (LO chip) model based on a microfluidic chip seeded with human PBMC at high density within a 3D collagen matrix. Perfusion of the SARS-CoV-2 Spike protein mimicked a vaccine boost by inducing a massive amplification of Spike-specific memory B cells, plasmablast differentiation, and Spike-specific antibody secretion. Features of lymphoid tissue, including the formation of activated CD4+ T cell/B cell clusters and the emigration of matured plasmablasts, were recapitulated in the LO chip. Importantly, myeloid cells were competent at capturing and expressing mRNA vectored by lipid nanoparticles, enabling the assessment of responses to mRNA vaccines. Comparison of on-chip responses to Wuhan monovalent and Wuhan/Omicron bivalent mRNA vaccine boosts showed equivalent induction of Omicron neutralizing antibodies, pointing at immune imprinting as reported in vivo. The LO chip thus represents a versatile platform suited to the preclinical evaluation of vaccine boosting strategies.
Keywords	covid19
Language	English
Publishing date	2024-02-02
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2024.02.02.578553
Database	COVID19

Full text online

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Respective contribution of the cephalic neural crest and mesoderm to SIX1-expressing head territories in the avian embryo.

Fonseca, Barbara F / Couly, Gérard / Dupin, Elisabeth

BMC developmental biology

2017 Volume 17, Issue 1, Page(s) 13

Abstract: Background: Vertebrate head development depends on a series of interactions between many cell populations of distinct embryological origins. Cranial mesenchymal tissues have a dual embryonic source: - the neural crest (NC), which generates most of ... ...

Abstract	Background: Vertebrate head development depends on a series of interactions between many cell populations of distinct embryological origins. Cranial mesenchymal tissues have a dual embryonic source: - the neural crest (NC), which generates most of craniofacial skeleton, dermis, pericytes, fat cells, and tenocytes; and - the mesoderm, which yields muscles, blood vessel endothelia and some posterior cranial bones. The molecular players that orchestrate co-development of cephalic NC and mesodermal cells to properly construct the head of vertebrates remain poorly understood. In this regard, Six1 gene, a vertebrate homolog of Drosophila Sine Oculis, is known to be required for development of ear, nose, tongue and cranial skeleton. However, the embryonic origin and fate of Six1-expressing cells have remained unclear. In this work, we addressed these issues in the avian embryo model by using quail-chick chimeras, cephalic NC cultures and immunostaining for SIX1. Results: Our data show that, at early NC migration stages, SIX1 is expressed by mesodermal cells but excluded from the NC cells (NCC). Then, SIX1 becomes widely expressed in NCC that colonize the pre-otic mesenchyme. In contrast, in the branchial arches (BAs), SIX1 is present only in mesodermal cells that give rise to jaw muscles. At later developmental stages, the distribution of SIX1-expressing cells in mesoderm-derived tissues is consistent with a possible role of this factor in the myogenic program of all types of head muscles, including pharyngeal, extraocular and tongue muscles. In NC derivatives, SIX1 is notably expressed in perichondrium and chondrocytes of the nasal septum and in the sclera, although other facial cartilages such as Meckel's were negative at the stages considered. Moreover, in cephalic NC cultures, chondrocytes and myofibroblasts, not the neural and melanocytic cells express SIX1. Conclusion: The present results point to a dynamic tissue-specific expression of SIX1 in a variety of cephalic NC- and mesoderm-derived cell types and tissues, opening the way for further analysis of Six1 function in the coordinated development of these two cellular populations during vertebrate head formation.
MeSH term(s)	Animals ; Embryo, Nonmammalian/embryology ; Mesoderm/embryology ; Neural Crest/embryology ; Quail/embryology
Language	English
Publishing date	2017-10-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1471-213X
ISSN (online)	1471-213X
DOI	10.1186/s12861-017-0155-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Telomeric repeat-containing RNA is dysregulated in acute myeloid leukemia.

Catto, Luiz Fernando B / Zanelatto, Leonardo C / Donaires, Flavia S / de Carvalho, Vinicius S / Santana, Bárbara A / Pinto, André L / Fantacini, Daianne / de Souza, Lucas Eduardo B / Fonseca, Natasha P / Telho, Bruno S / Ayrosa Madeira, Maria Isabel / Barbosa Pagnano, Katia Borgia / Firmato, Ana Beatriz / Fagundes, Evandro Maranhão / Higashi, Marcia / Nunes, Elenaide Coutinho / Traina, Fabiola / Lobo de F Pontes, Lorena / Rego, Eduardo M /

Calado, Rodrigo T

Blood advances

2023 Volume 7, Issue 22, Page(s) 7067–7078

Abstract: TERRA (telomeric repeat-containing RNA) is a class of long noncoding RNAs transcribed from subtelomeric and telomeric regions. TERRA binds to the subtelomeric and telomeric DNA-forming R-loops (DNA-RNA hybrids), which are involved in telomere maintenance ...

Abstract	TERRA (telomeric repeat-containing RNA) is a class of long noncoding RNAs transcribed from subtelomeric and telomeric regions. TERRA binds to the subtelomeric and telomeric DNA-forming R-loops (DNA-RNA hybrids), which are involved in telomere maintenance and telomerase function, but the role of TERRA in human cells is not well characterized. Here, we comprehensively investigated for the first time TERRA expression in primary human hematopoietic cells from an exploratory cohort of patients with acute myeloid leukemia (AML), patients with acute lymphoblastic leukemia (ALL), patients with telomere biology disorder (TBD), and healthy subjects. TERRA expression was repressed in primary human hematopoietic cells, including healthy donors, patients with ALL, and patients with TBD, irrespective of their telomere length, except for AML. A second cohort comprising 88 patients with AML showed that TERRA was overexpressed in an AML subgroup also characterized by higher R-loop formation, low TERT and RNAseH2 expression, and a paucity of somatic splicing factor mutations. Telomere length did not correlate with TERRA expression levels. To assess the role of TERRA R-loops in AML, we induced R-loop depletion by increasing RNAseH1 expression in 2 AML cell lines. Decreased TERRA R-loops in AML cell lines resulted in increased chemosensitivity to cytarabine. Our findings indicate that TERRA is uniformly repressed in primary human hematopoietic cells but abnormally expressed in an AML subset with low telomerase.
MeSH term(s)	Humans ; Telomerase ; Leukemia, Myeloid, Acute/genetics ; Cell Line ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; RNA, Long Noncoding ; DNA
Chemical Substances	Telomerase (EC 2.7.7.49) ; RNA, Long Noncoding ; DNA (9007-49-2)
Language	English
Publishing date	2023-09-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2023010658
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 7153: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Influence of previous Zika virus infection on acute dengue episode.

Estofolete, Cassia F / Versiani, Alice F / Dourado, Fernanda S / Milhim, Bruno H G A / Pacca, Carolina C / Silva, Gislaine C D / Zini, Nathalia / Santos, Barbara F Dos / Gandolfi, Flora A / Mistrão, Natalia F B / Garcia, Pedro H C / Rocha, Rodrigo S / Gehrke, Lee / Bosch, Irene / Marques, Rafael E / Teixeira, Mauro M / da Fonseca, Flavio G / Vasilakis, Nikos / Nogueira, Maurício L

PLoS neglected tropical diseases

2023 Volume 17, Issue 11, Page(s) e0011710

Abstract: Background: The co-circulation of flaviviruses in tropical regions has led to the hypothesis that immunity generated by a previous dengue infection could promote severe disease outcomes in subsequent infections by heterologous serotypes. This study ... ...

Abstract	Background: The co-circulation of flaviviruses in tropical regions has led to the hypothesis that immunity generated by a previous dengue infection could promote severe disease outcomes in subsequent infections by heterologous serotypes. This study investigated the influence of antibodies generated by previous Zika infection on the clinical outcomes of dengue infection. Methodology/principal findings: We enrolled 1,043 laboratory confirmed dengue patients and investigated their prior infection to Zika or dengue. Severe forms of dengue disease were more frequent in patients with previous Zika infection, but not in those previously exposed to dengue. Conclusions/significance: Our findings suggest that previous Zika infection may represent a risk factor for subsequent severe dengue disease, but we did not find evidence of antibody-dependent enhancement (higher viral titer or pro-inflammatory cytokine overexpression) contributing to exacerbation of the subsequent dengue infection.
MeSH term(s)	Humans ; Zika Virus Infection ; Dengue ; Dengue Virus ; Antibodies, Viral ; Zika Virus ; Cross Reactions
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2023-11-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0011710
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Effects of vitamin D supplementation on glycemic control of children and adolescents with type 1 diabetes mellitus: a systematic review.

Nascimento, Bárbara Folino / Moreira, Carolina F F / da Fonseca, Eliana R / Fedeszen, Pamela M K / de Paula, Tatiana P / de Sena, Ana Silvia S / de Almeida, Nathália F A / Bandeira Filho, Orlando C de S / Curval, Daniella R / Padilha, Patricia de C

Journal of pediatric endocrinology & metabolism : JPEM

2022 Volume 35, Issue 8, Page(s) 973–988

Abstract: Objectives: To evaluate the effect of vitamin D supplementation on glycemic control in children and adolescents with T1DM.: Content: A systematic search was conducted of the Medline/PubMed, Web of Science, Embase, BVS/Lilacs, Cochrane Library, Scopus, ...

Abstract	Objectives: To evaluate the effect of vitamin D supplementation on glycemic control in children and adolescents with T1DM. Content: A systematic search was conducted of the Medline/PubMed, Web of Science, Embase, BVS/Lilacs, Cochrane Library, Scopus, Cinahl, Food Science, and FSTA databases. Two reviewers independently extracted article data and assessed quality. Summary: A total of 1,613 eligible articles were retrieved, ten of which met the selection criteria: eight clinical trials, one retrospective cohort study, and one cross-sectional study. Regarding the cutoff points used to classify vitamin D status, most of the studies set deficiency at 25-hydroxyvitamin D <20 ng/mL, sufficiency at ≥30 ng/mL, and insufficiency as the interval between these values. Regarding intervention strategies, most used cholecalciferol for supplementation, but there was great variation in the dose and supplementation time. When evaluating the effect of vitamin D supplementation on HbA1c, a significant improvement in glycemic control was observed in 50% of the studies. However, only one of these studies was classified as being of positive methodological quality, with three having their quality classified as neutral and one as negative. Outlook: There is yet no consistent evidence on the effect of vitamin D supplementation on glycemic control as an adjuvant in the treatment of children and adolescents with T1DM.
MeSH term(s)	Adolescent ; Child ; Cross-Sectional Studies ; Diabetes Mellitus, Type 1/drug therapy ; Dietary Supplements ; Glycemic Control ; Humans ; Retrospective Studies ; Vitamin D ; Vitamin D Deficiency/drug therapy
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2022-07-18
Publishing country	Germany
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	1231070-0
ISSN	2191-0251 ; 0334-018X
ISSN (online)	2191-0251
ISSN	0334-018X
DOI	10.1515/jpem-2022-0044
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2258: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Respective contribution of the cephalic neural crest and mesoderm to SIX1-expressing head territories in the avian embryo

Barbara F. Fonseca / Gérard Couly / Elisabeth Dupin

BMC Developmental Biology, Vol 17, Iss 1, Pp 1-

2017 Volume 15

Abstract: Abstract Background Vertebrate head development depends on a series of interactions between many cell populations of distinct embryological origins. Cranial mesenchymal tissues have a dual embryonic source: - the neural crest (NC), which generates most ... ...

Abstract	Abstract Background Vertebrate head development depends on a series of interactions between many cell populations of distinct embryological origins. Cranial mesenchymal tissues have a dual embryonic source: - the neural crest (NC), which generates most of craniofacial skeleton, dermis, pericytes, fat cells, and tenocytes; and - the mesoderm, which yields muscles, blood vessel endothelia and some posterior cranial bones. The molecular players that orchestrate co-development of cephalic NC and mesodermal cells to properly construct the head of vertebrates remain poorly understood. In this regard, Six1 gene, a vertebrate homolog of Drosophila Sine Oculis, is known to be required for development of ear, nose, tongue and cranial skeleton. However, the embryonic origin and fate of Six1-expressing cells have remained unclear. In this work, we addressed these issues in the avian embryo model by using quail-chick chimeras, cephalic NC cultures and immunostaining for SIX1. Results Our data show that, at early NC migration stages, SIX1 is expressed by mesodermal cells but excluded from the NC cells (NCC). Then, SIX1 becomes widely expressed in NCC that colonize the pre-otic mesenchyme. In contrast, in the branchial arches (BAs), SIX1 is present only in mesodermal cells that give rise to jaw muscles. At later developmental stages, the distribution of SIX1-expressing cells in mesoderm-derived tissues is consistent with a possible role of this factor in the myogenic program of all types of head muscles, including pharyngeal, extraocular and tongue muscles. In NC derivatives, SIX1 is notably expressed in perichondrium and chondrocytes of the nasal septum and in the sclera, although other facial cartilages such as Meckel’s were negative at the stages considered. Moreover, in cephalic NC cultures, chondrocytes and myofibroblasts, not the neural and melanocytic cells express SIX1. Conclusion The present results point to a dynamic tissue-specific expression of SIX1 in a variety of cephalic NC- and mesoderm-derived cell types and tissues, opening the way for further analysis of Six1 function in the coordinated development of these two cellular populations during vertebrate head formation.
Keywords	SIX1 ; Neural crest ; Mesoderm ; Quail-chick chimera ; Branchial arch ; Biology (General) ; QH301-705.5
Subject code	612
Language	English
Publishing date	2017-10-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED