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Article ; Online: Non-inferiority of fundus photos using wide-field imaging to charting drawings in rhegmatogenous retinal detachment.

Nagpal, Manish / Mehrotra, Navneet / Sharma, Akansha / Gupta, Nivesh

2022 Volume 70, Issue 6, Page(s) 2197–2198

MeSH term(s)	Diagnostic Imaging ; Fundus Oculi ; Humans ; Retinal Detachment/diagnosis ; Retinal Detachment/surgery
Language	English
Publishing date	2022-06-14
Publishing country	India
Document type	Letter
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/ijo.IJO_99_22
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Article ; Online: Exploring the Prospective of Curcumin-loaded Nanomedicine in Brain Cancer Therapy: An Overview of Recent Updates and Patented Nanoformulations.

Verma, Ravinder / Rao, Lakshita / Nagpal, Diksha / Yadav, Manish / Kumar, Manish / Mittal, Vineet / Kaushik, Deepak

Recent patents on nanotechnology

2023

Abstract: Cancer is a complex, one of the fatal non-communicable diseases, and its treatment has enormous challenges, with variable efficacy of traditional anti-cancer agents. By 2025, it is expected that 420 million additional cases of cancer will be diagnosed ... ...

Abstract	Cancer is a complex, one of the fatal non-communicable diseases, and its treatment has enormous challenges, with variable efficacy of traditional anti-cancer agents. By 2025, it is expected that 420 million additional cases of cancer will be diagnosed yearly. However, among various types of cancer, brain cancer treatment is most difficult due to the presence of blood-brain barriers. Nowadays, phytoconstituents are gaining popularity because of their biosafety and low toxicity to healthy cells. This article reviews various aspects related to curcumin for brain cancer therapeutics, including epidemiology, the role of nanotechnology, and various challenges for development and clinical trials. Furthermore, it elaborates on the prospects of curcumin for brain cancer therapeutics. In this article, our objective is to illuminate the anti-cancer potential of curcumin for brain cancer therapy. Moreover, it also explores how to defeat its constraints of clinical application because of poor bioavailability, stability, and rapid metabolism. This review also emphasizes the possibility of curcumin for the cure of brain cancer using cuttingedge biotechnological methods based on nanomedicine. This review further highlights the recent patents on curcumin-loaded nanoformulations for brain cancer. Overall, this article provides an overview of curcumin's potential in brain cancer therapy by considering challenges to be overwhelmed and future prospective. Moreover, this review summarizes the reported literature on the latest research related to the utility of curcumin in brain cancer therapy and aims to provide a reference for advanced investigation on brain cancer treatment.
Language	English
Publishing date	2023-09-07
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	2212-4020
ISSN (online)	2212-4020
DOI	10.2174/1872210517666230823155328
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Article ; Online: Dosimetric correlation of bone marrow irradiation with acute hematological toxicity in concurrent chemoradiation of cervical carcinoma patients.

Pruthi, Deep S / Nagpal, Puneet / Pandey, Manish / Singh, Harpreet

Indian journal of cancer

2023 Volume 60, Issue 3, Page(s) 432–438

Abstract: Background: Many acute toxicities are associated with concurrent chemoradiation in cervical carcinoma, which includes burning micturition, burning defecation, pain lower abdomen, increased frequency of stools along with Acute Hematological Toxicity (AHT) ...

Abstract	Background: Many acute toxicities are associated with concurrent chemoradiation in cervical carcinoma, which includes burning micturition, burning defecation, pain lower abdomen, increased frequency of stools along with Acute Hematological Toxicity (AHT). AHT is often an expected adverse effect, which can lead to treatment interruptions and decreased response rates. The purpose of this study is to analyze if there are any dosimetric constraints on the volume of bone marrow irradiated with AHT in cervical carcinoma patients treated with concurrent chemoradiation. Material and methods: In this retrospective study of 215 patients, a total of 180 patients were eligible for analysis. Multiple parameters of bone marrow volumes (whole pelvis bone marrow and its sub-volumes--ilium, lower pelvis, and lumbosacral spine) which were contoured individually for all patients were assessed to have any statistically significant association with AHT. Results: The median age of the cohort was 57 years and majority of cases were locally advanced (stage IIB-IVA: 88.3%). Grade I, II, III leukopenia was seen in 44, 25, and 6 patients, respectively. A statistically significant correlation between grade 2+ and 3+ leukopenia was seen if bone marrow V10, V20, V30, and V40 were more than 95%, 82%, 62%, and 38%, respectively. In subvolume analysis, volumes of lumbosacral spine V20, V30, and V40 more than 95%, 90%, and 65%, respectively, were statistically significant for AHT. Conclusion: Bone marrow volumes should also be given a constraint and should be tried to be achieved so that it leads to minimal treatment breaks due to AHT.
MeSH term(s)	Humans ; Middle Aged ; Female ; Radiotherapy, Intensity-Modulated/adverse effects ; Retrospective Studies ; Radiotherapy Dosage ; Bone Marrow/pathology ; Chemoradiotherapy/adverse effects ; Carcinoma ; Anemia/etiology ; Leukopenia/etiology ; Uterine Cervical Neoplasms/complications ; Uterine Cervical Neoplasms/radiotherapy
Language	English
Publishing date	2023-03-02
Publishing country	India
Document type	Journal Article
ZDB-ID	410194-7
ISSN	1998-4774 ; 0019-509X
ISSN (online)	1998-4774
ISSN	0019-509X
DOI	10.4103/ijc.IJC_585_20
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Article: Effectiveness of 6D couch with daily cone beam computed tomography in reducing PTV margins for glioblastoma multiforme.

Pruthi, Deep Shankar / Nagpal, Puneet / Pandey, Manish

Journal of neurosciences in rural practice

2022 Volume 14, Issue 1, Page(s) 78–83

Abstract: Objectives: Image-guided radiotherapy maximizes therapeutic index of brain irradiation by reducing setup errors during treatment. The aim of study was to analyze setup errors in the radiation treatment of glioblastoma multiforme and if decrease in ... ...

Abstract	Objectives: Image-guided radiotherapy maximizes therapeutic index of brain irradiation by reducing setup errors during treatment. The aim of study was to analyze setup errors in the radiation treatment of glioblastoma multiforme and if decrease in planning target volume (PTV), margin is feasible using daily cone beam CT (CBCT) and 6D couch correction. Materials and methods: Twenty-one patients (630 fractions of radiotherapy) were studied in which corrections were made in 6° of freedom. We determined setup errors, impact of setup errors of initial three fractions CBCT versus rest of the treatment with daily CBCT, and mean difference in setup errors with or without application of 6D couch and volumetric benefit of reduction of PTV margin from 0.5 cm to 0.3 cm. Results: The mean shift in the conventional directions, namely, vertical, longitudinal, and lateral was 0.17 cm, 0.19 cm, and 0.11 cm. There was significant change in vertical shift when first three fractions were compared with rest of the treatment with daily CBCT. When the effect of 6D couch was nullified, all directions showed increased error with longitudinal shift being significant. The number of setup errors of magnitude >0.3 cm was more significant when only conventional shifts were applied as compared with 6D couch. There was significant decrease in volume of brain parenchyma irradiated when margin of PTV was reduced from 0.5 cm to 0.3 cm. Conclusion: Daily CBCT along with 6D couch correction can reduce setup error which allows reduction in PTV margin during radiotherapy planning in turn improving the therapeutic index.
Language	English
Publishing date	2022-10-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2601242-X
ISSN	0976-3155 ; 0976-3147
ISSN (online)	0976-3155
ISSN	0976-3147
DOI	10.25259/JNRP_2_2022
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Article ; Online: Chandelier-assisted scleral buckle surgery - contact versus non-contact wide-angle viewing system (CAB-CNV): A retrospective, multicenter, clinical study.

Kelkar, Aditya S / Nagpal, Manish / Mondal, Sukanya / Mehrotra, Navneet / Jain, Harsh / Sharma, Akansha / Camus, Erwin / Sathaye, Vaidehi

Indian journal of ophthalmology

2024

Abstract: Purpose: To investigate and compare the anatomic and functional outcomes of chandelier-assisted scleral buckling (CASB) surgery using contact versus non-contact lens-based wide-angle viewing systems (WAVSs) in rhegmatogenous retinal detachment (RRD) ... ...

Abstract	Purpose: To investigate and compare the anatomic and functional outcomes of chandelier-assisted scleral buckling (CASB) surgery using contact versus non-contact lens-based wide-angle viewing systems (WAVSs) in rhegmatogenous retinal detachment (RRD) patients. Methods: This was a retrospective, multicenter study evaluating the anatomic (reattachment rate) and visual acuity (VA) outcomes at 6 months post-CASB for primary RRD. Results: Forty-seven RRD patients underwent CASB with a non-contact WAVS (Group C1) and 90 with a contact lens WAVS (Group C2). Preoperative parameters including myopia, macula-off RRD, posterior vitreous detachment, number of retinal breaks, and retinal dialysis as the etiology of RRD did not differ significantly between the two groups. The outcomes of retinal attachment (85.11% of C1 patients and 76.67% of C2 patients, P = 0.34) and final visual outcome (VA ≥6/12: C1 = 61.7%; C2 = 46.67%, P = 0.13) were also comparable. Furthermore, no significant difference in postoperative complications such as cataracts, glaucoma, infection, buckle exposure, and buckle failure was observed. Finally, both groups were comparable in terms of re-detachment rates (10.64% in C1 and 23.33% in C2, P = 0.11). Conclusion: The two WAVS approaches used in CASB surgery have comparable surgical and functional outcomes and postoperative complications. The operating surgeon can freely choose between these viewing platforms during the contemporary scleral bucking (SB) surgery without impacting the outcome.
Language	English
Publishing date	2024-03-08
Publishing country	India
Document type	Journal Article
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/IJO.IJO_2820_23
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Article: Managing PVR in the Era of Small Gauge Surgery.

Nagpal, Manish / Juneja, Rakesh / Talati, Sham

Journal of ophthalmology

2021 Volume 2021, Page(s) 8959153

Abstract: Proliferative vitreoretinopathy (PVR) is the leading cause of failed rhegmatogenous retinal detachment (RRD) surgery. Based upon the presence of clinical features and due to associated underlying risk factors, it is classified into various grades based ... ...

Abstract	Proliferative vitreoretinopathy (PVR) is the leading cause of failed rhegmatogenous retinal detachment (RRD) surgery. Based upon the presence of clinical features and due to associated underlying risk factors, it is classified into various grades based upon its severity and extent of involvement. Despite excellent skills, flawless techniques, and high-end technology applied in the management of RRD, PVR still occurs in 5-10% of cases. Due to the advancements in wide angle viewing systems, advance vitrectomy machines and fluidics, early identification, use of long-term heavy silicon oil tamponades, high-speed cutters, small-gauge vitrectomies, use of perfluorocarbon liquid (PFCL), and small-gauge forceps and scissors, the success rate in the management of PVR has increased leading to improved anatomical outcomes. However, functional outcomes do not correlate well with improved anatomical outcomes. Various complications occur after RRD repair that are responsible for re-retinal detachment and recurrence of PVR. This article highlights causes, risk factors, classification, grading, diagnosis, and approach to management of PVR and post-PVR surgery complications.
Language	English
Publishing date	2021-12-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2546525-9
ISSN	2090-0058 ; 2090-004X
ISSN (online)	2090-0058
ISSN	2090-004X
DOI	10.1155/2021/8959153
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Article ; Online: Predictors of cardiac dose sparing in deep inspiratory breath-hold technique for radiation of left breast cancer patients.

Nagpal, Puneet / Pruthi, Deep Shankar / Shanmugam, Prabakar / Pandey, Manish Bhushan / Singh, Harpreet

Journal of cancer research and therapeutics

2023 Volume 19, Issue 3, Page(s) 573–578

Abstract: Introduction: Radiation therapy to left breast cancer patients results in significant exposure to heart resulting in long-term cardiac morbidity. This exposure can be reduced by performing deep inspiratory breath-hold (DIBH) technique, however, patient ... ...

Abstract	Introduction: Radiation therapy to left breast cancer patients results in significant exposure to heart resulting in long-term cardiac morbidity. This exposure can be reduced by performing deep inspiratory breath-hold (DIBH) technique, however, patient selection criteria or predictive parameters are not routinely used which can identify patients who will have significant benefit with this technique. This study intends to find and use these predictive parameters measured on free-breathing (FB) simulation scan which can help to select such patients so as to develop our institutional protocol. Methods: A total of 35 patients of left breast cancer postsurgery were recruited in the study. All patients underwent 2-3 sessions of DIBH coaching followed by planning computed tomography scan in both FB phase and DIBH phase. Various anatomical parameters such as cardiac contact distance parasagittal (CCDps), CCD axial, heart-chest distance (HCD), and D were measured on FB scan and were correlated with a mean heart dose achieved in DIBH scan. Results: Dose to normal structures, namely heart and lung, was drastically reduced for DIBH scan over FB scan. V5, V10, and V20 of heart also followed a similar reduction. The mean dose to heart in FB scan was 5.34 Gy, while in DIBH scan, it was 2.79 Gy which was statistically significant. Among all the parameters measured, CCDps and D had a statistically significant positive correlation with the mean heart dose in DIBH phase while HCD had a negative correlation which was statistically significant. Conclusion: Cardiac parameters on FB scan such as CCDps, HCD, and D predict the patients with usual cardiac risk who will benefit most with DIBH techniques setting an arbitrarily cutoff value.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/radiotherapy ; Radiotherapy Dosage ; Organs at Risk ; Unilateral Breast Neoplasms/radiotherapy ; Heart/diagnostic imaging ; Radiotherapy Planning, Computer-Assisted/methods
Language	English
Publishing date	2023-07-20
Publishing country	India
Document type	Journal Article
ZDB-ID	2187633-2
ISSN	1998-4138 ; 0973-1482
ISSN (online)	1998-4138
ISSN	0973-1482
DOI	10.4103/jcrt.jcrt_50_21
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Article ; Online: RWC Update: Improving Surgical Outcomes With Intraoperative Fluorescein Angiography; Myopic Macular Holes - When to Operate?; Harada's Disease.

Sharma, Ashish / Wu, Lihteh / Bloom, Steven / Stanga, Paulo / Sosa Lockward, Joaquin / Tadayoni, Ramin / Mateo, Carlos / Parolini, Barbara / Mirajkar, Anjana / Mehrotra, Navneet / Nagpal, Manish / Rezaei, Kourous A

Ophthalmic surgery, lasers & imaging retina

2024 Volume 55, Issue 1, Page(s) 5–8

MeSH term(s)	Humans ; Fluorescein Angiography ; Retinal Perforations/diagnosis ; Retinal Perforations/surgery ; Uveomeningoencephalitic Syndrome ; Treatment Outcome
Language	English
Publishing date	2024-01-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2701167-7
ISSN	2325-8179 ; 2325-8160
ISSN (online)	2325-8179
ISSN	2325-8160
DOI	10.3928/23258160-20231215-01
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Article ; Online: RWC Update: Sometimes Pulling Doesn't Win You the Tug of War; Wet AMD - How Do You Approach Nonexudative Macular Neovascularization; Central Retinal Artery Occlusion With Cilioretinal Sparing.

Sharma, Ashish / Wu, Lihteh / Bloom, Steven / Stanga, Paulo / Walinjkar, Jaydeep A / Patel, Afroz Qasim / Sarraf, David / Querques, Giuseppe / Sacconi, Riccardo / Kaiser, Peter / Guymer, Robyn / Khanani, Arshad M / Mirajkar, Anjana / Nagpal, Manish / Rezaei, Kourous A

Ophthalmic surgery, lasers & imaging retina

2024 Volume 55, Issue 2, Page(s) 66–69

MeSH term(s)	Humans ; Retinal Artery Occlusion ; Neovascularization, Pathologic ; Fluorescein Angiography ; Ciliary Arteries ; Retinal Artery
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2701167-7
ISSN	2325-8179 ; 2325-8160
ISSN (online)	2325-8179
ISSN	2325-8160
DOI	10.3928/23258160-20240111-01
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Article ; Online: Surgical management of complications in a case of progressive outer retinal necrosis.

Mehrotra, Navneet / Khandelwal, Jayesh / Nagpal, Manish

Taiwan journal of ophthalmology

2020 Volume 10, Issue 4, Page(s) 312–314

Abstract: We report a case of bilateral progressive outer retinal necrosis (PORN) in a patient with acquired immune deficiency syndrome with CD4 count 50 cells/μL. He was treated with standard intravenous and intravitreal antivirals but ultimately developed ... ...

Abstract	We report a case of bilateral progressive outer retinal necrosis (PORN) in a patient with acquired immune deficiency syndrome with CD4 count 50 cells/μL. He was treated with standard intravenous and intravitreal antivirals but ultimately developed complications such as retinal detachment and epiretinal membrane. His vision was preserved with early pars plana vitrectomy. This case demonstrates that prompt clinical diagnosis of PORN with its successful medical and surgical management can help prevent progression of this frightening disease.
Language	English
Publishing date	2020-03-31
Publishing country	India
Document type	Case Reports
ISSN	2211-5072
ISSN (online)	2211-5072
DOI	10.4103/tjo.tjo_27_19
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