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  1. Article ; Online: The bright future for Clinical and Experimental Ophthalmology in rapidly changing times in scientific publication.

    Goggin, Michael / Chen, Fred K

    Clinical & experimental ophthalmology

    2024  Volume 52, Issue 1, Page(s) 5–6

    MeSH term(s) Humans ; Ophthalmology ; Publishing
    Language English
    Publishing date 2024-01-19
    Publishing country Australia
    Document type Editorial
    ZDB-ID 2014008-3
    ISSN 1442-9071 ; 1442-6404
    ISSN (online) 1442-9071
    ISSN 1442-6404
    DOI 10.1111/ceo.14350
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    Zs.A 1064: Show issues Location:
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  2. Article ; Online: Health economic aspects of inherited retinal diseases: looking for cost-effective treatments.

    Kamien, Benjamin / Heath Jeffery, Rachael / Chen, Fred K

    The Medical journal of Australia

    2023  Volume 219, Issue 2, Page(s) 61–62

    MeSH term(s) Humans ; Cost-Benefit Analysis ; Retinal Diseases/genetics ; Retinal Diseases/therapy ; Retina ; Health Care Costs
    Language English
    Publishing date 2023-06-15
    Publishing country Australia
    Document type Editorial
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.52012
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  3. Article ; Online: Retreatment interval lengthening achieved in two thirds of eyes with prolonged intensive anti-VEGF therapy for neovascular age-related macular degeneration after switching to faricimab.

    Kenworthy, Matthew K / Alexis, Jonathan A / Ramakrishnan, Prathiba / Chen, Fred K

    Clinical & experimental ophthalmology

    2023  

    Language English
    Publishing date 2023-12-09
    Publishing country Australia
    Document type Letter
    ZDB-ID 2014008-3
    ISSN 1442-9071 ; 1442-6404
    ISSN (online) 1442-9071
    ISSN 1442-6404
    DOI 10.1111/ceo.14335
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  4. Article ; Online: Oral Sirolimus for Diffuse Choroidal Hemangioma in Sturge-Weber Syndrome.

    Kalantary, Amy / Halbert, Anne / Franchina, Maria / Heath Jeffery, Rachael C / O'Day, Rod / Chen, Fred K

    JAMA ophthalmology

    2024  

    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2024.0854
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  5. Article ; Online: Bilateral optic atrophy in Wilson disease: A case report and literature review.

    Chen, Fei / Chen, Chunli / Zhang, Yang / Jiang, Libin / Huang, Zhiqin / Chen, Fred K

    Clinics and research in hepatology and gastroenterology

    2024  Volume 48, Issue 3, Page(s) 102299

    Abstract: ... manifestations of WD are complex and variable, with Kayser-Fleischer ring (K-F ring) and the sunflower cataract ...

    Abstract Wilson disease (WD) is an autosomal recessive disorder of copper metabolism. The clinical manifestations of WD are complex and variable, with Kayser-Fleischer ring (K-F ring) and the sunflower cataract being the most common ocular findings. Visual impairment is rare in patients with WD. We report the case of a 17-year-old female with bilateral optic atrophy associated with WD and summarize the clinical features of previously reported cases of optic neuropathy in WD, Clinicians should be aware that WD is a rare cause of optic neuropathy and that optic neuropathy in patients with WD may need to be recognized and screened.
    MeSH term(s) Female ; Humans ; Adolescent ; Hepatolenticular Degeneration/complications ; Hepatolenticular Degeneration/diagnosis ; Copper ; Optic Nerve Diseases/complications ; Optic Atrophy/complications
    Chemical Substances Copper (789U1901C5)
    Language English
    Publishing date 2024-02-15
    Publishing country France
    Document type Review ; Case Reports
    ZDB-ID 2594333-9
    ISSN 2210-741X ; 2210-7401
    ISSN (online) 2210-741X
    ISSN 2210-7401
    DOI 10.1016/j.clinre.2024.102299
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  6. Article ; Online: Macular neovascularization in inherited retinal diseases: A review.

    Heath Jeffery, Rachael C / Chen, Fred K

    Survey of ophthalmology

    2023  Volume 69, Issue 1, Page(s) 1–23

    Abstract: Inherited retinal diseases (IRDs) are the most common cause of blindness in working-age adults. Macular neovascularization (MNV) may be a presenting feature or occurs as a late-stage complication in several IRDs. We performed an extensive literature ... ...

    Abstract Inherited retinal diseases (IRDs) are the most common cause of blindness in working-age adults. Macular neovascularization (MNV) may be a presenting feature or occurs as a late-stage complication in several IRDs. We performed an extensive literature review on MNV associated with IRDs. MNV is a well-known complication of Sorsby fundus dystrophy and pseudoxanthoma elasticum. Those with late-onset Stargardt disease may masquerade as exudative age-related macular degeneration (AMD) when MNV is the presenting feature. Peripherinopathies may develop MNV that responds well to a short course of anti-vascular endothelial growth factor (anti-VEGF) therapy, while bestrophinopathies tend to develop MNV in the early stages of the disease without vision loss. Enhanced S-cone syndrome manifests type 3 MNV that typically regresses into a subfoveal fibrotic nodule. MNV is only a rare complication in choroideraemia and rod-cone dystrophies. Most IRD-related MNVs exhibit a favorable visual prognosis requiring less intensive regimens of anti-vascular endothelial growth factor therapy compared to age-related macular degeneration. We discuss the role of key imaging modalities in the diagnosis of MNV across a wide spectrum of IRDs and highlight the gaps in our knowledge with respect to the natural history and prognosis to pave the way for future directions of research.
    MeSH term(s) Adult ; Humans ; Endothelial Growth Factors ; Retina ; Macular Degeneration/complications ; Macular Degeneration/diagnosis ; Retinal Degeneration/complications ; Neovascularization, Pathologic ; Fluorescein Angiography ; Tomography, Optical Coherence ; Choroidal Neovascularization ; Retrospective Studies ; Retinal Neovascularization/complications
    Chemical Substances Endothelial Growth Factors
    Language English
    Publishing date 2023-08-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 391346-6
    ISSN 1879-3304 ; 0039-6257
    ISSN (online) 1879-3304
    ISSN 0039-6257
    DOI 10.1016/j.survophthal.2023.07.007
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    Zs.A 283: Show issues Location:
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  7. Article ; Online: Day one 'patch-off' visual loss due to retinal ischaemic injury: can we blame sub-Tenon's or peribulbar anaesthesia?

    Chen, Fred K

    Clinical & experimental ophthalmology

    2017  Volume 45, Issue 6, Page(s) 565–567

    MeSH term(s) Anesthesia, Local ; Anesthesiology ; Anesthetics, Local ; Humans
    Chemical Substances Anesthetics, Local
    Language English
    Publishing date 2017-08-18
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 2014008-3
    ISSN 1442-9071 ; 1442-6404
    ISSN (online) 1442-9071
    ISSN 1442-6404
    DOI 10.1111/ceo.13010
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  8. Article ; Online: A Precision Therapy Approach for Retinitis Pigmentosa 11 Using Splice-Switching Antisense Oligonucleotides to Restore the Open Reading Frame of PRPF31.

    Grainok, Janya / Pitout, Ianthe L / Chen, Fred K / McLenachan, Samuel / Heath Jeffery, Rachael C / Mitrpant, Chalermchai / Fletcher, Sue

    International journal of molecular sciences

    2024  Volume 25, Issue 6

    Abstract: Retinitis pigmentosa 11 is an untreatable, dominantly inherited retinal disease caused by heterozygous mutations in pre-mRNA processing factor ... ...

    Abstract Retinitis pigmentosa 11 is an untreatable, dominantly inherited retinal disease caused by heterozygous mutations in pre-mRNA processing factor 31
    MeSH term(s) Humans ; RNA Precursors/genetics ; Oligonucleotides, Antisense/genetics ; Oligonucleotides, Antisense/therapeutic use ; Open Reading Frames ; Mutation ; Codon, Nonsense ; Eye Proteins/genetics ; Eye Proteins/metabolism ; Pedigree ; Retinitis Pigmentosa
    Chemical Substances RNA Precursors ; Oligonucleotides, Antisense ; Codon, Nonsense ; Eye Proteins ; PRPF31 protein, human
    Language English
    Publishing date 2024-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063391
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  9. Article ; Online: Peripapillary hyperreflective ovoid mass-like structures: Multimodal imaging-A review.

    Heath Jeffery, Rachael C / Chen, Fred K

    Clinical & experimental ophthalmology

    2022  Volume 51, Issue 1, Page(s) 67–80

    Abstract: Peripapillary hyperreflective ovoid mass-like structures (PHOMS) are a laterally bulging herniation of distended axons into the peripapillary region above the level of Bruch's membrane opening. Increased use of enhanced depth imaging-optical coherence ... ...

    Abstract Peripapillary hyperreflective ovoid mass-like structures (PHOMS) are a laterally bulging herniation of distended axons into the peripapillary region above the level of Bruch's membrane opening. Increased use of enhanced depth imaging-optical coherence tomography (EDI-OCT) in our evaluation of the optic nerve head (ONH) and greater recognition of the vast range of optic nerve pathologies with which PHOMS is associated provides convincing evidence that PHOMS is not just buried optic disc drusen (ODD) as previously described. The frequent coexistence of PHOMS with ODD, papilloedema, anterior ischaemic optic neuropathy, tilted optic disc syndrome, inflammatory demyelinating disorders and other diseases associated with axoplasmic stasis provides insight into its underlying pathophysiology. The present review will discuss the role of key imaging modalities in the differential diagnosis of PHOMS, explore the current literature on the relationship between PHOMS and common neuro-ophthalmic conditions, and highlight the gaps in our knowledge, with respect to disease classification and prognosis, to pave the way for future directions of research.
    MeSH term(s) Humans ; Optic Disk/pathology ; Optic Disk Drusen/complications ; Papilledema/complications ; Papilledema/diagnosis ; Papilledema/pathology ; Tomography, Optical Coherence/methods ; Multimodal Imaging
    Language English
    Publishing date 2022-11-06
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 2014008-3
    ISSN 1442-9071 ; 1442-6404
    ISSN (online) 1442-9071
    ISSN 1442-6404
    DOI 10.1111/ceo.14182
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  10. Article ; Online: Eye injuries: Understanding ocular trauma.

    Heath Jeffery, Rachael C / Dobes, Jacqueline / Chen, Fred K

    Australian journal of general practice

    2022  Volume 51, Issue 7, Page(s) 476–482

    Abstract: Background: Ocular trauma may result in pathology of the ocular surface and adnexa, extraocular muscles, orbital walls, eye and optic nerve. Detailed history followed by a complete ocular and, if indicated, radiological examination is therefore a ... ...

    Abstract Background: Ocular trauma may result in pathology of the ocular surface and adnexa, extraocular muscles, orbital walls, eye and optic nerve. Detailed history followed by a complete ocular and, if indicated, radiological examination is therefore a crucial part of any trauma assessment. It is important to determine whether a patient with ocular trauma can be reassured or requires immediate referral for further investigation and surgical repair.
    Objective: This review examines chemical eye injuries, orbital fractures, superficial corneal foreign bodies, closed globe injury and suspected open globe injury with or without intra-ocular foreign bodies. A structured approach to the history and examination is provided. The aim of this article is to enhance clinician confidence when encountering these patients.
    Discussion: Ocular trauma can lead to serious sight‑ and eye-threatening consequences. Accurate history-taking and astute observation are paramount for timely treatment or referral that may prevent blindness. This review discusses the management and referral pathways for common presentations of ocular trauma.
    MeSH term(s) Eye ; Eye Injuries/diagnosis ; Eye Injuries/etiology ; Eye Injuries/therapy ; Foreign Bodies ; Humans
    Language English
    Publishing date 2022-06-27
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 2924889-9
    ISSN 2208-7958 ; 2208-794X
    ISSN (online) 2208-7958
    ISSN 2208-794X
    DOI 10.31128/AJGP-03-21-5921
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