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Article ; Online: Egg yolk consumption, smoking and carotid plaque: reply to letters to the Editor by Sean Lucan and T Dylan Olver et al.

Spence, J David / Jenkins, David J A / Davignon, Jean

2013 Volume 227, Issue 1, Page(s) 189–191

MeSH term(s)	Carotid Arteries/pathology ; Carotid Artery Diseases/etiology ; Cholesterol, Dietary/adverse effects ; Egg Yolk/adverse effects ; Feeding Behavior ; Female ; Humans ; Male ; Plaque, Atherosclerotic
Chemical Substances	Cholesterol, Dietary
Language	English
Publishing date	2013-03
Publishing country	Ireland
Document type	Letter ; Comment
ZDB-ID	80061-2
ISSN	1879-1484 ; 0021-9150
ISSN (online)	1879-1484
ISSN	0021-9150
DOI	10.1016/j.atherosclerosis.2012.10.075
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Book: The actor's brain

Spence, Sean A.

exploring the cognitive neuroscience of free will

2009

Author's details	Sean A. Spence
Language	English
Size	434 S., [8] Bl. : Ill., graph. Darst.
Publisher	Oxford Univ. Press
Publishing place	New York
Publishing country	United States
Document type	Book
Note	Literaturverz. S. [397] - 425
HBZ-ID	HT015998539
ISBN	978-0-19-852666-7 ; 0-19-852666-0
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2009 A 3334	order for loan	Magazin

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Book ; Conference proceedings: Voices in the brain

Spence, Sean A.

the cognitive neuropsychiatry of auditory verbal hallucinations ; [Second Sheffield Psychopathology Symposium - Voices in the Brain, Sheffield, 19th September 2002]

(Cognitive neuropsychiatry ; 9,1/2 = Spec. issue)

2004

Event/congress	Sheffield Psychopathology Symposium (2, 2002, Sheffield)
Author's details	ed.: Sean A. Spence
Series title	Cognitive neuropsychiatry ; 9,1/2 = Spec. issue
Collection
Keywords	Auditory hallucinations
Subject code	616.89
Language	English
Size	151 S. : graph. Darst.
Publisher	Psychology Press
Publishing place	Hove
Publishing country	Great Britain
Document type	Book ; Conference proceedings
HBZ-ID	HT014113939
ISBN	1-84169-963-2 ; 978-1-84169-963-9
Database	Catalogue ZB MED Medicine, Health

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Zs A 4855 -9-	not available for loan	Zeitschriften-Lesesaal

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Article ; Online: The spin move to facilitate antegrade coronoid fixation in terrible triad injuries.

Low, Sara L / Spence, Sean A / Low, Joshua X / Baratz, Mark E

Journal of shoulder and elbow surgery

2022 Volume 32, Issue 4, Page(s) 738–743

Abstract: Background: The role of the coronoid process in elbow instability has been established. When necessary, coronoid fixation can be challenging. Placing fixation perpendicular to the fracture requires achieving a trajectory as close as possible to the ... ...

Abstract	Background: The role of the coronoid process in elbow instability has been established. When necessary, coronoid fixation can be challenging. Placing fixation perpendicular to the fracture requires achieving a trajectory as close as possible to the midline axis of the proximal ulna, either from anterior to posterior or vice versa. The aim of this study was to determine whether coronoid exposure-and the ability to place fixation from anterior to posterior-is improved via a lateral extensor-splitting approach with forearm supination, that is, the "spin move," with progressive stages of lateral elbow instability. Methods: The lateral extensor-splitting approach was performed on 9 cadaveric upper extremities. A 0.157-mm (0.062-inch) wire was drilled perpendicularly into the lateral aspect of the humerus just proximal to the lateral epicondyle. A second wire was drilled into the tip of the coronoid, aiming for a drill trajectory as close as possible to the midline axis. The angle between the 2 wires was measured as the initial angle. Three stages of progressive lateral elbow instability were produced by sequential release of the lateral ulnar collateral ligament (LUCL), common extensor origin (CEO), and posterior capsule. At each stage, the spin move was performed and the angle between the 2 wires was measured. The difference between this angle and the initial angle was calculated, with the average value reported as the Δ angle for each stage. The average difference between each stage and the next stage was reported. Results: The spin move resulted in Δ angles of 10.3° with the LUCL released, 20° with the CEO released, and 29.1° with the posterior capsule released. Progressing from LUCL release to CEO release to posterior capsule release, the Δ angle between the K-wires increased an average of 9.6° from the LUCL stage to the CEO stage and 9.1° from the CEO stage to the posterior capsule stage. Conclusion: The spin move is a simple maneuver that can improve exposure of the coronoid process regardless of the degree of elbow instability. This may facilitate a more perpendicular screw, bone tunnel, or suture anchor trajectory via the lateral approach, reducing the need for posterior-to-anterior fixation. The improved exposure is inferred from the differences in the K-wire angles with and without the spin move. This study has also quantified the change in coronoid exposure using the angles of the wires with progressive release of the LUCL, CEO, and posterior capsule. If necessary, releasing the CEO or posterior capsule with eventual repair may allow improved coronoid fixation from the lateral approach.
MeSH term(s)	Humans ; Elbow Joint/surgery ; Elbow Injuries ; Joint Instability/surgery ; Elbow/surgery ; Fractures, Bone ; Joint Dislocations/surgery ; Fracture Fixation, Internal/methods ; Ulna Fractures/surgery
Language	English
Publishing date	2022-12-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1170782-3
ISSN	1532-6500 ; 1058-2746
ISSN (online)	1532-6500
ISSN	1058-2746
DOI	10.1016/j.jse.2022.11.020
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3973: Show issues

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Article ; Online: Widespread Torpor Use in Hummingbirds from the Thermally Stable Lowland Tropics.

Pollock, Henry S / Lamont, Daniel / MacDonald, Sean E / Spence, Austin R / Brawn, Jeffrey D / Cheviron, Zachary A

Physiological and biochemical zoology : PBZ

2023 Volume 96, Issue 2, Page(s) 119–127

Abstract: AbstractTorpor, the temporary reduction of metabolic rate and body temperature, is a common energy-saving strategy in endotherms. Because of their small body size and energetically demanding life histories, hummingbirds have proven useful for ... ...

Abstract	AbstractTorpor, the temporary reduction of metabolic rate and body temperature, is a common energy-saving strategy in endotherms. Because of their small body size and energetically demanding life histories, hummingbirds have proven useful for understanding when and why endotherms use torpor. Previous studies of torpor in hummingbirds have been largely limited to tropical montane species or long-distance migrants that regularly experience challenging thermal conditions. Comparatively little is known, however, about the use of torpor in hummingbirds of the lowland tropics, where relatively high and stable year-round temperatures may at least partially negate the need for torpor. To fill this knowledge gap, we tested for the occurrence of torpor in tropical lowland hummingbirds (
MeSH term(s)	Animals ; Energy Metabolism ; Torpor ; Body Temperature Regulation ; Body Temperature ; Temperature ; Birds
Language	English
Publishing date	2023-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1473845-4
ISSN	1537-5293 ; 1522-2152
ISSN (online)	1537-5293
ISSN	1522-2152
DOI	10.1086/722477
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Glu298Asp variant of the endothelial nitric oxide synthase gene and acute coronary syndrome or premature coronary artery disease: A systematic review and meta-analysis.

Rai, Himanshu / Fitzgerald, Sean / Coughlan, J J / Spence, Mark / Colleran, Roisin / Joner, Michael / Byrne, Robert A

Nitric oxide : biology and chemistry

2023 Volume 138-139, Page(s) 85–95

Abstract: Introduction: Several published studies have reported an association between the Glu298Asp polymorphism (rs1799983), residing in the endothelial nitric oxide synthase (NOS3) gene, and lower levels of circulating nitric oxide, as well as an increased ... ...

Abstract	Introduction: Several published studies have reported an association between the Glu298Asp polymorphism (rs1799983), residing in the endothelial nitric oxide synthase (NOS3) gene, and lower levels of circulating nitric oxide, as well as an increased risk of coronary artery disease (CAD). However, association status of this genetic variant with acute coronary syndrome (ACS) or premature CAD (PCAD) is still unclear. Against this background, we conducted a systematic review and study level meta-analysis to assess the association of the NOS3 Glu298Asp polymorphism with ACS or PCAD. Materials and methods: A comprehensive online search to identify relevant studies was performed on several databases including PubMed, EMBASE, MEDLINE, Scopus, Cochrane library and Web of Science. The identified studies were stratified into two ancestral subgroups: 'European ancestry' and 'All other ancestries combined'. Study level odds ratios (ORs) and their 95% confidence intervals (CI) were pooled using random/fixed effects employing a Z test. Results: Out of a total of 195 distinct records identified through online search, 37 articles with 39 different studies, with a total sample size of 27,441 (11,516 cases/15,925 controls) were included for quantitative synthesis. Pooled results suggested significant associations of the NOS3 Glu298Asp polymorphism with ACS or PCAD through dominant as well as allelic genetic models (p ≤ 0.002), primarily driven by the 'All other ancestries combined' subgroup. The 'All other ancestries combined' subgroup demonstrated an additional risk of 36% for ACS or PCAD, through both dominant and allelic genetic models (OR = 1.36, 95%CI = 1.13, 1.63, p = 0.001 and OR = 1.36, 95%CI = 1.14, 1.61, p = 0.0005 respectively). On the other hand, the 'European ancestry' subgroup did not show any significant associations. Sensitivity analysis and a sub-analysis for the myocardial infarction endpoint further supported these observed associations. Conclusions: This meta-analysis indicates towards an association between the NOS3 Glu298Asp polymorphism and ACS or PCAD, predominantly driven by 'All other ancestries combined' subgroup. In contrast, the 'European ancestry' subgroup did not demonstrate any significant association. Further large-scale investigations are required to confirm our derived results.
MeSH term(s)	Humans ; Acute Coronary Syndrome/genetics ; Coronary Artery Disease/genetics ; Genetic Predisposition to Disease ; Genotype ; Nitric Oxide Synthase/genetics ; Nitric Oxide Synthase Type III/genetics ; Polymorphism, Single Nucleotide
Chemical Substances	Nitric Oxide Synthase (EC 1.14.13.39) ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; NOS3 protein, human (EC 1.14.13.39)
Language	English
Publishing date	2023-07-13
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	1362794-6
ISSN	1089-8611 ; 1089-8603
ISSN (online)	1089-8611
ISSN	1089-8603
DOI	10.1016/j.niox.2023.07.001
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Zs.A 4677: Show issues

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Article: Assessing ex situ genetic and ecogeographic conservation in a threatened but widespread oak after range-wide collecting effort.

Zumwalde, Bethany A / Fredlock, Bailie / Beckman Bruns, Emily / Duckett, Drew / McCauley, Ross A / Spence, Emma Suzuki / Hoban, Sean

Evolutionary applications

2022 Volume 15, Issue 6, Page(s) 1002–1017

Abstract: Although the genetic diversity and structure of in situ populations has been investigated in thousands of studies, the genetic composition of ex situ plant populations has rarely been studied. A better understanding of how much genetic diversity is ... ...

Abstract	Although the genetic diversity and structure of in situ populations has been investigated in thousands of studies, the genetic composition of ex situ plant populations has rarely been studied. A better understanding of how much genetic diversity is conserved ex situ, how it is distributed among locations (e.g., botanic gardens), and what minimum sample sizes are needed is necessary to improve conservation outcomes. Here we address these issues in a threatened desert oak species,
Language	English
Publishing date	2022-05-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2405496-3
ISSN	1752-4563 ; 1752-4571
ISSN (online)	1752-4563
ISSN	1752-4571
DOI	10.1111/eva.13391
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of restricted visitation policies during COVID-19 on critically ill adults, their families, critical care clinicians, and decision-makers: a qualitative interview study.

Fiest, Kirsten M / Krewulak, Karla D / Jaworska, Natalia / Spence, Krista L / Mizen, Sara J / Bagshaw, Sean M / Burns, Karen E A / Cook, Deborah J / Fowler, Robert A / Olafson, Kendiss / Patten, Scott B / Rewa, Oleksa G / Rochwerg, Bram / Spence, Sean / West, Andrew / Stelfox, Henry T / Parsons Leigh, Jeanna

Canadian journal of anaesthesia = Journal canadien d'anesthesie

2022 Volume 69, Issue 10, Page(s) 1248–1259

Abstract: Purpose: During the first wave of the COVID-19 pandemic, restricted visitation policies were enacted at acute care facilities to reduce the spread of COVID-19 and conserve personal protective equipment. In this study, we aimed to describe the impact of ... ...

Title translation	Impact des politiques de visites restreintes pendant la COVID-19 sur les adultes gravement malades, leurs familles, les intensivistes et les décideurs : une étude d’entrevue qualitative.
Abstract	Purpose: During the first wave of the COVID-19 pandemic, restricted visitation policies were enacted at acute care facilities to reduce the spread of COVID-19 and conserve personal protective equipment. In this study, we aimed to describe the impact of restricted visitation policies on critically ill patients, families, critical care clinicians, and decision-makers; highlight the challenges faced in translating these policies into practice; and delineate strategies to mitigate their effects. Method: A qualitative description design was used. We conducted semistructured interviews with critically ill adult patients and their family members, critical care clinicians, and decision-makers (i.e., policy makers or enforcers) affected by restricted visitation policies. We transcribed semistructured interviews verbatim and analyzed the transcripts using inductive thematic analysis. Results: Three patients, eight family members, 30 clinicians (13 physicians, 17 nurses from 23 Canadian intensive care units [ICUs]), and three decision-makers participated in interviews. Thematic analysis was used to identify five themes: 1) acceptance of restricted visitation (e.g., accepting with concerns); 2) impact of restricted visitation (e.g., ethical challenges, moral distress, patients dying alone, intensified workload); 3) trust in the healthcare system during the pandemic (e.g., mistrust of clinical team); 4) modes of communication (e.g., communication using virtual platforms); and 5) impact of policy implementation on clinical practice (e.g., frequent changes and inconsistent implementation). Conclusions: Restricted visitation policies across ICUs during the COVID-19 pandemic negatively affected critically ill patients and their families, critical care clinicians, and decision-makers.
MeSH term(s)	Adult ; COVID-19 ; Canada ; Critical Care ; Critical Illness/therapy ; Decision Making ; Family ; Humans ; Intensive Care Units ; Pandemics/prevention & control ; Policy ; Qualitative Research
Language	English
Publishing date	2022-08-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	91002-8
ISSN	1496-8975 ; 0832-610X
ISSN (online)	1496-8975
ISSN	0832-610X
DOI	10.1007/s12630-022-02301-5
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Zs.A 109: Show issues

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Article: Ex situ conservation of two rare oak species using microsatellite and SNP markers.

Koontz, Austin C / Schumacher, Emily K / Spence, Emma S / Hoban, Sean M

Evolutionary applications

2024 Volume 17, Issue 3, Page(s) e13650

Abstract: Plant collections held by botanic gardens and arboreta are key components of ex situ conservation. Maintaining genetic diversity in such collections allows them to be used as resources for supplementing wild populations. However, most recommended minimum ...

Abstract	Plant collections held by botanic gardens and arboreta are key components of ex situ conservation. Maintaining genetic diversity in such collections allows them to be used as resources for supplementing wild populations. However, most recommended minimum sample sizes for sufficient ex situ genetic diversity are based on microsatellite markers, and it remains unknown whether these sample sizes remain valid in light of more recently developed next-generation sequencing (NGS) approaches. To address this knowledge gap, we examine how ex situ conservation status and sampling recommendations differ when derived from microsatellites and single nucleotide polymorphisms (SNPs) in garden and wild samples of two threatened oak species. For
Language	English
Publishing date	2024-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2405496-3
ISSN	1752-4563 ; 1752-4571
ISSN (online)	1752-4563
ISSN	1752-4571
DOI	10.1111/eva.13650
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Article: Can pharmacology help enhance human morality?

Spence, Sean A

The British journal of psychiatry : the journal of mental science

2008 Volume 193, Issue 3, Page(s) 179–180

Abstract: A responsible person, a moral agent, takes account of their future behaviour and its likely impact upon others. Such an agent may choose to influence their future by exogenous means. If so, might pharmacology help them to do this? Is it doing so already? ...

Abstract	A responsible person, a moral agent, takes account of their future behaviour and its likely impact upon others. Such an agent may choose to influence their future by exogenous means. If so, might pharmacology help them to do this? Is it doing so already? I argue that it is.
MeSH term(s)	Cognition/drug effects ; Humans ; Moral Obligations ; Morals ; Psychotic Disorders/drug therapy ; Psychotic Disorders/psychology
Language	English
Publishing date	2008-09
Publishing country	England
Document type	Editorial
ZDB-ID	218103-4
ISSN	1472-1465 ; 0007-1250
ISSN (online)	1472-1465
ISSN	0007-1250
DOI	10.1192/bjp.bp.108.052316
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