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  1. AU=McKay Jennifer S
  2. AU="Frohn, Marina"
  3. AU="Blaksley, C"
  4. AU="Heri Hermasyah"
  5. AU="Charlier, Filip"
  6. AU="Mihalopoulos, N"
  7. AU="Fernandez, S Gomez"

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  1. Buch ; Online: Sea-surface temperature reconstruction of sediment core JT96-09PC, supplementary data to: Kienast, Stephanie S; McKay, Jennifer L (2001): Sea surface temperature in the subarctic Northeast Pacific reflect millennial-scale Climate Oscillations during the last 16 kyrs. Geophysical Research Letters, 28, 1563-1566

    Kienast, Stephanie S / McKay, Jennifer L

    2001  

    Abstract: Changes of sea surface temperature (SST) in the subarctic NE Pacific over the last 16,000 calendar years before present (16 kyr BP) have been inferred from the study of C37 alkenone unsaturation in a sediment core from the western Canadian continental ... ...

    Abstract Changes of sea surface temperature (SST) in the subarctic NE Pacific over the last 16,000 calendar years before present (16 kyr BP) have been inferred from the study of C37 alkenone unsaturation in a sediment core from the western Canadian continental slope. Between 16.0 and 11.0 kyr, three distinct cold phases (6-7°C) interrupt two warmer periods (9-10gC). Within the 20 range of the radiocarbon based time control, the observed SST oscillations correspond to the Oldest Dryas, the Bolling, the Older Dryas, the Allered, and the Younger Dryas periods in the GISP2 delta180 record. These results represent the first high resolution marine paleotemperature estimates off the northern West coast of North America and imply that the climate of this region may be very strongly coupled to that of the North Atlantic. Given the fast rates of SST change (1°C/40-8 yr), such coupling must be controlled by atmospheric transmission of the climate signal.
    Sprache Englisch
    Erscheinungsverlauf 2001-9999
    Umfang Online-Ressource
    Verlag PANGAEA - Data Publisher for Earth & Environmental Science
    Erscheinungsort Bremen/Bremerhaven
    Dokumenttyp Buch ; Online
    DOI 10.1594/PANGAEA.738484
    Datenquelle Katalog der Technische Informationsbibliothek Hannover

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  2. Artikel ; Online: Identifying behaviors that characterize emergence delirium: An observational study.

    O'Brien, Jennifer M / McKay, William P S / McDonald, Marguerite

    Paediatric anaesthesia

    2023  Band 33, Heft 8, Seite(n) 631–635

    Abstract: ... 10 s segments of the recordings showing patient activity were shown to an expert audience ...

    Abstract Background: Diagnostic criteria for emergence agitation are sensitive but not specific; they misclassify patients who are angry or upset as having emergence delirium.
    Aims: The aim of this three-phase study was to determine expert agreement on the behaviors that differentiate children with emergence delirium from those without.
    Methods: In the first phase of this observational study, pediatric dental patients were video recorded while awakening from anesthesia. In the second phase, salient 10 s segments of the recordings showing patient activity were shown to an expert audience of pediatric dentists, anesthesiologists and Post Anesthetic Care nurses, who scored the recordings as showing or not showing "true emergence delirium." In phase 3, the video segments were assessed by three research assistants using a behavior checklist for features that discriminate between those scored "true emergence delirium" and those scored "NOT true emergence delirium" by the experts.
    Results: One hundred and fifty-four pediatric dental patients were included. Subsequently, an expert audience consisting of 10 anesthesiologists, 12 anesthesiology residents, 3 pediatric dentists, and 4 experienced Post Anesthesia Care Unit nurses rated each 10-second video segment. This resulted in three groups of patients: a group for whom all experts agreed was "True emergence delirium" (n = 33; CI 21 to 45), a group for whom all agreed was "Not True emergence delirium" (n = 120; CI 107 to 133), and a group where experts disagreed (n = 11; CI 4 to 18). Three research assistants then completed a behavior checklist for each of the 33 "True emergence delirium" video segments and matched "Not True" controls. Twenty-four behaviors were identified as significantly different between videos scored True emergence delirium and those scored Not True emergence delirium. Research assistants reached almost perfect agreement (0.81-1.00) on one behavior, and substantial agreement (0.61-0.80) on seven behaviors that characterized "True emergence delirium."
    Conclusions: Eight behaviors that differentiate pediatric dental patients with emergence delirium from those without were found. These discriminators may be used to develop a scale that will lead to better diagnosis and treatment of emergence delirium.
    Mesh-Begriff(e) Child ; Humans ; Emergence Delirium/diagnosis ; Anesthesia ; Anesthesia Recovery Period
    Sprache Englisch
    Erscheinungsdatum 2023-04-25
    Erscheinungsland France
    Dokumenttyp Observational Study ; Journal Article
    ZDB-ID 1086049-6
    ISSN 1460-9592 ; 1155-5645
    ISSN (online) 1460-9592
    ISSN 1155-5645
    DOI 10.1111/pan.14678
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Corrigendum to "The Role of Stereotactic Ablative Body Radiotherapy in Renal Cell Carcinoma" [Eur Urol 2022].

    Ali, Muhammad / Mooi, Jennifer / Lawrentschuk, Nathan / McKay, Rana R / Hannan, Raquibul / Lo, Simon S / Hall, William A / Siva, Shankar

    European urology

    2022  Band 82, Heft 5, Seite(n) e152

    Sprache Englisch
    Erscheinungsdatum 2022-08-28
    Erscheinungsland Switzerland
    Dokumenttyp Published Erratum
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2022.08.018
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  4. Artikel ; Online: Gene expression analysis of Canine Demodicosis; A milieu promoting immune tolerance.

    Kelly, Pamela A / Browne, John / Peters, Susan / Bell, Frazer / McKay, Jennifer S / Lara-Saez, Irene / Breathnach, Rory

    Veterinary parasitology

    2023  Band 319, Seite(n) 109954

    Abstract: Canine demodicosis is a common skin disease seen in companion animal practice that results from an overpopulation of the commensal Demodex mite species. Common predisposing factors to the development of canine demodicosis include immunosuppressive ... ...

    Abstract Canine demodicosis is a common skin disease seen in companion animal practice that results from an overpopulation of the commensal Demodex mite species. Common predisposing factors to the development of canine demodicosis include immunosuppressive diseases, such as neoplasia and hypothyroidism, and administration of immunosuppressive therapies, such as corticosteroids. Despite this, the pathogenesis of development of canine demodicosis remains unclear. Previous studies have implicated a role for increased expression of toll like receptor 2 (TLR2), increased production of interleukin (IL)-10) and T cell exhaustion. Here, we investigate gene expression of formalin fixed paraffin embedded skin samples from twelve cases of canine demodicosis in comparison to twelve healthy controls, using a 770 gene panel (NanoString Canine IO Panel). Results show an increase in the T cell population, specifically Th1 and Treg cells in dogs with demodicosis. In addition, while there is an upregulation of immunosuppressive cytokines such as IL-10 and IL-13, there is also an upregulation of immune check point molecules including PD-1/PD-L1 and CTLA-4. These findings suggest that Demodex spp. mites are modulating the host immune system to their advantage through upregulation of several immune tolerance promoting pathways.
    Mesh-Begriff(e) Animals ; Dogs ; Mite Infestations/genetics ; Mite Infestations/veterinary ; Mites/physiology ; Dog Diseases/genetics ; Immune Tolerance ; Gene Expression Profiling/veterinary
    Sprache Englisch
    Erscheinungsdatum 2023-05-06
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 196831-2
    ISSN 1873-2550 ; 0304-4017
    ISSN (online) 1873-2550
    ISSN 0304-4017
    DOI 10.1016/j.vetpar.2023.109954
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Unveiling the Role of Endoplasmic Reticulum Stress Pathways in Canine Demodicosis.

    Kelly, Pamela A / McHugo, Gillian P / Scaife, Caitriona / Peters, Susan / Stevenson, M Lynn / McKay, Jennifer S / MacHugh, David E / Saez, Irene Lara / Breathnach, Rory

    Parasite immunology

    2024  Band 46, Heft 4, Seite(n) e13033

    Abstract: Canine demodicosis is a prevalent skin disease caused by overpopulation of a commensal species of Demodex mite, yet its precise cause remains unknown. Research suggests that T-cell exhaustion, increased immunosuppressive cytokines, induction of ... ...

    Abstract Canine demodicosis is a prevalent skin disease caused by overpopulation of a commensal species of Demodex mite, yet its precise cause remains unknown. Research suggests that T-cell exhaustion, increased immunosuppressive cytokines, induction of regulatory T cells and increased expression of immune checkpoint inhibitors may contribute to its pathogenesis. This study aimed to gain a deeper understanding of the molecular changes occurring in canine demodicosis using mass spectrometry and pathway enrichment analysis. The results indicate that endoplasmic reticulum stress promotes canine demodicosis through regulation of three linked signalling pathways: eIF2, mTOR, and eIF4 and p70S6K. These pathways are involved in the modulation of Toll-like receptors, most notably TLR2, and have been shown to play a role in the pathogenesis of skin diseases in both dogs and humans. Moreover, these pathways are also implicated in the promotion of immunosuppressive M2 phenotype macrophages. Immunohistochemical analysis, utilising common markers of dendritic cells and macrophages, verified the presence of M2 macrophages in canine demodicosis. The proteomic analysis also identified immunological disease, organismal injury and abnormalities and inflammatory response as the most significant underlying diseases and disorders associated with canine demodicosis. This study demonstrates that Demodex mites, through ER stress, unfolded protein response and M2 macrophages contribute to an immunosuppressive microenvironment, thereby assisting in their proliferation.
    Mesh-Begriff(e) Humans ; Dogs ; Animals ; Proteomics ; Endoplasmic Reticulum Stress ; Cytokines ; Macrophages ; Phenotype
    Chemische Substanzen Cytokines
    Sprache Englisch
    Erscheinungsdatum 2024-04-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 424444-8
    ISSN 1365-3024 ; 0141-9838
    ISSN (online) 1365-3024
    ISSN 0141-9838
    DOI 10.1111/pim.13033
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  6. Artikel ; Online: A retrospective study of cases of canine demodicosis submitted to a commercial diagnostic laboratory servicing the United Kingdom and Ireland (2017-2018) part 2; Aerobic culture and antimicrobial susceptibility results.

    Kelly, Pamela A / McKay, Jennifer S / Maguire, David / Jones, Matthew / Roberts, Larry / Powell, Frank / Breathnach, Rory

    Research in veterinary science

    2022  Band 153, Seite(n) 92–98

    Abstract: ... Resistance to one or more antimicrobial classes was noted in S. pseudintermedius isolates from 56.3% of JO ... cases with 10.3% of these cases being classified as Multi-Drug Resistant (MDR). Similarly, 51.9% of S ...

    Abstract Clinical diagnostic reports from 508 cases of canine demodicosis diagnosed either by histological or skin scraping analysis from a United Kingdom Accreditation Service (UKAS) accredited veterinary diagnostic laboratory servicing the United Kingdom (UK) and Ireland were evaluated. Of the 508 cases, 284 had skin swabs submitted for culture on the same day the skin biopsy and/or skin scraping were obtained. Dogs with juvenile-onset (JO) demodicosis represented 57.4% of these cases, whilst adult-onset (AO) cases comprised 42.6%. The data revealed that overgrowth of pathogenic bacteria was more common in AO demodicosis cases (75.2%) in comparison to the JO cases (57%). Adult-onset cases also had increased involvement of bacteria belonging to multiple genera and/or yeast (28.9%) in comparison to JO cases (18.4%). Pruritus was significantly associated with an overgrowth of Staphylococcus pseudintermedius (p < 0.001). Resistance to one or more antimicrobial classes was noted in S. pseudintermedius isolates from 56.3% of JO cases with 10.3% of these cases being classified as Multi-Drug Resistant (MDR). Similarly, 51.9% of S. pseudintermedius isolates from the AO cases were noted to be resistant to one or more antimicrobial class with 8.6% of these cases being considered MDR. Cephalosporins were the most frequently administered antimicrobial class noted in submission histories, followed by the penicillin and fluoroquinolone classes. Whilst our findings reveal a high prevalence of concurrent overgrowth of pathogenic bacteria warranting therapeutic intervention in canine demodicosis, the presence of resistance within isolates highlights the need for prudent selection and targeted use of antimicrobial therapy that encompass the key principles of antimicrobial stewardship.
    Sprache Englisch
    Erscheinungsdatum 2022-10-31
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 840961-4
    ISSN 1532-2661 ; 0034-5288
    ISSN (online) 1532-2661
    ISSN 0034-5288
    DOI 10.1016/j.rvsc.2022.10.021
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  7. Artikel ; Online: The Role of Stereotactic Ablative Body Radiotherapy in Renal Cell Carcinoma.

    Ali, Muhammad / Mooi, Jennifer / Lawrentschuk, Nathan / McKay, Rana R / Hannan, Raquibul / Lo, Simon S / Hall, William A / Siva, Shankar

    European urology

    2022  Band 82, Heft 6, Seite(n) 613–622

    Abstract: Context: Stereotactic ablative body radiotherapy (SABR) is an emerging treatment modality for primary and metastatic renal cell carcinoma (RCC).: Objective: To review and summarise the evidence on the use of SABR in RCC in a narrative review.: ... ...

    Abstract Context: Stereotactic ablative body radiotherapy (SABR) is an emerging treatment modality for primary and metastatic renal cell carcinoma (RCC).
    Objective: To review and summarise the evidence on the use of SABR in RCC in a narrative review.
    Evidence acquisition: We performed an online search of the PubMed database from January 2000 through December 2021. Studies of SABR/stereotactic radiosurgery (SRS) targeting primary, extracranial, or intracranial metastatic RCC were included.
    Evidence synthesis: Two meta-analyses (including 54 studies), and 13 prospective and 20 retrospective studies were included in this review. In aggregate, SABR for 589 primary RCCs in 575 patients resulted in a local control rate of above 90% with grade 3-4 toxicity of 0-9%. Similarly, the local control rate ranged between 90% and 97% with SRS in 1225 patients with intracranial metastatic RCC. SABR was able to delay systemic therapy for at least 1 yr in 70-90% of oligometastatic RCC patients with grade 3-4 toxicity of <10%. As per the early data, the combination of SABR with systemic therapy for metastatic RCC, such as targeted therapy or immunotherapy, appears safe, feasible, and tolerable.
    Conclusions: We outlined data supporting SABR in the key clinical scenarios of primary and metastatic, including oligometastatic, RCC in lieu of systemic therapy, in combination with systemic therapy, and palliation of brain and spinal metastases.
    Patient summary: Stereotactic ablative body radiotherapy (SABR) is a relatively new treatment option in kidney cancer. Here, we review the published literature on the experience of using SABR in kidney cancer. The accumulated evidence demonstrates that SABR can be used safely and effectively to treat selected cases of primary or secondary kidney cancer.
    Mesh-Begriff(e) Humans ; Carcinoma, Renal Cell/radiotherapy ; Carcinoma, Renal Cell/surgery ; Carcinoma, Renal Cell/secondary ; Radiosurgery/adverse effects ; Radiosurgery/methods ; Kidney Neoplasms/radiotherapy ; Kidney Neoplasms/surgery ; Kidney Neoplasms/pathology ; Retrospective Studies ; Prospective Studies
    Sprache Englisch
    Erscheinungsdatum 2022-07-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2022.06.017
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  8. Artikel: Validation of a Liquid Biopsy Protocol for Canine BRAFV595E Variant Detection in Dog Urine and Its Evaluation as a Diagnostic Test Complementary to Cytology.

    Gentilini, Fabio / Palgrave, Christopher J / Neta, Michal / Tornago, Raimondo / Furlanello, Tommaso / McKay, Jennifer S / Sacchini, Federico / Turba, Maria E

    Frontiers in veterinary science

    2022  Band 9, Seite(n) 909934

    Abstract: A significant proportion of canine urothelial carcinomas carry the driver valine to glutamic acid variation (V595E) in BRAF kinase. The detection of V595E may prove suitable to guide molecularly targeted therapies and support non-invasive diagnosis of ... ...

    Abstract A significant proportion of canine urothelial carcinomas carry the driver valine to glutamic acid variation (V595E) in BRAF kinase. The detection of V595E may prove suitable to guide molecularly targeted therapies and support non-invasive diagnosis of the urogenital system by means of a liquid biopsy approach using urine. Three cohorts and a control group were included in this multi-step validation study which included setting up a digital PCR assay. This was followed by investigation of preanalytical factors and two alternative PCR techniques on a liquid biopsy protocol. Finally, a blind study using urine as diagnostic sample has been carried out to verify its suitability as diagnostic test to complement cytology. The digital PCR (dPCR) assay proved consistently specific, sensitive, and linear. Using the dPCR assay, the prevalence of V595E in 22 urothelial carcinomas was 90.9%. When compared with histopathology as gold standard in the blind-label cases, the diagnostic accuracy of using the canine BRAF (cBRAF) variation as a surrogate assay against the histologic diagnosis was 85.7% with 92.3% positive predictive value and 80.0% negative predictive value. In all the cases, in which both biopsy tissue and the associated urine were assayed, the findings matched completely. Finally, when combined with urine sediment cytology examination in blind-label cases with clinical suspicion of malignancy, the dPCR assay significantly improved the overall diagnostic accuracy. A liquid biopsy approach on urine using the digital PCR may be a valuable breakthrough in the diagnostic of urothelial carcinomas in dogs.
    Sprache Englisch
    Erscheinungsdatum 2022-05-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2022.909934
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  9. Artikel ; Online: A retrospective study of cases of canine demodicosis submitted to a commercial diagnostic laboratory servicing the United Kingdom and Ireland (2017-2018): Part 1 - Signalment, lesion distribution, treatments, and concurrent diseases.

    Kelly, Pamela A / McKay, Jennifer S / Maguire, David / Jones, Matthew / Roberts, Larry / Powell, Frank / Breathnach, Rory

    Research in veterinary science

    2022  Band 153, Seite(n) 99–104

    Abstract: Canine demodicosis, due to an overpopulation of Demodex spp. mites, remains one of the most common dermatological diseases encountered in small animal practice. The aims of this study were to interrogate submitted histories and diagnostic report results ... ...

    Abstract Canine demodicosis, due to an overpopulation of Demodex spp. mites, remains one of the most common dermatological diseases encountered in small animal practice. The aims of this study were to interrogate submitted histories and diagnostic report results from a large cohort of dogs (n = 508) diagnosed with demodicosis either through histological analysis or the finding of Demodex spp. mites on skin scrapings by a UKAS accredited commercial laboratory servicing the United Kingdom (UK) and Ireland in the years 2017 and 2018. The main findings revealed that short-coated breeds were more likely to develop juvenile-onset (JO) demodicosis, whereas medium- and long-coated breeds were more likely to develop adult-onset (AO) disease. Pododemodicosis was reported more commonly in adult, long-coated breeds. Skin scrapings were positive in only 83.3% of samples that had a corresponding positive biopsy result; this finding highlights the necessity to perform further diagnostic tests if demodicosis remains clinically suspected despite a negative skin scraping result. Concurrent underlying diseases, potentially associated with immunosuppression, were reported in 42/221 (19%) of dogs with AO demodicosis. Serum allergy and Sarcoptes ELISA assays were positive in individual animals in both the JO and AO groups; the clinical significance of these latter findings requires careful interpretation in dogs with confirmed demodicosis.
    Sprache Englisch
    Erscheinungsdatum 2022-10-30
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 840961-4
    ISSN 1532-2661 ; 0034-5288
    ISSN (online) 1532-2661
    ISSN 0034-5288
    DOI 10.1016/j.rvsc.2022.10.022
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  10. Artikel ; Online: Reducing e-cigarette use among youth and young adults: evidence of the truth campaign's impact.

    Hair, Elizabeth C / Kreslake, Jennifer M / Tulsiani, Shreya / McKay, Tatum / Vallone, Donna

    Tobacco control

    2023  

    Abstract: Background: Mass media campaigns have been shown to be effective in reducing cigarette use. However, evidence is limited for whether campaigns can shift e-cigarette use among youth and young adults (YYA). To assess the impact of the truth anti-e- ... ...

    Abstract Background: Mass media campaigns have been shown to be effective in reducing cigarette use. However, evidence is limited for whether campaigns can shift e-cigarette use among youth and young adults (YYA). To assess the impact of the truth anti-e-cigarette campaign, which focused on the effects of vaping on mental health, this study examines the relationship between campaign awareness and e-cigarette behaviour among YYA.
    Methods: Data from weekly cross-sectional surveys of YYA aged 15-24 years from September 2021 to October 2022 were used for multilevel models assessing how weekly campaign awareness is related to intentions to use e-cigarettes and current e-cigarette use (past 30 days). Weekly campaign awareness was calculated by averaging individual-level awareness for each week. Control variables included individual-level campaign awareness, sociodemographics, perceived financial situation, parental smoking, sensation seeking, and mental health.
    Results: Weekly campaign awareness ranged from 50% to 78%, with most weeks (77%) being within 65% and 75% of weekly campaign awareness. At weekly awareness levels between 65% and 75%, there was a significant association with lower intentions to use e-cigarettes. A dose-response relationship was observed for current use: compared with weeks with lower (<65%) awareness, weeks with awareness of 65-70% had 14% lower odds of current use, weeks with 70-75% awareness had 16% lower odds and weeks with >75% weekly awareness had 18% lower odds (p=0.018, p=0.009 and p=0.007, respectively).
    Conclusions: Findings from this analysis of weekly campaign awareness demonstrate that exposure to the truth anti-e-cigarette campaign is associated with significantly lower odds of intentions to use and current use of e-cigarette among YYA.
    Sprache Englisch
    Erscheinungsdatum 2023-08-08
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1146554-2
    ISSN 1468-3318 ; 0964-4563
    ISSN (online) 1468-3318
    ISSN 0964-4563
    DOI 10.1136/tc-2023-057992
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