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Article ; Online: Jie Geng Tang reverses cisplatin resistance through the Nrf2 pathway in lung cancer.

Zhao, Jing / Hou, Manting / Ding, Kaixin / Li, Shixiong / Li, Hui / Zhang, Xili / Bai, Zhaofang / Liu, Wenlong

The Journal of pharmacy and pharmacology

2023 Volume 75, Issue 6, Page(s) 784–805

Abstract: Objectives: Jie Geng Tang (JGT) is an ancient traditional Chinese herbal decoction that exhibits ...

Abstract	Objectives: Jie Geng Tang (JGT) is an ancient traditional Chinese herbal decoction that exhibits various pharmacological activities, however, is poorly understood in the sensitivity of lung cancer to chemotherapy. Here, we explored the effect of JGT on sensitizing cisplatin (DDP)-resistant A549 cells (A549/DDP). Methods: Cell viability was assessed using cell counting kit-8 assay. Flow cytometry was applied to detected cell apoptosis, mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) levels. Western blotting and qRT-PCR were performed to determine protein and mRNA levels. Key findings: The results demonstrated that DDP co-treatment with JGT significantly increased the cytotoxicity of A549/DDP cells and exhibited efficacy in suppressing the migration and proliferation. The rate of apoptosis was increased by co-treatment with DDP and JGT, along with a higher rate of Bax/Bcl-2, and increased loss of MMP. Furthermore, the combination promoted ROS accumulation and increased γ-H2AX levels. Moreover, Nrf2 levels were suppressed in a dose- and time-dependent manner, Nrf2 stability was reduced following treatment with JGT. Notably, the combination induced inhibition of the Nrf2/ARE pathway at the mRNA and protein levels. Conclusions: Collectively, these results indicate that co-treatment with JGT and DDP can be considered a combinational approach to treating DDP resistance.
MeSH term(s)	Humans ; Cisplatin/pharmacology ; NF-E2-Related Factor 2/metabolism ; Reactive Oxygen Species/metabolism ; Drug Resistance, Neoplasm ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Apoptosis ; Cell Proliferation ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor
Chemical Substances	Cisplatin (Q20Q21Q62J) ; NF-E2-Related Factor 2 ; Reactive Oxygen Species ; Antineoplastic Agents
Language	English
Publishing date	2023-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	3107-0
ISSN	2042-7158 ; 0022-3573 ; 0373-1022
ISSN (online)	2042-7158
ISSN	0022-3573 ; 0373-1022
DOI	10.1093/jpp/rgad018
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Article: Qu-Du-San-Jie decoction induces growth inhibition and vascular normalization in NF2-associated vestibular schwannoma.

Lin, Jie / Li, Shi-Wei / Zhang, Jing / Chu, Fu-Hao / Li, Cheng-Ze / Bie, Zhi-Xu / Tang, Han-Lu / Gao, Shan / Li, Ping / Liao, Meng-Ting / Xin, Tian-Xi / Zhao, Fu / Liu, Pi-Nan / Ding, Xia

Frontiers in pharmacology

2022 Volume 13, Page(s) 941854

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-08-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.941854
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Article: Composition and Bioactivity of a Modified Huang-Lian-Jie-Du Decoction.

Lin, Mei-Yi / Chen, Lih-Geeng / Siao, Ying-Yu / Lin, Tao-Hsuan / Huang, I-An / Liu, Yi-Wen / Huang, Chin-Chin

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 2147923

Abstract: ... prepared a modified Huang-Lian-Jie-Du (mHLJD) decoction cream using 10 herbs, which effectively alleviated ...

Abstract	Background: Epidermal growth factor receptor inhibitors (EGFRIs) and tyrosine kinase inhibitors (TKIs) are key drugs in targeted cancer therapy. However, they may cause skin toxicity. We previously prepared a modified Huang-Lian-Jie-Du (mHLJD) decoction cream using 10 herbs, which effectively alleviated EGFRI/TKI-induced skin toxicity. In the present study, we identified the reference markers of the mHLJD decoction and investigated the anti-inflammatory and antibacterial effects of the mHLJD decoction extract. Methods: We performed high-performance liquid chromatography (HPLC) to determine the composition of the mHLJD decoction. Human epidermoid A431 cells were treated with tumor necrosis factor (TNF)- Results: HPLC results revealed that the mHLJD decoction primarily consisted of geniposide, berberine chloride, baicalin, coptisine, and palmatine. TNF-
Language	English
Publishing date	2022-09-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/2147923
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Article ; Online: Huang Lian Jie Du Decoction enhances the anti-tumor efficacy of immune checkpoint inhibitors by activating TLR7/8 signalling in melanoma.

Liu, Suqing / Zhang, Yaohua / Zhu, Xiaohua / He, Shan / Liu, Xiao / Lv, Xiang / Zuo, Fuguo / Wu, Jinfeng

BMC complementary medicine and therapies

2024 Volume 24, Issue 1, Page(s) 156

Abstract: ... Lian Jie Du Decoction (HLJD, Oren-gedoku-to in Japanese, Hwangryunhaedok-tang in Korean), a famous ...

Abstract	Background: The clinical application of immune checkpoint inhibitors (ICIs) is limited by their drug resistance, necessitating the development of ICI sensitizers to improve cancer immunotherapy outcomes. Huang Lian Jie Du Decoction (HLJD, Oren-gedoku-to in Japanese, Hwangryunhaedok-tang in Korean), a famous traditional Chinese medicinal prescription, has exhibited potential in the field of cancer treatment. This study aims to investigate the impact of HLJD on the efficacy of ICIs in melanoma and elucidate the underlying mechanisms. Methods: The potential synergistic effects of HLJD and ICIs were investigated on the tumor-bearing mice model of B16F10 melanoma, and the tumor infiltration of immune cells was tested by flow cytometry. The differential gene expression in tumors between HLJD and ICIs group and ICIs alone group were analyzed by RNA-seq. The effects of HLJD on oxidative stress, TLR7/8, and type I interferons (IFN-Is) signaling were further validated by immunofluorescence, PCR array, and immunochemistry in tumor tissue. Results: HLJD enhanced the anti-tumor effect of ICIs, significantly inhibited tumor growth, and prolonged the survival duration in melanoma. HLJD increased the tumor infiltration of anti-tumor immune cells, especially DCs, CD4 Conclusions: HLJD enhanced the therapeutic benefits of ICIs in melanoma, through increasing reactive oxygen species (ROS), promoting the TLR7/8 pathway, and activating IFN-Is signaling, which in turn activated DCs and T cells.
MeSH term(s)	Mice ; Animals ; Immune Checkpoint Inhibitors/pharmacology ; Coptis chinensis ; Toll-Like Receptor 7 ; Melanoma/drug therapy ; Signal Transduction ; Drugs, Chinese Herbal
Chemical Substances	oren gedoku to ; Immune Checkpoint Inhibitors ; Toll-Like Receptor 7 ; Drugs, Chinese Herbal
Language	English
Publishing date	2024-04-11
Publishing country	England
Document type	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-024-04444-y
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Article ; Online: Metabolomics and lipidomics combined with serum pharmacochemistry uncover the potential mechanism of Huang-Lian-Jie-Du decoction alleviates atherosclerosis in ApoE

Yang, Xiaoli / Chi, Chenglin / Li, Wenjing / Zhang, Yanyan / Yang, Shufang / Xu, Ruoxuan / Liu, Rongxia

Journal of ethnopharmacology

2024 Volume 324, Page(s) 117748

Abstract: ... accumulation and oxidative stress. Huang-Lian-Jie-Du decoction (HLJDD), a representative formula for clearing ...

Abstract	Ethnopharmacological relevance: Atherosclerosis (AS) is one of the main cardiovascular diseases (CVDs) leading to an increase in global mortality, and its key pathological features are lipid accumulation and oxidative stress. Huang-Lian-Jie-Du decoction (HLJDD), a representative formula for clearing heat and detoxifying, has been shown to reduce aortic lipid plaque and improve AS. However, multiple components and multiple targets of HLJDD pose a challenge in comprehending its comprehensive mechanism in the treatment of AS. Aim of the study: This study was designed to illustrate the anti-AS mechanisms of HLJDD in an apolipoprotein E-deficient (ApoE Materials and methods: ApoE Results: In this study, HLJDD treatment improved serum biochemical levels and histopathological conditions in AS mice. A total of 6 metabolic pathways (arginine biosynthesis, glycerophospholipid, sphingolipid, arachidonic acid, linoleic acid, and glycerolipid metabolism) related to 25 metabolic biomarkers and 41 lipid biomarkers were clarified, and 22 prototype components migrating to blood were identified after oral administration of HLJDD. Conclusion: HLJDD improved AS induced by HFD in ApoE
MeSH term(s)	Mice ; Animals ; Lipidomics ; Arachidonic Acid ; Linoleic Acid ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Metabolomics ; Atherosclerosis/drug therapy ; Apolipoproteins E/genetics ; Biomarkers ; Cholesterol ; Arginine
Chemical Substances	oren gedoku to ; Arachidonic Acid (27YG812J1I) ; Linoleic Acid (9KJL21T0QJ) ; Drugs, Chinese Herbal ; Apolipoproteins E ; Biomarkers ; Cholesterol (97C5T2UQ7J) ; Arginine (94ZLA3W45F)
Language	English
Publishing date	2024-01-10
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.117748
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Zs.A 1494: Show issues

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Article ; Online: San Jie Tong Mai Fang Protects Against Atherosclerosis Progression by Regulating Macroautophagy through the PI3K/AKT/mTOR Signaling Pathway.

Li, Pengfei / Li, Hongyu / Li, Xiaohui / Li, Shuangdi / Xu, Hanying / Cui, Junfeng / Cheng, Guangyu / Liu, Yinghui / Xu, Xiaolin / Xin, Yuning / Liu, Aidong

Journal of cardiovascular pharmacology

2023 Volume 82, Issue 4, Page(s) 333–343

Abstract: ... autophagy. We previously reported that the herbal formula San Jie Tong Mai Fang (SJTMF) elicits lipid ...

Abstract	Abstract: Many studies have confirmed that macrophage autophagy injury negatively impacts the pathogenesis of atherosclerosis (AS). Meanwhile, the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway affects AS progression by regulating macrophage autophagy. We previously reported that the herbal formula San Jie Tong Mai Fang (SJTMF) elicits lipid regulatory and anti-inflammatory properties. Hence, the current study used an ApoE -/- high-fat diet-fed mouse model to determine whether SJTMF elicits protective effects against AS progression by means of the regulation of macrophage autophagy through the PI3K/AKT/mTOR signaling pathway. Our results show that SJTMF reduced the number of atherosclerotic plaques, foam cell formation, and intimal thickness in mouse aorta. In addition, SJTMF improved blood lipid metabolism and inflammatory levels in mice. We also observed that SJTMF caused macrophages to be polarized toward the M2 phenotype through the inhibition of the PI3K/AKT/mTOR signaling pathway. In addition, the abundances of LC3-II/I and beclin1 proteins-key autophagy molecules-were increased, whereas that of p62 was decreased, resulting in the promotion of macrophage autophagy. Taken together, these findings indicate that SJTMF may regulate the polarization of macrophages by inhibiting the PI3K/AKT/mTOR signaling pathway, thereby reducing atherosclerotic plaque damage in ApoE -/- mice, thereby promoting macrophage autophagy and eliciting a significant antiarteriosclerosis effect. Hence, SJTMF may represent a promising new candidate drug for the treatment of AS.
MeSH term(s)	Mice ; Animals ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphatidylinositol 3-Kinase/metabolism ; Macroautophagy ; TOR Serine-Threonine Kinases/metabolism ; Mice, Knockout, ApoE ; Signal Transduction ; Atherosclerosis/drug therapy ; Atherosclerosis/prevention & control ; Atherosclerosis/genetics ; Plaque, Atherosclerotic ; Autophagy ; Apolipoproteins E/pharmacology ; Mammals/metabolism
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Apolipoproteins E
Language	English
Publishing date	2023-10-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391970-5
ISSN	1533-4023 ; 0160-2446
ISSN (online)	1533-4023
ISSN	0160-2446
DOI	10.1097/FJC.0000000000001452
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Zs.A 1471: Show issues

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Article ; Online: The Herbal Combination Shu Gan Jie Yu Regulates the SNCG/ER-a/AKT-ERK Pathway in DMBA-Induced Breast Cancer and Breast Cancer Cell Lines Based on RNA-Seq and IPA Analysis.

Zhao, Yi / Zhao, Linan / Wang, Tao / Liu, Zhenghao / Tang, Suyuan / Huang, Hongxia / Wu, Li / Sun, Youzhi

Integrative cancer therapies

2024 Volume 23, Page(s) 15347354241233258

Abstract: Background: Soothing the liver (called : The aim of the study: To investigate the inhibiting effect of SGJY on breast cancer in vivo and vitro, and to explore the potential mechanisms.: Materials and methods: SGJY herbal combination was extracted ... ...

Abstract	Background: Soothing the liver (called The aim of the study: To investigate the inhibiting effect of SGJY on breast cancer in vivo and vitro, and to explore the potential mechanisms. Materials and methods: SGJY herbal combination was extracted using water. A breast cancer rat model was developed by chemical DMBA by gavage, then treated with SGJY for 11 weeks. The tumor tissue was preserved for RNA sequencing and analyzed by IPA software. The inhibition effects of SGJY on MCF-7 and T47D breast cancer cells were investigated by SRB assay and cell apoptosis analysis, and the protein expression levels of SNCG, ER-α, Results: SGJY significantly reduced the tumor weight and volume, and the level of estradiol in serum. The results of IPA analysis reveal SGJY upregulated 7 canonical pathways and downregulated 16 canonical pathways. Estrogen receptor signaling was the key canonical pathway with 9 genes downregulated. The results of upstream regulator analysis reveal beta-estradiol was the central target; the upstream regulator network scheme showed that 86 genes could affect the expression of the beta-estradiol, including SNCG, CCL21 and MB. Additionally, SGJY was verified to significantly alter the expression of SNCG mRNA, CCL21 mRNA and MB mRNA which was consistent with the data of RNA-Seq. The inhibition effects of SGJY exhibited a dose-dependent response. The apoptosis rates of MCF7 and T47D cells were upregulated. The protein expression of SNCG, ER-α, Conclusion: The results demonstrate that SGJY may inhibit the growth of breast cancer. The mechanism might involve downregulating the level of serum estradiol, and suppressing the protein expression in the SNCG/ER-α/AKT-ERK pathway.
MeSH term(s)	Animals ; Female ; Humans ; Rats ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Estradiol ; gamma-Synuclein/genetics ; gamma-Synuclein/metabolism ; MAP Kinase Signaling System ; MCF-7 Cells ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, Estrogen/metabolism ; RNA, Messenger/metabolism ; RNA-Seq
Chemical Substances	Estradiol (4TI98Z838E) ; gamma-Synuclein ; Neoplasm Proteins ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Receptors, Estrogen ; RNA, Messenger ; SNCG protein, human
Language	English
Publishing date	2024-02-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2182320-0
ISSN	1552-695X ; 1534-7354
ISSN (online)	1552-695X
ISSN	1534-7354
DOI	10.1177/15347354241233258
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Article ; Online: Modified Huang-Lian-Jie-Du Decoction Ameliorates A

Liu, Yan / Du, Ting / Zhang, Wenlong / Lu, Weiye / Peng, Zhichao / Huang, Shuqiong / Sun, Xiangdong / Zhu, Xiaoqin / Chen, Chaojun / Qian, Linchao / Wen, Lei / Xu, Pingyi / Zhang, Yunlong

Oxidative medicine and cellular longevity

2019 Volume 2019, Page(s) 8340192

Abstract: ... dysfunction; however, the therapeutic strategies are not fully understood. Huang-Lian-Jie-Du-Decoction (HLJDD ...

Abstract	Alzheimer's disease (AD) is a common neurodegenerative disease, characterized by cognitive dysfunction; however, the therapeutic strategies are not fully understood. Huang-Lian-Jie-Du-Decoction (HLJDD) is a famous traditional Chinese herbal formula that has been widely used clinically to treat dementia. Recently, according to previous study and our clinical practice, we generate a new modification of HLJDD (named modified-HLJDD). In this study, we indicated that modified-HLJDD attenuated learning and memory deficiencies in A
MeSH term(s)	Alzheimer Disease/drug therapy ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/metabolism ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Humans ; Male ; Mice ; Neuronal Plasticity/drug effects ; Peptide Fragments/metabolism ; Synapses/chemistry ; Synapses/metabolism ; Synapses/pathology ; Synaptic Transmission/drug effects
Chemical Substances	Amyloid beta-Peptides ; Anti-Inflammatory Agents, Non-Steroidal ; Drugs, Chinese Herbal ; Peptide Fragments ; amyloid beta-protein (1-42) ; oren gedoku to
Language	English
Publishing date	2019-11-03
Publishing country	United States
Document type	Journal Article
ISSN	1942-0994
ISSN (online)	1942-0994
DOI	10.1155/2019/8340192
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Article: Real-World Study on Chai-Shi-Jie-Du Granules for the Treatment of Dengue Fever and the Possible Mechanisms Based on Network Pharmacology.

Yang, Huiqin / Ma, Dehong / Li, Qin / Zhou, Wen / Chen, Hongyi / Shan, Xiyun / Zheng, Haipeng / Luo, Chun / Ou, Zhiyue / Xu, Jielan / Wang, Changtai / Zhao, Lingzhai / Su, Rui / Chen, Yuehong / Liu, Qingquan / Tan, Xinghua / Lin, Luping / Jiang, Tao / Zhang, Fuchun

Evidence-based complementary and alternative medicine : eCAM

2023 Volume 2023, Page(s) 9942842

Abstract: ... for dengue fever. This real-world study aimed to evaluate the effects of Chai-Shi-Jie-Du (CSJD) granules ...

Abstract	Objectives: Traditional Chinese medicine (TCM) is a widely used method for treating dengue fever in China. TCM improves the symptoms of patients with dengue, but there is no standard TCM prescription for dengue fever. This real-world study aimed to evaluate the effects of Chai-Shi-Jie-Du (CSJD) granules for the treatment of dengue fever and the underlying mechanisms. Methods: We implemented a multicenter real-world study, an Results: 137 pairs of patients were successfully matched according to age, sex, and the time from onset to presentation. The time to defervescence (1.7 days vs. 2.5 days, Conclusions: CSJD granules exhibit high potential for the treatment of dengue fever, and the therapeutic mechanisms involved could be related to regulating immunity, moderating the oxidative stress response, and the response to lipopolysaccharide.
Language	English
Publishing date	2023-08-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2023/9942842
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Zs.A 5995: Show issues

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Article ; Online: Neuroprotective effects of Jie-du-huo-xue decoction on microglia pyroptosis after cerebral ischemia and reperfusion--From the perspective of glial-vascular unit.

Zhou, Chang / Li, Jin-Xia / Zheng, Cai-Xing / Zhou, Xiao-Qing / Chen, Cong / Qiu, Shi-Wei / Liu, Wang-Hua / Li, Hua

Journal of ethnopharmacology

2023 Volume 318, Issue Pt B, Page(s) 116990

Abstract: ... of life. Jie-Du-Huo-Xue decoction (JDHXD) is a classical and well-known Chinese formula for stroke ...

Abstract	Ethnopharmacological relevance: Ischemic stroke poses a serious risk to public health and quality of life. Jie-Du-Huo-Xue decoction (JDHXD) is a classical and well-known Chinese formula for stroke treatment, but the pharmacological mechanism is still unclear. Aim of the study: This study aims to investigate the mechanism underlying microglial pyroptosis and polarization, as well as the potential efficacy of JDHXD against cerebral ischemia-reperfusion injury (CIRI). Materials and methods: Models of CIRI were established by the middle cerebral artery occlusion/reperfusion (MCAO/R) method in rats. In the first stage, 36 SD rats were randomly divided into sham group, I/R group, JDHXD-L group (5.36 g/kg/day), JDHXD-M group (10.71 g/kg/day), JDHXD-H group (21.42 g/kg/day), and positive drug edaravone group. The effectiveness of JDHXD on CIRI was confirmed by neurological function testing and cerebral infarct measuring. The best dose (JDXHD-M) was subsequently chosen to perform the tests that followed. In the second stage, 36 SD rats were randomly divided into the sham group, the I/R group, and the JDHXD-M group. Detection of nerve damage using Nissl staining, proteins of pyroptosis, Iba-1, and NeuN expressions were detected by western blotting, and proteins of microglial pyroptosis and M1/M2 phenotypic polarization were detected by immunofluorescence. Results: In rats after CIRI, JDHXD significantly reduced neurological impairment and cerebral infarction. In addition, JDHXD facilitated the M1-to-M2 transition of microglia in order to minimize neuroinflammation and improve anti-inflammatory repair. In addition, JDXHD inhibited microglial pyroptosis by blocking the cleavage of caspase-1 P10 and gasdermin D, hence reducing neuronal damage and enhancing neuronal survival following reperfusion. Interestingly, JDHXD also demonstrated a protective effect on the glial-vascular unit (GVU). Conclusions: Our investigation demonstrated that JDHXD exerted a GVU-protective effect on CIRI rats by decreasing neuroinflammation-associated microglial pyroptosis, suppressing microglial M1 activation, and promoting microglial M2 activation.
MeSH term(s)	Rats ; Animals ; Microglia ; Pyroptosis ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Neuroprotective Agents/metabolism ; Neuroinflammatory Diseases ; Quality of Life ; Rats, Sprague-Dawley ; Brain Ischemia/drug therapy ; Brain Ischemia/metabolism ; Infarction, Middle Cerebral Artery/drug therapy ; Infarction, Middle Cerebral Artery/metabolism ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism ; Reperfusion
Chemical Substances	Neuroprotective Agents
Language	English
Publishing date	2023-08-01
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116990
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