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Article: In vitro

Anjum, Hina / Sofi, Ghulamuddin / Shahwan, Moyad / Khan, Mohd Shahnawaz / Shamsi, Anas / Shamsi, Shariq

2023 Volume 9, Issue 5, Page(s) e16154

Abstract: ... ...

Abstract	Panwad
Language	English
Publishing date	2023-05-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e16154
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: In vitro

Fathima A, Farhath / Khan, Imran / Irfhan N, Mohammed / Ahmed N, Zaheer / Anwar, Noman / Khan, Mohd Shahnawaz / Yadav, Dharmendra Kumar / Shamsi, Shariq / Shamsi, Anas

Heliyon

2024 Volume 10, Issue 3, Page(s) e25284

Abstract: ... ...

Abstract	Ustukhuddūs
Language	English
Publishing date	2024-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e25284
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Article ; Online: In vitro and In vivo study targeting the development of Unani Antidermatophytic Cream

Hina Anjum / Ghulamuddin Sofi / Moyad Shahwan / Mohd Shahnawaz Khan / Anas Shamsi / Shariq Shamsi

Heliyon, Vol 9, Iss 5, Pp e16154- (2023)

Implication of Herbal Formulations in Treatment of Dermatophytosis

2023

Abstract: Panwad (Cassia tora L.), Sarshaf (Brassica nigra L.) and Kunjad (Sesamum indicum L.) have been used in the treatment of ringworm infection since ancient times and are documented in classical literature of Unani Medicine. These plant drugs give promising ... ...

Abstract	Panwad (Cassia tora L.), Sarshaf (Brassica nigra L.) and Kunjad (Sesamum indicum L.) have been used in the treatment of ringworm infection since ancient times and are documented in classical literature of Unani Medicine. These plant drugs give promising results when used topically in the form of paste (zimad). Hence, the development and evaluation of a cream containing extracts of Tukhm-e-Panwad (Cassia tora L.), Sarshaf (Brassica nigra L.), and Kunjad (Sesamum indicum L.) was carried out to get better efficacy of the drugs. A total of 16 batches (F1–F16) of cream were prepared by adding varying concentrations of hydro-alcoholic extract of the drugs (20%, 40% and 50%) in water removable bases, and three batches were selected as final batches (F4-20%, F6-40% and F16-50%). In vitro antidermatophytic activity was conducted to optimize MIC against dermatophytosis-causing fungi. Dermal irritation of the prepared cream was determined in New Zealand Albino Rabbits. In vivo testing of the different concentrations of the prepared cream (20%, 40%, and 50%) was also carried out using Wistar rats to assess the antidermatophytic activity. Final batches showed good results in all the tested parameters and significant in vitro and in vivo antifungal activity in a dose-dependent manner. No microbial growth was seen in the prepared formulation. The study revealed significant antidermatophytic activity of the prepared cream against dermatophytosis-causing fungi. Hence, it can be concluded that the prepared cream can be an alternative topical agent with safe and effective antifungal activity for treating dermatophytosis.
Keywords	Chrysophanol ; Dermatophytosis ; Dermal irritation ; Ringworm ; Water removable base ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	630
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: In vitro and In vivo study targeting the development of Unani Antidermatophytic Cream: Implication of Herbal Formulations in Treatment of Dermatophytosis

Anjum, Ḥinā / Sofi, Ghulamuddin / Shahwan, Moyad / Khan, Mohd Shahnawaz / Shamsi, Anas / Shamsi, Shariq

Heliyon. 2023 May, v. 9, no. 5 p.e16154-

2023

Abstract	Panwad (Cassia tora L.), Sarshaf (Brassica nigra L.) and Kunjad (Sesamum indicum L.) have been used in the treatment of ringworm infection since ancient times and are documented in classical literature of Unani Medicine. These plant drugs give promising results when used topically in the form of paste (zimad). Hence, the development and evaluation of a cream containing extracts of Tukhm-e-Panwad (Cassia tora L.), Sarshaf (Brassica nigra L.), and Kunjad (Sesamum indicum L.) was carried out to get better efficacy of the drugs. A total of 16 batches (F1-F16) of cream were prepared by adding varying concentrations of hydro-alcoholic extract of the drugs (20%, 40% and 50%) in water removable bases, and three batches were selected as final batches (F4-20%, F6-40% and F16-50%). In vitro antidermatophytic activity was conducted to optimize MIC against dermatophytosis-causing fungi. Dermal irritation of the prepared cream was determined in New Zealand Albino Rabbits. In vivo testing of the different concentrations of the prepared cream (20%, 40%, and 50%) was also carried out using Wistar rats to assess the antidermatophytic activity. Final batches showed good results in all the tested parameters and significant in vitro and in vivo antifungal activity in a dose-dependent manner. No microbial growth was seen in the prepared formulation. The study revealed significant antidermatophytic activity of the prepared cream against dermatophytosis-causing fungi. Hence, it can be concluded that the prepared cream can be an alternative topical agent with safe and effective antifungal activity for treating dermatophytosis.
Keywords	Brassica nigra ; Senna tora ; Sesamum indicum ; antifungal properties ; cream ; dose response ; medicine ; microbial growth ; rabbits ; ringworm ; skin irritation ; Chrysophanol ; Dermatophytosis ; Dermal irritation ; Water removable base
Language	English
Dates of publication	2023-05
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e16154
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Antilithiatic activity of a non-pharmacopoeial Unani formulation in chemically induced urolithiasis in rats.

Parveen, Rehana / Wadud, Abdul / Shamsi, Shariq / Parveen, Shaista

Journal of complementary & integrative medicine

2021 Volume 18, Issue 4, Page(s) 685–694

Abstract: Objectives: Parshioshan: Methods: The experiment was carried out in Sprague Dawley rats divided into seven groups, serving as plain control, disease control, standard control, curative A and B and preventive A and B groups. Animals of plain control ... ...

Abstract	Objectives: Parshioshan Methods: The experiment was carried out in Sprague Dawley rats divided into seven groups, serving as plain control, disease control, standard control, curative A and B and preventive A and B groups. Animals of plain control received distilled water. Remaining six groups received Ethylene glycol 0.75% and Ammonium chloride 1% by adding in the drinking water for the first three days followed by 0.75% Ethylene glycol for 18 days. From 8th day till 21st day, standard control received Cystone in the dose of 750 mg/kg. Preventive and curative test groups were treated with hydroalcoholic extract of the test drug in the dose of 132 mg/kg and 264 mg/kg from 1st to 21st day and 8th to 21st day of calculi induction. Results: Test drug reduced the number of calcium oxalate crystals in the urine; the level of urinary calcium, creatinine, magnesium, phosphorus, sodium and chloride decreased significantly in standard and test groups. The urine volume increased significantly in all the test groups. The level of serum calcium, urea, phosphorus and creatinine were significantly reduced in all the test groups. Conclusions: These results indicated that the test drug reduced and prevented the growth of urinary stones. Moreover, the test drug also possessed significant antiurolithiatic activity. However, the protective effect was found more than its curative effect.
MeSH term(s)	Adiantum/chemistry ; Animals ; Apiaceae/chemistry ; Calcium Oxalate ; Kidney ; Physalis/chemistry ; Phytotherapy ; Plant Extracts/pharmacology ; Rats ; Rats, Sprague-Dawley ; Tribulus/chemistry ; Urolithiasis/chemically induced ; Urolithiasis/drug therapy
Chemical Substances	Plant Extracts ; Calcium Oxalate (2612HC57YE)
Language	English
Publishing date	2021-05-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2197618-1
ISSN	1553-3840 ; 2194-6329
ISSN (online)	1553-3840
ISSN	2194-6329
DOI	10.1515/jcim-2020-0426
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Original Research Article (Experimental): Design and Development of Unani Emulgel for Vitiligo

Shadab, Mohd / Shamsi, Shariq

Transdisciplinary University, Bangalore and World Ayurveda Foundation Journal of Ayurveda and integrative medicine. 2020 July, Sept., v. 11, no. 3

2020

Abstract: Vitiligo is not only a cosmetic problem, but also a social and psychological problem worldwide with the prevalence rate being highest in India. Treatment is unsatisfactory in Western System of Medicine. Unani System of Medicine (USM) possesses various ... ...

Abstract	Vitiligo is not only a cosmetic problem, but also a social and psychological problem worldwide with the prevalence rate being highest in India. Treatment is unsatisfactory in Western System of Medicine. Unani System of Medicine (USM) possesses various drugs to treat vitiligo in both topical and oral dosage forms. Safoof-e-Bars (SB) is an important powdered dosage form used widely to treat vitiligo, internally as Zulal. Externally as Sufl (Sediment remained after decanting the soaked drug) is used. Babchi, a component of SB, is reported to contain psoralen, an important therapeutically active compounds for treating vitiligo. But as Psoralen – the active marker compound is very slightly soluble in water, so only negligible amount of it comes in zulal and most of the amount remains in sufl. That might be the reason for local application of sufl as recommended by Hakeems. But clinically it is observed that application of sufl is not followed by most of the patients, due to side effects associated with its application on skin.The present study is designed to convert Safoof-e-Bars into a more convenient and appealing newly evolved dosage form ‘emulgel’ of same composition as of SB, so that it can be used by the patients easily without any side effects.Various batches of emulgel were prepared as preliminary batches and final batches using hydro-alcoholic extract of SB and different excipients in different concentrations. Preliminary batches were formed for selecting composition and concentration of extract and excipients for final batches. Total eight batches (F1F8) were prepared as final batches. Among these eight batches, batch F7 was selected as final batch, which was further evaluated on various parameters. Comparative quantitative analysis was done in Zulal, Hydro-alcoholic extract of SB and emulgel using HPLC.Optimized emulgel showed good result in physicochemical parameters. Highest percentage of psoralen was found in SB extract while lowest percentage was found in zulal. No growth of yeast and mould, and viable aerobic were found in emulgel on microbiological analysis. Emulgel was found to be stable for 3 months.Newly developed emulgel may be recommended with zulal instead of traditionally used sufl with zulal. In future emulgel will provide a solution for topical delivery of hydrophobic drugs and more convenient dosage form to apply locally.
Keywords	Ayurvedic medicine ; dosage forms ; drugs ; hydrophobicity ; oral administration ; psoralen ; quantitative analysis ; sediments ; yeasts ; India
Language	English
Dates of publication	2020-07
Size	p. 199-205.
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ISSN	0975-9476
DOI	10.1016/j.jaim.2018.01.006
Database	NAL-Catalogue (AGRICOLA)

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Article: Original Research Article (Experimental): Design and Development of Unani Emulgel for Vitiligo.

Shadab, Mohd / Shamsi, Shariq

Journal of Ayurveda and integrative medicine

2018 Volume 11, Issue 3, Page(s) 199–205

Abstract: Background: Vitiligo is not only a cosmetic problem, but also a social and psychological problem worldwide with the prevalence rate being highest in India. Treatment is unsatisfactory in Western System of Medicine. Unani System of Medicine (USM) ... ...

Abstract	Background: Vitiligo is not only a cosmetic problem, but also a social and psychological problem worldwide with the prevalence rate being highest in India. Treatment is unsatisfactory in Western System of Medicine. Unani System of Medicine (USM) possesses various drugs to treat vitiligo in both topical and oral dosage forms. Safoof-e-Bars (SB) is an important powdered dosage form used widely to treat vitiligo, internally as Zulal. Externally as Sufl (Sediment remained after decanting the soaked drug) is used. Babchi, a component of SB, is reported to contain psoralen, an important therapeutically active compounds for treating vitiligo. But as Psoralen - the active marker compound is very slightly soluble in water, so only negligible amount of it comes in zulal and most of the amount remains in sufl. That might be the reason for local application of sufl as recommended by Hakeems. But clinically it is observed that application of sufl is not followed by most of the patients, due to side effects associated with its application on skin. Objective: The present study is designed to convert Safoof-e-Bars into a more convenient and appealing newly evolved dosage form 'emulgel' of same composition as of SB, so that it can be used by the patients easily without any side effects. Materials & methods: Various batches of emulgel were prepared as preliminary batches and final batches using hydro-alcoholic extract of SB and different excipients in different concentrations. Preliminary batches were formed for selecting composition and concentration of extract and excipients for final batches. Total eight batches (F1F8) were prepared as final batches. Among these eight batches, batch F7 was selected as final batch, which was further evaluated on various parameters. Comparative quantitative analysis was done in Zulal, Hydro-alcoholic extract of SB and emulgel using HPLC. Results: Optimized emulgel showed good result in physicochemical parameters. Highest percentage of psoralen was found in SB extract while lowest percentage was found in zulal. No growth of yeast and mould, and viable aerobic were found in emulgel on microbiological analysis. Emulgel was found to be stable for 3 months. Conclusion: Newly developed emulgel may be recommended with zulal instead of traditionally used sufl with zulal. In future emulgel will provide a solution for topical delivery of hydrophobic drugs and more convenient dosage form to apply locally.
Language	English
Publishing date	2018-11-17
Publishing country	United States
Document type	Journal Article
ISSN	0975-9476
ISSN	0975-9476
DOI	10.1016/j.jaim.2018.01.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Homozygous CALR Mutation in Primary Myelofibrosis and Its Effect on Disease Phenotype: A Case Report and Review of the Literature.

Rizvi, Qurratulain / Zaidi, Uzma / Shahid, Saba / Ahmed, Shariq / Shamsi, Tahir

Case reports in hematology

2019 Volume 2019, Page(s) 1430170

Abstract: Somatic mutations ... ...

Abstract	Somatic mutations in
Language	English
Publishing date	2019-01-20
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627639-2
ISSN	2090-6579 ; 2090-6560
ISSN (online)	2090-6579
ISSN	2090-6560
DOI	10.1155/2019/1430170
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Article: A Novel Nonsense Mutation in

Shahid, Saba / Zaidi, Samreen / Ahmed, Shariq / Siddiqui, Saima / Abid, Aiysha / Malik, Shabbir / Shamsi, Tahir

Frontiers in genetics

2019 Volume 10, Page(s) 360

Abstract: Leukocyte adhesion deficiency-III (LAD3) is an extremely rare primary immunodeficiency disorder, transmitted with autosomal-recessive inheritance. It is caused by genetic alteration in ... ...

Abstract	Leukocyte adhesion deficiency-III (LAD3) is an extremely rare primary immunodeficiency disorder, transmitted with autosomal-recessive inheritance. It is caused by genetic alteration in the
Language	English
Publishing date	2019-04-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2019.00360
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Article ; Online: Sequencing of SARS-CoV-2 in local transmission cases through Oxford Nanopore MinION platform from Karachi Pakistan.

Mukry, Samina Naz / Ahmed, Shariq / Raza Bukhari, Ali / Shahni, Aneeta / Sufaida, Gul / Naz, Arshi / Shamsi, Tahir Sultan

Journal of infection in developing countries

2021 Volume 15, Issue 10, Page(s) 1376–1383

Abstract: Introduction: The first case of severe acute respiratory syndrome 2 (SARS-CoV-2) was imported to Pakistan in February 2020, since then 8,260 deaths have been witnessed. The virus has been constantly mutating and local transmission cases from different ... ...

Abstract	Introduction: The first case of severe acute respiratory syndrome 2 (SARS-CoV-2) was imported to Pakistan in February 2020, since then 8,260 deaths have been witnessed. The virus has been constantly mutating and local transmission cases from different countries vary due to host dependent viral adaptation. Many distinct clusters of variant SARS-CoV-2 have been defined globally. In this study, the epidemiology of SARS-CoV-2 was studied and locally transmitted SARS-CoV-2 isolates from Karachi were sequenced to compared and identify any possible variants. Methodology: The real time PCR was performed on nasopharyngeal specimen to confirm SARS-CoV-2 with Orf 1ab and E gene as targets. The virus isolates were sequenced through oxford nanopore technology MinION platform. Isolates from the first and second wave of COVID-19 outbreak in Karachi were compared. Results: The overall positivity rate for PCR was 26.24% with the highest number of positive cases in June. Approximately, 37.45% PCR positive subjects aged between 19-40 years. All the isolates belonged to GH clade and shared missense mutation D614G in spike protein linked to increased transmission rate worldwide. Another spike protein mutation A222V coexisted with D614G in the virus from the second wave of COVID-19. Conclusions: Based on the present findings it is suggested that the locally transmitted virus from Karachi varies from those reported from other parts of Pakistan. Slight variability was also observed between viruses from the first and second wave. Variability in any potential vaccine target may result in failed trials, therefore information on any local viral variants is always useful for effective vaccine design and/or selection.
MeSH term(s)	Adult ; COVID-19/epidemiology ; COVID-19/transmission ; COVID-19/virology ; Female ; Genome, Viral ; Humans ; Male ; Middle Aged ; Mutation ; Nanopores ; Nasopharynx/virology ; Pakistan ; Phylogeny ; Polymerase Chain Reaction ; SARS-CoV-2/genetics ; Whole Genome Sequencing/instrumentation ; Whole Genome Sequencing/methods ; Young Adult
Language	English
Publishing date	2021-10-31
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2394024-4
ISSN	1972-2680 ; 2036-6590
ISSN (online)	1972-2680
ISSN	2036-6590
DOI	10.3855/jidc.14900
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