LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 841

Search options

  1. Book ; Online: Online Continual Learning via the Knowledge Invariant and Spread-out Properties

    Han, Ya-nan / Liu, Jian-wei

    2023  

    Abstract: The goal of continual learning is to provide intelligent agents that are capable of learning continually a sequence of tasks using the knowledge obtained from previous tasks while performing well on prior tasks. However, a key challenge in this continual ...

    Abstract The goal of continual learning is to provide intelligent agents that are capable of learning continually a sequence of tasks using the knowledge obtained from previous tasks while performing well on prior tasks. However, a key challenge in this continual learning paradigm is catastrophic forgetting, namely adapting a model to new tasks often leads to severe performance degradation on prior tasks. Current memory-based approaches show their success in alleviating the catastrophic forgetting problem by replaying examples from past tasks when new tasks are learned. However, these methods are infeasible to transfer the structural knowledge from previous tasks i.e., similarities or dissimilarities between different instances. Furthermore, the learning bias between the current and prior tasks is also an urgent problem that should be solved. In this work, we propose a new method, named Online Continual Learning via the Knowledge Invariant and Spread-out Properties (OCLKISP), in which we constrain the evolution of the embedding features via Knowledge Invariant and Spread-out Properties (KISP). Thus, we can further transfer the inter-instance structural knowledge of previous tasks while alleviating the forgetting due to the learning bias. We empirically evaluate our proposed method on four popular benchmarks for continual learning: Split CIFAR 100, Split SVHN, Split CUB200 and Split Tiny-Image-Net. The experimental results show the efficacy of our proposed method compared to the state-of-the-art continual learning algorithms.

    Comment: 30 pages
    Keywords Computer Science - Computer Vision and Pattern Recognition ; 62P30 ; I.2.4
    Subject code 004 ; 006
    Publishing date 2023-02-01
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  2. Article ; Online: Highly sensitive ammonia sensor based on a PMMA/PANI microwire structure.

    Cheng, Cai-Hong / Han, Bo / Cheng, Liangliang / Zheng, Weizong / Xia, Feng / Zhao, Yong / Zhang, Ya-Nan

    Applied optics

    2024  Volume 63, Issue 4, Page(s) 959–966

    Abstract: In this paper, a highly sensitive ammonia ( ...

    Abstract In this paper, a highly sensitive ammonia (
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4522
    ISSN (online) 1539-4522
    DOI 10.1364/AO.501901
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Glutamic-acid grafted hyaluronic acid inhibits inflammatory factors via fibroblast and skin model tests.

    Jiang, Fang-Ru / Wang, Song / Han, Dong / Wei, Jian / Wu, Ya-Nan / Liu, Zhe

    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

    2024  Volume 30, Issue 1, Page(s) e13548

    Abstract: Background: Excessive inflammation may cause tissue damage and disrupt the function of the skin barrier. Hyaluronic acid (HA), an endogenous component, was found to regulate multiple inflammatory factors for skin health. This work aims to further ... ...

    Abstract Background: Excessive inflammation may cause tissue damage and disrupt the function of the skin barrier. Hyaluronic acid (HA), an endogenous component, was found to regulate multiple inflammatory factors for skin health. This work aims to further enhance its efficacy by grafting amino acid onto its molecule.
    Methods: Glutamic acid (Glu) was selected as the ligand to react with low-molecular-weight HA. Fibroblast tests and a 3D skin model were used to investigate the anti-inflammation efficacy of HA-Glu.
    Results: For IL-1α, IL-6 and TNF-α, the grafted compound presents stronger inhibition ability versus native HA. Moreover, HA-Glu could promote the repair of damaged skin by improving the compactness of the stratum corneum and increasing the thickness of the living cell layer.
    Conclusion: The application of HA-Glu compound in skin care formulas would be effective to alleviate inflammation-induced skin symptoms and skin aging.
    MeSH term(s) Humans ; Hyaluronic Acid/pharmacology ; Hyaluronic Acid/therapeutic use ; Hyaluronic Acid/chemistry ; Glutamic Acid/metabolism ; Skin/metabolism ; Inflammation/drug therapy ; Fibroblasts/metabolism
    Chemical Substances Hyaluronic Acid (9004-61-9) ; Glutamic Acid (3KX376GY7L)
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1229160-2
    ISSN 1600-0846 ; 0909-752X ; 1397-1344
    ISSN (online) 1600-0846
    ISSN 0909-752X ; 1397-1344
    DOI 10.1111/srt.13548
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Hydrogen-bonded organic frameworks in solution enables continuous and high-crystalline membranes.

    Yin, Qi / Pang, Kuan / Feng, Ya-Nan / Han, Lili / Morsali, Ali / Li, Xi-Ya / Liu, Tian-Fu

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 634

    Abstract: Hydrogen-Bonded organic frameworks (HOFs) are a type of emerging porous materials. At present, little research has been conducted on their solution state. This work demonstrates that HOFs fragment into small particles while maintaining their original ... ...

    Abstract Hydrogen-Bonded organic frameworks (HOFs) are a type of emerging porous materials. At present, little research has been conducted on their solution state. This work demonstrates that HOFs fragment into small particles while maintaining their original assemblies upon dispersing in solvents, as confirmed by Cryo-electron microscopy coupled with 3D electron diffraction technology. 1D and 2D-Nuclear Magnetic Resonance (NMR) and zeta potential analyses indicate the HOF-based colloid solution and the isolated molecular solution have significant differences in intermolecular interactions and aggregation behavior. Such unique solution processibility allows for fabricating diverse continuous HOF membranes with high crystallinity and porosity through solution-casting approach on various substrates. Among them, HOF-BTB@AAO membranes show high C
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-44921-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: Enterococcus

    Hu, Bin / Wang, Jia-Min / Zhang, Qing-Xun / Xu, Jing / Xing, Ya-Nan / Wang, Bo / Han, Shu-Yi / He, Hong-Xuan

    Zoological research

    2024  Volume 45, Issue 3, Page(s) 451–463

    Abstract: The gut microbiota significantly influences host physiology and provides essential ecosystem services. While diet can affect the composition of the gut microbiota, the gut microbiota can also help the host adapt to specific dietary habits. The carrion ... ...

    Abstract The gut microbiota significantly influences host physiology and provides essential ecosystem services. While diet can affect the composition of the gut microbiota, the gut microbiota can also help the host adapt to specific dietary habits. The carrion crow (
    MeSH term(s) Animals ; Mice ; Crows ; Enterococcus faecalis ; Ecosystem ; RNA, Ribosomal, 16S ; Feeding Behavior ; Birds
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2024-01-23
    Publishing country China
    Document type Journal Article
    ISSN 2095-8137
    ISSN 2095-8137
    DOI 10.24272/j.issn.2095-8137.2023.320
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Comparison of the assembly behavior and structural characteristics of arachin and conarachin amyloid-like fibrils

    Yang, Qin / Wang, Ya-Ru / Du, Ya-Nan / Chen, Han-Qing

    Food Hydrocolloids. 2023 May, v. 138 p.108479-

    2023  

    Abstract: In this study, the assembly behavior and structural characteristics of arachin (Ara) and conarachin (Con) amyloid-like fibrils formed by heating at 80 °C and 95 °C under acidic conditions were investigated. The results showed that Ara exhibited higher ... ...

    Abstract In this study, the assembly behavior and structural characteristics of arachin (Ara) and conarachin (Con) amyloid-like fibrils formed by heating at 80 °C and 95 °C under acidic conditions were investigated. The results showed that Ara exhibited higher Thioflavin T fluorescence intensity during the fibrillation process and assembled into longer amyloid-like fibrils compared to Con, indicating that Ara had a stronger ability to form amyloid-like fibrils. Ara and Con were hydrolyzed into small peptides during the initial heating process, leading to decreased average particle sizes, as evidenced by the degraded subunits. Then the average particle size increased with the small peptides assembling into ordered amyloid-like fibrils with high content of β-sheets. Based on the results of surface hydrophobicity and the content of free –SH, the hydrophobic interactions played a more important role in the fibrillation process of Ara, while more surface free –SH involved in the formation of Con fibrils. Higher temperature (95 °C) accelerated the hydrolysis of proteins and subsequent self-assembly process. Furthermore, these amyloid-like fibrils had no in vitro cytotoxicity, showing the potential application in future food production. In summary, this work provides us a deep understanding of the formation mechanism and structural characteristics of Ara and Con amyloid-like fibrils.
    Keywords cytotoxicity ; fluorescence ; food production ; hydrocolloids ; hydrolysis ; hydrophobicity ; particle size ; peptides ; temperature ; Arachin ; Conarachin ; Amyloid-like fibrils ; Self-assembly ; Structure
    Language English
    Dates of publication 2023-05
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 742742-6
    ISSN 1873-7137 ; 0268-005X
    ISSN (online) 1873-7137
    ISSN 0268-005X
    DOI 10.1016/j.foodhyd.2023.108479
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  7. Article ; Online: Awareness of HPV and HPV vaccines, acceptance to vaccination and its influence factors among parents of adolescents 9 to 18 years of age in China: A cross-sectional study.

    Xie, Hong / Zhu, Han-Yue / Jiang, Ni-Jie / Yin, Ya-Nan

    Journal of pediatric nursing

    2023  Volume 71, Page(s) 73–78

    Abstract: Background: Vaccination uptake rates for adolescents are still low in China despite safe and effective human papillomavirus vaccines being available. The awareness and attitudes of parents to HPV vaccines play a decisive role in adolescents' HPV ... ...

    Abstract Background: Vaccination uptake rates for adolescents are still low in China despite safe and effective human papillomavirus vaccines being available. The awareness and attitudes of parents to HPV vaccines play a decisive role in adolescents' HPV vaccination uptake.
    Methods: A cross-sectional study was conducted from March, 2022 to May, 2022 using an anonymous questionnaire among parents of 9 to 18 years of age from 73 cities in 23 provinces in mainland China. Demographic characteristics of parents, their knowledge and attitudes about HPV and HPV vaccination, as well as factors influencing HPV vaccination in adolescents were assessed.
    Results: More than two-thirds of parents heard of HPV (75.5%) and HPV vaccines (84.7%). Of these participants, mothers (83.8%) were in the majority. Parents willing to vaccinate themselves and their children against HPV were 84.9% and 87.6%, respectively. Parents were more likely to vaccinate their daughters against HPV than their sons (P < 0.001). Parents who had heard of the HPV vaccines (P = 0.028) or had vaccinated themselves (P < 0.001) were more likely to have HPV vaccination for their children. Parents who accepted the price of the HPV vaccines (P = 0.005) were more likely to have their children vaccinated against HPV.
    Conclusions: Children's gender, awareness of the HPV vaccines, parental HPV vaccination, and the price of the HPV vaccines are likely to be the reason for parents' vaccine hesitancy for adolescents.
    Practice implications: Nurses have a critical role in identifying parental hesitancy and providing individualized education to expand the parental awareness and knowledge and encourage on-time adolescents vaccination.
    MeSH term(s) Child ; Female ; Humans ; Adolescent ; Cross-Sectional Studies ; Papillomavirus Vaccines ; Papillomavirus Infections/prevention & control ; Health Knowledge, Attitudes, Practice ; Parents/education ; Vaccination ; China ; Surveys and Questionnaires ; Patient Acceptance of Health Care
    Chemical Substances Papillomavirus Vaccines
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632731-x
    ISSN 1532-8449 ; 0882-5963
    ISSN (online) 1532-8449
    ISSN 0882-5963
    DOI 10.1016/j.pedn.2023.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Total Tau Protein Mediates the Association of Ischemic Cerebrovascular Disease with Cognitive Decline.

    Han, Shuang-Ling / Ou, Ya-Nan / Han, Bao-Lin / Guo, Hai-Hua / Chi, Hao-Chen / Huang, Yi-Ming / Wang, Hui-Fu / Tan, Lan

    Journal of Alzheimer's disease : JAD

    2024  Volume 98, Issue 3, Page(s) 1133–1143

    Abstract: Background: Patients with transient ischemic attack (TIA) or ischemic stroke demonstrate an increased risk of cognitive dysfunction. Accumulating evidence indicates that ischemic cerebrovascular disease (ICVD) may interact with the amyloid/tau/ ... ...

    Abstract Background: Patients with transient ischemic attack (TIA) or ischemic stroke demonstrate an increased risk of cognitive dysfunction. Accumulating evidence indicates that ischemic cerebrovascular disease (ICVD) may interact with the amyloid/tau/neurodegeneration (AT[N]) biomarkers to promote dementia. However, the precise pathological mechanisms remain to be fully characterized.
    Objective: To elucidate the interrelationships among ICVD, ATN biomarkers in cerebrospinal fluid (CSF), and cognition.
    Methods: A total of 2524 participants were recruited from the CABLE study. ICVD referred to TIA/ischemic stroke. Cognitive performance was assessed by China Modified Mini-Mental State Examination (CM-MMSE) and Montreal Cognitive Assessment-b (MoCA-b). Multivariate linear regression analyses were performed to evaluate the associations of ICVD with CSF ATN biomarkers and cognition. Causal mediation analyses were used to identify whether the association was mediated by ATN biomarkers.
    Results: ICVD was associated with higher total-tau (t-tau) (p = 2.828×10-2) and poorer cognition (CM-MMSE: p = 1.539×10-5, MoCA-b: p = 4.552×10-6). Additionally, no discernible correlation surfaced between ICVD and amyloid-β (Aβ) 42 (p = 6.910×10-1) or phosphorylated tau (p-tau) (p = 4.324×10-1). The influence of ICVD on cognitive function was partially mediated by CSF t-tau (CM-MMSE: proportion: 2.74%, MoCA-b: proportion: 2.51%). Subgroup analyses revealed the influences of t-tau were especially evident in male (CM-MMSE: proportion: 5.45%, MoCA-b: proportion: 5.38%) and mid-life group (CM-MMSE: proportion: 9.83%, MoCA-b: proportion: 5.31%).
    Conclusions: These results delineated t-tau as a potential mediator for the influence of ICVD on cognition. Targeting brain ischemia and alleviating neuronal injury induced by ischemia may be a promising approach for preventing cognitive decline.
    MeSH term(s) Humans ; Male ; tau Proteins/cerebrospinal fluid ; Ischemic Attack, Transient ; Cognitive Dysfunction ; Amyloid beta-Peptides/cerebrospinal fluid ; Biomarkers/cerebrospinal fluid ; Ischemic Stroke ; Alzheimer Disease/psychology
    Chemical Substances tau Proteins ; Amyloid beta-Peptides ; Biomarkers
    Language English
    Publishing date 2024-04-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-231093
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Meta-Analysis of Anesthetic Efficacy and Safety of Propofol in Craniotomy Patients.

    Zhou, Qiang / Han, Ya'nan / Chen, Jun

    publication RETRACTED

    Contrast media & molecular imaging

    2022  Volume 2022, Page(s) 6318051

    Abstract: The anesthetic effect and safety of propofol in craniotomy patients by meta-analysis is investigated. Relevant studies consistent with the anesthetic effect and safety of propofol in craniotomy patients are searched and screened from domestic and foreign ...

    Abstract The anesthetic effect and safety of propofol in craniotomy patients by meta-analysis is investigated. Relevant studies consistent with the anesthetic effect and safety of propofol in craniotomy patients are searched and screened from domestic and foreign literature databases such as Wanfang Medical Center, CNKI, VIP, and PubMed, and meta-analysis is performed by RevMan 5.2 software. Experimental results show that the recovery time, intracranial pressure, cerebral edema, partial cerebral oxygen pressure, glutamate, and MDA in the propofol group are better than those in the control group (
    MeSH term(s) Anesthesia, Intravenous ; Anesthetics ; Craniotomy/methods ; Humans ; Oxygen ; Propofol/adverse effects
    Chemical Substances Anesthetics ; Oxygen (S88TT14065) ; Propofol (YI7VU623SF)
    Language English
    Publishing date 2022-08-18
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Retracted Publication
    ZDB-ID 2232678-9
    ISSN 1555-4317 ; 1555-4309
    ISSN (online) 1555-4317
    ISSN 1555-4309
    DOI 10.1155/2022/6318051
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article: [Systematic review and Meta-analysis on the auriculotherapy in treatment of insomnia].

    Jiao, Yue / Han, Ying / Zhou, Jin-Cao / Zhang, Jin-Ling / Zhao, Ya-Nan / Rong, Pei-Jing

    Zhongguo zhen jiu = Chinese acupuncture & moxibustion

    2023  Volume 42, Issue 10, Page(s) 1184–1194

    Abstract: Objective: To review the effectiveness and safety of auriculotherapy in treatment of insomnia.: Methods: The articles were collated by computer retrieval from 8 databases from the initiation to April 30, 2021, i.e. PubMed, EMbase, the Cochrane ... ...

    Abstract Objective: To review the effectiveness and safety of auriculotherapy in treatment of insomnia.
    Methods: The articles were collated by computer retrieval from 8 databases from the initiation to April 30, 2021, i.e. PubMed, EMbase, the Cochrane Library, the Web of Science, CNKI, Wanfang database, VIP and Chinese biomedical literature database (SinoMed). Meta-analysis was conducted with RevMan5.3 software.
    Results: A total of 38 articles were included, with 3 707 cases involved. The results showed: ①The effective rate of auriculotherapy was better than that of single application of western medication with sleeping pills (
    Conclusion: Auriculotherapy has certain curative advantages in treatment of insomnia compared with western and Chinese medications as well as conventional acupuncture. This therapy may relieve the symptoms of insomnia and has less adverse effects. But those outcomes need to be further verified with more high-quality randomized controlled trials.
    MeSH term(s) Humans ; Sleep Initiation and Maintenance Disorders/therapy ; Drugs, Chinese Herbal/therapeutic use ; Acupuncture Therapy ; Auriculotherapy
    Chemical Substances Drugs, Chinese Herbal
    Language Chinese
    Publishing date 2023-05-19
    Publishing country China
    Document type Meta-Analysis ; Systematic Review ; English Abstract ; Journal Article
    ISSN 0255-2930
    ISSN 0255-2930
    DOI 10.13703/j.0255-2930.20210706-0004
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top