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Article ; Online: Correction to: Association Between Antidiabetic Drugs and Delirium: A Study Based on the Adverse Drug Event Reporting Database in Japan.

Ishibashi, Yukiko / Sogawa, Rintaro / Ogata, Kenji / Matsuoka, Ayaka / Yamada, Haruna / Murakawa-Hirachi, Toru / Mizoguchi, Yoshito / Monji, Akira / Shimanoe, Chisato

Clinical drug investigation

2024 Volume 44, Issue 2, Page(s) 121

Language	English
Publishing date	2024-01-10
Publishing country	New Zealand
Document type	Published Erratum
ZDB-ID	1220136-4
ISSN	1179-1918 ; 0114-2402 ; 1173-2563
ISSN (online)	1179-1918
ISSN	0114-2402 ; 1173-2563
DOI	10.1007/s40261-024-01340-8
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Zs.A 2807: Show issues

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Article: Use of the Head-mounted 4K Camera for Recording the Procedure of a Flap Surgery.

Matsuoka, Yuki / Karakawa, Ryo / Yoshimatsu, Hidehiko / Kuramoto, Yukiko / Suesada, Nobuko / Yano, Tomoyuki

Plastic and reconstructive surgery. Global open

2023 Volume 11, Issue 9, Page(s) e5298

Language	English
Publishing date	2023-09-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2851682-5
ISSN	2169-7574 ; 2169-7574
ISSN (online)	2169-7574
ISSN	2169-7574
DOI	10.1097/GOX.0000000000005298
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Zs.A 7091: Show issues

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Article ; Online: Correction To: Increased expression of heme oxygenase-1 suppresses airway branching morphogenesis in fetal mouse lungs exposed to inflammation.

Arai, Yukio / Ito, Masato / Tanaka, Kosuke / Ozawa, Junichi / Motojima, Yukiko / Matsuoka, Kikumi / Igarashi, Kazuhiko / Namba, Fumihiko

Pediatric research

2023 Volume 94, Issue 4, Page(s) 1582

Language	English
Publishing date	2023-06-12
Publishing country	United States
Document type	Published Erratum
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-023-02663-6
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Zs.A 564: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 373: Show issues

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Article ; Online: An autopsy case of TAFRO syndrome with multiple cerebral infarctions caused by small vessel pathology.

Matsuoka, Chihiro / Takahashi, Hisashi / Yasuda, Rei / Ashida, Shinji / Tanaka, Eijirou / Sonobe, Yuta / Morinaga, Yukiko / Kondo, Masaki / Mizuno, Toshiki

eNeurologicalSci

2022 Volume 27, Page(s) 100402

Language	English
Publishing date	2022-04-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2838045-9
ISSN	2405-6502 ; 2405-6502
ISSN (online)	2405-6502
ISSN	2405-6502
DOI	10.1016/j.ensci.2022.100402
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Article ; Online: Nutritional and metabolic control of germ cell fate through O-GlcNAc regulation.

Hayashi, Yohei / Tando, Yukiko / Ito-Matsuoka, Yumi / Ikuta, Kaho / Takehara, Asuka / Morino, Katsutaro / Maegawa, Hiroshi / Matsui, Yasuhisa

EMBO reports

2023 Volume 24, Issue 11, Page(s) e56845

Abstract: Fate determination of primordial germ cells (PGCs) is regulated in a multi-layered manner, involving signaling pathways, epigenetic mechanisms, and transcriptional control. Chemical modification of macromolecules, including epigenetics, is expected to be ...

Abstract	Fate determination of primordial germ cells (PGCs) is regulated in a multi-layered manner, involving signaling pathways, epigenetic mechanisms, and transcriptional control. Chemical modification of macromolecules, including epigenetics, is expected to be closely related with metabolic mechanisms but the detailed molecular machinery linking these two layers remains poorly understood. Here, we show that the hexosamine biosynthetic pathway controls PGC fate determination via O-linked β-N-acetylglucosamine (O-GlcNAc) modification. Consistent with this model, reduction of carbohydrate metabolism via a maternal ketogenic diet that decreases O-GlcNAcylation levels causes repression of PGC formation in vivo. Moreover, maternal ketogenic diet intake until mid-gestation affects the number of ovarian germ cells in newborn pups. Taken together, we show that nutritional and metabolic mechanisms play a previously unappreciated role in PGC fate determination.
MeSH term(s)	Infant, Newborn ; Humans ; Signal Transduction/physiology ; Acetylglucosamine/chemistry ; Acetylglucosamine/metabolism ; Gene Expression Regulation ; Epigenesis, Genetic ; Germ Cells/metabolism ; Protein Processing, Post-Translational
Chemical Substances	Acetylglucosamine (V956696549)
Language	English
Publishing date	2023-10-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020896-0
ISSN	1469-3178 ; 1469-221X
ISSN (online)	1469-3178
ISSN	1469-221X
DOI	10.15252/embr.202356845
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Zs.A 5433: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 41: Show issues

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Article: Lung Oligometastasis of Breast Cancer: Prospective Cohort Study of Treatment Strategies (SBP-06).

Maeda, Reina / Shien, Tadahiko / Takahashi, Mina / Kawada, Kengo / Kajiwara, Yukiko / Kubo, Shinichiro / Takabatake, Daisuke / Ohtani, Shoichiro / Matsuoka, Kinya / Hikino, Hajime / Ogasawara, Yutaka / Taira, Naruto / Osumi, Shozo / Ikeda, Masahiko / Doihara, Hiroyoshi

Acta medica Okayama

2024 Volume 78, Issue 1, Page(s) 15–20

Abstract: While local treatment of metastases is considered to be unrelated to prognosis, previous studies have suggested that local treatment of isolated lung metastases may have positive prognostic impact. We designed this prospective cohort study to investigate ...

Abstract	While local treatment of metastases is considered to be unrelated to prognosis, previous studies have suggested that local treatment of isolated lung metastases may have positive prognostic impact. We designed this prospective cohort study to investigate the clinical situation and its outcomes. We enrolled patients with fewer than 3 lung nodules suspected of being oligometastases after curative breast cancer surgery. Treatments, including local and systemic therapy, were selected by the physician and patient in consultation. The primary outcome was overall survival (OS); secondary outcomes were the efficacy and the safety of the surgery for lung oligometastases. Between May 2015 and May 2019, 14 patients were enrolled. Resection of lung nodules (metastasectomy) was performed in 11 (78.6%) of 14 patients, and one of these cases was diagnosed as primary lung cancer. Metastasectomies were all performed employing video-assisted thoracic surgery (VATS) without perioperative complications. Systemic therapies were administered to all patients except one. The respective 3-year and 5-year OS rates of patients with lung oligometastases were 91.6% and 81.5%, respectively. Progression occurred in 6 patients: 3 of the 10 with metastasectomy and all 3 without this surgical procedure. Lung metastasectomy was worthwhile as a diagnostic evaluation and may provide long-term benefit in some patients.
MeSH term(s)	Humans ; Female ; Prospective Studies ; Breast Neoplasms/surgery ; Lung/pathology ; Prognosis ; Lung Neoplasms/pathology ; Retrospective Studies ; Pneumonectomy
Language	English
Publishing date	2024-02-29
Publishing country	Japan
Document type	Journal Article
ZDB-ID	188415-3
ISSN	0386-300X ; 0001-6152
ISSN	0386-300X ; 0001-6152
DOI	10.18926/AMO/66666
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Ua VI Zs.421: Show issues

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Article ; Online: Association Between Antidiabetic Drugs and Delirium: A Study Based on the Adverse Drug Event Reporting Database in Japan.

Ishibashi, Yukiko / Sogawa, Rintaro / Ogata, Kenji / Matsuoka, Ayaka / Yamada, Haruna / Murakawa-Hirachi, Toru / Mizoguchi, Yoshito / Monji, Akira / Shimanoe, Chisato

Clinical drug investigation

2023 Volume 44, Issue 2, Page(s) 115–120

Abstract: Background and objective: Several associations between diabetes mellitus and delirium have been reported; however, they have been inconsistent, and evidence on the effects of antidiabetic medications on delirium is also limited. This study aimed to ... ...

Abstract	Background and objective: Several associations between diabetes mellitus and delirium have been reported; however, they have been inconsistent, and evidence on the effects of antidiabetic medications on delirium is also limited. This study aimed to investigate whether the use of antidiabetic drugs is a risk factor for delirium development. Methods: Using the Japanese Adverse Event Reporting Database, we analyzed 662,899 reports between 2004 and 2022. Reporting odds ratios (RORs) and 95% confidence intervals (CIs) for delirium associated with diabetes and using each antidiabetic medication were calculated after adjusting for potential confounders. Results: Overall, 8892 of the reports analyzed were associated with delirium. A comparison of the incidence of delirium between patients with and without diabetes showed no significant difference, with 1.34% in patients without diabetes and 1.37% in those with diabetes. In each antidiabetic medication, signals for delirium were detected for sulfonylurea (crude ROR, 1.35; 95% CI 1.21-1.51) and insulin (crude ROR, 1.28; 95% CI 1.13-1.44). These results were maintained even after adjusting for factors with potential confounders (sulfonylurea: adjusted ROR, 1.75; 95% CI 1.54-2.00, insulin: adjusted ROR, 1.35; 95% CI 1.20-1.54). Conclusions: Our results suggest no association between diabetes and delirium; however, using sulfonylurea and insulin may be associated with delirium development. Nonetheless, these findings should be validated in future studies.
MeSH term(s)	Humans ; Hypoglycemic Agents/adverse effects ; Japan/epidemiology ; Diabetes Mellitus/chemically induced ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/epidemiology ; Drug-Related Side Effects and Adverse Reactions ; Sulfonylurea Compounds/adverse effects ; Insulin ; Delirium/chemically induced ; Delirium/epidemiology ; Adverse Drug Reaction Reporting Systems
Chemical Substances	Hypoglycemic Agents ; Sulfonylurea Compounds ; Insulin
Language	English
Publishing date	2023-12-23
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	1220136-4
ISSN	1179-1918 ; 0114-2402 ; 1173-2563
ISSN (online)	1179-1918
ISSN	0114-2402 ; 1173-2563
DOI	10.1007/s40261-023-01337-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2807: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Robust protein-based engineering of hepatocyte-like cells from human mesenchymal stem cells.

Takashina, Tomoki / Matsunaga, Akihiro / Shimizu, Yukiko / Sakuma, Tetsushi / Okamura, Tadashi / Matsuoka, Kunie / Yamamoto, Takashi / Ishizaka, Yukihito

Hepatology communications

2023 Volume 7, Issue 3, Page(s) e0051

Abstract: Background: Cells of interest can be prepared from somatic cells by forced expression of lineage-specific transcription factors, but it is required to establish a vector-free system for their clinical use. Here, we report a protein-based artificial ... ...

Abstract	Background: Cells of interest can be prepared from somatic cells by forced expression of lineage-specific transcription factors, but it is required to establish a vector-free system for their clinical use. Here, we report a protein-based artificial transcription system for engineering hepatocyte-like cells from human umbilical cord-derived mesenchymal stem cells (MSCs). Methods: MSCs were treated for 5 days with 4 artificial transcription factors (4F), which targeted hepatocyte nuclear factor (HNF)1α, HNF3γ, HNF4α, and GATA-binding protein 4 (GATA4). Then, engineered MSCs (4F-Heps) were subjected to epigenetic analysis, biochemical analysis and flow cytometry analysis with antibodies to marker proteins of mature hepatocytes and hepatic progenitors such as delta-like homolog 1 (DLK1) and trophoblast cell surface antigen 2 (TROP2). Functional properties of the cells were also examined by injecting them to mice with lethal hepatic failure. Results: Epigenetic analysis revealed that a 5-day treatment of 4F upregulated the expression of genes involved in hepatic differentiation, and repressed genes related to pluripotency of MSCs. Flow cytometry analysis detected that 4F-Heps were composed of small numbers of mature hepatocytes (at most 1%), bile duct cells (~19%) and hepatic progenitors (~50%). Interestingly, ~20% of 4F-Heps were positive for cytochrome P450 3A4, 80% of which were DLK1-positive. Injection of 4F-Heps significantly increased survival of mice with lethal hepatic failure, and transplanted 4F-Heps expanded to more than 50-fold of human albumin-positive cells in the mouse livers, well consistent with the observation that 4F-Heps contained DLK1-positive and/or TROP2-positive cells. Conclusion: Taken together with observations that 4F-Heps were not tumorigenic in immunocompromised mice for at least 2 years, we propose that this artificial transcription system is a versatile tool for cell therapy for hepatic failures.
MeSH term(s)	Humans ; Animals ; Mice ; Hepatocytes ; Immunologic Factors ; Liver Failure ; Cell Differentiation/genetics ; Bile Ducts
Chemical Substances	Immunologic Factors
Language	English
Publishing date	2023-02-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2471-254X
ISSN (online)	2471-254X
DOI	10.1097/HC9.0000000000000051
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Epi-mutations for spermatogenic defects by maternal exposure to di(2-ethylhexyl) phthalate.

Tando, Yukiko / Hiura, Hitoshi / Takehara, Asuka / Ito-Matsuoka, Yumi / Arima, Takahiro / Matsui, Yasuhisa

eLife

2021 Volume 10

Abstract: Exposure to environmental factors during fetal development may lead to epigenomic modifications in fetal germ cells, altering gene expression and promoting diseases in successive generations. In mouse, maternal exposure to di(2-ethylhexyl) phthalate ( ... ...

Abstract	Exposure to environmental factors during fetal development may lead to epigenomic modifications in fetal germ cells, altering gene expression and promoting diseases in successive generations. In mouse, maternal exposure to di(2-ethylhexyl) phthalate (DEHP) is known to induce defects in spermatogenesis in successive generations, but the mechanism(s) of impaired spermatogenesis are unclear. Here, we showed that maternal DEHP exposure results in DNA hypermethylation of promoters of spermatogenesis-related genes in fetal testicular germ cells in F1 mice, and hypermethylation of
MeSH term(s)	Animals ; DNA Methylation ; Diethylhexyl Phthalate/pharmacology ; Down-Regulation ; Female ; HEK293 Cells ; Humans ; Male ; Maternal Exposure/adverse effects ; Mice ; Mice, Inbred C57BL ; Mutation ; Phthalic Acids/adverse effects ; Phthalic Acids/chemistry ; Plasticizers/adverse effects ; Pregnancy ; Prenatal Exposure Delayed Effects/genetics ; Spermatogenesis/drug effects ; Spermatogenesis/genetics ; Spermatogonia/drug effects ; Testis/cytology ; Testis/drug effects
Chemical Substances	Phthalic Acids ; Plasticizers ; phthalic acid (6O7F7IX66E) ; Diethylhexyl Phthalate (C42K0PH13C)
Language	English
Publishing date	2021-07-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.70322
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Article ; Online: Epi-mutations for spermatogenic defects by maternal exposure to di(2-ethylhexyl) phthalate

Yukiko Tando / Hitoshi Hiura / Asuka Takehara / Yumi Ito-Matsuoka / Takahiro Arima / Yasuhisa Matsui

eLife, Vol

2021 Volume 10

Abstract	Exposure to environmental factors during fetal development may lead to epigenomic modifications in fetal germ cells, altering gene expression and promoting diseases in successive generations. In mouse, maternal exposure to di(2-ethylhexyl) phthalate (DEHP) is known to induce defects in spermatogenesis in successive generations, but the mechanism(s) of impaired spermatogenesis are unclear. Here, we showed that maternal DEHP exposure results in DNA hypermethylation of promoters of spermatogenesis-related genes in fetal testicular germ cells in F1 mice, and hypermethylation of Hist1h2ba, Sycp1, and Taf7l, which are crucial for spermatogenesis, persisted from fetal testicular cells to adult spermatogonia, resulting in the downregulation of expression of these genes. Forced methylation of these gene promoters silenced expression of these loci in a reporter assay. These results suggested that maternal DEHP exposure-induced hypermethylation of Hist1h2ba, Sycp1, and Taf7l results in downregulation of these genes in spermatogonia and subsequent defects in spermatogenesis, at least in the F1 generation.
Keywords	germ cell ; spermatogenesis ; DNA methylation ; Di (2-ethylhexyl) phthalate ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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