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Article ; Online: The immune cell transcriptome is modulated by vitamin D

Yeh, Wei Zhen / Gresle, Melissa / Lea, Rodney / Taylor, Bruce / Lucas, Robyn M / Ponsonby, Anne-Louise / Mason, Deborah / Andrew, Julie / Campbell, Hamish / Morahan, Julia / Sampangi, Sandeep / Campagna, Maria Pia / Stankovich, Jim / Van der Walt, Anneke / Jokubaitis, Vilija / Butzkueven, Helmut

Clinical immunology (Orlando, Fla.)

2024 Volume 262, Page(s) 110183

Abstract: Vitamin D deficiency is a risk factor for developing multiple sclerosis. The PrevANZ trial was ... conducted to determine if vitamin D ...

Abstract	Vitamin D deficiency is a risk factor for developing multiple sclerosis. The PrevANZ trial was conducted to determine if vitamin D
MeSH term(s)	Humans ; Cholecalciferol/pharmacology ; Cholecalciferol/therapeutic use ; Transcriptome ; Dietary Supplements ; Vitamin D Deficiency/drug therapy ; Vitamin D Deficiency/genetics ; Risk Factors ; Vitamin D/therapeutic use ; Double-Blind Method
Chemical Substances	Cholecalciferol (1C6V77QF41) ; Vitamin D (1406-16-2)
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2024.110183
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Article ; Online: Medicare Part D Coverage of Drugs Selected for the Drug Price Negotiation Program.

Patterson, Julie A / Wagner, Tyler D / O'Brien, John M / Campbell, Jonathan D

JAMA health forum

2024 Volume 5, Issue 2, Page(s) e235237

MeSH term(s)	United States ; Medicare Part D ; Negotiating ; Prescription Drugs ; Insurance Coverage ; Contracts
Chemical Substances	Prescription Drugs
Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article
ISSN	2689-0186
ISSN (online)	2689-0186
DOI	10.1001/jamahealthforum.2023.5237
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Article ; Online: Highlights from the 24th workshop on vitamin D in Austin, September 2022.

Meyer, Mark B / Bernal-Mizrachi, Carlos / Bikle, Daniel D / Biyani, Madhu / Campbell, Moray J / Chaudhari, Snehal N / Christakos, Sylvia / Ingles, Sue A / Knuth, Megan M / Lee, Seong Min / Lisse, Thomas S / Liu, Eva S / Piec, Isabelle / Plum, Lori A / Rao, Sudhaker D / Reynolds, Carmen J / Thacher, Tom D / White, John H / Cantorna, Margherita T

The Journal of steroid biochemistry and molecular biology

2023 Volume 228, Page(s) 106247

Abstract: The 24th Workshop on Vitamin D was held September 7-9, 2022 in Austin, Texas and covered a wide ... diversity of research in the vitamin D field from across the globe. Here, we summarize the meeting ...

Abstract	The 24th Workshop on Vitamin D was held September 7-9, 2022 in Austin, Texas and covered a wide diversity of research in the vitamin D field from across the globe. Here, we summarize the meeting, individual sessions, awards and presentations given.
MeSH term(s)	Humans ; Vitamin D ; Vitamin D Deficiency ; Vitamins
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins
Language	English
Publishing date	2023-01-10
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1049188-0
ISSN	1879-1220 ; 0960-0760
ISSN (online)	1879-1220
ISSN	0960-0760
DOI	10.1016/j.jsbmb.2023.106247
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Article ; Online: 1,25-Dihydroxyvitamin D

Saul, Louise / Mair, Iris / Ivens, Alasdair / Brown, Pamela / Samuel, Kay / Campbell, John D M / Soong, Daniel Y / Kamenjarin, Nadine / Mellanby, Richard J

Frontiers in immunology

2019 Volume 10, Page(s) 600

Abstract: ... adaptive immune response and play a crucial role in shaping the adaptive immune response. Vitamin D, a known ... of dendritic cells. Consequently, vitamin D metabolites are frequently used in protocols to develop therapeutic ... dendritic cell therapies for autoimmune diseases. However, the mechanisms by which vitamin D modulates DC ...

Abstract	Dendritic cells (DC) are specialized sentinel cells that bridge the innate and adaptive immune response and play a crucial role in shaping the adaptive immune response. Vitamin D, a known epidemiological risk factor for the development of several autoimmune diseases, influences the development of dendritic cells. Consequently, vitamin D metabolites are frequently used in protocols to develop therapeutic dendritic cell therapies for autoimmune diseases. However, the mechanisms by which vitamin D modulates DC function remain poorly understood. We investigated the effects of vitamin D on murine CD11c
MeSH term(s)	Animals ; CD11c Antigen/immunology ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Female ; Humans ; Mice, Transgenic ; Platelet Endothelial Cell Adhesion Molecule-1/immunology ; Up-Regulation/drug effects ; Vitamin D/analogs & derivatives ; Vitamin D/pharmacology ; Vitamins/pharmacology
Chemical Substances	CD11c Antigen ; Platelet Endothelial Cell Adhesion Molecule-1 ; Vitamins ; Vitamin D (1406-16-2) ; 1,25-dihydroxyvitamin D (66772-14-3)
Language	English
Publishing date	2019-03-28
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2019.00600
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Article: Pilot trial results of D-HOMES: a behavioral-activation based intervention for diabetes medication adherence and psychological wellness among people who have been homeless.

Vickery, Katherine Diaz / Gelberg, Lillian / Hyson, Audrey Rose / Strother, Ella / Carter, Jill / Oranday Perez, Oscar / Franco, Moncies / Kavistan, Silvio / Gust, Susan / Adair, Edward / Anderson-Campbell, Ali'Cia / Brito, Lelis / Butler, Annette / Robinson, Tahiti / Connett, John / Evans, Michael D / Emmons, Karen M / Comulada, W Scott / Busch, Andrew M

Frontiers in psychiatry

2024 Volume 15, Page(s) 1329138

Abstract: ... the Diabetes HOmeless MEdication Support (D-HOMES) program, a one-on-one, 3 month, coaching intervention ... trial (with baseline, 3 mo., 6 mo. assessments) comparing D-HOMES to enhanced usual care (EUC; brief ... improved more in D-HOMES than EUC between baseline and 6 mo. with between group mean differences ...

Abstract	Introduction: People living with type 2 diabetes who experience homelessness face a myriad of barriers to engaging in diabetes self-care behaviors that lead to premature complications and death. This is exacerbated by high rates of comorbid mental illness, substance use disorder, and other physical health problems. Despite strong evidence to support lay health coach and behavioral activation, little research has effectively engaged people living with type 2 diabetes who had experienced homelessness (DH). Methods: We used community engaged research and incremental behavioral treatment development to design the Diabetes HOmeless MEdication Support (D-HOMES) program, a one-on-one, 3 month, coaching intervention to improve medication adherence and psychological wellness for DH. We present results of our pilot randomized trial (with baseline, 3 mo., 6 mo. assessments) comparing D-HOMES to enhanced usual care (EUC; brief diabetes education session and routine care; NCT05258630). Participants were English-speaking adults with type 2 diabetes, current/recent (<24 mo.) homelessness, and an HbA1c‗7.5%. We focused on feasibility (recruitment, retention, engagement) and acceptability (Client Satisfaction Questionnaire, CSQ-8). Our primary clinical outcome was glycemic control (HbA1c) and primary behavioral outcome was medication adherence. Secondary outcomes included psychological wellness and diabetes self-care. Results: Thirty-six eligible participants enrolled, 18 in each arm. Most participants identified as Black males, had high rates of co-morbidities, and lived in subsidized housing. We retained 100% of participants at 3-months, and 94% at 6-months. Participants reported high satisfaction (mean CSQ-8 scores=28.64 [SD 3.94] of 32). HbA1c reduced to clinically significant levels in both groups, but we found no between group differences. Mean blood pressure improved more in D-HOMES than EUC between baseline and 6 mo. with between group mean differences of systolic -19.5 mmHg ( Conclusion: We effectively recruited and retained DH over 6 months. Data support that the D-HOMES intervention was acceptable and feasible. We observe preliminary blood pressure improvement favoring D-HOMES that were statistically and clinically significant. D-HOMES warrants testing in a fully powered trial which could inform future high quality behavioral trials to promote health equity. Clinical trial registration: https://clinicaltrials.gov/study/NCT05258630?term=D-HOMES&rank=1, identifier NCT05258630.
Language	English
Publishing date	2024-02-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2024.1329138
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Article ; Online: African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A.

Siddappa, Manjunath / Hussain, Shahid / Wani, Sajad A / White, Jason / Tang, Hancong / Gray, Jaimie S / Jafari, Hedieh / Wu, Hsu-Chang / Long, Mark D / Elhussin, Isra / Karanam, Balasubramanyam / Wang, Honghe / Morgan, Rebecca / Hardiman, Gary / Adelani, Isaacson B / Rotimi, Solomon O / Murphy, Adam R / Nonn, Larisa / Davis, Melissa B /

Kittles, Rick A / Hughes Halbert, Chanita / Sucheston-Campbell, Lara E / Yates, Clayton / Campbell, Moray J

Cancer research communications

2023 Volume 3, Issue 4, Page(s) 621–639

Abstract: African American (AA) prostate cancer associates with vitamin D: Significance: Our study ...

Abstract	African American (AA) prostate cancer associates with vitamin D Significance: Our study identified that genomic ancestry drives the VDR complex composition, genomic distribution, and transcriptional function, and is disrupted by BAZ1A and illustrates a novel driver for AA prostate cancer.
MeSH term(s)	Male ; Humans ; Receptors, Calcitriol/genetics ; Transcriptome/genetics ; Black or African American/genetics ; Prostatic Neoplasms/genetics ; Chromatin/genetics ; Chromosomal Proteins, Non-Histone/genetics
Chemical Substances	Receptors, Calcitriol ; Chromatin ; BAZ1A protein, human ; Chromosomal Proteins, Non-Histone
Language	English
Publishing date	2023-04-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2767-9764
ISSN (online)	2767-9764
DOI	10.1158/2767-9764.CRC-22-0389
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Article ; Online: Vitamin D and Systems Biology.

Hussain, Shahid / Yates, Clayton / Campbell, Moray J

Nutrients

2022 Volume 14, Issue 24

Abstract: The biological actions of the vitamin D receptor (VDR) have been investigated intensively for over ...

Abstract	The biological actions of the vitamin D receptor (VDR) have been investigated intensively for over 100 years and has led to the identification of significant insights into the repertoire of its biological actions. These were initially established to be centered on the regulation of calcium transport in the colon and deposition in bone. Beyond these well-known calcemic roles, other roles have emerged in the regulation of cell differentiation processes and have an impact on metabolism. The purpose of the current review is to consider where applying systems biology (SB) approaches may begin to generate a more precise understanding of where the VDR is, and is not, biologically impactful. Two SB approaches have been developed and begun to reveal insight into VDR biological functions. In a top-down SB approach genome-wide scale data are statistically analyzed, and from which a role for the VDR emerges in terms of being a hub in a biological network. Such approaches have confirmed significant roles, for example, in myeloid differentiation and the control of inflammation and innate immunity. In a bottom-up SB approach, current biological understanding is built into a kinetic model which is then applied to existing biological data to explain the function and identify unknown behavior. To date, this has not been applied to the VDR, but has to the related ERα and identified previously unknown mechanisms of control. One arena where applying top-down and bottom-up SB approaches may be informative is in the setting of prostate cancer health disparities.
Language	English
Publishing date	2022-12-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14245197
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Article ; Online: A Young Surgeon on D-Day.

Campbell, Darrell A

Journal of the American College of Surgeons

2020 Volume 230, Issue 6, Page(s) 1058–1063

MeSH term(s)	History, 20th Century ; Humans ; Military Medicine/history ; Mobile Health Units/history ; Surgeons/history ; Surgeons/psychology ; Traumatology/history ; World War II
Language	English
Publishing date	2020-03-10
Publishing country	United States
Document type	Historical Article ; Journal Article
ZDB-ID	1181115-8
ISSN	1879-1190 ; 1072-7515
ISSN (online)	1879-1190
ISSN	1072-7515
DOI	10.1016/j.jamcollsurg.2020.02.044
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Article ; Online: Étude D-CBP : Évaluation des délais de prise en charge du cancer broncho- pulmonaire au sein du service de Pneumologie et d’Oncologie Thoracique du CHU de Caen.

Deshayes, S / Leite Ferreira, D / Madelaine, J / Oulkhouir, Y / Campbell, K / Fouquet, H / Teulier, S / Magnier, R / Heyndrickx, M / Lerouge, D / Bergot, E / Justet, A

Revue des maladies respiratoires

2021 Volume 38, Issue 9, Page(s) 894–903

Abstract: Introduction: Lung cancer is the leading cause of cancer-related death. Delays may have an impact on patient survival. The objective of this study was to evaluate the diagnostic and therapeutic management times for patients admitted for lung cancer ... ...

Title translation	D-CBP study: Evaluation of lung cancer management times.
Abstract	Introduction: Lung cancer is the leading cause of cancer-related death. Delays may have an impact on patient survival. The objective of this study was to evaluate the diagnostic and therapeutic management times for patients admitted for lung cancer treatment in the Respiratory Department of CHU de Caen Normandie. Materials and methods: This is a retrospective, single-center and observational study, conducted on all patients treated for lung cancer from June 2017 to January 2018 in our department of pneumology in the Caen Normandie CHU. The main median times were investigated were: Global Time (abnormal imaging-treatment), Diagnosis time (abnormal imaging-diagnosis) and Treatment Time (diagnosis-treatment). Results: One hundred and twenty-seven (127) patients were included. Median global time was 55.5 days [31,25; 393], median diagnosis time was 22 days [13; 49], and median treatment time was 24.5 days [12,25; 45]. Discussion: Our treatment times are consistent with those previously published. Areas for improvement are being developed in accordance with the 2014-2019 cancer plan, in particularly the creation in our institution of a specific care pathway for patients with lung cancer.
MeSH term(s)	Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/epidemiology ; Lung Neoplasms/therapy ; Retrospective Studies ; Time Factors
Language	French
Publishing date	2021-10-28
Publishing country	France
Document type	Journal Article ; Observational Study
ZDB-ID	605743-3
ISSN	1776-2588 ; 0301-0279 ; 0761-8425
ISSN (online)	1776-2588
ISSN	0301-0279 ; 0761-8425
DOI	10.1016/j.rmr.2021.09.002
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Article ; Online: A High-Performance 3-D Imaging Technique Using Simultaneous Azimuth and Elevation Compounding.

Campbell, Nicholas A / MacMullin, Nicole / Kiefl, Rachel / Nashnoush, Eptehal / Latham, Katherine / Emery, Charles D / Brown, Jeremy A

IEEE transactions on ultrasonics, ferroelectrics, and frequency control

2022 Volume 69, Issue 12, Page(s) 3327–3337

Abstract: A new technique for 3-D imaging with a row-column array (RCA) configuration has been developed ...

Abstract	A new technique for 3-D imaging with a row-column array (RCA) configuration has been developed. The technique requires an electrostrictive piezoelectric for the active substrate. While the top set of electrodes is connected to RF transmit and receive channels for conventional diverging wave imaging (DWI), the orthogonal bottom set of electrodes is connected to independently controlled variable dc bias channels. By implementing modulated bias patterns compounded across multiple pulses, fine delay control across the bottom elements can be achieved simultaneously with imaging with the top set of electrodes. This resulted in a high-quality two-way focus in both azimuth and elevation. A 20-MHz electrostrictive composite substrate was fabricated, and 64 top ×64 bottom electrodes were patterned and connected to custom beamforming and biasing electronics. The point spread functions were generated in all dimensions, and the -6 dB resolution was measured to be 93 [Formula: see text] axially, [Formula: see text] in the azimuth, and 328 [Formula: see text] in the elevation dimension. This was in good agreement with the simulated resolutions of 80, 273, and 280 [Formula: see text], respectively.
MeSH term(s)	Transducers ; Ultrasonography/methods ; Phantoms, Imaging ; Imaging, Three-Dimensional ; Electrodes
Language	English
Publishing date	2022-11-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1525-8955
ISSN (online)	1525-8955
DOI	10.1109/TUFFC.2022.3218732
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