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  1. Book ; Online: Natural Products Chemistry: Advances in Synthetic, Analytical and Bioactivity Studies

    Ribaudo, Giovanni

    2023  

    Keywords Research & information: general ; Chemistry ; vitamin D ; deuterium labeling ; liquid-chromatography tandem mass spectrometry ; measurement of vitamin D metabolites in blood ; docosahexaenoic acids ; ovary ; granulosa cells ; cyclophosphamide ; macamide ; larvae of Musca domestica ; D-IBS ; GI dysfunction ; 5-HT ; gut microbiota ; chemoenzymatic ; natural product synthesis ; biocatalysis ; loonamycin ; triple negative breast cancer ; p53 ; PI3K/AKT/mTOR ; O-glycan ; marine fungi ; sesquiterpenoids ; Aspergillus ; bioactivity ; Trapa bispinosa Roxb ; TbUGGT ; molecular cloning ; expression analysis ; flavones ; chrysin ; kaempferol ; hybrids ; 1,2,3-triazole ; anticancer activity ; phenolics ; curcumin ; protocatechuic ; quinones ; stilbenes ; curcuminoids ; ovarian cancer ; natural compounds ; semi-synthetic compounds ; medicinal chemistry ; anti-metastasis ; apoptosis ; pyridone alkaloids ; Arthrinium sp. ; endophytic fungus ; antibacterial ; cytotoxicity ; n/a
    Language English
    Size 1 electronic resource (228 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note English
    HBZ-ID HT030381349
    ISBN 9783036584850 ; 3036584854
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Synthesis of Flavonoids or Other Nature-Inspired Small Molecules

    Ribaudo, Giovanni

    2022  

    Keywords Research & information: general ; quercetin ; flavonoids ; semi-synthetic ; PDE ; sildenafil ; molecular modeling ; Garcinia porrecta ; Clusiaceae ; xanthone ; Lansium domesticum ; Meliaceae ; MCF-7 ; triterpene onoceranoid ; hydrazone ; valproic acid ; technology ; terpenoid ; anticonvulsant activity ; 1,2,3-triazole ; anticancer ; aminoquinoline ; hybrid compound ; kokosanolide ; tetranortriterpenoid ; C. dichotoma ; antidiabetic ; α-glucosidase ; α-amylase ; docking ; ADMET ; curcumin analog ; organic synthesis ; photophysical properties ; steady-state fluorescence ; DFT calculation ; 7-hydroxy-2H-chromen-2-one ; O-acylation reaction ; coumarin ; lupeol derivative ; benzylidene derivative ; α-glucosidase inhibition ; Oxone® ; n/a
    Language 0|e
    Size 1 electronic resource (82 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021611248
    ISBN 9783036532455 ; 3036532455
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: From a Molecule to a Drug: Chemical Features Enhancing Pharmacological Potential

    Ribaudo, Giovanni / Orian, Laura

    2022  

    Keywords Medicine ; Pharmacology ; SARS-CoV-2 ; benzoic acid derivatives ; gallic acid ; molecular docking ; reactivity parameters ; selenoxide elimination ; one-pot ; imine-enamine ; reaction mechanism ; DFT calculations ; selenium ; anti-inflammatory drugs ; QSAR ; pain management ; cyclooxygenase ; multitarget drug ; cannabinoid ; neuropathic pain ; clopidogrel ; NMR study ; oxone ; peroxymonosulfate ; sodium halide ; thienopyridine ; drug discovery ; precision medicine ; pharmacodynamics ; pharmacokinetics ; coronavirus SARS-CoV-2 ; COVID-19 ; 3-chymotrypsin-like protease ; pyrimidonic pharmaceuticals ; molecular dynamics simulations ; binding free energy ; β-carrageenan ; antioxidant activity ; Box-Behken ; extraction ; Eucheuma gelatinae ; physic-chemistry ; rheology ; quercetin ; quercetin 3-O-glucuronide ; cisplatin ; nephrotoxicity ; cytoprotection ; lithium therapy ; neurocytology ; toxicology ; neuroprotection ; chemoinformatics ; big data ; methadone hydrochloride ; pharmaceutical solutions ; drug compounding ; high performance liquid chromatography ; stability study ; microbiology ; fucoidan ; alginate ; L-selectin ; E-selectin ; MCP-1 ; ICAM-1 ; THP-1 macrophage ; monocyte migration ; protein binding ; breast milk ; M/P ratio ; statistical modeling ; molecular descriptors ; chromatographic descriptors ; affinity chromatography ; anti-ACE ; anti-DPP-IV ; gastrointestinal digestion ; in silico ; molecular dynamics ; paramyosin ; seafood ; target fishing ; n/a
    Language 0|e
    Size 1 electronic resource (234 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021613206
    ISBN 9783036547541 ; 3036547541
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Natural Products Chemistry: Advances in Synthetic, Analytical and Bioactivity Studies.

    Ribaudo, Giovanni

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 14

    Abstract: The chemistry of natural compounds inspired and still guides several branches of modern chemical sciences [ ... ]. ...

    Abstract The chemistry of natural compounds inspired and still guides several branches of modern chemical sciences [...].
    MeSH term(s) Biological Products/pharmacology ; Biological Products/chemistry ; Chemistry, Organic
    Chemical Substances Biological Products
    Language English
    Publishing date 2023-07-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28145577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  5. Article ; Online: Synthesis of Flavonoids or Other Nature-Inspired Small Molecules

    Giovanni Ribaudo

    Molbank, Vol 2022, Iss M1313, p M

    2022  Volume 1313

    Abstract: Natural compounds are endowed with an intriguing variety of scaffolds, functional groups and stereochemical properties [.] ...

    Abstract Natural compounds are endowed with an intriguing variety of scaffolds, functional groups and stereochemical properties [.]
    Keywords n/a ; Inorganic chemistry ; QD146-197
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article: An Updated Overview on the Role of Small Molecules and Natural Compounds in the "Young Science" of Rejuvenation.

    Ribaudo, Giovanni / Gianoncelli, Alessandra

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: Aging is a gradual process that occurs over time which leads to a progressive decline of cells and tissues. Telomere shortening, genetic instability, epigenetic alteration, and the accumulation of misfolded proteins represent the main hallmarks that ... ...

    Abstract Aging is a gradual process that occurs over time which leads to a progressive decline of cells and tissues. Telomere shortening, genetic instability, epigenetic alteration, and the accumulation of misfolded proteins represent the main hallmarks that cause perturbed cellular functions; this occurs in conjunction with the progression of the so-called "aging clocks". Rejuvenation aims to influence the natural evolution of such aging clocks and to enhance regenerative capacity, thus overcoming the limitations of common anti-aging interventions. Current rejuvenation processes are based on heterochronic parabiosis, cell damage dilution through asymmetrical cell division, the excretion of extracellular vesicles, the modulation of genetic instability involving G-quadruplexes and DNA methylation, and cell reprogramming using Yamanaka factors and the actions of antioxidant species. In this context, we reviewed the most recent contributions that report on small molecules acting as senotherapeutics; these molecules act by promoting one or more of the abovementioned processes. Candidate drugs and natural compounds that are being studied as potential rejuvenation therapies act by interfering with CDGSH iron-sulfur domain 2 (CISD2) expression, G-quadruplex structures, DNA methylation, and mitochondrial decay. Moreover, direct and indirect antioxidants have been reported to counteract or revert aging through a combination of mixed mechanisms.
    Language English
    Publishing date 2023-01-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12020288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: An Updated Overview on the Role of Small Molecules and Natural Compounds in the “Young Science” of Rejuvenation

    Ribaudo, Giovanni / Gianoncelli, Alessandra

    Antioxidants. 2023 Jan. 27, v. 12, no. 2

    2023  

    Abstract: Aging is a gradual process that occurs over time which leads to a progressive decline of cells and tissues. Telomere shortening, genetic instability, epigenetic alteration, and the accumulation of misfolded proteins represent the main hallmarks that ... ...

    Abstract Aging is a gradual process that occurs over time which leads to a progressive decline of cells and tissues. Telomere shortening, genetic instability, epigenetic alteration, and the accumulation of misfolded proteins represent the main hallmarks that cause perturbed cellular functions; this occurs in conjunction with the progression of the so-called “aging clocks”. Rejuvenation aims to influence the natural evolution of such aging clocks and to enhance regenerative capacity, thus overcoming the limitations of common anti-aging interventions. Current rejuvenation processes are based on heterochronic parabiosis, cell damage dilution through asymmetrical cell division, the excretion of extracellular vesicles, the modulation of genetic instability involving G-quadruplexes and DNA methylation, and cell reprogramming using Yamanaka factors and the actions of antioxidant species. In this context, we reviewed the most recent contributions that report on small molecules acting as senotherapeutics; these molecules act by promoting one or more of the abovementioned processes. Candidate drugs and natural compounds that are being studied as potential rejuvenation therapies act by interfering with CDGSH iron-sulfur domain 2 (CISD2) expression, G-quadruplex structures, DNA methylation, and mitochondrial decay. Moreover, direct and indirect antioxidants have been reported to counteract or revert aging through a combination of mixed mechanisms.
    Keywords DNA methylation ; antioxidants ; cell division ; epigenetics ; evolution ; excretion ; genetic instability ; mitochondria ; telomeres
    Language English
    Dates of publication 2023-0127
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12020288
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: From a Molecule to a Drug: Chemical Features Enhancing Pharmacological Potential.

    Ribaudo, Giovanni / Orian, Laura

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 13

    Abstract: Health is a fundamental human right and is a global goal to which extensive research effort is devoted in all fields [ ... ]. ...

    Abstract Health is a fundamental human right and is a global goal to which extensive research effort is devoted in all fields [...].
    Language English
    Publishing date 2022-06-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27134144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  9. Article ; Online: From a Molecule to a Drug

    Giovanni Ribaudo / Laura Orian

    Molecules, Vol 27, Iss 13, p

    Chemical Features Enhancing Pharmacological Potential

    2022  Volume 4144

    Abstract: Health is a fundamental human right and is a global goal to which extensive research effort is devoted in all fields [.] ...

    Abstract Health is a fundamental human right and is a global goal to which extensive research effort is devoted in all fields [.]
    Keywords n/a ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article: Cannabidiol preferentially binds TRPV2: a novel mechanism of action.

    Landucci, Elisa / Pellegrini-Giampietro, Domenico E / Gianoncelli, Alessandra / Ribaudo, Giovanni

    Neural regeneration research

    2022  Volume 17, Issue 12, Page(s) 2693–2694

    Language English
    Publishing date 2022-05-17
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.335821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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