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Article ; Online: Schwannoma-like pleomorphic adenoma: A pathological quandary.

Gautam, Rashmi / Tomar, Reena / Rana, Deepika / Khurana, Nita / Singh, Ishwar

Indian journal of pathology & microbiology

2024

Abstract: Abstract: Pleomorphic adenoma usually presents as a painless growing mass in locations of the salivary glands and is notorious for local recurrence if previous surgical resection is incomplete. Schwannoma is a benign peripheral nerve tumor with ... ...

Abstract	Abstract: Pleomorphic adenoma usually presents as a painless growing mass in locations of the salivary glands and is notorious for local recurrence if previous surgical resection is incomplete. Schwannoma is a benign peripheral nerve tumor with microscopic features of sheets of spindle-shaped cells with nuclear palisading. However, when a pathologist encounters a salivary gland tumor with microscopic morphological features of biphasic components with areas of schwannoma-like morphology, it is crucial to make a prudent diagnosis by differentiating Schwannoma-like pleomorphic adenoma and its differential diagnosis as they have remarkably different outcome in patients. We herein present a case of Schwannoma-like pleomorphic adenoma and discuss its approach to diagnosis and literature search.
Language	English
Publishing date	2024-02-19
Publishing country	India
Document type	Journal Article
ZDB-ID	197621-7
ISSN	0974-5130 ; 0377-4929
ISSN (online)	0974-5130
ISSN	0377-4929
DOI	10.4103/ijpm.ijpm_552_23
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Article ; Online: CRISPR/Cas9: an overview of recent developments and applications in cancer research.

Devi, Shamjetsabam Nandibala / Rana, Rashmi / Malik, Priyanka / Ganguly, Nirmal Kumar

International journal of surgery (London, England)

2024

Abstract: CRISPR-Cas9 has risen as a potent gene editing method with vast potential across numerous domains, including its application in cancer research and therapy. This review article provides an extensive overview of the research that has been done so far on ... ...

Abstract	CRISPR-Cas9 has risen as a potent gene editing method with vast potential across numerous domains, including its application in cancer research and therapy. This review article provides an extensive overview of the research that has been done so far on CRISPR-Cas9 with an emphasis on how it could be utilized in the treatment of cancer. We go into the underlying ideas behind CRISPR-Cas9, its mechanisms of action, and its application for the study of cancer biology. Furthermore, we investigate the various uses of CRISPR-Cas9 in cancer research, spanning from the discovery of genes and the disease to the creation of novel therapeutic approaches. We additionally discuss the challenges and limitations posed by CRISPR-Cas9 technology and offer insights into the potential applications and future directions of this cutting-edge field of research. The article intends to consolidate the present understanding and stimulate more research into CRISPR-Cas9's promise as a game-changing tool for cancer research and therapy.
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1097/JS9.0000000000001081
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Article ; Online: Prevention starts here: effectiveness of substance abuse prevention module among adolescent students in Bengaluru - a quasi experimental study.

Ramamurthy, Deepthi / Manjunath, Smitha / Sarvar, Rana / Nair, Aparna S / Kundapur, Rashmi / Rashmi, Anusha / Modi, Bhavesh / Kadri, Amiruddin M

International journal of adolescent medicine and health

2024 Volume 36, Issue 1, Page(s) 79–84

Abstract: Objectives: This study aims to evaluate the effectiveness of a structured educational module on substance abuse prevention program among adolescents in enhancing their knowledge against substance abuse.: Methods: A quasi-experimental design was ... ...

Abstract	Objectives: This study aims to evaluate the effectiveness of a structured educational module on substance abuse prevention program among adolescents in enhancing their knowledge against substance abuse. Methods: A quasi-experimental design was employed involving 120 students (mean age: 14.3±1.03 years, 59.2% boys) from two English medium schools. Participants were exposed to a structured module on substance abuse over a month. The study assessed changes in knowledge through pretest and post-test evaluations. Statistical analyses examined improvements in scores and the relationship between class of study and post-test knowledge scores. Results: The intervention significantly improved students' knowledge about substance abuse (p<0.001) across all measured domains, genders, and classes, with the exception of the 7th class. A positive correlation was found between the class of study and post-test scores (Rs=0.288, p<0.001), indicating that higher classes were associated with greater improvements in knowledge. These findings suggest that the training effectively increased awareness and understanding of substance abuse among participants. Conclusions: The substance abuse prevention program successfully enhanced adolescents' knowledge and equipped them with resilience and coping strategies, thus reducing their vulnerability to peer pressure and substance abuse. Despite the lack of significant improvement in the 7th class, the overall positive outcomes underscore the importance of implementing such educational interventions to foster healthy development and well-being among students. Further research is encouraged to explore the specific barriers to effectiveness in younger classes and to refine program content accordingly.
MeSH term(s)	Humans ; Male ; Female ; Adolescent ; Students ; Schools ; Substance-Related Disorders/prevention & control
Language	English
Publishing date	2024-02-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639287-8
ISSN	2191-0278 ; 0334-0139
ISSN (online)	2191-0278
ISSN	0334-0139
DOI	10.1515/ijamh-2023-0191
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Article ; Online: Leiomyosarcoma of sphenoid sinus- A rare tumor at an unusual site.

Rana, Deepika / Gautam, Rashmi / Mallya, Varuna / Khurana, Nita / Mehar, Ravi / Singh, Kishore

Journal of cancer research and therapeutics

2024 Volume 20, Issue 1, Page(s) 485–487

Abstract: Leimyosarcoma (lms) is a malignant soft tissue tumor of smooth muscles. The tumor arises intramuscularly and in subcutaneous locations. It is unusual to encounter lms in head and neck region, even more infrequent to discover lms in nasal and paranasal ... ...

Abstract	Leimyosarcoma (lms) is a malignant soft tissue tumor of smooth muscles. The tumor arises intramuscularly and in subcutaneous locations. It is unusual to encounter lms in head and neck region, even more infrequent to discover lms in nasal and paranasal sinuses. A case of 28 years old male with leiomyosarcoma originating from sphenoid sinus with intracranial extension is being presented with aim to highlight its rarity and to highlight the differential diagnosis and the need for prudent diagnosis in the work-up of the patient.
MeSH term(s)	Humans ; Male ; Adult ; Sphenoid Sinus/diagnostic imaging ; Sphenoid Sinus/pathology ; Paranasal Sinus Neoplasms/diagnostic imaging ; Paranasal Sinus Neoplasms/surgery ; Leiomyosarcoma/diagnosis ; Leiomyosarcoma/surgery ; Leiomyosarcoma/pathology ; Paranasal Sinuses/pathology ; Diagnosis, Differential
Language	English
Publishing date	2024-03-29
Publishing country	India
Document type	Case Reports ; Journal Article
ZDB-ID	2187633-2
ISSN	1998-4138 ; 0973-1482
ISSN (online)	1998-4138
ISSN	0973-1482
DOI	10.4103/jcrt.jcrt_1883_22
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Article ; Online: Drug target therapy and emerging clinical relevance of exosomes in meningeal tumors.

Sharma, Swati / Rana, Rashmi / Prakash, Prem / Ganguly, Nirmal Kumar

Molecular and cellular biochemistry

2023 Volume 479, Issue 1, Page(s) 127–170

Abstract: Meningioma is the most common central nervous system (CNS) tumor. In recent decades, several efforts have been made to eradicate this disease. Surgery and radiotherapy remain the standard treatment options for these tumors. Drug therapy comes to play its ...

Abstract	Meningioma is the most common central nervous system (CNS) tumor. In recent decades, several efforts have been made to eradicate this disease. Surgery and radiotherapy remain the standard treatment options for these tumors. Drug therapy comes to play its role when both surgery and radiotherapy fail to treat the tumor. This mostly happens when the tumors are close to vital brain structures and are nonbenign. Although a wide variety of chemotherapeutic drugs and molecular targeted drugs such as tyrosine kinase inhibitors, alkylating agents, endocrine drugs, interferon, and targeted molecular pathway inhibitors have been studied, the roles of numerous drugs remain unexplored. Recent interest is growing toward studying and engineering exosomes for the treatment of different types of cancer including meningioma. The latest studies have shown the involvement of exosomes in the theragnostic of various cancers such as the lung and pancreas in the form of biomarkers, drug delivery vehicles, and vaccines. Proper attention to this new emerging technology can be a boon in finding the consistent treatment of meningioma.
MeSH term(s)	Humans ; Exosomes/metabolism ; Meningioma/drug therapy ; Meningioma/metabolism ; Clinical Relevance ; Drug Delivery Systems ; Meningeal Neoplasms/drug therapy ; Meningeal Neoplasms/metabolism
Language	English
Publishing date	2023-04-04
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-023-04715-1
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Article: Mining legume germplasm for genetic gains: An Indian perspective.

Gayacharan / Parida, Swarup K / Mondal, Nupur / Yadav, Rashmi / Vishwakarma, Harinder / Rana, Jai C

Frontiers in genetics

2023 Volume 14, Page(s) 996828

Abstract: Legumes play a significant role in food and nutritional security and contribute to environmental sustainability. Although legumes are highly beneficial crops, it has not yet been possible to enhance their yield and production to a satisfactory level. ... ...

Abstract	Legumes play a significant role in food and nutritional security and contribute to environmental sustainability. Although legumes are highly beneficial crops, it has not yet been possible to enhance their yield and production to a satisfactory level. Amid a rising population and low yield levels,
Language	English
Publishing date	2023-01-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2023.996828
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Article: An update on SARS-CoV-2 immunization and future directions.

Rana, Rashmi / Kant, Ravi / Kumra, Tanya / Gupta, Sneha / Rana, Devinder Singh / Ganguly, Nirmal Kumar

Frontiers in pharmacology

2023 Volume 14, Page(s) 1125305

Abstract: Millions of people have died as a result of SARS-CoV-2, which was first discovered in China and has since spread globally. Patients with SARS-CoV-2 infection may show a range of symptoms, including fever, coughing, and shortness of breath, or they may ... ...

Abstract	Millions of people have died as a result of SARS-CoV-2, which was first discovered in China and has since spread globally. Patients with SARS-CoV-2 infection may show a range of symptoms, including fever, coughing, and shortness of breath, or they may show no symptoms at all. To treat COVID-19 symptoms and avoid serious infections, many medications and vaccinations have been employed. However, to entirely eradicate COVID-19 from the world, next-generation vaccine research is required because of the devastating consequences it is having for humanity and every nation's economy. Scientists are working hard to eradicate this dangerous virus across the world. SARS-CoV-2 has also undergone significant mutation, leading to distinct viral types such as the alpha, beta, gamma, delta, and omicron variants. This has sparked discussion about the effectiveness of current vaccines for the newly formed variants. A proper comparison of these vaccinations is required to compare their efficacy as the number of people immunized against SARS-CoV-2 globally increases. Population-level statistics evaluating the capacity of these vaccines to reduce infection are therefore being developed. In this paper, we analyze the many vaccines on the market in terms of their production process, price, dosage needed, and efficacy. This article also discusses the challenges of achieving herd immunity, the likelihood of reinfection, and the importance of convalescent plasma therapy in reducing infection.
Language	English
Publishing date	2023-03-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1125305
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Article: In Vitro Comparison to Evaluate Metal Ion Release: Nickel-Titanium vs. Titanium-Molybdenum Orthodontic Archwires.

Chikhale, Rana / Akhare, Pankaj / Umre, Utkarsh / Jawlekar, Rashmi / Kalokhe, Shantanu / Badole, Neha / Beri, Arushi

Cureus

2024 Volume 16, Issue 3, Page(s) e56595

Abstract: Background When metals used in orthodontic materials are exposed to the oral environment, teeth, and gingivae over an extended period of time, they may gradually deteriorate. As a result, the patient is exposed to higher concentrations of metals and ... ...

Abstract	Background When metals used in orthodontic materials are exposed to the oral environment, teeth, and gingivae over an extended period of time, they may gradually deteriorate. As a result, the patient is exposed to higher concentrations of metals and metal ions than what they would be exposed to through food and other sources. The goal of the current in vitro experiment was to evaluate and contrast the metal ion release from orthodontic archwires made of titanium-molybdenum alloy (TMA) and nickel-titanium (NiTi). Methods For 90 days, 20 orthodontic archwires in each group were immersed in 50 milliliters of simulated saliva using different containers. Atomic Absorption Spectrometry (AAS) (Shimadzu Corporation, Kyoto, Japan) was used to assess and compare metal ion emission. The unit of measurement is parts per million (PPM). Results The findings indicated that the discharge of nickel metal from the NiTi archwire (Group A) was much higher than that from the TMA archwire (Group B), with a statistical significance level of p < 0.001. It was discovered that Group B's release of titanium was statistically significantly (p < 0.05) higher than Group A's titanium release, which did not include the release of any other metals. Conclusion The study findings indicated that the amounts of metal ions released from the orthodontic archwires made of titanium molybdenum and nickel-titanium alloy were within safety limits.
Language	English
Publishing date	2024-03-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.56595
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Article: Agro-morphological and nutritional assessment of chenopod and quinoa germplasm-Highly adaptable potential crops.

Bhardwaj, Rakesh / Yadav, Rashmi / Vishwakarma, Harinder / Sharma, Kriti / Chandora, Rahul / Rana, Jai Chand / Riar, Amritbir

Food science & nutrition

2023 Volume 11, Issue 9, Page(s) 5446–5459

Abstract: Quinoa belongs to the ... ...

Abstract	Quinoa belongs to the family
Language	English
Publishing date	2023-07-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703010-6
ISSN	2048-7177
ISSN	2048-7177
DOI	10.1002/fsn3.3502
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Article ; Online: Drinking Water Quality Assessment and Predictive Mapping

Arushi Rana and Rashmi Sharma

Nature Environment and Pollution Technology, Vol 19, Iss 3, Pp 1219-

Impact of Kota Stone Mining in Ramganjmandi Tehsil, Rajasthan, India

2020 Volume 1225

Abstract: Rajasthan generates 1055 million litres per day as wastewater, out of which 27 million litres is treated and nearly 1028 million litres untreated wastewater is discharged in various water resources. The present study is based on the impact of Kota stone ... ...

Abstract	Rajasthan generates 1055 million litres per day as wastewater, out of which 27 million litres is treated and nearly 1028 million litres untreated wastewater is discharged in various water resources. The present study is based on the impact of Kota stone or limestone mining on water resources. Among those villages and census towns, experiencing mining activity, a total of 26 surface water and groundwater samples were tested and analysed. Mining waste often creates eutrophication, toxification, temporary hardness and sometimes permanent hardness. The mining belt was 17.54 km2 in the year 2000 which further increased to 24.25 km2 in the year 2018. The parameters analysed were pH, EC, TDS, alkalinity, total hardness, calcium and magnesium hardness, DO, COD, chloride, sodium and potassium. The predictive mapping for the mining belt was executed in Arc GIS software using Inverse Distance Weightage (IDW) method. The mean of pH was 9.13, TDS 457.12 mg/L, total hardness 593.52 mg/L, calcium hardness is 205.54 mg/L, magnesium hardness 387.53 mg/L, COD 442.2 mg/L, Na+ 139.9 mg/L, K+ 19.40 mg/L, Cl- 318.29, DO 3.04mg/L and alkalinity 14.02 mg/L.
Keywords	water quality ; predictive mapping ; inverse distance weightage ; mining ; Environmental effects of industries and plants ; TD194-195 ; Science (General) ; Q1-390
Subject code	669
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Technoscience Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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