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  1. Article ; Online: A comprehensive review on current understanding of bradykinin in COVID-19 and inflammatory diseases.

    Rex, Devasahayam Arokiar Balaya / Vaid, Neelanchal / Deepak, K / Dagamajalu, Shobha / Prasad, T S Keshava

    Molecular biology reports

    2022  Volume 49, Issue 10, Page(s) 9915–9927

    Abstract: Bradykinin, a member of the kallikrein-kinin system (KKS), is a potent, short-lived vasoactive peptide that acts as a vasodilator and an inflammatory mediator in a number of signaling mechanisms. Bradykinin induced signaling is mediated through kinin B1 ( ...

    Abstract Bradykinin, a member of the kallikrein-kinin system (KKS), is a potent, short-lived vasoactive peptide that acts as a vasodilator and an inflammatory mediator in a number of signaling mechanisms. Bradykinin induced signaling is mediated through kinin B1 (BDKRB1) and B2 (BDKRB2) transmembrane receptors coupled with different subunits of G proteins (G
    MeSH term(s) Bradykinin ; COVID-19 ; Humans ; Interleukin-2 ; Interleukin-6 ; Interleukin-8 ; Receptors, Bradykinin/physiology ; SARS-CoV-2 ; Vasodilator Agents
    Chemical Substances Interleukin-2 ; Interleukin-6 ; Interleukin-8 ; Receptors, Bradykinin ; Vasodilator Agents ; Bradykinin (S8TIM42R2W)
    Language English
    Publishing date 2022-05-21
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-07539-2
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  2. Article ; Online: A comprehensive review on current understanding of bradykinin in COVID-19 and inflammatory diseases

    Rex, Devasahayam Arokiar Balaya / Vaid, Neelanchal / Deepak, K. / Dagamajalu, Shobha / Prasad, T. S. Keshava

    Mol Biol Rep. 2022 Oct., v. 49, no. 10 p.9915-9927

    2022  

    Abstract: Bradykinin, a member of the kallikrein–kinin system (KKS), is a potent, short-lived vasoactive peptide that acts as a vasodilator and an inflammatory mediator in a number of signaling mechanisms. Bradykinin induced signaling is mediated through kinin B1 ( ...

    Abstract Bradykinin, a member of the kallikrein–kinin system (KKS), is a potent, short-lived vasoactive peptide that acts as a vasodilator and an inflammatory mediator in a number of signaling mechanisms. Bradykinin induced signaling is mediated through kinin B1 (BDKRB1) and B2 (BDKRB2) transmembrane receptors coupled with different subunits of G proteins (Gαᵢ/Gα₀, Gαq and Gᵦ₁ᵧ₂). The bradykinin-mediated signaling mechanism activates excessive pro-inflammatory cytokines, including IL-6, IL-1β, IL-8 and IL-2. Upregulation of these cytokines has implications in a wide range of clinical conditions such as inflammation leading to fibrosis, cardiovascular diseases, and most recently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In SARS-CoV-2 infection, bradykinin is found to be at raised levels and is reported to trigger a diverse array of symptoms. All of this brings bradykinin to the core point as a molecule of immense therapeutic value. Our understanding of its involvement in various pathways has expanded with time. Therefore, there is a need to look at the overall picture that emerges from the developments made by deciphering the bradykinin mediated signaling mechanisms involved in the pathological conditions. It will help devise strategies for developing better treatment modalities in the implicated diseases. This review summarizes the current state of knowledge on bradykinin mediated signaling in the diverse conditions described above, with a marked emphasis on the therapeutic potential of targeting the bradykinin receptor.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; bradykinin ; fibrosis ; inflammation ; interleukin-2 ; interleukin-6 ; interleukin-8 ; therapeutics
    Language English
    Dates of publication 2022-10
    Size p. 9915-9927.
    Publishing place Springer Netherlands
    Document type Article ; Online
    Note Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-07539-2
    Database NAL-Catalogue (AGRICOLA)

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