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  1. Article ; Online: Stroke Associated with COVID-19 Vaccines.

    Kakovan, Maryam / Ghorbani Shirkouhi, Samaneh / Zarei, Mojtaba / Andalib, Sasan

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2022  Volume 31, Issue 6, Page(s) 106440

    Abstract: Objectives: Development of safe and effective vaccines against coronavirus disease 2019 (COVID-19) remains the cornerstone of controlling this pandemic. However, there are increasing reports of various types of stroke including ischemic stroke, and ... ...

    Abstract Objectives: Development of safe and effective vaccines against coronavirus disease 2019 (COVID-19) remains the cornerstone of controlling this pandemic. However, there are increasing reports of various types of stroke including ischemic stroke, and hemorrhagic stroke, as well as cerebral venous sinus thrombosis (CVST) after COVID-19 vaccination. This paper aims to review reports of stroke associated with COVID-19 vaccines and provide a coherent clinical picture of this condition.
    Materials and methods: A literature review was performed with a focus on data from recent studies.
    Results: Most of such patients are women under 60 years of age and who had received ChAdOx1 nCoV-19 vaccine. Most studies reported CVST with or without secondary ischemic or hemorrhagic stroke, and some with Vaccine-induced Thrombotic Thrombocytopenia (VITT). The most common clinical symptom of CVST seen after COVID-19 vaccination was headache. The clinical course of CVST after COVID-19 vaccination may be more severe than CVST not associated with COVID vaccination. Management of CVST following COVID-19 vaccination is challenging and may differ from the standard treatment of CVST. Low molecular weight heparin is commonly used in the treatment of CVST; however, it may worsen outcomes in CVST associated with VITT. Furthermore, administration of intravenous immunoglobulin and high-dose glucocorticoids have been recommended with various success rates.
    Conclusion: These contradictory observations are a source of confusion in clinical decision-making and warrant further study and development of clinical guidelines. Clinicians should be aware of clinical presentation, diagnosis, and management of stroke associated with COVID-19 vaccination.
    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; ChAdOx1 nCoV-19 ; Female ; Hemorrhagic Stroke/chemically induced ; Hemorrhagic Stroke/epidemiology ; Humans ; Ischemic Stroke/chemically induced ; Ischemic Stroke/epidemiology ; Male ; SARS-CoV-2 ; Thrombocytopenia
    Chemical Substances COVID-19 Vaccines ; ChAdOx1 nCoV-19 (B5S3K2V0G8)
    Language English
    Publishing date 2022-03-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2022.106440
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3519: Show issues Location:
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  2. Article ; Online: Double nerve transfer for restoration of hand grasp and release in C7 tetraplegia following complete cervical spinal cord injury.

    Emamhadi, Mohammadreza / Andalib, Sasan

    Acta neurochirurgica

    2018  Volume 160, Issue 11, Page(s) 2219–2224

    Abstract: Cervical spinal cord injury (SCI) can cause tetraplegia. Nerve transfer has been routinely utilized for reconstruction of hand in brachial plexus injuries. Here, we report reconstruction of finger flexion (hand grasp) and extension (hand release) in a ... ...

    Abstract Cervical spinal cord injury (SCI) can cause tetraplegia. Nerve transfer has been routinely utilized for reconstruction of hand in brachial plexus injuries. Here, we report reconstruction of finger flexion (hand grasp) and extension (hand release) in a victim of cervical spinal cord injury with tetraplegia. We also focus on importance of extension phase in restoration of hand function in the tetraplegic case, in addition to provision of a detailed description of both operations including text, photographs, and a video. We used double nerve transfer, namely brachialis branches of musculocutaneous nerve to anterior interosseous nerve (AIN) and supinator branch of radial nerve to posterior interosseous nerve (PIN). We found that brachialis nerve transfer to AIN (for finger flexion) and supinator branch nerve transfer to PIN (for finger extension) can provide finger flexion and extension simultaneously. Brachialis nerve transfer to AIN and supinator branch nerve transfer to PIN may be an acceptable surgical technique to restore hand grasp and release in tetraplegia after SCI.
    MeSH term(s) Adult ; Cervical Vertebrae/surgery ; Hand Strength ; Humans ; Male ; Median Nerve/surgery ; Nerve Transfer/adverse effects ; Nerve Transfer/methods ; Quadriplegia/surgery ; Spinal Cord Injuries/surgery
    Language English
    Publishing date 2018-09-14
    Publishing country Austria
    Document type Case Reports ; Journal Article
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-018-3671-0
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  3. Article ; Online: Successful recovery of sensation loss in upper brachial plexus injuries.

    Emamhadi, Mohammadreza / Andalib, Sasan

    Acta neurochirurgica

    2018  Volume 160, Issue 10, Page(s) 2019–2023

    Abstract: Objective: Injuries of the upper trunk of the brachial plexus may trigger motor and sensory deficits. There exists a growing body of literature with respect to the reconstruction of motor deficits in upper trunk brachial plexus injuries by using nerve ... ...

    Abstract Objective: Injuries of the upper trunk of the brachial plexus may trigger motor and sensory deficits. There exists a growing body of literature with respect to the reconstruction of motor deficits in upper trunk brachial plexus injuries by using nerve transfers; albeit to date, very few old reports have focused on the reconstruction of sensory loss resulting from upper trunk injuries. In this case series, we review six cases (five males and one female) with upper trunk brachial plexus injuries undergoing sensory nerve transfers.
    Methods: Sensory reconstruction was carried out by using transfer of the ulnar to the median nerves, innervating adjacent aspects of the little and ring fingers (the fourth web space) and adjacent aspects of the thumb and the index finger (the first web space), respectively.
    Results: The mean age of our six patients was 30.5 ± 9 years old (range 20-45). The mean time interval between the injury and subsequent surgery was 6.6 ± 1.8 months (range 5-10). Five patients achieved S3 or S3+ in both the thumb and the index finger while the sixth one regained S2+ in the index finger while also achieving S3 in the thumb according to the Highet-Zachary system scoring scale.
    Conclusion: These results suggest that nerve transfers can achieve satisfactory outcomes in patients having sensory reconstruction after upper brachial plexus injuries, and thus, we lay emphasis on reviving the use of sensory nerve transfer techniques in such patients.
    MeSH term(s) Adult ; Brachial Plexus/injuries ; Brachial Plexus Neuropathies/surgery ; Female ; Fingers/innervation ; Humans ; Male ; Middle Aged ; Nerve Transfer/methods ; Reconstructive Surgical Procedures/methods ; Recovery of Function ; Sensation
    Language English
    Publishing date 2018-08-09
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-018-3648-z
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  4. Article ; Online: CHRONIC SUBDURAL HEMATOMA AND ARACHNOID CYST IN AN ADOLESCENT PATIENT WITH 10Q CHROMOSOMAL DELETION

    Sasan ANDALIB / Babak ALIJANI / Mostafa RAMEZANI-SHAMAMI

    Romanian Journal of Neurology, Vol 19, Iss 2, Pp 110-

    2020  Volume 113

    Abstract: ackground. Presence of related symptoms of chronic subdural hematoma (SDH) as a part of a syndrome with some atypical presentations in children may be a confusing manifestation. Here we report an adolescent chronic subdural hematoma and arachnoid cyst in ...

    Abstract ackground. Presence of related symptoms of chronic subdural hematoma (SDH) as a part of a syndrome with some atypical presentations in children may be a confusing manifestation. Here we report an adolescent chronic subdural hematoma and arachnoid cyst in an adolescent case with 10q chromosomal deletion.case presentation. A 14-year-old boy with chromosomal deletion of 10q leading to tyrosine phosphatase deficiency and arachnoid cyst in left parieto-occipital region beside of Sylvain fissure visited our clinic. He had history of occasional headaches all over the head with exacerbation since one month before admission. Decreased consciousness, imbalance, ataxia, and nausea and vomiting with decreased GCS of 8 were seen in this patient. He had no history of head trauma. The patient underwent surgery for the treatment of chronic subdural hematoma located in the right frontotemporal region and the burr hole trephination was carried out. After operation the patient was discharged from the hospital with GCS of 15.conclusions. Chronic subdural hematoma accompanying with arachnoid cyst in cases with syndrome manifestations should be considered as a part of inheriting biochemical disorders and further assessment by genetic and bio- chemical tests should be considered to diagnose possible syndromes and improve the prognosis with required additional treatments.
    Keywords chronic subdural hematoma ; arachnoid cyst ; pediatric ; Medicine ; R ; Neurology. Diseases of the nervous system ; RC346-429
    Subject code 610
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Amaltea Medical Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The First Experience of Triple Nerve Transfer in Proximal Radial Nerve Palsy.

    Emamhadi, Mohammadreza / Andalib, Sasan

    World neurosurgery

    2017  

    Abstract: Background: Injury to distal of posterior cord of brachial plexus leads to palsy of the radial and axillary nerves. The symptoms are usually motor deficits of the deltoid muscle, triceps brachii muscle, and the extensor muscles of the wrist, thumb and ... ...

    Abstract Background: Injury to distal of posterior cord of brachial plexus leads to palsy of the radial and axillary nerves. The symptoms are usually motor deficits of the deltoid muscle, triceps brachii muscle, and the extensor muscles of the wrist, thumb and fingers. Tendon transfers, nerve grafts, and nerve transfers are options of surgical treatment of proximal radial nerve palsy to restore some motor functions. Tendon transfer is painful, requires a long immobilization, and decreases donor muscle strength; nevertheless, nerve transfer produces promising outcome. Here, we present a patient with proximal radial nerve palsy following a blunt injury.
    Clinical presentation: Our patient was involved in a motorcycle accident with complete palsy of the radial and axillary nerves. Six months later on admission, he showed a spontaneous recovery in axillary nerve, but radial palsy remained. We performed triple nerve transfers, a fascicle of ulnar nerve to long head of triceps branch of radial nerve, flexor digitorum superficialis branch of median nerve to extensor carpi radialis brevis (ECRB) branch of radial nerve, and flexor carpi radialis branch of median nerve to posterior interoseous nerve for restoration of elbow, wrist, and finger extensions, respectively.
    Results: Our experience confirmed functional elbow, wrist, and finger extensions.
    Conclusion: Triple nerve transfers will restore functions of upper limb in patients who presented with debilitating radial nerve palsy after blunt injuries.
    Language English
    Publishing date 2017-10-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2017.10.033
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1159: Show issues Location:
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  6. Article ; Online: Nerve transfer to relieve pain in upper brachial plexus injuries: Does it work?

    Emamhadi, Mohammadreza / Andalib, Sasan

    Clinical neurology and neurosurgery

    2017  Volume 163, Page(s) 67–70

    Abstract: Objectives: Patients with C5 and C6 nerve root avulsion may complain from pain. For these patients, end-to-side nerve transfer of the superficial radial nerve into the median nerve is suggested to relieve pain.: Patients and methods: Eleven patients ( ...

    Abstract Objectives: Patients with C5 and C6 nerve root avulsion may complain from pain. For these patients, end-to-side nerve transfer of the superficial radial nerve into the median nerve is suggested to relieve pain.
    Patients and methods: Eleven patients (with a primary brachial plexus reconstruction) undergoing end-to-side nerve transfer of the superficial radial nerve into the ulnovolar part of the median nerve were assessed. Pain before surgery was compared to that at 6-month follow-up using visual analog scale (VAS) scores.
    Results: A significant difference was seen between the mean VAS before (8.5) and after surgery (0.7) (P=0.0). After the six-month follow-up, 6 patients felt no pain according to VAS, notwithstanding 5 patients with a mild pain.
    Conclusion: The evidence from the present study suggests that end-to-side nerve transfer of the superficial radial nerve into the ulnovolar part of the median nerve is an effective technique in reducing pain in patients with C5 and C6 nerve root avulsion.
    MeSH term(s) Adult ; Brachial Plexus/surgery ; Female ; Humans ; Male ; Median Nerve/surgery ; Middle Aged ; Nerve Transfer/methods ; Pain/surgery ; Radial Nerve/surgery ; Radiculopathy/surgery ; Spinal Nerve Roots/surgery ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2017-10-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2017.10.009
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  7. Article: Anti-inflammatory effects of alosetron mediated through 5-HT

    Motavallian, Azadeh / Minaiyan, Mohsen / Rabbani, Mohammad / Mahzouni, Parvin / Andalib, Sasan

    Research in pharmaceutical sciences

    2019  Volume 14, Issue 3, Page(s) 228–236

    Abstract: Development of new medicine with fewer deleterious effects and more efficacies for treatment of inflammatory bowel disease is needed. 5-Hydroxytryptamine 3 receptor (5- ... ...

    Abstract Development of new medicine with fewer deleterious effects and more efficacies for treatment of inflammatory bowel disease is needed. 5-Hydroxytryptamine 3 receptor (5-HT
    Language English
    Publishing date 2019-05-30
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2400156-9
    ISSN 1735-9414 ; 1735-5362
    ISSN (online) 1735-9414
    ISSN 1735-5362
    DOI 10.4103/1735-5362.258489
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  8. Article ; Online: Saffron as a promising therapy for diabetes and Alzheimer's disease: mechanistic insights.

    Sanaie, Sarvin / Nikanfar, Saba / Kalekhane, Zahra Yousefi / Azizi-Zeinalhajlou, Akbar / Sadigh-Eteghad, Saeed / Araj-Khodaei, Mostafa / Ayati, Mohammad Hossein / Andalib, Sasan

    Metabolic brain disease

    2022  Volume 38, Issue 1, Page(s) 137–162

    Abstract: The prevalence of both Alzheimer's disease (AD) and diabetes mellitus is increasing with the societies' aging and has become an essential social concern worldwide. Accumulation of amyloid plaques and neurofibrillary tangles (NFTs) of tau proteins in the ... ...

    Abstract The prevalence of both Alzheimer's disease (AD) and diabetes mellitus is increasing with the societies' aging and has become an essential social concern worldwide. Accumulation of amyloid plaques and neurofibrillary tangles (NFTs) of tau proteins in the brain are hallmarks of AD. Diabetes is an underlying risk factor for AD. Insulin resistance has been proposed to be involved in amyloid-beta (Aβ) aggregation in the brain. It seems that diabetic conditions can result in AD pathology by setting off a cascade of processes, including inflammation, mitochondrial dysfunction, and ROS and advanced glycation end products (AGEs) synthesis. Due to the several side effects of chemical drugs and their high cost, using herbal medicine has recently attracted attention for the treatment of diabetes and AD. Saffron and its active ingredients have been used for its anti-inflammatory, anti-oxidant, anti-diabetic, and anti-AD properties. Therefore, in the present review paper, we take account of the clinical, in vivo and in vitro evidence regarding the anti-diabetic and anti-AD effects of saffron and discuss the preventive or postponing properties of saffron or its components on AD development via its anti-diabetic effects.
    MeSH term(s) Humans ; Alzheimer Disease/metabolism ; Crocus/metabolism ; Amyloid beta-Peptides/metabolism ; Neurofibrillary Tangles/metabolism ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/metabolism ; tau Proteins/metabolism
    Chemical Substances Amyloid beta-Peptides ; tau Proteins
    Language English
    Publishing date 2022-08-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632824-6
    ISSN 1573-7365 ; 0885-7490
    ISSN (online) 1573-7365
    ISSN 0885-7490
    DOI 10.1007/s11011-022-01059-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2155: Show issues Location:
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  9. Article ; Online: Vagus Nerve Stimulation in Ischemic Stroke.

    Andalib, Sasan / Divani, Afshin A / Ayata, Cenk / Baig, Sheharyar / Arsava, Ethem Murat / Topcuoglu, Mehmet Akif / Cáceres, Eder Leonardo / Parikh, Vinay / Desai, Masoom J / Majid, Arshad / Girolami, Sara / Di Napoli, Mario

    Current neurology and neuroscience reports

    2023  Volume 23, Issue 12, Page(s) 947–962

    Abstract: Purpose of review: Vagus nerve stimulation (VNS) has emerged as a potential therapeutic approach for neurological and psychiatric disorders. In recent years, there has been increasing interest in VNS for treating ischemic stroke. This review discusses ... ...

    Abstract Purpose of review: Vagus nerve stimulation (VNS) has emerged as a potential therapeutic approach for neurological and psychiatric disorders. In recent years, there has been increasing interest in VNS for treating ischemic stroke. This review discusses the evidence supporting VNS as a treatment option for ischemic stroke and elucidates its underlying mechanisms.
    Recent findings: Preclinical studies investigating VNS in stroke models have shown reduced infarct volumes and improved neurological deficits. Additionally, VNS has been found to reduce reperfusion injury. VNS may promote neuroprotection by reducing inflammation, enhancing cerebral blood flow, and modulating the release of neurotransmitters. Additionally, VNS may stimulate neuroplasticity, thereby facilitating post-stroke recovery. The Food and Drug Administration has approved invasive VNS (iVNS) combined with rehabilitation for ischemic stroke patients with moderate to severe upper limb deficits. However, iVNS is not feasible in acute stroke due to its time-sensitive nature. Non-invasive VNS (nVNS) may be an alternative approach for treating ischemic stroke. While the evidence from preclinical studies and clinical trials of nVNS is promising, the mechanisms through which VNS exerts its beneficial effects on ischemic stroke are still being elucidated. Therefore, further research is needed to better understand the efficacy and underlying mechanisms of nVNS in ischemic stroke. Moreover, large-scale randomized clinical trials are necessary to determine the optimal nVNS protocols, assess its long-term effects on stroke recovery and outcomes, and identify the potential benefits of combining nVNS with other rehabilitation strategies.
    MeSH term(s) Humans ; Ischemic Stroke ; Brain Ischemia/therapy ; Vagus Nerve Stimulation/methods ; Stroke/therapy ; Upper Extremity ; Stroke Rehabilitation
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057363-7
    ISSN 1534-6293 ; 1528-4042
    ISSN (online) 1534-6293
    ISSN 1528-4042
    DOI 10.1007/s11910-023-01323-w
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    Zs.A 5549: Show issues Location:
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  10. Article ; Online: Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke.

    Alsbrook, Diana L / Di Napoli, Mario / Bhatia, Kunal / Biller, José / Andalib, Sasan / Hinduja, Archana / Rodrigues, Roysten / Rodriguez, Miguel / Sabbagh, Sara Y / Selim, Magdy / Farahabadi, Maryam Hosseini / Jafarli, Alibay / Divani, Afshin A

    Current neurology and neuroscience reports

    2023  Volume 23, Issue 8, Page(s) 407–431

    Abstract: Purpose of review: This review aims to provide an overview of neuroinflammation in ischemic and hemorrhagic stroke, including recent findings on the mechanisms and cellular players involved in the inflammatory response to brain injury.: Recent ... ...

    Abstract Purpose of review: This review aims to provide an overview of neuroinflammation in ischemic and hemorrhagic stroke, including recent findings on the mechanisms and cellular players involved in the inflammatory response to brain injury.
    Recent findings: Neuroinflammation is a crucial process following acute ischemic stroke (AIS) and hemorrhagic stroke (HS). In AIS, neuroinflammation is initiated within minutes of the ischemia onset and continues for several days. In HS, neuroinflammation is initiated by blood byproducts in the subarachnoid space and/or brain parenchyma. In both cases, neuroinflammation is characterized by the activation of resident immune cells, such as microglia and astrocytes, and infiltration of peripheral immune cells, leading to the release of pro-inflammatory cytokines, chemokines, and reactive oxygen species. These inflammatory mediators contribute to blood-brain barrier disruption, neuronal damage, and cerebral edema, promoting neuronal apoptosis and impairing neuroplasticity, ultimately exacerbating the neurologic deficit. However, neuroinflammation can also have beneficial effects by clearing cellular debris and promoting tissue repair. The role of neuroinflammation in AIS and ICH is complex and multifaceted, and further research is necessary to develop effective therapies that target this process. Intracerebral hemorrhage (ICH) will be the HS subtype addressed in this review. Neuroinflammation is a significant contributor to brain tissue damage following AIS and HS. Understanding the mechanisms and cellular players involved in neuroinflammation is essential for developing effective therapies to reduce secondary injury and improve stroke outcomes. Recent findings have provided new insights into the pathophysiology of neuroinflammation, highlighting the potential for targeting specific cytokines, chemokines, and glial cells as therapeutic strategies.
    MeSH term(s) Humans ; Hemorrhagic Stroke/complications ; Neuroinflammatory Diseases ; Ischemic Stroke ; Stroke/complications ; Cerebral Hemorrhage/drug therapy ; Cytokines/therapeutic use ; Ischemia ; Brain Injuries/complications
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057363-7
    ISSN 1534-6293 ; 1528-4042
    ISSN (online) 1534-6293
    ISSN 1528-4042
    DOI 10.1007/s11910-023-01282-2
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