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Article ; Online: Maternal PCMT1 gene polymorphisms and the risk of neural tube defects in a Chinese population of Lvliang high-risk area.

Zhao, Huizhi / Wang, Fang / Wang, Jianhua / Xie, Hua / Guo, Jin / Liu, Chi / Wang, Li / Lu, Xiaolin / Bao, Yihua / Wang, Guoliang / Zhong, Rugang / Niu, Bo / Zhang, Ting

Gene

2012 Volume 505, Issue 2, Page(s) 340–344

Abstract: ... to investigate a possible association between maternal PCMT1 and NTDs in Lvliang high-risk area of Shanxi ...

Abstract	Protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 (PCMT1) gene encodes for the protein repair enzyme L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), which is known to protect certain neural cells from Bax-induced apoptosis. Previous study has shown that PCMT1 polymorphisms rs4552 and rs4816 of infant are associated with spina bifida in the Californian population. The association between maternal polymorphism and neural tube defects is still uncovered. A case-control study was conducted to investigate a possible association between maternal PCMT1 and NTDs in Lvliang high-risk area of Shanxi Province in China, using a high-resolution DNA melting analysis genotyping method. We found that increased risk for anencephaly in isolated NTDs compared with the normal control group was observed for the G (vs. A) allele (p=0.034, OR=1.896, 95% CI, 1.04-3.45) and genotypes GG+GA (p=0.025, OR=2.237, 95% CI, 1.09-4.57). Although the significance was lost after multiple comparison correction, the results implied that maternal polymorphisms in PCMT1 might be a potential genetic risk factor for isolated anencephaly in this Chinese population.
MeSH term(s)	Adult ; Asian Continental Ancestry Group/genetics ; Asian Continental Ancestry Group/statistics & numerical data ; Case-Control Studies ; China/epidemiology ; Female ; Humans ; Incidence ; Infant ; Neural Tube Defects/epidemiology ; Neural Tube Defects/genetics ; Polymorphism, Genetic ; Pregnancy ; Prevalence ; Protein D-Aspartate-L-Isoaspartate Methyltransferase/genetics ; Risk ; Young Adult
Chemical Substances	PCMT1 protein, human (EC 2.1.1.77) ; Protein D-Aspartate-L-Isoaspartate Methyltransferase (EC 2.1.1.77)
Language	English
Publishing date	2012-09-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2012.05.035
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Article: Maternal PCMT1 gene polymorphisms and the risk of neural tube defects in a Chinese population of Lvliang high-risk area

Zhao, Huizhi / Wang, Fang / Wang, Jianhua / Xie, Hua / Guo, Jin / Liu, Chi / Wang, Li / Lu, Xiaolin / Bao, Yihua / Wang, Guoliang / Zhong, Rugang / Niu, Bo / Zhang, Ting

Gene. 2012 Sept. 1, v. 505, no. 2

2012

Abstract: ... to investigate a possible association between maternal PCMT1 and NTDs in Lvliang high-risk area of Shanxi ...

Abstract	Protein-l-isoaspartate (d-aspartate) O-methyltransferase 1 (PCMT1) gene encodes for the protein repair enzyme l-isoaspartate (d-aspartate) O-methyltransferase (PIMT), which is known to protect certain neural cells from Bax-induced apoptosis. Previous study has shown that PCMT1 polymorphisms rs4552 and rs4816 of infant are associated with spina bifida in the Californian population. The association between maternal polymorphism and neural tube defects is still uncovered. A case–control study was conducted to investigate a possible association between maternal PCMT1 and NTDs in Lvliang high-risk area of Shanxi Province in China, using a high-resolution DNA melting analysis genotyping method. We found that increased risk for anencephaly in isolated NTDs compared with the normal control group was observed for the G (vs. A) allele (p=0.034, OR=1.896, 95% CI, 1.04–3.45) and genotypes GG+GA (p=0.025, OR=2.237, 95% CI, 1.09–4.57). Although the significance was lost after multiple comparison correction, the results implied that maternal polymorphisms in PCMT1 might be a potential genetic risk factor for isolated anencephaly in this Chinese population.
Keywords	DNA ; alleles ; apoptosis ; genotype ; genotyping ; melting ; risk ; risk factors ; spina bifida ; China
Language	English
Dates of publication	2012-0901
Size	p. 340-344.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2012.05.035
Database	NAL-Catalogue (AGRICOLA)

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Article: Associated adverse health outcomes of polypharmacy and potentially inappropriate medications in community-dwelling older adults with diabetes.

Lu, Lvliang / Wang, Shuang / Chen, Jiaqi / Yang, Yujie / Wang, Kai / Zheng, Jing / Guo, Pi / Cai, Yunpeng / Zhang, Qingying

Frontiers in pharmacology

2023 Volume 14, Page(s) 1284287

Abstract: Aim: ...

Abstract	Aim:
Language	English
Publishing date	2023-11-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1284287
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Article ; Online: Prevalence of potentially inappropriate medications and association with comorbidities in older adults with diabetes in an outpatient visitation setting.

Lu, Lvliang / Yao, Keqin / Chen, Jiaqi / Yang, Yujie / Wang, Kai / Zheng, Jing / Guo, Pi / Cai, Yunpeng / Zhang, Qingying

Frontiers in public health

2022 Volume 10, Page(s) 995948

Abstract: Aims: Potentially inappropriate medications had been found associated with adverse drug events such as falls, emergency department admissions and hospital readmissions. There is lack of information about the prevalence of potentially inappropriate ... ...

Abstract	Aims: Potentially inappropriate medications had been found associated with adverse drug events such as falls, emergency department admissions and hospital readmissions. There is lack of information about the prevalence of potentially inappropriate medications and associated chronic conditions in older patients with diabetes in China. This study aimed to assess the prevalence of potentially inappropriate medications in older adults with diabetes in an outpatient visitation setting and the association with polypharmacy due to comorbidities. Materials and methods: This was a 3-year repeated cross-sectional study which conducted in outpatient setting of 52 hospitals in Shenzhen, China, using 2019 Beers criteria. The prevalence of potentially inappropriate medications, polypharmacy and comorbidities in older adults with diabetes in an outpatient setting was expressed as percentages. Logistic models were used to investigate the association between potentially inappropriate medication exposure and age, sex, polypharmacy and comorbidities. Results: Among the 28,484 older adults with diabetes in 2015, 31,757 in 2016 and 24,675 in 2017, the prevalence of potentially inappropriate medications was 43.2%, 44.88% and 42.40%, respectively. The top five potentially inappropriate medications were diuretics (20.56%), benzodiazepines (13.85%), androgens (13.18%), non-steroidal anti-inflammatory drugs (12.94%) and sulfonylureas (6.23%). After adjustment for age and polypharmacy, the probability of potentially inappropriate medication exposure was associated with chronic gastrointestinal diseases, followed by osteoarthritis and rheumatoid arthritis, chronic pulmonary disease, chronic kidney disease, tumor, dementia, chronic liver disease, hypertension, cardiovascular disease, cerebrovascular disease and hyperlipemia. Conclusion: Potentially inappropriate medications were common in older patients with diabetes in an outpatient visitation setting. Higher probability of potentially inappropriate medication exposure was associated with the comorbidity chronic gastrointestinal diseases as well as osteoarthritis and rheumatoid arthritis. To ensure that iatrogenic risks remain minimal for older adults with diabetes, the clinical comorbidities should be considered.
MeSH term(s)	Aged ; Anti-Inflammatory Agents ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/etiology ; Benzodiazepines/therapeutic use ; Chronic Disease ; Comorbidity ; Cross-Sectional Studies ; Diabetes Mellitus/epidemiology ; Diuretics/therapeutic use ; Gastrointestinal Diseases/drug therapy ; Gastrointestinal Diseases/etiology ; Humans ; Inappropriate Prescribing/adverse effects ; Osteoarthritis/drug therapy ; Osteoarthritis/etiology ; Outpatients ; Potentially Inappropriate Medication List ; Prevalence ; Risk Factors
Chemical Substances	Anti-Inflammatory Agents ; Diuretics ; Benzodiazepines (12794-10-4)
Language	English
Publishing date	2022-09-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2022.995948
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Article ; Online: A comparison of mortality-related risk factors of COVID-19, SARS, and MERS

Lu, Lvliang / Zhong, Wenyu / Bian, Ziwei / Li, Zhiming / Zhang, Ke / Liang, Boxuan / Zhong, Yizhou / Hu, Manjiang / Lin, Li / Liu, Jun / Lin, Xi / Huang, Yuji / Jiang, Junying / Yang, Xingfen / Zhang, Xin / Huang, Zhenlie

Journal of Infection

A systematic review and meta-analysis

2020 Volume 81, Issue 4, Page(s) e18–e25

Keywords	Microbiology (medical) ; Infectious Diseases ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2020.07.002
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A comparison of mortality-related risk factors of COVID-19, SARS, and MERS: A systematic review and meta-analysis.

The Journal of infection

2020 Volume 81, Issue 4, Page(s) e18–e25

Abstract: Objective: Coronavirus Disease 2019 (COVID-19) is a pandemic. This systematic review compares mortality risk factors including clinical, demographic and laboratory features of COVID-19, Severe Acute Respiratory Syndrome (SARS) and Middle East ... ...

Abstract	Objective: Coronavirus Disease 2019 (COVID-19) is a pandemic. This systematic review compares mortality risk factors including clinical, demographic and laboratory features of COVID-19, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). The aim is to provide new strategies for COVID-19 prevention and treatment. Methods: We performed a systematic review with meta-analysis, using five databases to compare the predictors of death for COVID-19, SARS and MERS. A random-effects model meta-analysis calculated odds ratios (OR) and 95% confidence intervals (95% CI). Results: 845 articles up through 11/4/2020 were retrieved, but only 28 studies were included in this meta-analysis. The results showed that males had a higher likelihood of death than females (OR = 1.82, 95% CI 1.56-2.13). Age (OR = 7.86, 95% CI 5.46-11.29), diabetes comorbidity (OR = 3.73, 95% CI 2.35-5.90), chronic lung disease (OR = 3.43, 95% CI 1.80-6.52) and hypertension (OR = 3.38, 95% CI 2.45-4.67) were the mortality risk factors. The laboratory indicators lactic dehydrogenase (OR = 37.52, 95% CI 24.68-57.03), C-reactive protein (OR = 12.11, 95% CI 5.24-27.98), and neutrophils (OR = 17.56, 95% CI 10.67-28.90) had stronger correlations with COVID-19 mortality than with SARS or MERS mortality. Consolidation and ground-glass opacity imaging features were similar among COVID-19, SARS, and MERS patients. Conclusions: COVID-19's mortality factors are similar to those of SARS and MERS. Age and laboratory indicators could be effective predictors of COVID-19 mortality outcomes.
MeSH term(s)	Betacoronavirus ; C-Reactive Protein/analysis ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Diabetes Mellitus/pathology ; Female ; Humans ; Hypertension/pathology ; L-Lactate Dehydrogenase/blood ; Lung Diseases/pathology ; Male ; Middle East Respiratory Syndrome Coronavirus ; Neutrophils/cytology ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Risk Factors ; SARS Virus ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/epidemiology ; Severe Acute Respiratory Syndrome/mortality ; Sex Factors
Chemical Substances	C-Reactive Protein (9007-41-4) ; L-Lactate Dehydrogenase (EC 1.1.1.27)
Keywords	covid19
Language	English
Publishing date	2020-07-04
Publishing country	England
Document type	Comparative Study ; Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2020.07.002
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Article ; Online: MicroRNA-29b-3p aggravates 1,2-dichloroethane-induced brain edema by targeting aquaporin 4 in Sprague-Dawley rats and CD-1 mice.

Zhong, Yizhou / Liang, Boxuan / Hu, Manjiang / Liu, Jun / Lin, Li / Jiang, Junying / Lin, Xi / Huang, Yuji / Lu, Lvliang / Jiang, Liang / Wu, Jiejiao / Jia, Xiaohui / Zhang, Yating / Rong, Weifeng / Xie, Zhiwei / Zeng, Lihai / Zhang, Xin / Yang, Xingfen / Huang, Zhenlie

Toxicology letters

2019 Volume 319, Page(s) 160–167

Abstract: Overexposure to 1,2-dichloroethane (1,2-DCE) can induce brain edema, but the underlying mechanisms remain largely unknown. Aquaporin 4 (AQP4) is the most prevalent water channel in the brain, and the pool of AQP4 facilitates brain edema by controlling ... ...

Abstract	Overexposure to 1,2-dichloroethane (1,2-DCE) can induce brain edema, but the underlying mechanisms remain largely unknown. Aquaporin 4 (AQP4) is the most prevalent water channel in the brain, and the pool of AQP4 facilitates brain edema by controlling the inflow and clearance of brain water. MicroRNAs play an important role in the regulation of brain edema via RNA silencing and post-transcriptional regulation of gene expression. To explore the regulation role of AQP4 and microRNA in 1,2-DCE-induced brain edema, Sprague-Dawley (SD) rats and AQP4 knockout CD-1 mice were exposed to 1,2-DCE by inhalation for 7 days (0, 600, 1,800 mg/m
MeSH term(s)	Administration, Inhalation ; Animals ; Aquaporin 4/drug effects ; Aquaporin 4/genetics ; Body Water/metabolism ; Brain Chemistry/drug effects ; Brain Edema/chemically induced ; Brain Edema/pathology ; Ethylene Dichlorides/toxicity ; Female ; Male ; Mice ; Mice, Knockout ; MicroRNAs/biosynthesis ; MicroRNAs/genetics ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Aqp4 protein, mouse ; Aqp4 protein, rat ; Aquaporin 4 ; Ethylene Dichlorides ; MIRN29 microRNA, mouse ; MIRN29 microRNA, rat ; MicroRNAs ; ethylene dichloride (55163IJI47)
Language	English
Publishing date	2019-11-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	433788-8
ISSN	1879-3169 ; 0378-4274
ISSN (online)	1879-3169
ISSN	0378-4274
DOI	10.1016/j.toxlet.2019.11.011
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Article ; Online: A Comparison of Mortality-related Risk Factors of COVID-19, SARS, and MERS

reponame:Expeditio Repositorio Institucional UJTL ; instname:Universidad de Bogotá Jorge Tadeo Lozano

A Systematic Review and Meta-analysis

2020

Abstract: Attached you will find a manuscript “A Comparison of Mortality-related Risk Factors of COVID-19, SARS, and MERS: A Systematic Review and Meta-analysis”, which we are submitting for consideration as an original research paper in Journal of Infection. ... ...

Abstract	Attached you will find a manuscript “A Comparison of Mortality-related Risk Factors of COVID-19, SARS, and MERS: A Systematic Review and Meta-analysis”, which we are submitting for consideration as an original research paper in Journal of Infection. Coronavirus Disease 2019 (COVID-19) is a pandemic. Few case-control or cohort studies have addressed COVID-19 mortality. Several commonalities among the pathogenicity, clinical features and transmissibility of COVID-19, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) have been identified. To explicate the clinical, laboratory and image features of COVID-19, we performed a systematic review with meta-analysis, using five databases to compare the predictors of death for COVID-19, SARS, and MERS patients. We ran a random-effects model meta-analysis to calculate odds ratios (OR) and 95% confidence intervals (95% CI).
Keywords	Risk factors ; COVID-19 ; SARS ; MERS ; Síndrome respiratorio agudo grave ; SARS-CoV-2 ; Coronavirus ; covid19
Publisher	Journal of Infection
Publishing country	co
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: 1,2-Dichloroethane induces cerebellum granular cell apoptosis via mitochondrial pathway in vitro and in vivo.

Toxicology letters

2020 Volume 322, Page(s) 87–97

Abstract: 1,2-Dichloroethane (1,2-DCE) is a widely used chlorinated organic toxicant, but little is known about the cerebellar dysfunction induced by excessive exposure to it. To uncover 1,2-DCE-induced neurotoxicity in cerebellar granular cells (CGCs), and to ... ...

Abstract	1,2-Dichloroethane (1,2-DCE) is a widely used chlorinated organic toxicant, but little is known about the cerebellar dysfunction induced by excessive exposure to it. To uncover 1,2-DCE-induced neurotoxicity in cerebellar granular cells (CGCs), and to investigate the underlying mechanisms, we explored this, both in vitro and in vivo. Our findings showed significant cell viability inhibition in human CGCs (HCGCs) treated with 1,2-DCE. Flow cytometry and mitochondrial membrane potential analyses discovered an increase in apoptotic-mediated cell death in HCGCs after 1,2-DCE treatment. This HCGC apoptosis was involved in the increases of protein expression in Cytochrome c, Caspase-3, Bad, Bim, transformation related protein 53, Caspase-8, tumor necrosis factor-α, and Survivin. Quantitative real-time PCR (qPCR) and western blot confirmed the increases in Cytochrome c, Caspase-3, cleaved Caspase-3, and Bad in HCGCs after 1,2-DCE treatment. Bax inhibitor peptide V5 rescued 1,2-DCE-induced HCGC apoptosis. Furthermore, 80 CD-1 male mice were exposed to 1,2-DCE by inhalation at 0, 100, 350, and 700 mg/m
MeSH term(s)	Animals ; Apoptosis/drug effects ; Apoptosis Regulatory Proteins/metabolism ; Behavior, Animal/drug effects ; Cells, Cultured ; Cerebellum/drug effects ; Cerebellum/metabolism ; Cerebellum/pathology ; Cerebellum/physiopathology ; Ethylene Dichlorides/toxicity ; Humans ; Locomotion/drug effects ; Male ; Membrane Potential, Mitochondrial/drug effects ; Mice ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/pathology ; Neurons/drug effects ; Neurons/metabolism ; Neurons/pathology ; Risk Assessment ; Signal Transduction
Chemical Substances	Apoptosis Regulatory Proteins ; Ethylene Dichlorides ; ethylene dichloride (55163IJI47)
Language	English
Publishing date	2020-01-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	433788-8
ISSN	1879-3169 ; 0378-4274
ISSN (online)	1879-3169
ISSN	0378-4274
DOI	10.1016/j.toxlet.2020.01.004
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Article: A comparison of mortality-related risk factors of COVID-19, SARS, and MERS: A systematic review and meta-analysis

J Infect

Abstract: OBJECTIVE: Coronavirus Disease 2019 (COVID-19) is a pandemic. This systematic review compares mortality risk factors including clinical, demographic and laboratory features of COVID-19, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory ...

Abstract	OBJECTIVE: Coronavirus Disease 2019 (COVID-19) is a pandemic. This systematic review compares mortality risk factors including clinical, demographic and laboratory features of COVID-19, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). The aim is to provide new strategies for COVID-19 prevention and treatment. METHODS: We performed a systematic review with meta-analysis, using five databases to compare the predictors of death for COVID-19, SARS and MERS. A random-effects model meta-analysis calculated odds ratios (OR) and 95% confidence intervals (95% CI). RESULTS: 845 articles up through 11/4/2020 were retrieved, but only 28 studies were included in this meta-analysis. The results showed that males had a higher likelihood of death than females (ORâ¯=â¯1.82, 95% CI 1.56-2.13). Age (ORâ¯=â¯7.86, 95% CI 5.46-11.29), diabetes comorbidity (ORâ¯=â¯3.73, 95% CI 2.35-5.90), chronic lung disease (ORâ¯=â¯3.43, 95% CI 1.80-6.52) and hypertension (ORâ¯=â¯3.38, 95% CI 2.45-4.67) were the mortality risk factors. The laboratory indicators lactic dehydrogenase (ORâ¯=â¯37.52, 95% CI 24.68-57.03), C-reactive protein (ORâ¯=â¯12.11, 95% CI 5.24-27.98), and neutrophils (ORâ¯=â¯17.56, 95% CI 10.67-28.90) had stronger correlations with COVID-19 mortality than with SARS or MERS mortality. Consolidation and ground-glass opacity imaging features were similar among COVID-19, SARS, and MERS patients. CONCLUSIONS: COVID-19's mortality factors are similar to those of SARS and MERS. Age and laboratory indicators could be effective predictors of COVID-19 mortality outcomes.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #629626
Database	COVID19

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